Regulation of retention of FosB intron 4 by PTB

PLoS ONE

Volumn 2, Issue 9, 2007, Pages

  Marinescu, Victor ^a   Loomis, Patricia A ^a   Ehmann, Svetlana ^a   Beales, Mitchell ^a   Potashkin, Judith A ^a  

^a ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; MESSENGER RNA PRECURSOR; POLYPYRIMIDINE TRACT BINDING PROTEIN; PROTEIN U2AF65; SMALL NUCLEAR RIBONUCLEOPROTEIN; TRANSCRIPTION FACTOR FOSB; UNCLASSIFIED DRUG; FOSB PROTEIN, HUMAN; PROTEIN C FOS;

ALTERNATIVE RNA SPLICING; AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRON; NONHUMAN; OPEN READING FRAME; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; STOP CODON; WILD TYPE; ANIMAL; BINDING SITE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOPRECIPITATION; METABOLISM; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; PHYSIOLOGY; RNA SPLICING; SEQUENCE HOMOLOGY;

ANIMALS; BASE SEQUENCE; BINDING SITES; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENE EXPRESSION REGULATION; HELA CELLS; HUMANS; IMMUNOPRECIPITATION; INTRONS; PHOSPHORYLATION; POLYPYRIMIDINE TRACT-BINDING PROTEIN; PROTO-ONCOGENE PROTEINS C-FOS; RNA SPLICING; SEQUENCE HOMOLOGY, NUCLEIC ACID;

EID: 41049106183     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0000828     Document Type: Article

References (53)

1. Nestler EJ, Kelz MB, Chen J (1999) DeltaFosB: a molecular mediator of long-term neural and behavioral plasticity. Brain Res 835: 10-17.
2. Perez-Otano I, Mandelzys A, Morgan JI (1998) MPTP-Parkinsonism is accompanied by persistent expression of a delta-FosB-like protein in dopaminergic pathways. Brain Res Mol Brain Res 53: 41-52.
3. Perrotti LI, Hadeishi Y, Ulery PG, Barrot M, Monteggia L, et al. (2004) Induction of DeltaFosB in reward-related brain structures after chronic stress. J Neurosci 24: 10594-10602.
4. Hiroi N, Marek GJ, Brown JR, Ye H, Saudou F, et al. (1998) Essential role of the fosB gene in molecular, cellular, and behavioral actions of chronic electroconvulsive seizures. J Neurosci 18: 6952-6962.
5. Miyata S, Tsujioka H, Itoh M, Matsunaga W, Kuramoto H, et al. (2001) Time course of Fos and Fras expression in the hypothalamic supraoptic neurons during chronic osmotic stimulation. Brain Res Mol Brain Res 90: 39-47.
6. Hope BT, Nye HE, Kelz MB, Self DW, Iadarola MJ, et al. (1994) Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments. Neuron 13: 1235-1244.
7. Chen J, Kelz MB, Hope BT, Nakabeppu Y, Nestler EJ (1997) Chronic Fos-related antigens: stable variants of deltaFosB induced in brain by chronic treatments. J Neurosci 17: 4933-4941.
8. Alibhai IN, Green TA, Potashkin JA, Nestler EJ (2007) Regulation of fosB and DeltaFosB mRNA expression: in vivo and in vitro studies. Brain Res 1143: 22-33.
9. Chen J, Nye HE, Kelz MB, Hiroi N, Nakabeppu Y, et al. (1995) Regulation of delta FosB and FosB-like proteins by electroconvulsive seizure and cocaine treatments. Mol Pharmacol 48: 880-889.
10. Acquaviva C, Brockly F, Ferrara P, Bossis G, Salvat C, et al. (2001) Identification of a C-terminal tripeptide motif involved in the control of rapid proteasomal degradation of c-Fos proto-oncoprotein during the G(0)-to-S phase transition. Oncogene 20: 7563-7572.
11. Ulery PG, Rudenko G, Nestler EJ (2006) Regulation of DeltaFosB stability by phosphorylation. J Neurosci 26: 5131-5142.
12. Gravelcy BR (2001) Alternative splicing: increasing diversity in the proteomic world. Trends Genet 17: 100-107.
13. Modrek B, Resch A, Grasso C, Lee C (2001) Genome-wide detection of alternative splicing in expressed sequences of human genes. Nucleic Acids Res 29: 2850-2859.
14. Smith CW, Valcarcel J (2000) Alternative pre-mRNA splicing: the logic of combinatorial control. Trends Biochem Sci 25: 381-388.
15. Faustino NA, Cooper TA (2003) Pre-mRNA splicing and human disease. Genes Dev 17: 419-437.
16. Grabowski PJ, Black DL (2001) Alternative RNA splicing in the nervous system. Prog Neurobiol 65: 289-308.
17. Dredge BK, Polydorides AD, Darnell RB (2001) The splice of life: alternative splicing and neurological disease. Nat Rev Neurosci 2: 43-50.
18. Ladd AN, Cooper TA (2002) Finding signals that regulate alternative splicing in the post-genomic era. Genome Biol 3: reviews0008.
19. Goren A, Ram O, Amit M, Keren H, Lev-Maor G, et al. (2006) Comparative analysis identifies exanic splicing regulatory sequences - The complex definition of enhancers and silencers. Mol Cell 22: 769-781.
20. Black DL (1992) Activation of c-src neuron-specific splicing by an unusual RNA element in vivo and in vitro. Cell 69: 795-807.
21. Zhang L, Ashiya M, Sherman TG, Grabowski PJ (1996) Essential nucleotides direct neuron-specific splicing of gamma 2 pre-mRNA. Rna 2; 682-699.
22. Wagner EJ, Garcia-Blanco MA (2001) Polypyrimidine tract binding protein antagonizes exon definition. Mol Cell Biol 21: 3281-3288.
23. Lou H, Helfman DM, Gagel RF, Berget SM (1999) Polypyrimidine tract-binding protein positively regulates inclusion of an alternative 3′-terminal exon. Mol Cell Biol 19: 78-85.
24. Paradis C, Cloutier P, Shkreta L, Toutant J, Klarskov K, et al. (2007) hnRNP I/PTB can antagonize the splicing repressor activity of SRp30c. Rna.
25. Mumberger D, Lucibello FC, Shuermann M, Muller R (1991) Alternative splicing of fosB transcripts results in differentially expressed mRNAs encoding functionally antagonistic proteins. Genes Dev 5: 1242-1223.
26. Xie J, Lee JA, Kress TL, Mowry, KL, Black DL, (2003) Protein kinase A phosphorylation modulates transport of the polypyrimidine tract-binding protein. Proc Natl Acad Sci U S A 100: 8776-8781.
27. Boutz PL, Stoilov P, Li Q, Lin CH, Chawla G, et al. (2007) A: post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative spliding in developing neurons. Genes Dev 21: 1636-1652.
28. Herdegen T, Leah JD (1998) Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins. Brain Res Brain Res Rev 28: 370-490.
29. Ulery PG, Nestler EJ (2007) Regulation of DeltaFosB transcriptional activity by Ser27 phosphorylation. Eur J Neurosci 25: 224-230.
30. Nestler EJ (2001) Molecular basis of long-term plasticity underlying addiction. Nat Rev Neurosci 2: 119-128.
31. Nakabeppu Y, Nathans D (1991) A naturally occurring truncated form of FosB that inhibits Fos/Jun transcriptional activity. Cell 64: 751-759.
32. Valcarcel J, Gebauer F (1997) Post-transcriptional regulation: the dawn of PTB. Curr Biol 7: R705-708.
33. Singh R, Valcarcel J, Green MR (1995) Distinct binding specificities and functions of higher eukaryotic polypyrimidine tract-binding proteins. Science 268: 1173-1176.
34. Lin CH, Patton JG (1995) Regulation of alternative 3′ splice site selection by constitutive splicing factors. Rna 1: 234-245.
35. Martin AJ, Southby J, Gooding C, Smith CW (2007) Repression of {alpha}-actinin SM exon splicing by assisted binding of PTB to the polypyrimidine tract. Rna.
36. Izquierdo JM, Majos N, Bonnal S, Martinez C, Castelo R, et al. (2005) Regulation of Fas alternative splicing by antagonistic effects of TIA-1 and PTB on exon definition. Mol Cell 19: 475-484.
37. Sharma S, Falick AM, Black DL (2005) Polypyrimidine tract binding protein blocks the 5′ splice site-dependent assembly of U2AF and the prespliceosomal E complex. Mol Cell 19: 485-496.
38. Ashiya M, Grabowski PJ (1997) A neuron-specific splicing switch mediated by an array of pre-mRNA repressor sites: evidence of a regulatory role for the polypyrimidine tract binding protein and a brain-specific PTB counterpart. Rna 3: 996-1015.
39. Kikuchi T, Ichikawa, M, Arai J, Tateiwa H, Fu L, et al. (2000) Molecular cloning and characterization of a new neuron-specific homologue of rat polypyrimidine tract binding protein. J Biochem (Tokyo) 128: 811-821.
40. Polydorides AD, Okano HJ, Yang YY, Stefani C, Darnell RB (2000) A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing. Proc Natl Acad Sci U S A 97: 6350-6355.
41. Markovtsov V, Nikolic JM, Goldman JA, Turck CW, Chou MY, et al. (2000) Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein. Mol Cell Biol 20: 7463-7479.
42. Makeyev EV, Zhang J, Carrasco MA, Maniatis T (2007) The MicroRNA miR-124 Promotes Neuronal Differentiation by Triggering Brain-Specific Alternative Pre-mRNA Splicing. Mol Cell 27: 435-448.
43. Spellman R, Llorian M, Smith CW (2007) Crossregulation and Functional Redundancy between the Splicing Regulator PTB and Its Paralogs nPTB and ROD1. Mol Cell 27: 420-434.
44. Galante PA, Sakabe NJ, Kirschbaum-Slager N, de Souza SJ (2004) Detection and evaluation of intron retention events in the human transcriptome. Rna 10: 757-765.
45. Zavolan M, van Nimwegen E (2006) The types and prevalence of alternative splice forms. Curr Opin Struct Biol 16: 362-367.
46. Hampson RK, Rottman FM (1987) Alternative processing of bovine growth hormone mRNA: nonsplicing of the final intron predicts a high molecular weight variant of bovine growth hormone. Proc Natl Acad Sci U S A 84: 2673-2677.
47. Sun Q, Mayeda A, Hampson RK, Krainer AR, Rottman FM (1993) General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer. Genes Dev 7: 2598-2608.
48. Dignam JD, Martin PL, Shastry BS, Roeder RG (1983) Eukaryotic gene transcription with purified components. Methods Enzymol 101: 582-598.
49. Mayeda A, Krainer AR (1999) Preparation of HeLa cell nuclear and cytosolic S100 extracts for in vitro splicing. Methods Mol Biol 118: 309-314.
50. Mayeda A, Krainer AR (1999) Mammalian in vitro splicing assays. Methods Mot Biol 118: 315-321.
51. Zhang L, Liu W, Grabowski PJ (1999) Coordinate repression of a trio of neuron-specific splicing events by the splicing regulator PTB. Rna 5: 117-130.
52. Chou MY, Underwood JG, Nikolic J, Luu MH, Black DL (2000) Multisite RNA binding and release of polypyrimidine tract binding protein during the regulation of c-src neural-specific splicing. Mol Cell 5: 949-957.
53. Southby J, Gooding C, Smith CW (1999) Polypyrimidine tract binding protein functions as a repressor to regulate alternative splicing of alpha-actinin mutally exclusive exons. Mol Cell Biol 19: 2699-2711.