Effect of OPC-12759 on EGF receptor activation, p44/p42 MAPK activity, and secretion in conjunctival goblet cells

Experimental Eye Research

Volumn 86, Issue 4, 2008, Pages 629-636

  Ríos, J David ^a   Shatos, Marie A ^a   Urashima, Hiroki ^b   Dartt, Darlene A ^a  

^a SCHEPENS EYE RESEARCH INSTITUTE   (United States)

^b OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

conjunctiva; goblet cells; mucin secretion; signal transduction

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; CARBACHOL; EPIDERMAL GROWTH FACTOR RECEPTOR; GLYCOCONJUGATE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MUCIN; REBAMIPIDE; ULEX EUROPAEUS AGGLUTININ;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONJUNCTIVA; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; GOBLET CELL; MALE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RAT; WESTERN BLOTTING;

ALANINE; ANIMALS; CELLS, CULTURED; CONJUNCTIVA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; EYE PROTEINS; GOBLET CELLS; MALE; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; QUINOLONES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 41049085751     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2008.01.007     Document Type: Article

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