Low oxygen stimulates the immune system

Kidney International

Volumn 73, Issue 7, 2008, Pages 797-799

  Maltzman, J S ^a   Haase, V H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 2ALPHA; INTERLEUKIN 17; INTERLEUKIN 4; OXYGEN; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UBIQUITIN PROTEIN LIGASE E3; VON HIPPEL LINDAU PROTEIN;

ANTIGEN EXPRESSION; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL HYPOXIA; CELL MATURATION; CELL PROLIFERATION; CELL TYPE; CHRONIC KIDNEY DISEASE; DENDRITIC CELL; DISEASE COURSE; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOMODULATION; IMMUNOSTIMULATION; INFLAMMATORY CELL; INFLAMMATORY INFILTRATE; KIDNEY ISCHEMIA; KIDNEY PARENCHYMA; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; NOTE; OXYGEN TISSUE LEVEL; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

EID: 40849137743     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2008.15     Document Type: Note

References (14)

1. Rama I, Bruene B, Torras J et al. Hypoxia stimulus: an adaptive immune response during dendritic cell maturation. Kidney Int 2008; 73: 816-825.
2. John R, Nelson PJ. Dendritic cells in the kidney. J Am Soc Nephrol 2007; 18: 2628-2635.
3. Burne MJ, Daniels F, El Ghandour A et al. Identification of the CD4(+) T cell as a major pathogenic factor in ischemic acute renal failure. J Clin Invest 2001; 108: 1283-1290.
4. Dong X, Swaminathan S, Bachman LA et al. Resident dendritic cells are the predominant TNF-secreting cell in early renal ischemia-reperfusion injury. Kidney Int 2007; 71: 619-628.
5. Haase VH. Hypoxia-inducible factors in the kidney. Am J Physiol Renal Physiol 2006; 291: F271-F281.
6. Neumann AK, Yang J, Biju MP et al. Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction. Proc Natl Acad Sci USA 2005; 102: 17071-17076.
7. Sitkovsky M, Lukashev D. Regulation of immune cells by local-tissue oxygen tension: HIF1 alpha and adenosine receptors. Nat Rev Immunol 2005; 5: 712-721.
8. Cramer T, Yamanishi Y, Clausen BE et al. HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell 2003; 112: 645-657.
9. Kong T, Eltzschig HK, Karhausen J et al. Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression. Proc Natl Acad Sci USA 2004; 101: 10440-10445.
10. Rosenberger C, Pratschke J, Rudolph B et al. Immunohistochemical detection of hypoxia-inducible factor-1alpha in human renal allograft biopsies. J Am Soc Nephrol 2007; 18: 343-351.
11. Fine LG, Bandyopadhay D, Norman JT. Is there a common mechanism for the progression of different types of renal diseases other than proteinuria? Towards the unifying theme of chronic hypoxia. Kidney Int 2000; 57(Suppl 75): S22-S26.
12. Higgins DF, Kimura K, Bernhardt WM et al. Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J Clin Invest 2007; 117: 3810-3820.
13. Anders HJ, Ninichuk V, Schlondorff D. Progression of kidney disease: blocking leukocyte recruitment with chemokine receptor CCR1 antagonists. Kidney Int 2006; 69: 29-32.
14. Hudson CC, Liu M, Chiang GG et al. Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of rapamycin. Mol Cell Biol 2002; 22: 7004-7014.