Inhibition of human dental pulp stem cell differentiation by notch signaling

Journal of Dental Research

Volumn 87, Issue 3, 2008, Pages 250-255

  Zhang, C ^a   Chang, J ^b   Sonoyama, W ^c   Shi, S ^c   Wang, C Y ^b  

^a PEKING UNIVERSITY SCHOOL AND HOSPITAL OF STOMATOLOGY   (China)

^b UCLA SCHOOL OF DENTISTRY   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Dental pulp stem cells; Differentiation; Notch; Odontoblasts; Tooth development

Indexed keywords

ALIZARIN; ALKALINE PHOSPHATASE; ANTHRAQUINONE DERIVATIVE; CALCIUM; CALCIUM BINDING PROTEIN; COLORING AGENT; DIAGNOSTIC AGENT; DSPP PROTEIN, HUMAN; MEMBRANE PROTEIN; NOTCH1 PROTEIN, HUMAN; NOTCH1 RECEPTOR; PHOSPHOPROTEIN; SCLEROPROTEIN; SERRATE PROTEINS; SIALOGLYCOPROTEIN; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; BONE MINERALIZATION; CELL CULTURE; CELL DIFFERENTIATION; CELL TRANSPLANTATION; CYTOLOGY; HUMAN; MESENCHYMAL STEM CELL; MOUSE; NUDE MOUSE; ODONTOBLAST; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STEM CELL; TOOTH PULP; WESTERN BLOTTING;

ALKALINE PHOSPHATASE; ANIMALS; ANTHRAQUINONES; BLOTTING, WESTERN; CALCIFICATION, PHYSIOLOGIC; CALCIUM; CALCIUM-BINDING PROTEINS; CELL DIFFERENTIATION; CELL TRANSPLANTATION; CELLS, CULTURED; COLORING AGENTS; DENTAL PULP; EXTRACELLULAR MATRIX PROTEINS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MESENCHYMAL STEM CELLS; MICE; MICE, NUDE; ODONTOBLASTS; PHOSPHOPROTEINS; RECEPTOR, NOTCH1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIALOGLYCOPROTEINS; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 41149086071     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/154405910808700312     Document Type: Article

References (23)

1. Chang J. Zhang C, Tani-Ishii N, Shi S, Wang CY (2005). NF-kappa B activation in human dental pulp stem cells by TNF and LPS. J Dent Res 84:994-998.
2. Chen S, Rani S, Wu Y, Unterbrink A, Gu TT, Gluhak-Heinrich J, el al. (2005). Differential regulation of dentin sialophosphoprotein expression by Runx2 during odontoblast cytodifferentiation. J Biol Chem 280:29717-29727.
3. Gaikwad JS, Hoffmann M, Cavender A, Bronckers AL, D'Souza RN (2001). Molecular insights into the lineage-specific determination of odontoblasts: the role of Cbfal. Adv Dent Res 15:19-24.
4. Gronthos S, Mankani M, Brahim J, Robey PG, Shi S (2000). Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci USA 97:13625-13630.
5. Gronthos S, Brahim J, Li W, Fisher LW, Cherman N, Boyde A, et al. (2002). Stem cell properties of human dental pulp stem cells. J Dent Res 81:531-535.
6. Harada H, Kettunen P, Jung HS, Mustonen T, Wang YA, Thesleff I (1999). Localization of putative stem cells in dental epithelium and their association with Notch and FGF signaling. J Cell Biol 147:105-120.
7. Hiratochi M, Nagase H, Kuramochi Y, Koh CS, Ohkawara T, Nakayama K (2007). The Delta intracellular domain mediates TGF-beta/Activin signaling through binding to Smads and has an important bi-directional function in the Notch-Delta signaling pathway. Nucleic Acids Res 35:912-922.
8. Kato H, Taniguchi Y, Kurooka H, Minoguchi S, Sakai T, Nomura-Okazaki S. et al. (1997). Involvement of RBP-J in biological functions of mouse Notchl and its derivatives. Development 124:4133-4141.
9. LaVoie MJ, Selkoe DJ (2003). The Notch ligands. Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments. J Biol Chem 278:34427-4437.
10. Lovschall H, Tummers M, Thesleff I, Fuchtbauer EM, Poulsen K (2005). Activation of the Notch signaling pathway in response to pulp capping of rat molars. Eur J Oral Sci 113:312-317.
11. McLarren KW, Theriault FM, Stifani S (2001). Association with the nuclear matrix and interaction with Groucho and RUNX proteins regulate the transcription repression activity of the basic helix loop helix factor Hus1. J Biol Chem 276:1578-1584.
12. Mitsiadis TA, Henrique D, Thesleff I, Lendahl U (1997). Mouse serrate-1 (Jagged-1): expression in the developing tooth is regulated by epithelial-mesenchymal interactions and fibroblast growth factor-4. Development 124:1473-1483.
13. Mitsiadis TA, Hirsinger E, Lendahl U, Goridis C (1998). Delta-notch signaling in odontogenesis: correlation with cytodifferentiation and evidence for feedback regulation. Dev Biol 204:420-431.
14. Mitsiadis TA, Romeas A, Lendahl U, Sharpe PT, Farges JC (2003). Notch2 protein distribution in human teeth under normal and pathological conditions. Exp Cell Res 282:101-109.
15. Morsczeck C, Götz W, Schierholz J, Zeilhofer F, Kühn U, Möhl C, et al. (2005). Isolation of precursor cells (PCs) from human dental follicle of wisdom teeth. Matrix Biol 24:155-165.
16. Nobta M, Tsukazaki T, Shibata Y, Xin C, Moriishi T, Sakano S, et al. (2005). Critical regulation of bone morphogenetic protein-induced osteoblastic differentiation by Delta1/Jagged1-activated Notch1 signaling. J Biol Chem 280:15842-15848.
17. Nofziger D, Miyamoto A, Lyons KM, Weinmaster G (1999). Notch signaling imposes two blocks in the differentiation of C2C12 myoblasts. Development 126:1689-1702.
18. Rehman AO, Wang C-Y (2006). Notch signaling in the regulation of tumor angiogenesis. Trends Cell Biol 16:293-300.
19. Sciaudone M, Gazzerro E, Priest L, Delany AM, Canalis E (2003). Notch 1 impairs osteoblastic cell differentiation. Endocrinology 144:5631-5639.
20. Shawber CJ, Kitajewski J (2004). Notch function in the vasculature: insights from zebrafish, mouse and man. Bioessays 26:225-234.
21. Shi S, Gronthos S (2003). Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp. J Bone Miner Res 18:696-704.
22. Stanford CM, Jacobson PA, Eanes ED, Lembke LA, Midura RJ (1995). Rapidly forming apatitic mineral in an osteoblastic cell line (UMR 106-01 BSP). J Biol Chem 270:9420-9428.
23. Zeng Q, Li S, Chepeha DB, Giordano TJ, Li J, Zhang H, et al. (2005). Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling. Can Cell 8:13-23.