Spiradoline, a kappa opioid receptor agonist, produces tonic- and use-dependent block of sodium channels expressed in Xenopus oocytes

General Pharmacology: The Vascular System

Volumn 34, Issue 6, 2000, Pages 417-427

  Pugsley, Michael K ^a   Yu, Esther J ^a   Goldin, Alan L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Local anesthetic; Membrane currents; Sodium channel; Spiradoline; Xenopus oocyte

Indexed keywords

KAPPA OPIATE RECEPTOR AGONIST; SODIUM CHANNEL; SPIRADOLINE;

ANIMAL CELL; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING; DRUG EFFECT; DRUG STRUCTURE; FEMALE; HEART ELECTROPHYSIOLOGY; HYPERPOLARIZATION; LOCAL ANESTHESIA; MEMBRANE STEADY POTENTIAL; NERVE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RAT; XENOPUS LAEVIS;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; CELL MEMBRANE; FEMALE; HEART; MODELS, ANIMAL; OOCYTES; PATCH-CLAMP TECHNIQUES; PYRROLIDINES; RATS; RECEPTORS, OPIOID, KAPPA; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; XENOPUS;

EID: 0034434816     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(01)00079-9     Document Type: Article

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