Upregulation of Neutrophil Gelatinase-associated Lipocalin, NGAL/Lcn2, in β-Thalassemia Patients

Archives of Medical Research

Volumn 39, Issue 4, 2008, Pages 402-407

  Roudkenar, Mehryar Habibi ^a   Halabian, Raheleh ^b   Oodi, Arezo ^a   Roushandeh, Amaneh Mohammadi ^c   Yaghmai, Parichehr ^b   Najar, Mohamad Reza ^a   Amirizadeh, Nasser ^a   Shokrgozar, Mohammad Ali ^d  

^a IRANIAN BLOOD TRANSFUSION ORGANIZATION   (Iran)

^b ISLAMIC AZAD UNIVERSITY   (Iran)

^c TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d PASTEUR INSTITUTE OF IRAN   (Iran)

Author keywords

ELISA; Iron overload; NGAL Lcn2; Real time PCR; Thalassemia

Indexed keywords

GELATINASE; IRON; LIPOCALIN; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; REACTIVE OXYGEN METABOLITE;

ADULT; ARTICLE; BETA THALASSEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MALE; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ACUTE-PHASE PROTEINS; ADOLESCENT; ADULT; BETA-THALASSEMIA; CHILD; FEMALE; FERRITINS; HUMANS; IRON OVERLOAD; LIPOCALINS; MALE; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS; UP-REGULATION;

EID: 41049113795     PISSN: 01884409     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arcmed.2007.12.002     Document Type: Article

References (40)

1. Gu X., and Zeng Y. A review of the molecular diagnosis of thalassemia. Hematology 7 (2002) 203-209
2. Weatherall D.J., Pressley L., Wood W.G., Higgs D.R., and Clegg J.B. Molecular basis for mild forms of homozygous beta-thalassaemia. Lancet 1 (1981) 527-529
3. Hoffbrand A.V. Diagnosing myocardial iron overload. Eur Heart J 22 (2001) 2140-2141
4. Kushner J.P., Porter J.P., and Olivieri N.F. Secondary iron overload. Hematology Am Soc Hematol Educ Program (2001) 47-61
5. Prati D. Benefits and complications of regular blood transfusion in patients with beta-thalassaemia major. Vox Sang 79 (2000) 129-137
6. Amer J., Goldfarb A., and Fibach E. Flow cytometric analysis of the oxidative status of normal and thalassemic red blood cells. Cytometry A 60 (2004) 73-80
7. Livrea M.A., Tesoriere L., Pintaudi A.M., Calabrese A., Maggio A., Freisleben H.J., et al. Oxidative stress and antioxidant status in β-thalassemia major: iron overload and depletion of lipid-soluble antioxidants. Blood 88 (1996) 3608-3614
8. Walter B.P., Fung B.E., Killilea W.D., Jiang Q., Hudes M., Madden J., et al. Oxidative stress and inflammation in iron-overloaded patients with β-thalassaemia or sickle cell disease. Br J Haematol 135 (2006) 254-263
9. Chiou S.S., Chang T.T., Tsai S.P., Jang R.C., Lin S.K., Lee S.C., et al. Lipid peroxidation and antioxidative status in β-thalassemia major patients with or without hepatitis C virus infection. Clin Chem Lab Med 44 (2006) 1226-1233
10. Hebbel R.P. Auto-oxidation and a membrane associated "Fenton Reagent": a possible explanation for development of membrane lesions in sickle erythrocytes. Clin Haematol 14 (1985) 129-140
11. Hershko C., Graham G., Bates G.W., and Rachmilewitz E.A. Non-specific serum iron in thalassaemia: an abnormal serum iron fraction of potential toxicity. Br J Haematol 40 (1978) 255-263
12. Flower D.R., North A.C., and Sansom C.E. The lipocalin protein family: structural and sequence overview. Biochim Biophys Acta 1482 (2000) 9-24
13. 35S]methionine into a glycoprotein and five superinducible proteins. Biochem Biophys Res Commun 108 (1982) 158-166
14. Hamilton R.T., Nilsen-Hamilton M., and Adams G. Superinduction by cycloheximide of mitogen-induced secreted proteins produced by Balb/c 3T3 cells. J Cell Physiol 123 (1985) 201-208
15. Kjeldsen L., Johnsen A.H., Sengeløv H., and Borregaard N. Isolation of primary structure of Ngal, a novel protein associated with human neutrophil gelatinase. J Biol Chem 268 (1993) 10425-10432
16. Cowland J.B., and Borregaard N. Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans. Genomics 45 (1997) 17-23
17. Bundgaard J.R., Sengelov H., Borregaard N., and Kjeldsen L. Molecular cloning and expression of a cDNA encoding Ngal: a lipocalin expressed in human neutrophils. Biochem Biophys Res Commun 202 (1994) 1468-1475
18. Nielsen B.S., Borregaard N., Bundgaard J.R., Timshel S., Sehested M., and Kjeldsen L. Induction of NGAL synthesis in epithelial cells of human colorectal neoplasia and inflammatory bowel disease. Gut 38 (1996) 414-420
19. Anderson G. Non-transferrin-bound iron and cellular toxicity. J Gastroenterol Hepatol 14 (1999) 105-108
20. Stern W.O., Adamsky K., Amariglio N., Breda L.E., Rivella S., and Rechavi G. mRNA expression of iron regulatory genes β-thalassemia intermedia and β-thalassemia major mouse models. Am J Hematol 81 (2006) 479-483
21. Roudkenar M.H., Kuwahara Y., Baba T., Roushandeh A.M., Ebishima S.h., Abe S.h., et al. Oxidative stress-induced lipocalin 2 gene expression, addressing its expression under the harmful condition. J. Radiat Res 48 (2007) 39-44
22. Kirstin M., Ju-Seog L., Patricia A.D., Wen-Qing C.M., Sambasiva R., Snorri S.T., et al. Molecular profiling of hepatocellular carcinomas developing spontaneously in acyl-CoA oxidase deficient mice: comparison with liver tumors induced in wild-type mice by a peroxisome proliferator and a genotoxic carcinogen. Carcinogenesis 24 (2003) 975-984
23. Nielsen B.S., Borregaard N., Bundgaard J.R., Timshel S., Sehested M., and Kjeldsen L. Induction of NGAL synthesis in epithelial cells of human colorectal neoplasia and inflammatory bowel diseases. Gut 38 (1996) 414-420
24. Missiaglia E., Blaveri E., Terris B., Wang Y.H., Costello E., Neoptolemos J.P., et al. Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumorigenesis and metastasis. Int J Cancer 112 (2004) 100-112
25. Mishra J., Mori K., Ma Q., Kelly C., Barasch J., and Devarajan P. Neutrophil gelatinase-associated lipocalin: a novel early urinary biomarker for cisplatin nephrotoxicity. Am J Nephrol 24 (2004) 307-315
26. Mishra J., Ma Q., Prada A., Mitsnefes M., Zahedi K., Yang J., et al. Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol 14 (2003) 2534-2543
27. Mishra J., Ma Q., Kelly C., Mitsnefes M., Mori K., Barasch J., et al. Kidney NGAL is a novel early marker of acute injury following transplantation. Pediatr Nephrol 21 (2006) 856-863
28. Hemdahl A.L., Gabrielsen A., Zhu C., Eriksson P., Hedin U., Kastrup J., et al. Expression of neutrophil gelatinase-associated lipocalin in atherosclerosis and myocardial infarction. Arterioscler Thromb Vasc Biol 26 (2006) 136-142
29. Mishra J., Dent C., Tarabishi R., Mitsnefes M.M., Ma Q., Kelly C., et al. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 365 (2005) 1231-1238
30. Horton J.W. Free radicals and lipid peroxidation mediated injury in burn trauma: the role of antioxidant therapy. Toxicology 189 (2003) 75-88
31. Vemula M., Berthiaume F., Jayaraman A., and Yarmush M.L. Expression profiling analysis of the metabolic and inflammatory changes following burn injury in rats. Physiol Genomics 18 (2004) 87-98
32. Breuer W., Hershko C., and Cabantchik Z.I. The importance of non-transferrin bound iron in disorders of iron metabolism. Transfus Sci 23 (2001) 185-192
33. Gosriwatana I., Loreal O., Lu S., Brissot P., Porter J., and Hider R.C. Quantification of non-transferrinbound iron in the presence of unsaturated transferrin. Anal Biochem 273 (1999) 212-220
34. Esposito B.P., Breuer W., Sirankapracha P., Pootrakul P., Hershko C., and Cabantchik Z.I. Labile plasma iron in iron overload: redox activity and susceptibility to chelation. Blood 102 (2003) 2670-2677
35. Hershko C.M., Link G.M., Konijn A.M., and Cabantchik Z.I. Iron chelation therapy. Curr Hematol Rep 4 (2005) 110-116
36. Yang J., Goetz D., Li J.Y., Wang W., Mori K., Setlik D., et al. An iron delivery pathway mediated by a lipocalin. Mol Cell 10 (2002) 1045-1056
37. Tesoriere L., D'Arpa D., Butera D., Allegra M., Renda D., Maggio A., et al. Oral supplements of vitamin E improve measures of oxidative stress in plasma and reduce oxidative damage to LDL and erythrocytes in β-thalassemia intermedia patients. Free Radic Res 34 (2001) 529-540
38. Kattamis A., Papassotiriou I., Palaiologou D., Apostolakou F., Galani A., Ladis V., et al. The effects of erythropoetic activity and iron burden on hepcidin expression in patients with thalassemia major. Haematologica 91 (2006) 809-812
39. Origa R., Galanello R., Ganz T., Giagu N., Maccioni L., Faa F., et al. Liver iron concentrations and urinary hepcidin in b-thalassemia. Haematologica 92 (2007) 583-588
40. Mishra J., Mori K., Ma Q., Kelly C., Yang J., Mitsnefes M., et al. Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin. J Am Soc Nephrol 15 (2004) 3073-3082