Reduced adipogenic gene expression in thigh adipose tissue precedes human immunodeficiency virus-associated lipoatrophy

Journal of Clinical Endocrinology and Metabolism

Volumn 93, Issue 3, 2008, Pages 959-966

  Kratz, Mario ^a,f   Purnell, Jonathan Q ^e   Breen, Patricia A ^a   Thomas, Katherine K ^b   Utzschneider, Kristina M ^a,d   Carr, Darcy B ^b   Kahn, Steven E ^a,d   Hughes, James P ^b   Rutledge, Elizabeth A ^c   Van Yserloo, Brian ^c   Yukawa, Michi ^a   Weigle, David S ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c Molecular and Genetics Core   (United States)

^d VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^f Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTE; ADIPOSE TISSUE; ADULT; ARTICLE; BODY FAT DISTRIBUTION; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE EXPRESSION; GLUCOSE TOLERANCE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INSULIN SENSITIVITY; LIPID BLOOD LEVEL; LIPID TRANSPORT; LIPOATROPHY; MALE; PRIORITY JOURNAL; UNITED STATES;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 40849147033     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2007-0197     Document Type: Article

References (26)

1. Yeni P 2006 Update on HAART in HIV. J Hepatol 44:S100-S103
2. Koutkia P, Grinspoon S 2004 HIV-associated lipodystrophy: pathogenesis, prognosis, treatment, and controversies. Annu Rev Med 55:303-317
3. Kamin DS, Grinspoon SK 2005 Cardiovascular disease in HIV-positive patients. AIDS 19:641-652
4. Lichtenstein KA 2005 Redefining lipodystrophy syndrome: risks and impact on clinical decision making. J Acquir Immune Defic Syndr 39:395-400
5. Bacchetti P, Gripshover B, Grunfeld C, Heymsfield S, McCreath H, Osmond D, Saag M, Scherzer R, Shlipak M, Tien P 2005 Fat distribution in men with HIV infection. J Acquir Immune Defic Syndr 40:121-131
6. Domingo P, Matias-Guiu X, Pujol RM, Francia E, Lagarda E, Sambeat MA, Vazquez G 1999 Subcutaneous adipocyte apoptosis in HIV-1 protease inhibitor-associated lipodystrophy. AIDS 13:2261-2267
7. Grigem S, Fischer-Posovszky P, Debatin KM, Loizon E, Vidal H, Wabitsch M 2005 The effect of the HIV protease inhibitor ritonavir on proliferation, differentiation, lipogenesis, gene expression and apoptosis of human preadipocytes and adipocytes. Horm Metab Res 37:602-609
8. Dowell P, Flexner C, Kwiterovich PO, Lane MD 2000 Suppression of preadipocyte differentiation and promotion of adipocyte death by HIV protease inhibitors. J Biol Chem 275:41325-41332
9. Jones SP, Janneh O, Back DJ, Pirmohamed M 2005 Altered adipokine response in murine 3T3-F442A adipocytes treated with protease inhibitors and nucleoside reverse transcriptase inhibitors. Antivir Ther 10:207-213
10. Lenhard JM, Furfine ES, Jain RG, Ittoop O, Orband-Miller LA, Blanchard SG, Paulik MA, Weiel JE 2000 HIV protease inhibitors block adipogenesis and increase lipolysis in vitro. Antiviral Res 47:121-129
11. Bastard JP, Caron M, Vidal H, Jan V, Auclair M, Vigouroux C, Luboinski J, Laville M, Maachi M, Girard PM, Rozenbaum W, Levan P, Capeau J 2002 Association between altered expression of adipogenic factor SREBP1 in lipoatrophic adipose tissue from HIV-1-infected patients and abnormal adipocyte differentiation and insulin resistance. Lancet 359:1026-1031
12. Shuman WP, Morris LL, Leonetti DL, Wahl PW, Moceri VM, Moss AA, Fujimoto WY 1986 Abnormal body fat distribution detected by computed tomography in diabetic men. Invest Radiol 21:483-487
13. Beard JC, Bergman RN, Ward WK, Porte Jr D 1986 The insulin sensitivity index in nondiabetic man. Correlation between clamp-derived and IVGTT-derived values. Diabetes 35:362-369
14. Bergman RN, Ider YZ, Bowden CR, Cobelli C 1979 Quantitative estimation of insulin sensitivity. Am J Physiol 236:E667-E677
15. Bustin SA 2002 Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. J Mol Endocrinol 29:23-39
16. Sutinen J, Hakkinen AM, Westerbacka J, Seppala-Lindroos A, Vehkavaara S, Halavaara J, Jarvinen A, Ristola M, Yki-Jarvinen H 2002 Increased fat accumulation in the liver in HIV-infected patients with antiretroviral therapy-associated lipodystrophy. AIDS 16:2183-2193
17. Gan SK, Samaras K, Thompson CH, Kraegen EW, Carr A, Cooper DA, Chisholm DJ 2002 Altered myocellular and abdominal fat partitioning predict disturbance in insulin action in HIV protease inhibitor-related lipodystrophy. Diabetes 51:3163-3169
18. Addy CL, Gavrila A, Tsiodras S, Brodovicz K, Karchmer AW, Mantzoros CS 2003 Hypoadiponectinemia is associated with insulin resistance, hypertriglyceridemia, and fat redistribution in human immunodeficiency virus-infected patients treated with highly active antiretroviral therapy. J Clin Endocrinol Metab 88:627-636
19. Nagy GS, Tsiodras S, Martin LD, Avihingsanon A, Gavrila A, Hsu WC, Karchmer AW, Mantzoros CS 2003 Human immunodeficiency virus type 1-related lipoatrophy and lipohypertrophy are associated with serum concentrations of leptin. Clin Infect Dis 36:795-802
20. Lee JH, Chan JL, Sourlas E, Raptopoulos V, Mantzoros CS 2006 Recombinant methionyl human leptin therapy in replacement doses improves insulin resistance and metabolic profile in patients with lipoatrophy and metabolic syndrome induced by the highly active antiretroviral therapy. J Clin Endocrinol Metab 91:2605-2611
21. Murata H, Hruz PW, Mueckler M 2000 The mechanism of insulin resistance caused by HIV protease inhibitor therapy. J Biol Chem 275:20251-20254
22. Hruz PW, Murata H, Qiu H, Mueckler M 2002 Indinavir induces acute and reversible peripheral insulin resistance in rats. Diabetes 51:937-942
23. Periard D, Telenti A, Sudre P, Cheseaux JJ, Halfon P, Reymond MJ, Marcovina SM, Glauser MP, Nicod P, Darioli R, Mooser V 1999 Atherogenic dyslipidemia in HIV-infected individuals treated with protease inhibitors. The Swiss HIV Cohort Study. Circulation 100:700-705
24. Purnell JQ, Zambon A, Knopp RH, Pizzuti DJ, Achari R, Leonard JM, Locke C, Brunzell JD 2000 Effect of ritonavir on lipids and post-heparin lipase activities in normal subjects. AIDS 14:51-57
25. Sutinen J, Kannisto K, Korsheninnikova E, Nyman T, Ehrenborg E, Andrew R, Wake DJ, Hamsten A, Walker BR, Yki-Jarvinen H 2004 In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11β-hydroxysteroid dehydrogenase type 1 in adipose tissue. Diabetologia 47:1668-1671
26. Rolland V, Le L, X, Houbiguian ML, Lavau M, Dugail I 1995 C/EBPα expression in adipose tissue of genetically obese Zucker rats. Biochem Biophys Res Commun 207:761-767