CD44 gene vaccination for insulin-dependent diabetes mellitus in non-obese diabetic mice

Israel Medical Association Journal

Volumn 10, Issue 1, 2008, Pages 20-25

  Weiss, Lola ^a   Botero Anug, Ana Maria ^b   Hand, Carla ^c   Slavin, Shimon ^a   Naor, David ^d  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c Kenneth S Warren Institute   (United States)

^d HEBREW UNIVERSITY   (Israel)

Author keywords

Adhesion molecules; Autoimmunity; cDNA; Type 1diabetes; Vaccination; Virtual lymph nodes

Indexed keywords

CD44V ANTIGEN; DNA VACCINE; HERMES ANTIGEN; PLASMID DNA; POLYVINYL ACETATE; SILICONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL TRANSFER; CELLULAR IMMUNITY; CONTROLLED STUDY; DNA IMMUNIZATION; FEMALE; HISTOPATHOLOGY; IMMUNOREACTIVITY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS ISLET; SPLEEN CELL; ANIMAL; GENETICS; IMMUNOLOGY; METABOLISM; METHODOLOGY; PANCREAS; PATHOLOGY; VACCINATION;

ANIMALS; ANTIGENS, CD44; DIABETES MELLITUS, TYPE 1; FEMALE; ISLETS OF LANGERHANS; MALE; MICE; PANCREAS; VACCINATION; VACCINES, DNA;

EID: 41149101607     PISSN: 15651088     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Naor D, Nedvetzki S, Golan I, et al. CD44 in Cancer. Crit Rev Clin Lab Sci 2002;39:527-79.
2. Lesley J, Hyman R, Kincade PW. CD44 and its interaction with extracellular matrix. Adv Immunol 1993;54:271-335.
3. Naor D, Vgt-Sionov R, Ish-Shalom D. CD44: structure, function, and association with the malignant process. Adv Cancer Res 1997; 71:241-319.
4. Ponta H, Sherman L, Herrlich PA. D44: from adhesion molecules to signaling regulators. Nat Rev Mol Cell Biol 2003;4:33-45.
5. Van Weering DH, Baas PD, Bos JL. A PCR-based method for the analysis of human CD44 splice products. PCR Methods Appl 1993;3: 100-6.
6. Hofmann M, Rudy W, Zoller M, et al. CD44 splice variants confer metastatic behavior in rats: homologous sequences are expressed in human tumor cell lines. Cancer Res 1991;51:5292-7.
7. Nedvetzki S, Golan I, Assayag N, et al. A mutation in a CD44 variant of inflammatory cells enhances the mitogenic interaction of FGF with its receptor. J Clin Invest 2003;111:1211-20.
8. Eshkar Sebban L, Ronen D, Levartovsky D, et al. The involvement of CD44 and its novel ligand galectin-8 in apoptotic regulation of autoimmune inflammation. J Immunol 2007;179:1225-35.
9. Golan I, Nedvetzki S, Golan I, et al. Expression of extra trinucleotide in CD44 variant of rheumatoid arthritis patients allows generation of disease-specific monoclonal antibody. J Autoimmun 2007;28:99-113.
10. Zahalka MA, Okon E, Gosslar U, Holzmann B, Naor D. Lymph node (but not spleen) invasion by murine lymphoma is both CD44 and hyaluronate-dependent. J Immunol 1995;154:5345-55.
11. Bach JF. Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr Rev 1994;15:516-42.
12. Castano L, Eisenbarth GS. Type-1 diabetes: a chronic autoimmune disease of human, mouse, and rat. Annu Rev Immunol 1990; 8:647-79.
13. Tisch R, McDevitt HO. Insulin dependent diabetes mellitus. Cell 1996;85:291-7.
14. Delovitch T, Singh B. The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD. Immunity 1997;7:727-38.
15. Tisch R, Yang XD, Singer SM, Liblau RS, Fugger L, McDevitt HO. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 1993;366:72-5.
16. Kaufman DL, Clare-Salzler M, Tian J, et al. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulindependent diabetes. Nature 1993;366:69-72.
17. Weiss L, Slavin S, Reich S, et al. Induction of resistance to diabetes in non-obese diabetic mice by targeting CD44 with specific monoclonal antibody. Proc Natl Acad Sci USA 2000;97:285-90.
18. Garin T, Rubinstein A, Grigoriadis N, et al. CD44 variant DNA vaccination with virtual lymph node ameliorates experimental autoimmune encephalomyelitis through the induction of apoptosis. J Neurol Sci 2007;258:17-26.
19. Wallach-Dayan SB, Grabovsky V, Moll J, et al. CD44-dependent lymphoma cell dissemination: a cell surface CD44 variant, rather than standard CD44, supports in vitro lymphoma cell rolling on hyaluronic acid substrate and its in vivo accumulation in the peripheral lymph nodes. J Cell Sci 2001;114:3463-77.
20. Gurunathan S, Klinman DM, Seder RA. DNA vaccines: immunology, application and optimization. Annu Rev Immunol 2000;18:927-74.
21. Balasa B, Boehm BO, Fortnagel A, et al. Vaccination with glutamic acid decarboxylase plasmid DNA protects mice from spontaneous autoimmune diabetes and B7/CD28 costimulation circumvents that protection. Clin Immunol 2001;99:241-52.
22. Tisch R, Wang B, Weaver DJ, et al. Antigen-specific mediated suppression of beta cell autoimmunity by plasmid DNA vaccination. J Immunol 2001;166:2122-32.
23. Li A, Ojogho O, Franco E, Baron P, Iwaki Y, Escher A. Pro-apoptotic DNA vaccination ameliorates new onset of autoimmune diabetes in NOD mice and induces foxp3+ regulatory T cells in vitro. Vaccine 2006;24:5036-46.
24. Chang Y, Yap S, Ge X, et al. DNA vaccination with an insulin construct and a chimeric protein binding to both CTLA4 and CD40 ameliorates type 1 diabetes in NOD mice. Gene Ther 2005; 12:1679-85.
25. Baker D, Hankey DJ. Gene therapy in autoimmune, demyelinating disease of the central nervous system. Gene Ther 2003;10:844-53.
26. Jégou JF, Chan P, Schouft MT, et al. Protective DNA vaccination against myelin oligodendrocyte glycoprotein is overcome by C3d in experimental autoimmune encephalomyelitis. Mol Immunol 2007; 44:3691-701.
27. Gregor PD, Wolchok JD, Ferrone CR, et al. CTLA-4 blockade in combination with xenogeneic DNA vaccines enhances T-cell responses, tumor immunity and autoimmunity to self antigens in animal and cellular model systems. Vaccine 2004;22:1700-8.
28. Pupa SM, Iezzi M, Di Carlo E, et al. Inhibition of mammary carcinoma development in HER-2/neu transgenic mice through induction of autoimmunity by xenogeneic DNA vaccination. Cancer Res 2005;65:1071-8.
29. Encke J, Bernardin J, Geib J, Barbakadze G, Bujdoso R, Stremmel W. Genetic vaccination with Flt3-L and GM-CSF as adjuvants: enhancement of cellular and humoral immune responses that results in protective immunity in a murine model of hepatitis C virus infection. World J Gastroenterol; 2006;12:7118-25.