-
1
-
-
0042524191
-
Evolution of sporadic isolates of methicillin-resistant Staphylococcus aureus (MRSA) in hospitals and their similarities to isolates of community-acquired MRSA
-
Aires de Sousa, M., and H. de Lencastre. 2003. Evolution of sporadic isolates of methicillin-resistant Staphylococcus aureus (MRSA) in hospitals and their similarities to isolates of community-acquired MRSA. J. Clin. Microbiol. 41:3806-3815.
-
(2003)
J. Clin. Microbiol
, vol.41
, pp. 3806-3815
-
-
Aires de Sousa, M.1
de Lencastre, H.2
-
2
-
-
34248351181
-
Molecular epidemiology of methicillin-resistant Staphylococcus aureus in Majorcan hospitals: High prevalence of the epidemic clone EMRSA-15
-
Alcoceba, E., A. Mena, M. Cruz Perez, E. Ruiz de Gopegui, E. Padilla, J. Gil, A. Ramirez, C. Gallegos, A. Serra, J.L. Perez, and A. Oliver. 2007. Molecular epidemiology of methicillin-resistant Staphylococcus aureus in Majorcan hospitals: high prevalence of the epidemic clone EMRSA-15. Clin. Microbiol. Infect. 13:599-605.
-
(2007)
Clin. Microbiol. Infect
, vol.13
, pp. 599-605
-
-
Alcoceba, E.1
Mena, A.2
Cruz Perez, M.3
Ruiz de Gopegui, E.4
Padilla, E.5
Gil, J.6
Ramirez, A.7
Gallegos, C.8
Serra, A.9
Perez, J.L.10
Oliver, A.11
-
3
-
-
34548702625
-
Changes in the clonal nature and antibiotic resistance profiles in methicillin-resistant Staphylococcus aureus isolates associated with the spread of EMRSA-15 clone in a tertiary-care Portuguese hospital
-
Amorim, M.L., N.A. Faria, D.C. Oliveira, C. Vasconcelos, J.C. Cabeda, A.C. Mendes, E. Calado, A.P. Castro, M.H. Ramos, J.M. Amorim, and H. de Lencastre. 2007. Changes in the clonal nature and antibiotic resistance profiles in methicillin-resistant Staphylococcus aureus isolates associated with the spread of EMRSA-15 clone in a tertiary-care Portuguese hospital. J. Clin. Microbiol. 45:2881-2888.
-
(2007)
J. Clin. Microbiol
, vol.45
, pp. 2881-2888
-
-
Amorim, M.L.1
Faria, N.A.2
Oliveira, D.C.3
Vasconcelos, C.4
Cabeda, J.C.5
Mendes, A.C.6
Calado, E.7
Castro, A.P.8
Ramos, M.H.9
Amorim, J.M.10
de Lencastre, H.11
-
4
-
-
0033664479
-
-
Chung, M., H. de Lencastre, P. Matthews, A. Tomasz, I. Adamsson, M. Aires de Sousa, T. Camou, C. Cocuzza, A. Corso, I. Couto, A. Dominguez, M. Gniadkowski, R. Goering, A. Gomes, K. Kikuchi, A. Marchese, R. Mato, O. Melter, D. Oliveira, R. Palacio, R. Sa-Leao, I. Santos Sanches, J.H. Song, P.T. Tassios, and P. Villari. 2000. Molecular typing of methicillin-resistant Staphylococcus aureus by pulsed-field gel electrophoresis: comparison of results obtained in a multilaboratory effort using identical protocols and MRSA strains. Microb. Drug Resist. 6:189-198.
-
Chung, M., H. de Lencastre, P. Matthews, A. Tomasz, I. Adamsson, M. Aires de Sousa, T. Camou, C. Cocuzza, A. Corso, I. Couto, A. Dominguez, M. Gniadkowski, R. Goering, A. Gomes, K. Kikuchi, A. Marchese, R. Mato, O. Melter, D. Oliveira, R. Palacio, R. Sa-Leao, I. Santos Sanches, J.H. Song, P.T. Tassios, and P. Villari. 2000. Molecular typing of methicillin-resistant Staphylococcus aureus by pulsed-field gel electrophoresis: comparison of results obtained in a multilaboratory effort using identical protocols and MRSA strains. Microb. Drug Resist. 6:189-198.
-
-
-
-
5
-
-
41149145506
-
-
Clinical and Laboratory Standards Institute. 2006. Performance Standards for Antimicrobial Susceptibility Testing. CLSI Approved Standard M100-S15. CLSI, Wayne, PA.
-
[CLSI] Clinical and Laboratory Standards Institute. 2006. Performance Standards for Antimicrobial Susceptibility Testing. CLSI Approved Standard M100-S15. CLSI, Wayne, PA.
-
-
-
-
6
-
-
0035859931
-
The evolution of methicillin resistance in Staphylococcus aureus: Similarity of genetic backgrounds in historically early methicillin-susceptible and -resistant isolates and contemporary epidemic clones
-
Crisóstomo, M.I., H. Westh, A. Tomasz, M. Chung, D.C. Oliveira, and H. de Lencastre. 2001. The evolution of methicillin resistance in Staphylococcus aureus: similarity of genetic backgrounds in historically early methicillin-susceptible and -resistant isolates and contemporary epidemic clones. Proc. Natl. Acad. Sci. U S A 98:9865-9870.
-
(2001)
Proc. Natl. Acad. Sci. U S A
, vol.98
, pp. 9865-9870
-
-
Crisóstomo, M.I.1
Westh, H.2
Tomasz, A.3
Chung, M.4
Oliveira, D.C.5
de Lencastre, H.6
-
7
-
-
0034005677
-
Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus
-
Enright, M.C., N.P. Day, C.E. Davies, S.J. Peacock, and B.G. Spratt. 2000. Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus. J. Clin. Microbiol. 38:1008-1015.
-
(2000)
J. Clin. Microbiol
, vol.38
, pp. 1008-1015
-
-
Enright, M.C.1
Day, N.P.2
Davies, C.E.3
Peacock, S.J.4
Spratt, B.G.5
-
8
-
-
0037188519
-
The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA)
-
Enright, M.C., D.A. Robinson, G. Randle, E.J. Feil, H. Grundmann, and B.G. Spratt. 2002. The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA). Proc. Natl. Acad. Sci. U S A 99:7687-7692.
-
(2002)
Proc. Natl. Acad. Sci. U S A
, vol.99
, pp. 7687-7692
-
-
Enright, M.C.1
Robinson, D.A.2
Randle, G.3
Feil, E.J.4
Grundmann, H.5
Spratt, B.G.6
-
9
-
-
2342570378
-
Glycopeptide resistance in Staphylococcus aureus: Is it a real threat?
-
Gemmell, C.G. 2004. Glycopeptide resistance in Staphylococcus aureus: is it a real threat? J. Infect. Chemother. 10:69-75.
-
(2004)
J. Infect. Chemother
, vol.10
, pp. 69-75
-
-
Gemmell, C.G.1
-
10
-
-
0031852393
-
Activated cell-wall synthesis is associated with vancomycin resistance in methicillin-resistant Staphylococcus aureus clinical strains Mu3 and Mu50
-
Hanaki, H., K. Kuwahara-Arai, S. Boyle-Vavra, R.S. Daum, H. Labischinski, and K. Hiramatsu. 1998. Activated cell-wall synthesis is associated with vancomycin resistance in methicillin-resistant Staphylococcus aureus clinical strains Mu3 and Mu50. J. Antimicrob. Chemother. 42:199-209.
-
(1998)
J. Antimicrob. Chemother
, vol.42
, pp. 199-209
-
-
Hanaki, H.1
Kuwahara-Arai, K.2
Boyle-Vavra, S.3
Daum, R.S.4
Labischinski, H.5
Hiramatsu, K.6
-
11
-
-
0031566835
-
Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin
-
Hiramatsu, K., N. Aritaka, H. Hanaki, S. Kawasaki, Y. Hosoda, S. Hori, Y. Fukuchi, and I. Kobayashi. 1997. Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin. Lancet 350:1670-1673.
-
(1997)
Lancet
, vol.350
, pp. 1670-1673
-
-
Hiramatsu, K.1
Aritaka, N.2
Hanaki, H.3
Kawasaki, S.4
Hosoda, Y.5
Hori, S.6
Fukuchi, Y.7
Kobayashi, I.8
-
12
-
-
2142695240
-
Vancomycin susceptibility within methicillin-resistant Staphylococcus aureus lineages
-
Howe, R.A., A. Monk, M. Wootton, T.R. Walsh, and M.C. Enright. 2004. Vancomycin susceptibility within methicillin-resistant Staphylococcus aureus lineages. Emerg. Infect. Dis. 10:855-857.
-
(2004)
Emerg. Infect. Dis
, vol.10
, pp. 855-857
-
-
Howe, R.A.1
Monk, A.2
Wootton, M.3
Walsh, T.R.4
Enright, M.C.5
-
13
-
-
33847657516
-
Evolving EMRSA-15 epidemic in Singapore hospitals
-
Hsu, L.Y., N. Loomba-Chlebicka, Y.L. Koh, T.Y. Tan, P. Krishnan, R.T. Lin, N.W. Tee, D.A. Fisher, and T.H. Koh. 2007. Evolving EMRSA-15 epidemic in Singapore hospitals. J. Med. Microbiol. 56:376-379.
-
(2007)
J. Med. Microbiol
, vol.56
, pp. 376-379
-
-
Hsu, L.Y.1
Loomba-Chlebicka, N.2
Koh, Y.L.3
Tan, T.Y.4
Krishnan, P.5
Lin, R.T.6
Tee, N.W.7
Fisher, D.A.8
Koh, T.H.9
-
14
-
-
2142751063
-
Vancomycin-resistant Staphylococcus aureus - New York, 2004
-
Kaccia, M., and L.C. McDonald. 2004. Vancomycin-resistant Staphylococcus aureus - New York, 2004. Morb. Mortal. Wkly. Rep. 53:322-323.
-
(2004)
Morb. Mortal. Wkly. Rep
, vol.53
, pp. 322-323
-
-
Kaccia, M.1
McDonald, L.C.2
-
15
-
-
0032415856
-
Antimicrobial resistance in staphylococci and enterococci in 10 Portuguese hospitals in 1996 and 1997. POSGAR. Portuguese Study Group of Antimicrobial Resistance
-
Melo-Cristino, J. 1998. Antimicrobial resistance in staphylococci and enterococci in 10 Portuguese hospitals in 1996 and 1997. POSGAR. Portuguese Study Group of Antimicrobial Resistance. Microb. Drug Resist. 4:319-324.
-
(1998)
Microb. Drug Resist
, vol.4
, pp. 319-324
-
-
Melo-Cristino, J.1
-
16
-
-
33749168159
-
-
Melter, O., P. Urbaskova, V. Jakubu, B. Mackova, and H. Zemlickova. 2006. Emergence of EMRSA-15 clone in hospitals throughout the Czech Republic. Euro. Surveill. 11:E060803 6.
-
Melter, O., P. Urbaskova, V. Jakubu, B. Mackova, and H. Zemlickova. 2006. Emergence of EMRSA-15 clone in hospitals throughout the Czech Republic. Euro. Surveill. 11:E060803 6.
-
-
-
-
17
-
-
34447565048
-
Multiplex PCR strategy for subtyping the staphylococcal cassette chromosome mec type IV in methicillin-resistant Staphylococcus aureus: 'SCCmec IV multiplex'
-
Milheiriço, C., D.C. Oliveira, and H. de Lencastre. 2007. Multiplex PCR strategy for subtyping the staphylococcal cassette chromosome mec type IV in methicillin-resistant Staphylococcus aureus: 'SCCmec IV multiplex'. J. Antimicrob. Chemother. 60:42-48.
-
(2007)
J. Antimicrob. Chemother
, vol.60
, pp. 42-48
-
-
Milheiriço, C.1
Oliveira, D.C.2
de Lencastre, H.3
-
18
-
-
0000214977
-
Vancomycin-resistant Staphylococcus aureus - Pennsylvania, 2002
-
Miller, D., V. Urdaneta, and A. Weltman. 2002. Vancomycin-resistant Staphylococcus aureus - Pennsylvania, 2002. Morb. Mortal. Wkly. Rep. 51:902.
-
(2002)
Morb. Mortal. Wkly. Rep
, vol.51
, pp. 902
-
-
Miller, D.1
Urdaneta, V.2
Weltman, A.3
-
19
-
-
0036245954
-
Molecular characterisation of the dominant UK methicillin-resistant Staphylococcus aureus strains, EMRSA-15 and EMRSA-16
-
Moore, P.C., and J.A. Lindsay. 2002. Molecular characterisation of the dominant UK methicillin-resistant Staphylococcus aureus strains, EMRSA-15 and EMRSA-16. J. Med. Microbiol. 51:516-521.
-
(2002)
J. Med. Microbiol
, vol.51
, pp. 516-521
-
-
Moore, P.C.1
Lindsay, J.A.2
-
20
-
-
34547226145
-
Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencing
-
Mwangi, M.M., S.W. Wu, Y. Zhou, K. Sieradzki, H. de Lencastre, P. Richardson, D. Bruce, E. Rubin, E. Myers, E.D. Siggia, and A. Tomasz. 2007. Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencing. Proc. Natl. Acad. Sci. U S A 104:9451-9456.
-
(2007)
Proc. Natl. Acad. Sci. U S A
, vol.104
, pp. 9451-9456
-
-
Mwangi, M.M.1
Wu, S.W.2
Zhou, Y.3
Sieradzki, K.4
de Lencastre, H.5
Richardson, P.6
Bruce, D.7
Rubin, E.8
Myers, E.9
Siggia, E.D.10
Tomasz, A.11
-
21
-
-
0036839953
-
Dissemination of new methicillin-resistant Staphylococcus aureus clones in the community
-
Okuma, K., K. Iwakawa, J.D. Turnidge, W.B. Grubb, J.M. Bell, F.G. O'Brien, G.W. Coombs, J.W. Pearman, F.C. Tenover, M. Kapi, C. Tiensasitorn, T. Ito, and K. Hiramatsu. 2002. Dissemination of new methicillin-resistant Staphylococcus aureus clones in the community. J. Clin. Microbiol. 40:4289-4294.
-
(2002)
J. Clin. Microbiol
, vol.40
, pp. 4289-4294
-
-
Okuma, K.1
Iwakawa, K.2
Turnidge, J.D.3
Grubb, W.B.4
Bell, J.M.5
O'Brien, F.G.6
Coombs, G.W.7
Pearman, J.W.8
Tenover, F.C.9
Kapi, M.10
Tiensasitorn, C.11
Ito, T.12
Hiramatsu, K.13
-
22
-
-
0035984786
-
Multiplex PCR strategy for rapid identification of structural types and variants of the mec element in methicillin-resistant Staphylococcus aureus
-
Oliveira, D.C., and H. de Lencastre. 2002. Multiplex PCR strategy for rapid identification of structural types and variants of the mec element in methicillin-resistant Staphylococcus aureus. Antimicrob. Agents. Chemother. 46:2155-2161.
-
(2002)
Antimicrob. Agents. Chemother
, vol.46
, pp. 2155-2161
-
-
Oliveira, D.C.1
de Lencastre, H.2
-
23
-
-
0002195707
-
Antibiotic resistance in staphylococci
-
V.A. Fischetti, R.P. Novick, J.J. Ferreti, D.A. Portnoy, and J.I. Rood ed, American Society for Microbiology, Washington, DC, pp
-
Projan, S.J. 2000. Antibiotic resistance in staphylococci. In V.A. Fischetti, R.P. Novick, J.J. Ferreti, D.A. Portnoy, and J.I. Rood (ed.), Gram-Positive Pathogens. American Society for Microbiology, Washington, DC, pp. 463-470.
-
(2000)
Gram-Positive Pathogens
, pp. 463-470
-
-
Projan, S.J.1
-
24
-
-
0027380488
-
Characterization of a strain of methicillin-resistant Staphylococcus aureus (EMRSA-15) by conventional and molecular methods
-
Richardson, J.F., and S. Reith. 1993. Characterization of a strain of methicillin-resistant Staphylococcus aureus (EMRSA-15) by conventional and molecular methods. J. Hosp. Infect. 25:45-52.
-
(1993)
J. Hosp. Infect
, vol.25
, pp. 45-52
-
-
Richardson, J.F.1
Reith, S.2
-
25
-
-
33644748275
-
-
Available at, Michigan Department of Community Health, Lansing
-
Rudrick, J.T. Michigan Department of Community Health. Available at http://www.michigan.gov/documents/VRSA_Feb05_HAN_118391_7.pdf. Michigan Department of Community Health, Lansing.
-
Michigan Department of Community Health
-
-
Rudrick, J.T.1
-
26
-
-
38349049171
-
Identification and characterization of a vancomycin-resistant Staphylococcus aureus isolated from Kolkata (South Asia)
-
Saha, B., A.K. Singh, A. Ghosh, and M. Bal. 2008. Identification and characterization of a vancomycin-resistant Staphylococcus aureus isolated from Kolkata (South Asia). J. Med. Microbiol. 57:72-79.
-
(2008)
J. Med. Microbiol
, vol.57
, pp. 72-79
-
-
Saha, B.1
Singh, A.K.2
Ghosh, A.3
Bal, M.4
-
27
-
-
33645760459
-
Induction of daptomycin heterogeneous susceptibility in Staphylococcus aureus by exposure to vancomycin
-
Sakoulas, G., J. Alder, C. Thauvin-Eliopoulos, R.C. Moellering, Jr., and G.M. Eliopoulos. 2006. Induction of daptomycin heterogeneous susceptibility in Staphylococcus aureus by exposure to vancomycin. Antimicrob. Agents Chemother. 50:1581-1585.
-
(2006)
Antimicrob. Agents Chemother
, vol.50
, pp. 1581-1585
-
-
Sakoulas, G.1
Alder, J.2
Thauvin-Eliopoulos, C.3
Moellering Jr., R.C.4
Eliopoulos, G.M.5
-
28
-
-
0036237753
-
Accessory gene regulator (agr) locus in geographically diverse Staphylococcus aureus isolates with reduced susceptibility to vancomycin
-
Sakoulas, G., G.M. Eliopoulos, R.C. Moellering, Jr., C. Wennersten, L. Venkataraman, R.P. Novick, and H.S. Gold. 2002. Accessory gene regulator (agr) locus in geographically diverse Staphylococcus aureus isolates with reduced susceptibility to vancomycin. Antimicrob. Agents Chemother. 46:1492-1502.
-
(2002)
Antimicrob. Agents Chemother
, vol.46
, pp. 1492-1502
-
-
Sakoulas, G.1
Eliopoulos, G.M.2
Moellering Jr., R.C.3
Wennersten, C.4
Venkataraman, L.5
Novick, R.P.6
Gold, H.S.7
-
29
-
-
0032881231
-
Evaluation of protein A gene polymorphic region DNA sequencing for typing of Staphylococcus aureus strains
-
Shopsin, B., M. Gomez, S.O. Montgomery, D.H. Smith, M. Waddington, D.E. Dodge, D.A. Bost, M. Riehman, S. Naidich, and B.N. Kreiswirth. 1999. Evaluation of protein A gene polymorphic region DNA sequencing for typing of Staphylococcus aureus strains. J. Clin. Microbiol. 37:3556-3563.
-
(1999)
J. Clin. Microbiol
, vol.37
, pp. 3556-3563
-
-
Shopsin, B.1
Gomez, M.2
Montgomery, S.O.3
Smith, D.H.4
Waddington, M.5
Dodge, D.E.6
Bost, D.A.7
Riehman, M.8
Naidich, S.9
Kreiswirth, B.N.10
-
30
-
-
0032763820
-
Gradual alterations in cell wall structure and metabolism in vancomycin- resistant mutants of Staphylococcus aureus
-
Sieradzki, K., and A. Tomasz. 1999. Gradual alterations in cell wall structure and metabolism in vancomycin- resistant mutants of Staphylococcus aureus. J. Bacteriol. 181:7566-7570.
-
(1999)
J. Bacteriol
, vol.181
, pp. 7566-7570
-
-
Sieradzki, K.1
Tomasz, A.2
-
31
-
-
0030899029
-
Inhibition of cell wall turnover and autolysis by vancomycin in a highly vancomycin-resistant mutant of Staphylococcus aureus
-
Sieradzki, K., and A. Tomasz. 1997. Inhibition of cell wall turnover and autolysis by vancomycin in a highly vancomycin-resistant mutant of Staphylococcus aureus. J. Bacteriol. 179:2557-2566.
-
(1997)
J. Bacteriol
, vol.179
, pp. 2557-2566
-
-
Sieradzki, K.1
Tomasz, A.2
-
32
-
-
0037024849
-
Staphylococcus resistant to vancomycin - United States, 2002
-
Sievert, D.M., M.L. Boulton, G. Stoltman, D. Johnson, M.G. Stobierski, F.P. Downes, P.A. Somsel, J.T. Rudrik, W. Brown, W. Hafeez, T. Lundstrom, E. Flanagan, R. Johnson, J. Mitchell, and S. Chang 2002. Staphylococcus resistant to vancomycin - United States, 2002. Morb. Mortal Wkly Rep 51:565-567.
-
(2002)
Morb. Mortal Wkly Rep
, vol.51
, pp. 565-567
-
-
Sievert, D.M.1
Boulton, M.L.2
Stoltman, G.3
Johnson, D.4
Stobierski, M.G.5
Downes, F.P.6
Somsel, P.A.7
Rudrik, J.T.8
Brown, W.9
Hafeez, W.10
Lundstrom, T.11
Flanagan, E.12
Johnson, R.13
Mitchell, J.14
Chang, S.15
-
33
-
-
41149092806
-
-
Annual Report, Available at, National Institute for Public Health and the Environment, Bilthoven, the Netherlands
-
[EARSS] European Antimicrobial Resistance Surveillance System. Annual Report 2005. Available at http://www.rivm. nl/earss/. National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
-
(2005)
-
-
-
34
-
-
34247282090
-
The rationale for revising the clinical and laboratory standards institute vancomycin minimal inhibitory concentration interpretive criteria for Staphylococcus aureus
-
Tenover, F.C., and R.C. Moellering, Jr. 2007. The rationale for revising the clinical and laboratory standards institute vancomycin minimal inhibitory concentration interpretive criteria for Staphylococcus aureus. Clin. Infect. Dis. 44:1208-1215.
-
(2007)
Clin. Infect. Dis
, vol.44
, pp. 1208-1215
-
-
Tenover, F.C.1
Moellering Jr., R.C.2
-
35
-
-
0026085381
-
Stable classes of phenotypic expression in methicillin-resistant clinical isolates of staphylococci
-
Tomasz, A., S. Nachman, and H. Leaf. 1991. Stable classes of phenotypic expression in methicillin-resistant clinical isolates of staphylococci. Antimicrob. Agents Chemother. 35:124-129.
-
(1991)
Antimicrob. Agents Chemother
, vol.35
, pp. 124-129
-
-
Tomasz, A.1
Nachman, S.2
Leaf, H.3
-
36
-
-
0036403740
-
The prevalence and mechanisms of vancomycin resistance in Staphylococcus aureus
-
Walsh, T.R., and R.A. Howe. 2002. The prevalence and mechanisms of vancomycin resistance in Staphylococcus aureus. Annu. Rev. Microbiol. 56:657-675.
-
(2002)
Annu. Rev. Microbiol
, vol.56
, pp. 657-675
-
-
Walsh, T.R.1
Howe, R.A.2
-
37
-
-
38649083439
-
Vancomycin-resistant Staphylococcus aureus associated with inc18-like vanA plasmids in Michigan
-
Zhu, W., N.C. Clark, L.K. McDougal, J. Hageman, L.C. McDonald, and J.B. Patel. 2008. Vancomycin-resistant Staphylococcus aureus associated with inc18-like vanA plasmids in Michigan. Antimicrob. Agents Chemother. 52:452-457.
-
(2008)
Antimicrob. Agents Chemother
, vol.52
, pp. 452-457
-
-
Zhu, W.1
Clark, N.C.2
McDougal, L.K.3
Hageman, J.4
McDonald, L.C.5
Patel, J.B.6
|