The Effects of Endogenous Sex Hormones and Acute Hypoxia on Vasoconstriction in Isolated Rat Pulmonary Artery Rings

Journal of Surgical Research

Volumn 146, Issue 1, 2008, Pages 121-126

  Patel, Ketan M ^a   Lahm, Tim ^a   Crisostomo, Paul R ^a   Herring, Christine ^a   Markel, Troy ^a   Wang, Meijing ^a   Meldrum, Daniel R ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

estrogen; gender differences; hypoxic pulmonary vasoconstriction; sex hormones; testosterone

Indexed keywords

SEX HORMONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CASTRATION; CONTROLLED STUDY; DEPLETION; FEMALE; HYPOXIC LUNG VASOCONSTRICTION; MALE; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; VASODILATATION;

ANALYSIS OF VARIANCE; ANIMALS; CELL HYPOXIA; ESTROGENS; FEMALE; GONADAL STEROID HORMONES; MALE; ORCHIECTOMY; OVARIECTOMY; PHENYLEPHRINE; PULMONARY ARTERY; RATS; RATS, SPRAGUE-DAWLEY; SEX CHARACTERISTICS; TESTOSTERONE; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS;

EID: 41149117045     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2007.05.023     Document Type: Article

References (45)

1. Leinwand L.A. Sex is a potent modifier of the cardiovascular system. J Clin Invest 112 (2003) 302
2. Wang M., Crisostomo P., Wairiuko G.M., et al. Estrogen receptor-alpha mediates acute myocardial protection in females. Am J Physiol Heart Circ Physiol 290 (2006) H2204
3. Wang M., Tsai B.M., Crisostomo P.R., et al. Tumor necrosis factor receptor 1 signaling resistance in the female myocardium during ischemia. Circulation 114 (2006) I282
4. Rubin L.J. Primary pulmonary hypertension. N Engl J Med 336 (1997) 111
5. McLaughlin V.V., and McGoon M.D. Pulmonary arterial hypertension. Circulation 114 (2006) 1417
6. Gaine S.P., and Rubin L.J. Primary pulmonary hypertension. Lancet 352 (1998) 719
7. Rabinovitch M., Gamble W.J., Miettinen O.S., et al. Age and sex influence on pulmonary hypertension of chronic hypoxia and on recovery. Am J Physiol 240 (1981) H62
8. Sunyer J., Anto J.M., McFarlane D., et al. Sex differences in mortality of people who visited emergency rooms for asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 158 (1998) 851
9. Resta T.C., Kanagy N.L., and Walker B.R. Estradiol-induced attenuation of pulmonary hypertension is not associated with altered eNOS expression. Am J Physiol Lung Cell Mol Physiol 280 (2001) L88
10. Earley S., and Resta T.C. Estradiol attenuates hypoxia-induced pulmonary endothelin-1 gene expression. Am J Physiol Lung Cell Mol Physiol 283 (2002) L86
11. Sullivan J.C., and Davison C.A. Gender differences in the effect of age on electrical field stimulation (EFS)-induced adrenergic vasoconstriction in rat mesenteric resistance arteries. J Pharmacol Exp Ther 296 (2001) 782
12. Matteis M., Troisi E., Monaldo B.C., et al. Age and sex differences in cerebral hemodynamics: A transcranial Doppler study. Stroke 29 (1998) 963
13. English K.M., Jones R.D., Jones T.H., et al. Gender differences in the vasomotor effects of different steroid hormones in rat pulmonary and coronary arteries. Horm Metab Res 33 (2001) 645
14. Warner M., and Gustafsson J.A. Nongenomic effects of estrogen: Why all the uncertainty. Steroids 71 (2006) 91
15. Kauser K., and Rubanyi G.M. Potential cellular signaling mechanisms mediating upregulation of endothelial nitric oxide production by estrogen. J Vasc Res 34 (1997) 229
16. Gonzales R.J., and Kanagy N.L. Endothelium-independent relaxation of vascular smooth muscle by 17beta-estradiol. J Cardiovasc Pharmacol Ther 4 (1999) 227
17. Gonzales R.J., Walker B.R., and Kanagy N.L. 17beta-estradiol increases nitric oxide-dependent dilation in rat pulmonary arteries and thoracic aorta. Am J Physiol Lung Cell Mol Physiol 280 (2001) L555
18. Ihionkhan C.E., Chambliss K.L., Gibson L.L., et al. Estrogen causes dynamic alterations in endothelial estrogen receptor expression. Circ Res 91 (2002) 814
19. Wang M., Tsai B.M., Kher A., et al. Role of endogenous testosterone in myocardial proinflammatory and proapoptotic signaling after acute ischemia-reperfusion. Am J Physiol Heart Circ Physiol 288 (2005) H221
20. Crisostomo P.R., Wang M., Wairiuko G.M., et al. Brief exposure to exogenous testosterone increases death signaling and adversely affects myocardial function after ischemia. Am J Physiol Regul Integr Comp Physiol 290 (2006) R1168
21. English K.M., Jones R.D., Jones T.H., et al. Testosterone acts as a coronary vasodilator by a calcium antagonistic action. J Endocrinol Invest 25 (2002) 455
22. Jones R.D., English K.M., Pugh P.J., et al. Pulmonary vasodilatory action of testosterone: Evidence of a calcium antagonistic action. J Cardiovasc Pharmacol 39 (2002) 814
23. Wetzel R.C., and Sylvester J.T. Gender differences in hypoxic vascular response of isolated sheep lungs. J Appl Physiol 55 (1983) 100
24. Wetzel R.C., Zacur H.A., and Sylvester J.T. Effect of puberty and estradiol on hypoxic vasomotor response in isolated sheep lungs. J Appl Physiol 56 (1984) 1199
25. Gordon J.B., Wetzel R.C., McGeady M.L., et al. Effects of indomethacin on estradiol-induced attenuation of hypoxic vasoconstriction in lamb lungs. J Appl Physiol 61 (1986) 2116
26. Wang M., Tsai B.M., Reiger K.M., et al. 17-beta-Estradiol decreases p38 MAPK-mediated myocardial inflammation and dysfunction following acute ischemia. J Mol Cell Cardiol 40 (2006) 205
27. Chaouat A., Bugnet A.S., Kadaoui N., et al. Severe pulmonary hypertension and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 172 (2005) 189
28. Farhat M.Y., Chen M.F., Bhatti T., et al. Protection by oestradiol against the development of cardiovascular changes associated with monocrotaline pulmonary hypertension in rats. Br J Pharmacol 110 (1993) 719
29. Parker T.A., Ivy D.D., Galan H.L., et al. Estradiol improves pulmonary hemodynamics and vascular remodeling in perinatal pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 278 (2000) L374
30. Hampl V., Bibova J., Ostadalova I., et al. Gender differences in the long-term effects of perinatal hypoxia on pulmonary circulation in rats. Am J Physiol Lung Cell Mol Physiol 285 (2003) L386
31. Bonnet S., Dumas-de-La-Roque E., Begueret H., et al. Dehydroepiandrosterone (DHEA) prevents and reverses chronic hypoxic pulmonary hypertension. Proc Natl Acad Sci USA 100 (2003) 9488
32. Tsai B.M., Wang M., Pitcher J.M., et al. Hypoxic pulmonary vasoconstriction and pulmonary artery tissue cytokine expression are mediated by protein kinase C. Am J Physiol Lung Cell Mol Physiol 287 (2004) L1215
33. Liu S.F., Dewar A., Crawley D.E., et al. Effect of tumor necrosis factor on hypoxic pulmonary vasoconstriction. J Appl Physiol 72 (1992) 1044
34. Ertel W., Morrison M.H., Ayala A., et al. Hypoxemia in the absence of blood loss or significant hypotension causes inflammatory cytokine release. Am J Physiol 269 (1995) R160
35. Ward J.P., Knock G.A., Snetkov V.A., et al. Protein kinases in vascular smooth muscle tone-role in the pulmonary vasculature and hypoxic pulmonary vasoconstriction. Pharmacol Ther 104 (2004) 207
36. Morrell E.D., Tsai B.M., Crisostomo P.R., et al. Experimental therapies for hypoxia-induced pulmonary hypertension during acute lung injury. Shock 25 (2006) 214
37. Stevens T., Janssen P.L., and Tucker A. Acute and long-term TNF-alpha administration increases pulmonary vascular reactivity in isolated rat lungs. J Appl Physiol 73 (1992) 708
38. Morrell E.D., Tsai B.M., Crisostomo P.R., et al. Therapeutic concepts for hypoxic pulmonary vasoconstriction involving ion regulation and the smooth muscle contractile apparatus. J Mol Cell Cardiol 40 (2006) 751
39. Morrell E.D., Tsai B.M., Wang M., et al. p38 mitogen-activated protein kinase mediates the sustained phase of hypoxic pulmonary vasoconstriction and plays a role in phase I vasodilation. J Surg Res 134 (2006) 335
40. Yue P., Chatterjee K., Beale C., et al. Testosterone relaxes rabbit coronary arteries and aorta. Circulation 91 (1995) 1154
41. Hakim T.S., and Mortola J.P. Pulmonary vascular resistance in adult rats exposed to hypoxia in the neonatal period. Can J Physiol Pharmacol 68 (1990) 419
42. Hampl V., and Herget J. Perinatal hypoxia increases hypoxic pulmonary vasoconstriction in adult rats recovering from chronic exposure to hypoxia. Am Rev Respir Dis 142 (1990) 619
43. Keith I.M., Tjen A.L.S., Kraiczi H., et al. Three-week neonatal hypoxia reduces blood CGRP and causes persistent pulmonary hypertension in rats. Am J Physiol Heart Circ Physiol 279 (2000) H1571
44. Packer C.S., Johnson T.C., Vijay P., et al. Gender differences in pulmonary arterial reactivity to dilatory agonists in pulmonary hypertension. J Gend Specif Med 6 (2003) 30
45. Hubscher C.H., Brooks D.L., and Johnson J.R. A quantitative method for assessing stages of the rat estrous cycle. Biotech Histochem 80 (2005) 79