ACE genotype and the muscle hypertrophic and strength responses to strength training

Medicine and Science in Sports and Exercise

Volumn 40, Issue 4, 2008, Pages 677-683

  Charbonneau, David E ^a   Hanson, Erik D ^a   Ludlow, Andrew T ^a   Delmonico, Matthew J ^a,b   Hurley, Ben F ^a   Roth, Stephen M ^a  

^a UNIVERSITY OF MARYLAND   (United States)

^b UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

Angiotensin converting enzyme; Genetics; Muscle mass; Muscle size; Skeletal muscle

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE;

ADULT; AGED; ARTICLE; BODY WEIGHT; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENOTYPE; HUMAN; MALE; MUSCLE HYPERTROPHY; MUSCLE MASS; MUSCLE STRENGTH; PHENOTYPE; SEX DIFFERENCE;

ADAPTATION, PHYSIOLOGICAL; AGED; AGED, 80 AND OVER; BODY COMPOSITION; BODY MASS INDEX; FEMALE; GENOTYPE; HUMANS; ISOMETRIC CONTRACTION; MALE; MIDDLE AGED; MUSCLE STRENGTH; MUSCLE, SKELETAL; PEPTIDYL-DIPEPTIDASE A; PHENOTYPE; PROSPECTIVE STUDIES; WEIGHT LIFTING;

EID: 40949138282     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0b013e318161eab9     Document Type: Article

References (36)

1. Arden NK, Spector TD. Genetic influences on muscle strength, lean body mass, and bone mineral density: a twin study. J Bone Miner Res. 1997;12:2076-81.
2. Barley J, Blackwood A, Carter ND, et al. Angiotensin converting enzyme insertion/deletion polymorphism: association with ethnic origin. J Hypertens. 1994;12:955-7.
3. Barley J, Blackwood A, Miller M, et al. Angiotensin converting enzyme gene I/D polymorphism, blood pressure and the reninangiotensin system in Caucasian and Afro-Caribbean peoples. J Hum Hypertens. 1996;10:31-5.
4. Berk BC, Vekshtein V, Gordon HM, et al. Angiotensin II-stimulated protein synthesis in cultured vascular smooth muscle cells. Hypertension. 1989;13:305-14.
5. Buikema H, Pinto YM, Rooks G, et al. The deletion polymorphism of the angiotensin-converting enzyme gene is related to phenotypic differences in human arteries. Eur Heart J. 1996;17:787-94.
6. Danser AH, Schalekamp MA, Bax WA, et al. Angiotensin-converting enzyme in the human heart. Effect of the deletion/insertion polymorphism. Circulation. 1995;92:1387-8.
7. Folland J, Leach B, Little T, et al. Angiotensin-converting enzyme genotype affects the response of human skeletal muscle to functional overload. Exp Physiol. 2000;85:575-9.
8. Geisterfer AA, Peach MJ, Owens GK. Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells. Circ Res. 1988;62:749-56.
9. Giaccaglia V, Nicklas B, Kritchevsky S, et al. Interaction between angiotensin converting enzyme insertion/deletion genotype and exercise training on knee extensor strength in older individuals. Int J Sports Med. 2008;29(1):40-4.
10. Gordon SE, Davis BS, Carlson CJ, et al. ANG II is required for optimal overload-induced skeletal muscle hypertrophy. Am J Physiol Endocrinol Metab. 2001;280:E150-9.
11. Kostek MC, Delmonico MJ, Reichel JB, et al. Muscle strength response to strength training is influenced by insulin-like growth factor 1 genotype in older adults. J Appl Physiol. 2005;98:2147-54.
12. Kritchevsky SB, Nicklas BJ, Visser M, et al. Angiotensin-converting enzyme insertion/deletion genotype, exercise, and physical decline. JAMA. 2005;294:691-8.
13. Lemmer JT, Hurlbut DE, Martel GF, et al. Age and gender responses to strength training and detraining. Med Sci Sports Exerc. 2000;32(8):1505-12.
14. Loos R, Thomis M, Maes HH, et al. Gender-specific regional changes in genetic structure of muscularity in early adolescence. J Appl Physiol. 1997;82:1802-10.
15. Mathew J, Basheeruddin K, Prabhakar S. Differences in frequency of the deletion polymorphism of the angiotensin-converting enzyme gene in different ethnic groups. Angiology. 2001;52:375-9.
16. McBride TA. AT1 receptors are necessary for eccentric training-induced hypertrophy and strength gains in rat skeletal muscle. Exp Physiol. 2006;91:413-21.
17. McEwan PE, Gray GA, Sherry L, et al. Differential effects of angiotensin II on cardiac cell proliferation and intramyocardial perivascular fibrosis in vivo. Circulation. 1998;98:2765-73.
18. Montgomery HE, Clarkson P, Dollery CM, et al. Association of angiotensin-converting enzyme gene I/D polymorphism with change in left ventricular mass in response to physical training. Circulation. 1997;96:741-7.
19. Pescatello LS, Kostek MA, Gordish-Dressman H, et al. ACE ID genotype and the muscle strength and size response to unilateral resistance training. Med Sci Sports Exerc. 2006;38(6):1074-81.
20. Rankinen T, Bray MS, Hagberg JM, et al. The human gene map for performance and health-related fitness phenotypes: the 2005 update. Med Sci Sports Exerc. 2006;38(11):1863-88.
21. Reed T, Fabsitz RR, Selby JV, et al. Genetic influences and grip strength norms in the NHLBI twin study males aged 59-69. Ann Hum Biol. 1991;18:425-32.
22. Rigat B, Hubert C, Henc-Gelas F, et al. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 1990;86:1343-46.
23. Sadoshima J, Xu Y, Slayter HS, et al. Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell. 1993;75:977-84.
24. Sanchez-Andres A, Mesa MS. Heritabilities of morphological and body composition characteristics in a Spanish population. Anthropol Anz. 1994;52:341-9.
25. Silva GJ, Moreira ED, Pereira AC, et al. ACE gene dosage modulates pressure-induced cardiac hypertrophy in mice and men. Physiol Genomics. 2006;27:237-44.
26. Thibault MC, Simoneau JA, Cote C, et al. Inheritance of human muscle enzyme adaptation to isokinetic strength training. Hum Hered. 1986;36:341-7.
27. Thomis MA, Beunen GP, Maes HH, et al. Strength training: importance of genetic factors. Med Sci Sports Exerc. 1998;30:724-31.
28. Thomis MA, Beunen GP, Van LM, et al. Inheritance of static and dynamic arm strength and some of its determinants. Acta Physiol Scand. 1998;163:59-71.
29. Thomis MA, Huygens W, Heuninckx S, et al. Exploration of myostatin polymorphisms and the angiotensin-converting enzyme insertion/deletion genotype in responses of human muscle to strength training. Eur J Appl Physiol. 2004;92:267-74.
30. Tiainen K, Sipila S, Alen M, et al. Heritability of maximal isometric muscle strength in older female twins. J Appl Physiol. 2004;96:173-80.
31. Tiret L, Rigat B, Visvikis S, et al. Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels. Am J Hum Genet. 1992;51:197-205.
32. Tracy BL, Ivey FM, Hurlbut DE, et al. Muscle quality. II. Effects of strength training in 65- to 75-yr-old men and women. J Appl Physiol. 1999;86:195-201.
33. Tracy BL, Ivey FM, Jeffrey ME, et al. A more efficient magnetic resonance imaging-based strategy for measuring quadriceps muscle volume. Med Sci Sports Exerc. 2003;35(3):425-33.
34. Westerkamp CM, Gordon SE. Angiotensin-converting enzyme inhibition attenuates myonuclear addition in overloaded slow-twitch skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2005;289:R1223-31.
35. Williams AG, Day SH, Folland JP, et al. Circulating angiotensin converting enzyme activity is correlated with muscle strength. Med Sci Sports Exerc. 2005;37(6):944-8.
36. Woods DR, Humphries SE, Montgomery HE. The ACE I/D polymorphism and human physical performance. Trends Endocrinol Metab. 2000;11:416-20.