Gene discovery in venous thrombosis: Progress and promise

JAMA

Volumn 299, Issue 11, 2008, Pages 1362-1363

  Bovill, Edwin G ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN; BLOOD CLOTTING FACTOR 5 LEIDEN; PROTEIN C; PROTEIN S;

CYP4V2 GENE; DEEP VEIN THROMBOSIS; EDITORIAL; ENVIRONMENTAL FACTOR; GENE; GENE CONTROL; GENE EXPRESSION; GENE FREQUENCY; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; GP6 GENE; HAPLOTYPE; HEREDITY; HOMOZYGOSITY; HUMAN; POPULATION GENETICS; PRIORITY JOURNAL; RISK FACTOR; SERPINC1 GENE; SINGLE NUCLEOTIDE POLYMORPHISM; GENETICS; GENOMICS; NOTE; VEIN THROMBOSIS;

GENOMICS; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; VENOUS THROMBOSIS;

EID: 40949123419     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.299.11.1362     Document Type: Editorial

References (22)

1. Petretto E, Liu ET, Aitman TJ. A gene harvest revealing the archeology and complexity of human disease. Nat Genet. 2007;39(11):1299-1301.
2. Baker M. Genome studies: genetics by numbers. Science. 2008;451(7178):516-518.
3. International HapMap Project Web site. http://www.hapmap.org. Accessed February 25, 2008. .
4. Smith NL, Hindorff LA, Heckbert SR, et al. Genetic variations and nonfatal venous thrombosis in postmenopausal women. JAMA. 2007;297(5):489-498.
5. Bezemer ID, Bare LA, Doggen CJM, et al. Gene variants associated with deep vein thrombosis. JAMA. 2008;299(11):1306-1314.
6. Koster T, Rosendaal FR, De Ronde H, et al. Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study. Lancet. 1993;342(8886-8887):569-576.
7. Blom JW, Doggen CJM, Osanto S, Rosendaal FR. Malignancies, prothrombotic mutations, and the risk of venous thrombosis. JAMA. 2005;293(6):715-722.
8. Dupuis J, O'Donnell CJ. Interpreting results of large-scale genetic association studies: separating gold from fool's gold. JAMA. 2007;297(5):529-531.
9. Shiffman D, Ellis SG, Rowland CM, et al. Identification of four genes associated with myocardial infarction. Am J Hum Genet. 2005;77(4):596-605.
10. Souto JC, Almasy L, Borrell M, et al. Genetic susceptibility to thrombosis and its relationship to physiological risk factors: the GAIT study.Am J Hum Genet. 2000;67(6):1452-1459.
11. Meijers JC, Tekelenburg WL, Bouma BN, Bertina RM, Rosendaal FR. High levels of factor XI as a risk factor for venous thrombosis. N Engl J Med. 2000;342(10):696-701.
12. van Hylckama Vlieg A, van der Linden IK, Bertina RM. High levels of factor IX increase the risk of venous thrombosis. Blood. 2000;95(12):3678-3682.
13. Seligson U, Zivelin A. Thrombophilia as a multigenic disorder. Thromb Haemost. 1997;78:712-717.
14. Hasstedt SJ, Bovill EG, Callas PW, Long GL. An unknown genetic defect increases venous thrombosis risk, through interaction with protein C deficiency. Am J Hum Genet. 1998;63(2):569-576.
15. Bovill EG, Hasstedt SJ, Leppert MF, Long GL. Hereditary thrombophilia as a model for multigenic disease. Thromb Haemost. 1999;82(2):662-666.
16. Rosendaal FR. Venous thrombosis: a multicausal disease. Lancet. 1999;353(9159):1167-1173.
17. Tracy RP. "Deep phenotyping" characterizing populations in the era of genomics and systems biology. Genet Mol Biol. In press.
18. Encode Project Consortium. Identification and analysis of functional elements in 1% of the human genome by the ENCODE project. Nature. 2007;447(7146):799-816.
19. Ohno S. So much "junk" in our DNA. Brookhaven Symp Biol. 1972;23:366-370.
20. Gerstein MB, Bruce C, Rozowsky JS, et al. What is a gene, post ENCODE? history and update definition. Genome Res. 2007;17(6):669-681.
21. Grosshans H, Filipowicz W. The expanding world of small RNAs. Nature. 2008;451(7177):414-416.
22. McPhereson R, Pertsemlidis A, Kavaslar N, et al. A common allele on chromosome 9 associated with coronary disease. Science. 2007;316(5830):1488-1491.