Xylarinic acids A and B, new antifungal polypropionates from the fruiting body of Xylaria polymorpha

Journal of Antibiotics

Volumn 60, Issue 11, 2007, Pages 696-699

  Jang, Yun Woo ^a   Lee, In Kyoung ^a   Kim, Young Sook ^a   Lee, Sangku ^a   Lee, Ho Jae ^a   Yu, Seung Hun ^b   Yun, Bong Sik ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Chungnam National University   (South Korea)

Author keywords

Antifungal activity; Mushroom; Polypropionate; Xylaria polymorpha; Xylarinic acid

Indexed keywords

ANTIFUNGAL AGENT; NATURAL PRODUCT; PROPIONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; XYLARINIC ACID A; XYLARINIC ACID B; 2,4,6 TRIMETHYL 2 OCTENOIC ACID; 2,4,6-TRIMETHYL-2-OCTENOIC ACID; 4,6,8 TRIMETHYL 2,4 DECADIENOIC ACID; 4,6,8-TRIMETHYL-2,4-DECADIENOIC ACID; MONOUNSATURATED FATTY ACID; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE; UNSATURATED FATTY ACID;

ALTERNARIA; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; ASPERGILLUS NIGER; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ISOLATION; DRUG PURIFICATION; DRUG STRUCTURE; FRUITING BODY; FUSARIUM OXYSPORUM; HUMAN; HUMAN CELL; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PYTHIUM; STEREOCHEMISTRY; XYLARIA POLYMORPHA; XYLARIALES; ASCOMYCETES; BACTERIUM; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; INFRARED SPECTROPHOTOMETRY; ISOLATION AND PURIFICATION; MICROBIOLOGICAL EXAMINATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TUMOR CELL LINE; ULTRAVIOLET SPECTROPHOTOMETRY;

ALTERNARIA PANAX; ASPERGILLUS NIGER; BASIDIOMYCOTA; FUNGI; FUSARIUM OXYSPORUM; MAGNAPORTHE GRISEA; PYTHIUM; XYLARIA POLYMORPHA;

ANTIBIOTICS, ANTIFUNGAL; ASCOMYCOTA; BACTERIA; CELL LINE, TUMOR; CHEMISTRY, PHYSICAL; DRUG SCREENING ASSAYS, ANTITUMOR; FATTY ACIDS, MONOUNSATURATED; FATTY ACIDS, UNSATURATED; FRUITING BODIES, FUNGAL; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; SPECTROPHOTOMETRY, INFRARED; SPECTROPHOTOMETRY, ULTRAVIOLET; TETRAZOLIUM SALTS; THIAZOLES;

EID: 40949093255     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2007.89     Document Type: Article

References (10)

1. Jayasuriya H, Herath KB, Ondeyka JG, Polishook JD, Bills GF, Dombrowsky AW, Springer MS, Siciliano S, Malkowitz L, Sanchez M, Guan Z, Tiwari S, Stevenson DW, Borris RP, Singh S. Isolation and structure of antagonists of chemokine receptor (CCR5). J Nat Prod 67: 1036-1038 (2004)
2. Boonphong S, Kittakoop P, Isaka M, Pittayakhajonwut D, Tanticharoen M, Thebtaranonth Y. Multiplolides A and B, new antifungal 10-membered lactones from Xylaria multiplex. J Nat Prod 64: 965-967 (2001)
3. Smith CJ, Morin NR, Bills GF, Dombrowski AW, Salituro GM, Smith SK, Zhao A, MacNeil DJ. Novel sesquiterpenoids from the fermentation of Xylaria persicaria are selective ligands for the NPY Y5 receptor. J Org Chem 67: 5001-5004 (2002)
4. Lin Y, Wu X, Feng S, Jiang G, Luo J, Zhou S, Vrijmoed LLP, Jones EBG, Krohn K, Steingrover K, Zsila F. Five unique compounds: xyloketals from mangrove fungus Xylaria sp. from the South China Sea coast. J Org Chem 66: 6252-6256 (2001)
5. Davis RA. Isolation and structure elucidation of the new fungal metabolite (-)-xylariamide A. J Nat Prod 68: 769-772 (2005).
6. Healy PC, Hocking A, Tran-Dinh N, Pitt JI, Shivas RG, Mitchell JK, Kotiw M, Davis RA. Xanthones from a microfungus of the genus Xylaria. Phytochemistry 65: 2373-2378 (2004)
7. Imazeki R, Hongo T. Colored Illustrations of Mushrooms of Japan. pp. 589-590, Hoikusha, Osaka (1989)
8. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxic assays. J Immunol Methods 65: 55-63 (1983)
9. White JD, Johnson A. Synthesis of the aliphatic depside (+)-bourgeanic acid. J Org Chem 59: 3347-3358 (1994)
10. Davies-Coleman MT, Garson M. Marine polypropionates. J Nat Prod Rep 15: 477-493 (1998)