Paclitaxel associated with cholesterol-rich nanoemulsions promotes atherosclerosis regression in the rabbit

Atherosclerosis

Volumn 197, Issue 2, 2008, Pages 959-966

  Maranhão, Raul C ^a   Tavares, Elaine R ^a   Padoveze, Amanda F ^a   Valduga, Claudete J ^a   Rodrigues, Debora G ^a   Pereira, Maria D ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Drug targeting; Emulsions; Low density lipoprotein (LDL) receptors; Paclitaxel

Indexed keywords

CHOLESTEROL; CHOLESTEROL RICH NANOEMULSION; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; NANOPARTICLE; PACLITAXEL; PACLITAXEL OLEATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ARCH; ARTERY INTIMA PROLIFERATION; ARTICLE; ATHEROSCLEROSIS; CELL LABELING; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFICACY; EMULSION; GENE OVEREXPRESSION; MACROPHAGE MIGRATION; MALE; NANOBIOTECHNOLOGY; NANOMEDICINE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RADIOISOTOPE DISTRIBUTION; REMISSION; SMOOTH MUSCLE FIBER;

EID: 40949141352     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2007.12.051     Document Type: Article

References (37)

1. Rowinsky E.K., Cazenave L.A., and Doneiiower R.C. Taxol-a novel investigational antimicrotubule agent. J Natl Cancer Inst 82 (1990) 1247-1259
2. Rowinsky E.K., and Doneiiower R.C. Paclitaxel (taxol). N Engl J Med 332 15 (1995) 1004-1014
3. Lee S.H., et al. Sirolimus-versus paclitaxel-eluting stent implantation for unprotected left main coronary artery stenosis. Cardiology 104 4 (2005) 181-185
4. Heldman A.W., Cheng L., Jenkins G.M., et al. Paclitaxel stent coating inhibits neointimal hyperplasia at 4 weeks in a porcine model of coronary restenosis. Circulation 103 (2001) 2289-2295
5. Stone G.W., et al. Comparison of a polymer-based paclitaxel-eluting stent with a bare metal stent in patients with complex coronary artery disease: a randomized controlled trial. JAMA 294 10 (2005) 1215-1223
6. Rowinsky E.K., Chaudhry V., Forastiere A.A., et al. Phase I and pharmacologic study of paclitaxel and cisplatin with granulocyte colony-stimulating factor: neuromuscular toxicity is dose-limiting. J Clin Oncol 11 10 (1993) 2010-2020
7. Maranhão R.C., Roland I.A., Toffoletto O., et al. Plasma kinetic behavior in hyperlipidemic subjects of a lipidic microemulsion that binds to low density lipoprotein receptors. Lipids 32 6 (1997) 627-633
8. Ruiz J., Kouiavskaia D., Migliorini M., et al. The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor. J Lipid Res 46 8 (2005) 1721-1731
9. Pinheiro K.V., Hungria V.T., Ficker E.S., et al. Plasma kinetics of a cholesterol-rich microemulsion (LDE) in patients with Hodgkin's and non-Hodgkin's lymphoma and a preliminary study on the toxicity of etoposide associated with LDE. Cancer Chemother Pharmacol 57 5 (2006) 624-630
10. Maranhão R.C., Graziani S.R., Yamaguchi N., et al. Association of carmustine with a lipid emulsion: in vitro, in vivo and preliminary studies in cancer patients. Cancer Chemother Pharmacol 49 6 (2002) 487-498
11. Valduga C.J., Fernandes D.C., Lo Prete A.C., et al. Use of a cholesterol-rich microemulsion that binds to low-density lipoprotein receptors as vehicle for etoposide. J Pharm Pharmacol 55 12 (2003) 1615-1622
12. Rodrigues D.G., Maria D.A., Fernandes D.C., et al. Improvement of paclitaxel therapeutic index by derivatization and association to a cholesterol-rich microemulsion: in vitro and in vivo studies. Cancer Chemother Pharmacol 55 6 (2005) 565-576
13. Graziani S.R., Igreja F.A., Hegg R., et al. Uptake of a cholesterol-rich emulsion by breast cancer. Ginecol Oncol 85 (2002) 493-497
14. Ades A., Carvalho J.P., Graziani S.R., et al. Uptake of a cholesterol-rich emulsion by neoplastic ovarian tissues. Gynecol Oncol 81 1 (2001) 84-87
15. Maranhão R.C., Garicochea B., Silva E.L., et al. Plasma kinetics and biodistribution of a lipid emulsion resembling low-density lipoprotein in patients with acute leukemia. Cancer Res 54 (1994) 4660-4666
16. Hungria V.T., Latrilha M.C., Rodrigues D.G., et al. Metabolism of a cholesterol-rich microemulsion (LDE) in patients with multiple myeloma and a preliminary clinical study of LDE as a drug vehicle for treatment of the disease. Cancer Chemother Pharmacol 53 (2004) 51-60
17. Dias M.L.N., Carvalho J.P., Rodrigues D.G., Graziani S.R., and Maranhão R.C. Pharmacokinetics and tumor uptake of a derivatized form of paclitaxel associated to a cholesterol-rich nanoemulsion (LDE) in patients with gynecologic cancers. Cancer Chemother Pharmacol 59 1 (2007) 105-111
18. David-Couto R., Dallan L.A.O., Lisboa L.A.F., et al. Deposition of cholesterol from a lipid microemulsion in fragments of blood vessels excised from patients during coronary bypass surgery. Atheroscler Suppl 2 (2003) 227-228 [Abstract]
19. Folch J., Lees M., and Sloane-Stanley G.H. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 206 (1957) 2443-2450
20. Ginsburg G.S., Small D.M., and Atkinson D. Microemulsions of phospholipids and cholesterol esters. Protein-free models of low-density lipoprotein. J Biol Chem 257 (1982) 8216-8227
21. Maranhão R.C., Cesar T.B., Pedroso-Mariani S.R., Hirata M.H., and Mesquita C.H. Metabolic behavior in rats of a non-protein microemulsion resembling low density lipoprotein. Lipids 28 (1993) 691-696
22. Matthews C.M. The theory of tracer experiments with l31I-labeled plasma proteins. Phys Med Biol 2 (1957) 36-41
23. Lewis G.F., Lamarche B., Uffelman K.D., et al. Clearance of postprandial and lipolytically modified human HDL in rabbits and rats. J Lipid Res 38 9 (1997) 1771-1778
24. Maranhão R.C., Cesar T.B., Pedroso-Mariani S.R., Hirata M.H., and Mesquita C.H. Metabolic behavior in rats of a nonprotein microemulsion resembling low-density lipoprotein. Lipids 28 8 (1993) 691-696
25. Shah V.P., Midha K.K., Dighe S., et al. Analytical methods validation: bioavailability, bioequivalence and pharmacokinetic studies. Conference report. Eur J Drug Metab Pharmacokinet 16 4 (1991) 249-255
26. Onetto N., Canetta R., Winograd B., et al. Overview of taxol safety. J Natl Cancer Inst Monogr 15 (1993) 131-139
27. Rowinsky E.K., Eisenhauer E.A., Chaudhry V., Arbuck S.G., and Donehower R.C. Clinical toxicities encountered with paclitaxel (taxol). Semin Oncol 20 4 Suppl 3 (1993) 1-15
28. Weiss R.B., Donehower R.C., Wiernik P.H., et al. Hypersensitivity reactions from taxol. J Clin Oncol 8 7 (1990) 1263-1268
29. Kolodgie F.D., John M., Khurana C., et al. Sustained reduction of in-stent neointimal growth with the use of a novel systemic nanoparticle paclitaxel. Circulation 106 10 (2002) 1195-1198
30. Azevedo C.H., Carvalho J.P., Valduga C.J., and Maranhão R.C. Plasma kinetics and uptake by the tumor of a cholesterol-rich microemulsion (LDE) associated to etoposide oleate in patients with ovarian carcinoma. Gynecol Oncol 97 1 (2005) 178-182
31. Teixeira R.S., Cury R., and Maranhão R.C. Effects on Walker 256 tumour of carmustine associated with a cholesterol-rich microemulsion (LDE). J Pharm Pharmacol 56 7 (2004) 909-914
32. Lo Prete A., Maria D.A., Rodrigues D.G., et al. Evaluation in melanoma-bearing mice of an etoposide derivative associated to a cholesterol-rich nanoemulsion. J Pharm Pharmacol 58 6 (2006) 801-808
33. Zhang J.Q., Zhang Z.R., Yang H., et al. Lyophilized paclitaxel magnetoliposomes as a potential drug delivery system for breast carcinoma via parenteral administration: in vitro and in vivo studies. Pharm Res 22 4 (2005) 573-583
34. Goble S., and Bear H.D. Emerging role of taxanes in adjuvant and neoadjuvant therapy for breast cancer: the potential and the questions. Surg Clin North Am 83 4 (2003) 943-971
35. Naoum F.A., Gualandro S.F., Latrilha M.C., and Maranhão R.C. Plasma kinetics of a cholesterol-rich microemulsion in subjects with heterozygous beta-thalassemia. Am J Hematol 77 4 (2004) 340-345
36. Zhu Y., Bujo H., Yamazaki H., et al. Enhanced expression of the LDL receptor family member LR11 increases migration of smooth muscle cells in vitro. Circulation 105 15 (2002) 1830-1836
37. Wang J., Wang S., Lu Y., Weng Y., and Gown A.M. GM-CSF and M-CSF expression is associated with macrophage proliferation in progressing and regressing rabbit atheromatous lesions. Exp Mol Pathol 61 2 (1994) 109-118