Isolation and structure of antagonists of chemokine receptor (CCR5)

Journal of Natural Products

Volumn 67, Issue 6, 2004, Pages 1036-1038

  Jayasuriya, Hiranthi ^a   Herath, Kithsiri B ^a   Ondeyka, John G ^a   Polishook, Jon D ^a   Bills, Gerald F ^b   Dombrowski, Anne W ^a   Springer, Marty S ^a   Siciliano, Sal ^a   Malkowitz, Lorraine ^a   Sanchez, Manuel ^b   Guan, Ziqiang ^a   Tiwari, Suroojnauth ^c   Stevenson, Dennis W ^c   Borris, Robert P ^a   Singh, Sheo B ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Medical affairs Merck sharp and Dohme ltd   (Spain)

^c INSTITUTE OF ECONOMIC BOTANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

19,20 EPOXYCYTOCHALASIN Q; ALKALOID DERIVATIVE; ANIBAMINE; ANTIVIRUS AGENT; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; ENVELOPE PROTEIN; G PROTEIN COUPLED RECEPTOR; GLYCOPROTEIN GP 120; IODINE 125; NATURAL PRODUCT; OPHIOBOLIN C; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANGIOSPERM; ANIBA; ARTICLE; BINDING ASSAY; CARBON NUCLEAR MAGNETIC RESONANCE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; FERMENTATION; FUNGUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IC 50; INTERNALIZATION; MASS SPECTROMETRY; MOLLISIA; NONHUMAN; PROTEIN PROTEIN INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; RECEPTOR BINDING; STRUCTURE ANALYSIS; ULTRAVIOLET SPECTROSCOPY; VIRUS INFECTIVITY; VIRUS VIRULENCE; XYLARIA;

ANTIGENS, CD4; CYTOCHALASINS; FUNGI; HIV ENVELOPE PROTEIN GP120; HUMANS; INHIBITORY CONCENTRATION 50; LAURACEAE; MOLECULAR STRUCTURE; PYRIDINES; RECEPTORS, CCR5; TERPENES;

ANIBA; FUNGI; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MAGNOLIOPHYTA; MOLLISIA; RNA VIRUSES; XYLARIA;

EID: 3042575830     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np049974l     Document Type: Article

References (16)

1. Fauci, A. S. Nature 1996, 381, 529.
2. Dragic, T.; Litwin, V.; Allaway, G. P.; Matrin, S. R.; Huang, Y.; Nagashima, K. A.; Cayanan, C.; Maddon, P. J.; Koup, R. A.; Moore, J. P.; Paxton, W. A. Nature 1996, 381, 667-673.
3. Deng, H.; Liu, R.; Ellmeier, W.; Choe, S.; Unutmaz, D.; Burkhart, M.; Di Marzio, P.; Marmon, S.; Sutton, R. E.; Hill, C. M.; Davis, C. B.; Peiper, S. C.; Schall, T. J.; Littman, D. R.; Landau, N. R. Nature 1996, 381, 661-666.
4. Mack, M.; Kleinschmidt, A.; Bruhl, H.; Klier, C.; Nelson, P. J.; Cihak, J.; Plachw, J.; Stangassinger, M.; Erfle, V.; Schlondorff, D. Nat. Med. 2000, 6, 769-775.
5. Cascieri, M. A.; Springer, M. S. Curr. Opin. Chem. Biol. 2000, 4, 420-427.
6. Willoughby, C. A.; Rosauer, K. G.; Hale, J. J.; Budhu, R. J.; Mills, S. G.; Chapman, K. T.; MacCoss, M.; Malkowitz, L.; Springer, M. S.; Gould, S. L.; DeMartino, J. A.; Siciliano, S. J.; Cascieri, M. A.; Carella, A.; Carver, G.; Homes, K.; Schleif, W. A.; Danzeisen, R.; Hazuda, D.; Kessler, J.; Lineberger, J.; Miller, M.; Emini, E. A. Bioorg. Med. Chem. Lett. 2003, 13, 427-431.
7. Young, S. D. In Annual Report of Medicinal Chemistry; Doherty, A. M., Ed.; Elsevier: Amsterdam, 2003; Vol. 38, pp 173-182.
8. Au, T. K.; Chick, W. S. H.; Leung, P. C. Life Sci. 2000, 67, 733-742.
9. Singh, S. B.; Smith, J. L.; Sabnis, G. S.; Dombrowski, A. W.; Schaeffer, J. M.; Goetz, M. A.; Bills, G. F. Tetrahedron 1991, 47, 6931-6938.
10. Tsipouras, A.; Adefarati, A. A.; Tkacz, J. S.; Frazier, E. G.; Rohrer, S. P.; Birzin, E.; Rosegay, A.; Zink, D. L.; Goetz, M. A.; Singh, S. B.; Schaeffer, J. M. Bioorg. Med. Chem. 1996, 4, 531-536.
11. Espada, A.; Rivera-Sagredo, A.; de la Fuente, J. M.; Hueso-Rodriguez, J. A.; Elson, S. W. Tetrahedron 1997, 53, 6485-6492.
12. Yoshida, W. Y.; Scheuer, P. J. Heterocyles 1998, 47, 1023-1027.
13. Singh, S. B.; Jayasuriya, H.; Dewey, R.; Polishook, J. D.; Dombrowski, A. D.; Zink, D. L.; Guan, Z.; Collado, J.; Platas, G.; Pelaez, F.; Felock, P. J.; Hazuda, D. J. J. Ind. Microbiol. Biotechnol. 2004, 30, 721-731.
14. Ondeyka, J.; Hensens, O. D.; Zink, D.; Ball, R.; Lingham, R. B.; Bills, G.; Dombrowski, A.; Goetz, M. J. Antibiot. 1992, 45, 679-685.
15. Yoganathan, K.; Rossant, C.; Ng, S.; Huang, Y.; Butler, M.; Buss, A. D. J. Nat. Prod. 2003, 66, 1116-1117.
16. Hegde, V. R.; Chan, T.-M.; Pu, H.; Gullo, V. P.; Patel, M. G.; Das, P.; Wagner, N.; Parameswaran, P. S.; Naik, C. G. Bioorg. Med. Chem. Lett. 2002, 12, 3203-3205.