메뉴 건너뛰기




Volumn 50, Issue SUPPL. 1, 2005, Pages

Gastroprotective agent rebamipide induces cyclooxygenase-2 (COX-2) in gastric epithelial cells

Author keywords

COX 2; Gastric epithelial cells; Rebamipide; Reporter assay

Indexed keywords

GASTROINTESTINAL MUCOSA PROTECTIVE AGENT; PROSTAGLANDIN E2; REBAMIPIDE; ALANINE; ANTIULCER AGENT; CYCLOOXYGENASE 2; DRUG DERIVATIVE; PROSTAGLANDIN SYNTHASE; QUINOLONE DERIVATIVE;

EID: 25644456769     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-005-2809-0     Document Type: Article
Times cited : (22)

References (29)
  • 1
    • 17744405690 scopus 로고
    • Mild irritants prevent gastric necrosis through "adaptive cytoprotection" mediated by prostaglandins
    • Robert A, Nazamis JE, Lancaster C, Davis JP, Field SO, Hanchar J: Mild irritants prevent gastric necrosis through "adaptive cytoprotection" mediated by prostaglandins. Am J Physiol 245:G113-G121, 1983
    • (1983) Am J Physiol , vol.245
    • Robert, A.1    Nazamis, J.E.2    Lancaster, C.3    Davis, J.P.4    Field, S.O.5    Hanchar, J.6
  • 3
    • 0020858787 scopus 로고
    • Protective effects of prostaglandins against mucosal damage: Current knowledge and proposed mechanism
    • Miller TA: Protective effects of prostaglandins against mucosal damage: current knowledge and proposed mechanism. Am J Physiol 245:G601-G623, 1983
    • (1983) Am J Physiol , vol.245
    • Miller, T.A.1
  • 4
    • 0025871150 scopus 로고
    • TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue
    • Kujubu DA, Fletcher BS, Varnum BC, Lim RW, Herschman HR: TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J Biol Chem 266:12866-12872, 1991
    • (1991) J Biol Chem , vol.266 , pp. 12866-12872
    • Kujubu, D.A.1    Fletcher, B.S.2    Varnum, B.C.3    Lim, R.W.4    Herschman, H.R.5
  • 5
    • 0028180129 scopus 로고
    • Induction of cyclooxygenase-2 by interleukin-1 alpha. Evidence for posttranscriptional regulation
    • Ristimaki A, Garfinkel S, Wessendorf J, Maciag T, Hla T: Induction of cyclooxygenase-2 by interleukin-1 alpha. Evidence for posttranscriptional regulation. J Biol Chem 269:11769-11775, 1994
    • (1994) J Biol Chem , vol.269 , pp. 11769-11775
    • Ristimaki, A.1    Garfinkel, S.2    Wessendorf, J.3    Maciag, T.4    Hla, T.5
  • 7
    • 0031052116 scopus 로고    scopus 로고
    • Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice
    • Mizuno H, Sakamoto C, Matsuda K, Wada K, Uchida T, Noguchi H, Akamatsu T, Kasuga M: Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. Gastroenterology 112:387-397, 1997
    • (1997) Gastroenterology , vol.112 , pp. 387-397
    • Mizuno, H.1    Sakamoto, C.2    Matsuda, K.3    Wada, K.4    Uchida, T.5    Noguchi, H.6    Akamatsu, T.7    Kasuga, M.8
  • 8
    • 0036314075 scopus 로고    scopus 로고
    • Rebamipide prevents delay of acetic acid-induced gastric ulcer healing caused by Helicobacter pylori infection in Mongolian gerbils
    • Watanabe T, Higuchi K, Hamaguchi M, Tanigawa T, Wada R, Tominaga K, Fujiwara Y, Arakawa T: Rebamipide prevents delay of acetic acid-induced gastric ulcer healing caused by Helicobacter pylori infection in Mongolian gerbils. Dig Dis Sci 47:1582-1589, 2002
    • (2002) Dig Dis Sci , vol.47 , pp. 1582-1589
    • Watanabe, T.1    Higuchi, K.2    Hamaguchi, M.3    Tanigawa, T.4    Wada, R.5    Tominaga, K.6    Fujiwara, Y.7    Arakawa, T.8
  • 9
    • 0023629705 scopus 로고
    • Gastric mucosal protection by OPC-12759, a novel antiulcer compound in the rat
    • Yamasaki K, Kanbe T, Chijiwa T, Ishiyama H, Morita S: Gastric mucosal protection by OPC-12759, a novel antiulcer compound in the rat. Eur J Pharmacol 142:23-29, 1987
    • (1987) Eur J Pharmacol , vol.142 , pp. 23-29
    • Yamasaki, K.1    Kanbe, T.2    Chijiwa, T.3    Ishiyama, H.4    Morita, S.5
  • 10
    • 0043286736 scopus 로고    scopus 로고
    • Clinical significance of mucosal-protective agents: Acid, inflammation, carcinogenesis and rebamipide
    • Haruma K, Ito M: Clinical significance of mucosal-protective agents: acid, inflammation, carcinogenesis and rebamipide. Aliment Pharmacol Ther 18(Suppl 1):153-159, 2003
    • (2003) Aliment Pharmacol Ther , vol.18 , Issue.1 SUPPL. , pp. 153-159
    • Haruma, K.1    Ito, M.2
  • 11
    • 0242684447 scopus 로고    scopus 로고
    • Effects of rebamipide, a gastro-protective drug on the Helicobacter pylori status and inflammation in the gastric mucosa of patients with gastric ulcer: A randomized double-blind placebo-controlled multicenter trial
    • Fujioka T, Arakawa T, Shimoyama T, Yoshikawa T, Ito M, Asaka M, Ishii H, Kuwayama H, Sato R, Kawai S, Takemoto T, Kobayashi K: Effects of rebamipide, a gastro-protective drug on the Helicobacter pylori status and inflammation in the gastric mucosa of patients with gastric ulcer: a randomized double-blind placebo-controlled multicenter trial. Aliment Pharmacol Ther 18(Suppl 1):146-152, 2003
    • (2003) Aliment Pharmacol Ther , vol.18 , Issue.1 SUPPL. , pp. 146-152
    • Fujioka, T.1    Arakawa, T.2    Shimoyama, T.3    Yoshikawa, T.4    Ito, M.5    Asaka, M.6    Ishii, H.7    Kuwayama, H.8    Sato, R.9    Kawai, S.10    Takemoto, T.11    Kobayashi, K.12
  • 12
    • 0028895213 scopus 로고
    • Rebamipide, novel prostaglandin-inducer accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer. Comparison with cimetidine
    • Arakawa T, Watanabe T, Fukuda T, Yamasaki K, Kobayashi K: Rebamipide, novel prostaglandin-inducer accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer. Comparison with cimetidine. Dig Dis Sci 40:2469-2472, 1995
    • (1995) Dig Dis Sci , vol.40 , pp. 2469-2472
    • Arakawa, T.1    Watanabe, T.2    Fukuda, T.3    Yamasaki, K.4    Kobayashi, K.5
  • 13
    • 0028843812 scopus 로고
    • Preventive effect of rebamipide on gastric lesions induced by ischemia-reperfusion in the rat
    • Kim CD, Hong KW: Preventive effect of rebamipide on gastric lesions induced by ischemia-reperfusion in the rat. J Pharmacol Exp Ther 275:340-344, 1995
    • (1995) J Pharmacol Exp Ther , vol.275 , pp. 340-344
    • Kim, C.D.1    Hong, K.W.2
  • 14
    • 0031710628 scopus 로고    scopus 로고
    • Rebamipide prevented delay of wound repair induced by hydrogen peroxide and suppressed apoptosis of gastric epithelial cells in vitro
    • Watanabe S, Wang XE, Hirose M, Osada T, Tanaka H, Sato N: Rebamipide prevented delay of wound repair induced by hydrogen peroxide and suppressed apoptosis of gastric epithelial cells in vitro. Dig Dis Sci 43(Suppl):107S-112S, 1998
    • (1998) Dig Dis Sci , vol.43 , Issue.SUPPL.
    • Watanabe, S.1    Wang, X.E.2    Hirose, M.3    Osada, T.4    Tanaka, H.5    Sato, N.6
  • 15
    • 0027460826 scopus 로고
    • Free radical scavenging activity of the novel anti-ulcer agent rebamipide studied by electron spin resonance
    • Yoshikawa T, Naito Y, Tanigawa T, Kondo M: Free radical scavenging activity of the novel anti-ulcer agent rebamipide studied by electron spin resonance. Arzneimittelforschung 43:363-366, 1993
    • (1993) Arzneimittelforschung , vol.43 , pp. 363-366
    • Yoshikawa, T.1    Naito, Y.2    Tanigawa, T.3    Kondo, M.4
  • 16
    • 0026557227 scopus 로고
    • Antiulcer mechanism of action of rebamipide, a novel antiulcer compound, on diethyldithiocarbamate-induced antral gastric ulcers in rats
    • Ogino K, Hobara T, Ishiyama H, Yamasaki K, Kobayashi H, Izumi Y, Oka S: Antiulcer mechanism of action of rebamipide, a novel antiulcer compound, on diethyldithiocarbamate-induced antral gastric ulcers in rats. Eur J Pharmacol 212:9-13, 1992
    • (1992) Eur J Pharmacol , vol.212 , pp. 9-13
    • Ogino, K.1    Hobara, T.2    Ishiyama, H.3    Yamasaki, K.4    Kobayashi, H.5    Izumi, Y.6    Oka, S.7
  • 17
    • 0031715660 scopus 로고    scopus 로고
    • Rebamipide prevents indomethacin-induced gastric mucosal lesion formation by inhibiting activation of neutrophils in rats
    • Murakami K, Okajima K, Harada N, Isobe H, Okabe H: Rebamipide prevents indomethacin-induced gastric mucosal lesion formation by inhibiting activation of neutrophils in rats. Dig Dis Sci 43(Suppl):139S-142S, 1998
    • (1998) Dig Dis Sci , vol.43 , Issue.SUPPL.
    • Murakami, K.1    Okajima, K.2    Harada, N.3    Isobe, H.4    Okabe, H.5
  • 18
    • 0028102593 scopus 로고
    • Rebamipide, a novel antiulcer agent, attenuates Helicobacter pylori induced gastric mucosal cell injury associated with neutrophil derived oxidants
    • Suzuki M, Miura S, Mori M, Kai A, Suzuki H, Fukumura D, Suematsu M, Tsuchiya M: Rebamipide, a novel antiulcer agent, attenuates Helicobacter pylori induced gastric mucosal cell injury associated with neutrophil derived oxidants. Gut 35:1375-1378, 1994.
    • (1994) Gut , vol.35 , pp. 1375-1378
    • Suzuki, M.1    Miura, S.2    Mori, M.3    Kai, A.4    Suzuki, H.5    Fukumura, D.6    Suematsu, M.7    Tsuchiya, M.8
  • 19
    • 0037298904 scopus 로고    scopus 로고
    • Effect of rebamipide on acetic acid-induced gastric ulcer in rats: Involvement of hepatocyte growth factor
    • Udagawa A, Shiota G, Ichiba M, Murawaki Y: Effect of rebamipide on acetic acid-induced gastric ulcer in rats: involvement of hepatocyte growth factor. Scand J Gastroenterol 38:141-146, 2003
    • (2003) Scand J Gastroenterol , vol.38 , pp. 141-146
    • Udagawa, A.1    Shiota, G.2    Ichiba, M.3    Murawaki, Y.4
  • 20
    • 0032489318 scopus 로고    scopus 로고
    • Transcriptional role of the nuclear factor kappa B site in the induction by lipopolysaccharide and suppression by dexamethasone of cyclooxygenase-2 in U937 cells
    • Inoue H, Tanabe T: Transcriptional role of the nuclear factor kappa B site in the induction by lipopolysaccharide and suppression by dexamethasone of cyclooxygenase-2 in U937 cells. Biochem Biophys Res Commun 244:143-148, 1998
    • (1998) Biochem Biophys Res Commun , vol.244 , pp. 143-148
    • Inoue, H.1    Tanabe, T.2
  • 21
    • 0033582253 scopus 로고    scopus 로고
    • Glucocorticoid-mediated suppression of the promoter activity of the cyclooxygenase-2 gene is modulated by expression of its receptor in vascular endothelial cells
    • Inoue H, Umesono K, Nishimori T, Hirata Y, Tanabe T: Glucocorticoid- mediated suppression of the promoter activity of the cyclooxygenase-2 gene is modulated by expression of its receptor in vascular endothelial cells. Biochem Biophys Res Commun 254:292-298, 1999
    • (1999) Biochem Biophys Res Commun , vol.254 , pp. 292-298
    • Inoue, H.1    Umesono, K.2    Nishimori, T.3    Hirata, Y.4    Tanabe, T.5
  • 22
    • 0031667425 scopus 로고    scopus 로고
    • Rebamipide treatment activates epidermal growth factor and its receptor expression in normal and ulcerated gastric mucosa in rats: One mechanism for its ulcer healing action?
    • Tarnawski AS, Arakawa T, Kobayashi K: Rebamipide treatment activates epidermal growth factor and its receptor expression in normal and ulcerated gastric mucosa in rats: one mechanism for its ulcer healing action? Dig Dis Sci 43(Suppl):90S-98S, 1998
    • (1998) Dig Dis Sci , vol.43 , Issue.SUPPL.
    • Tarnawski, A.S.1    Arakawa, T.2    Kobayashi, K.3
  • 23
    • 1642362822 scopus 로고    scopus 로고
    • Rebamipide activates genes encoding angiogenic growth factors and Cox2 and stimulates angiogenesis: A key to its ulcer healing action?
    • Tarnawski AS, Chai J, Pai R, Chiou SK: Rebamipide activates genes encoding angiogenic growth factors and Cox2 and stimulates angiogenesis: a key to its ulcer healing action? Dig Dis Sci 49:202-209, 2004
    • (2004) Dig Dis Sci , vol.49 , pp. 202-209
    • Tarnawski, A.S.1    Chai, J.2    Pai, R.3    Chiou, S.K.4
  • 25
    • 0036006453 scopus 로고    scopus 로고
    • 2 transactivates EGF receptor: A novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy
    • 2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy. Nat Med 8:289-293, 2002
    • (2002) Nat Med , vol.8 , pp. 289-293
    • Pai, R.1    Soreghan, B.2    Szabo, I.L.3    Pavelka, M.4    Baatar, D.5    Tarnawski, A.S.6
  • 26
    • 0034070950 scopus 로고    scopus 로고
    • Inhibition of lipid peroxidation, NF-kappa B activation and IL-8 production by rebamipide in Helicobacter pylori-stimulated gastric epithelial cells
    • Kim H, Seo JY, Kim KH: Inhibition of lipid peroxidation, NF-kappa B activation and IL-8 production by rebamipide in Helicobacter pylori-stimulated gastric epithelial cells. Dig Dis Sci 45:621-628, 2000
    • (2000) Dig Dis Sci , vol.45 , pp. 621-628
    • Kim, H.1    Seo, J.Y.2    Kim, K.H.3
  • 27
    • 0003504049 scopus 로고    scopus 로고
    • Cyclooxygenase regulates angiogenesis induced by colon cancer cells
    • Tsujii M, Kawano S, Tsuji S, Sawaoka H, Hori M, DuBois RN: Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 93:705-716, 1998
    • (1998) Cell , vol.93 , pp. 705-716
    • Tsujii, M.1    Kawano, S.2    Tsuji, S.3    Sawaoka, H.4    Hori, M.5    DuBois, R.N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.