Fabrication and characterization of porous hydroxyapatite microspheres by spray-drying method

Frontiers of Materials Science in China

Volumn 2, Issue 1, 2008, Pages 95-98

  Sun, Rui Xue ^a   Lu, Yu Peng ^b  

^a QINGDAO UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

Characterization; Hydroxyapatite (HA); Porous microspheres; Spray drying

Indexed keywords

EID: 41149123177     PISSN: 16737377     EISSN: 16737482     Source Type: Journal    
DOI: 10.1007/s11706-008-0017-5     Document Type: Article

References (14)

1. Mizushima Y, Ikoma T, Tanaka J, et al. Injectable porous hydroxyapatite microparticles as a new carrier for protein and lipophilic drugs. Journal of Controlled Release, 2006, 110(2): 260-265
2. He Q J, Huang Z L. Controlled growth and kinetics of porous hydroxyapatite spheres by a template-directed method. Journal of Crystal Growth, 2007, 300(2): 460-466
3. Murugan R, Ramakrishna S. Production of ultra-fine bioresorbable carbonated hydroxyapatite. Acta Biomaterialia, 2006, 2(2): 201-206
4. Ginebra M-P, Traykova T, Planell J A. Calcium phosphate cements: Competitive drug carriers for the musculoskeletal system? Biomaterials, 2006, 27(10): 2171-2177
5. Paul W, Nesamony J, Sharma C P. Delivery of insulin from hydroxyapatite ceramic microspheres: Preliminary in vivo studies. Journal of Biomedical Materials Research, 2002, 61(4): 660-662
6. Matsunoto T, Okazaki M, Inoue M, et al. Hydroxyapatite particles as a controlled release carrier of protein. Biomaterials, 2004, 25(17): 3807-3812
7. Sivakumar M, Rao K P. Preparation, characterization and in vitro release of gentamicin fromcoralline hydroxyapatite-gelatin composite microspheres. Biomaterials, 2002, 23(15): 3175-3181
8. Sun R X, Li M S, Lu Y P, et al. Dissolution behavior of hollow hydroxyapatite microspheres immersed in deionized water. Materials Research Bulletin, 2006, 41(6): 1138-1145
9. Paul W, Sharma C P. Development of porous spherical hydroxyapatite granules: application towards protein delivery. Journal of Materials Science: Materials in Medicine, 1999, 10(7): 383-388
10. Komlev V S, Barinov S M, Koplik E V. A method to fabricate porous spherical hydroxyapatite granules intended for time-controlled drug release. Biomaterials, 2002, 23(16): 3449-3454
11. Sunny M C, Ramesh P, Varma H K. Microstructured microspheres of hydroxyapatite bioceramic. Journal of Materials Science: Materials in Medicine, 2002, 13(7): 623-632
12. Patel N, Gibson I R, Ke S, et al. Calcining influence on the powder properties of hydroxyapatite. Journal of Materials Science: Materials in Medicine, 2001, 12(2): 181-188
13. Luo P, Nieh T G. Synthesis of ultrafine hydroxyapatite particles by a spray dry method. Materials Science and Engineering: C, 1995, 3(2): 75-78
14. Chang M C, Ko C-C, Douglas W H. Preparation of hydroxyapatite-gelatin nanocomposite. Biomaterials, 2003, 24(17): 2853-2862