Myosin IIA is required for neurite outgrowth inhibition produced by repulsive guidance molecule

Journal of Neurochemistry

Volumn 105, Issue 1, 2008, Pages 113-126

  Kubo, Takekazu ^a,b   Endo, Mitsuharu ^a   Hata, Katsuhiko ^a   Taniguchi, Junko ^a,b   Kitajo, Keiko ^a   Tomura, Sayaka ^a,b   Yamaguchi, Atsushi ^a   Mueller, Bernhard K ^c   Yamashita, Toshihide ^a,b  

^a CHIBA UNIVERSITY   (Japan)

^b BioClues Inc   (Japan)

^c ABBOTT GMBH AND CO KG   (Germany)

Author keywords

Axon; Myosin II; Repulsive guidance molecule; Rho; Rho kinase; Spinal cord injury

Indexed keywords

BLEBBISTATIN; ISOPROTEIN; MEMBRANE PROTEIN; MYOSIN IIA; MYOSIN IIB; MYOSIN LIGHT CHAIN; PROTEIN RGMA; RHO KINASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GRANULE CELL; GROWTH CONE; GROWTH INHIBITION; NERVE CELL; NERVE FIBER; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; SPINAL CORD INJURY;

ACTINS; ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; CEREBELLUM; FEMALE; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; IMMUNOPRECIPITATION; IN SITU NICK-END LABELING; LAMINECTOMY; MEMBRANE GLYCOPROTEINS; MYOSIN LIGHT CHAINS; MYOSIN TYPE II; NERVE TISSUE PROTEINS; NEURAL INHIBITION; NEURITES; NEURONS; PHOSPHORYLATION; RATS; RATS, WISTAR; RHO-ASSOCIATED KINASES; RNA, SMALL INTERFERING; TRANSFECTION;

RATTUS;

EID: 41149110043     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2007.05125.x     Document Type: Article

References (36)

1. Alabed Y. Z., Grados-Munro E., Ferraro G. B., Hsieh S. H. Fournier A. E. (2006) Neuronal responses to myelin are mediated by rho kinase. J. Neurochem. 96, 1616 1625.
2. Amano M., Ito M., Kimura K., Fukata Y., Chihara K., Nakano T., Matsuura Y. Kaibuchi K. (1996) Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J. Biol. Chem. 271, 20246 20249.
3. Amano M., Chihara K., Nakamura N., Fukata Y., Yano T., Shibata M., Ikebe M. Kaibuchi K. (1998) Myosin II activation promotes neurite retraction during the action of Rho and Rho-kinase. Genes Cells 3, 177 188.
4. Brown M. E. Bridgman P. C. (2004) Myosin function in nervous and sensory systems. J. Neurobiol. 58, 118 130.
5. Diefenbach T. J., Latham V. M., Yimlamai D., Liu C. A., Herman I. M. Jay D. G. (2002) Myosin 1c and myosin IIB serve opposing roles in lamellipodial dynamics of the neuronal growth cone. J. Cell Biol. 158, 1207 1217.
6. Drescher U., Bonhoeffer F. Muller B. K. (1997) The Eph family in retinal axon guidance. Curr. Opin. Neurobiol. 7, 75 80.
7. Dubreuil C. I., Winton M. J. McKerracher L. (2003) Rho activation patterns after spinal cord injury and the role of activated Rho in apoptosis in the central nervous system. J. Cell Biol. 162, 233 243.
8. Fritsche J., Reber B. F., Schindelholz B. Bandtlow C. E. (1999) Differential cytoskeletal changes during growth cone collapse in response to hSema III and thrombin. Mol. Cell. Neurosci. 14, 398 418.
9. Gallo G. (2004) Myosin II activity is required for severing-induced axon retraction in vitro. Exp. Neurol. 189, 112 121.
10. Gallo G. Letourneau P. C. (2004) Regulation of growth cone actin filaments by guidance cues. J. Neurobiol. 58, 92 102.
11. Gallo G., Yee Jr. H. F. Letourneau P. C. (2002) Actin turnover is required to prevent axon retraction driven by endogenous actomyosin contractility. J. Cell Biol. 158, 1219 1228.
12. Hata K., Fujitani M., Yasuda Y., Doya H., Saito T., Yamagishi S., Mueller B. K. Yamashita T. (2006) RGMa inhibition promotes axonal growth and recovery after spinal cord injury. J. Cell Biol. 173, 47 58.
13. Hsieh S. H. K., Ferraro G. B. Fournier A. E. (2006) Myelin-associated inhibitors regulate cofilin phosphorylation and neuronal inhibition through LIM kinase and Slingshot phosphatase. J. Neurosci. 26, 1006 1015.
14. Ikebe M. Hartshorne D. J. (1985) Phosphorylation of smooth muscle myosin at two distinct sites by myosin light chain kinase. J. Biol. Chem. 260, 10027 10031.
15. Ikebe M., Hartshorne D. J. Elzinga M. (1986) Identification, phosphorylation, and dephosphorylation of a second site for myosin light chain kinase on the 20,000-dalton light chain of smooth muscle myosin. J. Biol. Chem. 261, 36 39.
16. Kawamoto S. Adelstein R. S. (1991) Chicken nonmuscle myosin heavy chains: differential expression of two mRNAs and evidence for two different polypeptides. J. Cell Biol. 112, 915 924.
17. Kimura K., Ito M., Amano M. et al. (1996) Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 273, 245 248.
18. Limouze J., Straight A. F., Mitchison T. Sellers J. R. (2004) Specificity of blebbistatin, an inhibitor of myosin II. J. Muscle Res. Cell Motil. 25, 337 341.
19. Madura T., Yamashita T., Kubo T., Fujitani M., Hosokawa K. Tohyama M. (2004) Activation of Rho in the injured axons following spinal cord injury. EMBO Rep. 5, 412 417.
20. Medeiros N. A., Burnette D. T. Forscher P. (2006) Myosin II functions in actin-bundle turnover in neuronal growth cones. Nat. Cell Biol. 8, 215 226.
21. Mimura F., Yamagishi S., Arimura N., Fujitani M., Kubo T., Kaibuchi K. Yamashita T. (2006) Myelin-associated glycoprotein inhibits microtubule assembly by a Rho-kinase-dependent mechanism. J. Biol. Chem. 281, 15970 15979.
22. Monnier P. P., Sierra A., Macchi P. et al. (2002) RGM is a repulsive guidance molecule for retinal axons. Nature 419, 392 395.
23. Mueller B. K., Mack H. Teusch N. (2005) Rho kinase, a promising drug target for neurological disorders. Nat. Rev. Drug Discov. 4, 387 398.
24. Niederkofler V., Salie R., Sigrist M. Arber S. (2004) Repulsive guidance molecule (RGM) gene function is required for neural tube closure but not retinal topography in the mouse visual system. J. Neurosci. 24, 808 818.
25. Rochlin M. W., Itoh K., Adelstein R. S. Bridgman P. C. (1995) Localization of myosin II A and B isoforms in cultured neurons. J. Cell Sci. 108, 3661 3670.
26. Ryu J., Liu L., Wong T. P., Wu D. C., Burette A., Weinberg R., Wang Y. T. Sheng M. (2006) A critical role for myosin IIb in dendritic spine morphology and synaptic function. Neuron 49, 175 182.
27. Sakurada K., Seto M. Sasaki Y. (1998) Dynamics of myosin light chain phosphorylation at Ser19 and Thr18/Ser19 in smooth muscle cells in culture. Am. J. Physiol. 274, C1563 C1572.
28. Sandquist J. C., Swenson K. I., Demali K. A., Burridge K. Means A. R. (2006) Rho kinase differentially regulates phosphorylation of nonmuscle myosin II isoforms A and B during cell rounding and migration. J. Biol. Chem. 281, 35873 35883.
29. Schmidtmer J. Engelkamp D. (2004) Isolation and expression pattern of three mouse homologues of chick Rgm. Gene Expr. Patterns 4, 105 110.
30. Schwab J. M., Conrad S., Monnier P. P., Julien S., Mueller B. K. Schluesener H. J. (2005a) Spinal cord injury-induced lesional expression of the repulsive guidance molecule (RGM). Eur. J. Neurosci. 21, 1569 1576.
31. Schwab J. M., Monnier P. P., Schluesener H. J., Conrad S., Beschorner R., Chen L., Meyermann R. Mueller B. K. (2005b) Central nervous system injury-induced repulsive guidance molecule expression in the adult human brain. Arch. Neurol. 62, 1561 1568.
32. Straight A. F., Cheung A., Limouze J., Chen I., Westwood N. J., Sellers J. R. Mitchison T. J. (2003) Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor. Science 299, 1743 1747.
33. Tullio A. N., Bridgman P. C., Tresser N. J., Chan C. C., Conti M. A., Adelstein R. S. Hara Y. (2001) Structural abnormalities develop in the brain after ablation of the gene encoding nonmuscle myosin II-B heavy chain. J. Comp. Neurol. 433, 62 74.
34. Turney S. G. Bridgman P. C. (2005) Laminin stimulates and guides axonal outgrowth via growth cone myosin II activity. Nat. Neurosci. 8, 717 719.
35. Wylie S. R., Wu P. J., Patel H. Chantler P. D. (1998) A conventional myosin motor drives neurite outgrowth. Proc. Natl Acad. Sci. USA 95, 12967 12972.
36. Yamashita T., Fujitani M., Yamagishi S., Hata K. Mimura F. (2005) Multiple signals regulate axon regeneration through the Nogo receptor complex. Mol. Neurobiol. 32, 105 111.