Modifications of aliphatic side chain of 20(S)-ginsenoside Rg3 cause an enhancement or loss of brain Na+ channel current inhibitions

Biological and Pharmaceutical Bulletin

Volumn 31, Issue 3, 2008, Pages 480-486

  Lee, Jun Ho ^a   Choi, Sun Hye ^a   Lee, Byung Hwan ^a   Yoon, In Soo ^a   Shin, Tae Jun ^a   Pyo, Mi Kyung ^a   Lee, Sang Mok ^a   Rhim, Hyewhon ^b   Park, Myung Hwan ^c   Park, Tae Yoon ^c   Nah, Seung Yeol ^a  

^a Konkuk University   (South Korea)

^b Konkuk University   (South Korea)

^c Ambo Institute   (South Korea)

Author keywords

20(S) ginsenoside Rg3; Aliphatic side chain; Na V1.2 channel; Panax ginseng

Indexed keywords

ALIPHATIC COMPOUND; CARBOHYDRATE; GINSENOSIDE RG 3; SODIUM CHANNEL; SODIUM CHANNEL NAV1.2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG ACTIVITY; DRUG EFFECT; DRUG HYDROXYLATION; DRUG INHIBITION; DRUG STRUCTURE; NONHUMAN; OXYGENATION;

ANIMALS; BRAIN; ELECTROPHYSIOLOGY; GINSENOSIDES; ION CHANNEL GATING; MUTAGENESIS, SITE-DIRECTED; NERVE TISSUE PROTEINS; OOCYTES; PATCH-CLAMP TECHNIQUES; RATS; SODIUM CHANNELS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 41149123051     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.31.480     Document Type: Article

References (18)

1. Goldin A. L., Voltage-gated Na channels, "Ligand- and Voltage-Gated Ion Channels," CRC Press, Boca Raton, FL, 1995, pp. 73-89.
2. Stuart G. J., Sakmann B., Nature (London), 367, 60-72 (1994).
3. Jeong S. M., Lee J. H., Kim J. H., Lee B. H., Yoon I. S., Lee J. H., Kim D. H., Rhim H., Kim Y., Nah S.Y., Mol. Cells, 18, 383-389 (2004).
4. Lee J. H., Jeong S. M., Kim J. H., Lee B. H., Yoon I. S., Lee J. H., Choi S. H., Kim D. H., Rhim H., Kim S. S., Kim J. I., Jang C. G., Song J. H., Nah S. Y., Mol. Pharmacol., 68, 1114-1126 (2005).
5. Nah S. Y., Korea J. Ginseng Sci., 21, 1-12 (1997).
6. Dascal N., CRC Crit. Rev. Biochem., 22, 317-387 (1987).
7. Choi S., Jung S. Y., Ko Y. S., Koh S. R., Rhim H., Nah S. Y., Mol. Pharmacol., 61, 928-935 (2002).
8. Choi S., Lee J. H., Kim Y. I., Kang M. J., Rhim H., Lee S. M., Nah S. Y., Eur. J. Pharmacol., 468, 83-92 (2003).
9. Kim J. H., Lee J. H., Jeong S. M., Lee B. H., Yoon I. S., Lee J. H., Choi S. H., Kim D. H., Park T. K., Kim B. K., Nah S. Y., Biol. Pharm. Bull., 29, 365-370 (2006).
10. Lansman J. B., Hess P., Tsien R. W., J. Gen. Physiol., 88, 321-347 (1986).
11. Pugsley M. K., Goldin A. L., Eur. J. Pharmacol., 342, 93-104 (1998).
12. Pugsley M. K., Yu E. J., Goldin A. L., Gen. Pharmacol., 34, 417-427 (2000).
13. Hondeghem L. M., Katzung B. G., Annu. Rev. Pharmacol. Toxicol., 24, 387-423 (1984).
14. Claydon T. W., Boyett M. R., Sivaprasadarao A., Orchard C. H., Am. J. Physiol. Cell. Physiol., 283, C1114-C1121 (2002).
15. Kang D. I., Lee J. Y., Yang J. Y., Jeong S. M., Lee J. H., Nah S. Y., Kim Y., Biochem. Biophys. Res. Commun., 333, 1194-1201 (2005).
16. Xie H. T., Wang G. J., Sun J. G., Tucker I., Zhao X. C., Xie Y. Y., Li H., Jiang X. L., Wang R., Xu M. J., Wang W., J. Chromatogr. B, 818, 167-173 (2005).
17. Qian T., Cai Z., Wong R. N., Mak N. K., Jiang Z. H., J. Chromatogr. B, 816, 223-232 (2005).
18. Tachikawa E., Kudo K., Kashimoto T., Takahashi E., J. Pharm. Exp. Ther., 273, 629-636 (1995).