Fenofibrate prevents orotic acid-Induced hepatic steatosis in rats

Life Sciences

Volumn 82, Issue 15-16, 2008, Pages 876-883

  Ferreira, Adaliene Versiani Matos ^a   Parreira, Gleydes Gambogi ^a   Porto, Laura Cristina Jardim ^a   Mario, Érica Guihen ^a   Delpuerto, Helen Lima ^a   Martins, Almir Sousa ^a   Botion, Leida Maria ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Adipose tissue; Fenofibrate; Hepatic steatosis; Lipid metabolism; PPAR

Indexed keywords

ACYL COENZYME A OXIDASE; CARNITINE PALMITOYLTRANSFERASE; FENOFIBRATE; LIPID; LIPOPROTEIN LIPASE; MESSENGER RNA; OROTIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVITY; FATTY ACID OXIDATION; FATTY LIVER; LIPID BLOOD LEVEL; LIPID LIVER LEVEL; LIPOGENESIS; MALE; METABOLIC DISORDER; NONHUMAN; PROTEIN EXPRESSION; RAT;

ACYL-COA OXIDASE; ADIPOCYTES; ADRENERGIC BETA-AGONISTS; ANIMALS; ANTILIPEMIC AGENTS; CELL SEPARATION; DIET; HEPATIC INSUFFICIENCY; HYPOGLYCEMIC AGENTS; INSULIN; ISOPROTERENOL; LIPID METABOLISM; LIPIDS; LIPOLYSIS; LIPOPROTEIN LIPASE; LIVER; MALE; OROTIC ACID; PPAR ALPHA; PROCETOFEN; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

RATTUS; RATTUS NORVEGICUS;

EID: 41149085927     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2008.02.003     Document Type: Article

References (52)

1. Aoyama Y., and Wada M. Supplementation of orotic acid to the casein, but not egg protein, soy protein, or wheat gluten diets, increases serum ornithine carbamoyltransferase activity. The Journal of Nutritional Biochemistry 11 (2000) 306-310
2. Aoyama T., Peters J.M., Iritani N., Nakajima T., Furihata K., Hashimoto T., et al. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha). Journal of Biological Chemistry 273 (1998) 5678-5684
3. Belfrage P., and Vaughan M. Simple liquid-liquid partition system for isolation of labeled oleic acid from mixtures with glycerides. Journal of Lipid Research 10 (1969) 341-344
4. Breen K.J., Schenker S., and Heimberg M. Fatty liver induced by tetracycline in the rat, dose-response relationships and effect of sex. Gastroenterology 69 (1975) 714-723
5. Buang Y., Wang Y.M., Cha J.Y., Nagao K., and Yanagita T. Dietary phosphatidylcholine alleviates fatty liver induced by orotic acid. Nutrition 21 7-8 (2005) 867-873
6. Chomczynski P., and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analytical Biochemistry 162 (1987) 156-159
7. Costet P., Legendre C., More J., Edgar A., Galtier P., and Pineau T. Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis. Journal of Biological Chemistry 273 (1998) 29577-29585
8. Degrace P., Demizieux L., Du Z.Y., Gresti J., Caverot L., Djaouti L., Jourdan T., Moindrot B., Guilland J.C., Hocquette J.F., and Clouet P. Regulation of lipid flux between liver and adipose tissue during transient hepatic steatosis in carnitine-depleted rats. Journal of Biological Chemistry 282 29 (2007) 20816-20826
9. Desvergne B., and Wahli W. Peroxisome proliferator activated-receptors, nuclear control of metabolism. Endocrine Reviews 20 5 (1999) 649-688
10. Everett L., Galli A., and Crabb D. The role of hepatic peroxisome proliferator-activated receptors (PPARs) in health and disease. Liver 20 (2000) 191-199
11. Fan C.Y., Pan J., Chu R., Lee D., Kluckman K.D., Usuda N., et al. Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene. Journal of Biological Chemistry 271 (1996) 24698-24710
12. Ferdinandy P., Fazekas T., and Kádár É. Effects of orotic acid on ischaemic/reperfused myocardial function and glycogen content in isolated working rat hearts. Pharmacological Research 37 2 (1998) 111-114
13. Ferreira A.V.M., Parreira G.G., Green A., and Botion L.M. Effects of fenofibrate on lipid metabolism in adipose tissue of rats. Metabolism, Clinical and Experimental 55 (2006) 731-735
14. Folch J., Lees M., and Stanley G.A. A simple method for the isolation and purification of total lipids from animal tissues. Journal of Biological Chemistry 226 (1957) 497-509
15. Fromenty B., Fisch C., Berson A., Letteron P., Larrey D., and Pessayre D. Dual effect of amiodarone on mitochondrial respiration. Initial protonophoric uncoupling effect followed by inhibition of the respiratory chain at the level of complex I and complex II. The Journal of Pharmacology and Experimental Therapeutics 255 (1990) 1377-1384
16. Fukuwatari T., Morikawa Y., Sugimoto E., and Shibata K. Effects of fatty liver induced by niacin-free diet with orotic acid on the metabolism of tryptophan to niacin in rats. Bioscience, Biotechnology, and Biochemistry 66 6 (2002) 1196-1204
17. Gasic S., and Green A. Gi down-regulation and heterologous desensitization in adipocytes after treatment with α agonist UK 14304. Biochemical Pharmacology 49 (1995) 785-790
18. Griffin J.L., Bonney S.A., Mann C., Hebbachi A.M., Gibbons G.F., Nicholson J.K., et al. An integrated reverse functional genomic and metabolic approach to understanding orotic acid-induced fatty liver. Physiological Genomics 17 (2004) 140-149
19. Harano Y., Yasui K., Toyama T., Nakajima T., Mitsuyoshi H., Mimani M., et al. Fenofibrate, a peroxisome proliferator-activated receptor a agonist, reduces hepatic steatosis and lipid peroxidation in fatty liver shionogi mice with hereditary fatty liver. Liver International 26 (2006) 613-620
20. Hashimoto T. Individual peroxisomal beta-oxidation enzymes. Annals of the New York Academy of Sciences 386 (1982) 5-12
21. Hay R., Fleming R., O'Connell W., Kirschner J., and Oppliger W. Apolipoproteins of the orotic acid fatty liver, implications for the biogenesis of plasma lipoproteins. Journal of Lipid Research 29 (1988) 981-995
22. Ip E., Farrell G.C., Robertson G., Hall P., Kirsch R., and Leclercq I. Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice. Hepatology 38 (2003) 123-132
23. Iverius P.H., and Ostlund-Lindqvist A.M. Preparation, characterization, and measurement of lipoprotein lipase. Methods in Enzymology 129 (1986) 691-704
24. Kettelhut I.C., Foss M.C., and Migliorini R.H. Glucose homeostasis in a carnivorous animal (cat) and in rats fed a high-protein diet. The American Journal of Physiology 239 (1980) 437-444
25. Kolak M., Westerbacka J., Velagapudi V.R., Wågsäter D., Yetukuri L., Makkonen J., Rissanen A., Häkkinen A.M., Lindell M., Bergholm R., Hamsten A., Eriksson P., Fisher R.M., Orešič M., and Yki-Järvinen H. Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity. Diabetes 56 (2007) 1960-1968
26. Lee H.J., Choi S.S., Park M.K., An Y.J., Seo S.Y., Kim M.C., et al. Fenofibrate lowers abdominal and skeletal adiposity and improves insulin sensitivity in OLETF rats. Biochemical and Biophysical Research Communications 296 (2002) 293-299
27. Lefebvre P., Chinetti G., Fruchart J.C., and Staels B. Sorting out the roles of PPARα in energy metabolism and vascular homeostasis. Journal of Clinical Investigation 116 (2006) 571-580
28. Leone T.C., Weinheimer C.J., and Kelly D.P. A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response, the PPARalpha-null mouse as a model of fatty acid oxidation disorders. Proceedings of the National Academy of Sciences of the United States of America 96 (1999) 7473-7478
29. Malmendier C.L., Lontie J.F., Delcroix C., Dubois D.Y., Magot T., and De Roy L. Apolipoproteins C-II and C-III metabolism in hypertriglyceridemic patients. Effect of a drastic triglyceride reduction by combined diet restriction and fenofibrate administration. Atherosclerosis 77 (1989) 139-149
30. Mancini F.P., Lanni A., Sabatino L., Moreno M., Giannino A., Contaldo F., et al. Fenofibrate prevents and reduces body weight gain and adiposity in diet-induced obese rats. The FEBS Journal 491 (2001) 154-158
31. Martin A., Biol M.C., Raisonnier A., Infante R., Louisot P., and Richard M. Impaired glycosylation in liver microsomes of orotic acid fed rats. Biochimica et Biophysica Acta 718 1 (1982) 85-91
32. Nagai Y., Nishio Y., Nakamura T., Maegawa H., Kikkawa R., and Kashiwagi A. Amelioration of high fructose-induced metabolic derangements by activation of PPARα. American Journal of Physiology: Endocrinology and Metabolism 282 (2002) 1180-1190
33. Neuschwander-Tetri B., and Caldwell S. Nonalcaholic steatohepatitis, summary of an AASLD single topic conference. Hepatology 37 (2003) 1202-1219
34. Nilsson-Ehle P.E., and Schotz M.C. A stable radioactive substrate emulsion for assay of lipoprotein lipase. Journal of Lipid Research (1976) 536-541
35. Peters J.M., Hennuyer N., Staels B., Fruchart J.C., Fievet C., Gonzalez F.J., et al. Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice. Journal of Biological Chemistry 272 (1997) 27307-27312
36. Reddy J.K., and Mannaerts G.P. Peroxisomal lipid metabolism. Annual Review Nutrition 14 (1994) 343-370
37. Reddy J.K., and Hashimoto T. Peroxisomal β oxidation and peroxisome proliferators-activated receptor α, an adaptive metabolic system. Annual Review Nutrition 21 (2001) 193-230
38. Rodbell M. Metabolism of isolated fat cells. I. Effects of hormones on glucose metabolism and lipolysis. Journal of Biological Chemistry 239 (1964) 375-380
39. Roheim P.S., Switzer S., Girard A., and Eder H.A. The mechanism of inhibition of lipoprotein synthesis by orotic acid. Biochemistry and Biophysics Research Communication 20 4 (1965) 416-421
40. Shiri-Sverdlov R., Wouters K., van Gorp P.J., Gijbels M.J., Noel B., Buffat L., Staels B., Maeda N., van Bilsen M., and Hofker M.H. Early diet-induced non-alcoholic steatohepatitis in APOE2 knock-in mice and its prevention by fibrates. Journal of Hepatology 44 4 (2006) 732-741.4
41. Staels B., Vu-Dac N., Kosykh V.A., Saladin R., Fruchart J.-C., Dallongeville J., and Auwerx J. Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates. Journal of Clinical Investigation 95 (1995) 705-712
42. Staels B., Koenig W., Habib A., Merval R., Lebret M., Torra P.I., Delerive P., Fadel A., Chinetti G., Fruchart J.-C., Najib J., Maclouf J., and Tedgui A. Activation of human aortic smooth-muscle cells is inhibited by PPAR but not by PPAR activators. Nature 393 (1998) 790-793
43. Standerfer S.B., and Handler P. Fatty liver induced by orotic acid feeding. Proceedings of the Society for Experimental Biology and Medicine 90 (1955) 270-271
44. Stienstra R., Mandard S., Patsouris D., Maass C., Kersten S., and Müller M. Peroxisome proliferator-activated receptor alpha protects against obesity-induced hepatic inflammation. Endocrinology 148 6 (2007) 2753-2763
45. Tolbert N.E. Metabolic pathways in peroxisomes and glyoxysomes. Annual Review of Biochemistry 50 (1981) 133-157
46. Tsutsumi M., and Takase S. Effect of fenofibrate on fatty liver in rats treated with alcohol. Alcoholism, Clinical and Experimental Research 25 6 Suppl (2001) 75S-79S
47. Tugwood J.D., Issemann I., Anderson R.G., Bundell K.R., Mcpheat W.L., and Green S. The mouse peroxisome proliferators activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene. The EMBO Journal 11 (1992) 433-439
48. Unger R.H., and Orci L. Lipotoxic diseases of non adipose tissue in obesity. International journal of obesity and related metabolic disorders. Journal of the International Association for the Study of Obesity 24 suppl. 4 (2000) 28-32
49. Vu-Dac N., Schoonjans K., Kosykh V., Dallongeville J., Fruchart J.C., Staels B., et al. Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor. Journal of Clinical Investigation 96 (1995) 741-750
50. Windmueller H.G., and Spaeth A.E. Perfusion in situ with tritium oxide to measure hepatic lipogenesis and lipid secretion. Normal and orotic acid-fed rats. Journal of Biological Chemistry 241 (1966) 2891-2899
51. Windmueller H.G., and Levy R. Total inhibition of hepatic β-lipoprotein production in the rat by orotic acid. Journal of Biological Chemistry 242 9 (1967) 2246-2254
52. Ye M.J., Doyle P.J., Iglesias M.A., Watson D.G., Cooney G.J., and Kraegen E.W. Peroxisome proliferator-activated receptor (PPAR) α activation lowers muscle lipids and improves insulin sensivity in high fat fed rats, comparasion with PPARγ activation. Diabetes 50 (2001) 411-417