Examination of the mechanism of human brain aspartoacylase through the binding of an intermediate analogue

Biochemistry

Volumn 47, Issue 11, 2008, Pages 3484-3492

  Le Coq, Johanne ^a,d   Pavlovsky, Alexander ^a   Malik, Radhika ^a   Sanishvili, Ruslan ^c   Xu, Chengfu ^b   Viola, Ronald E ^a  

^a UNIVERSITY OF TOLEDO   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c ARGONNE NATIONAL LABORATORY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE BOND; BINDING GROUPS; METABOLIC ENZYME;

AMIDES; BINDING SITES; CATALYST ACTIVITY; DISEASES; METABOLISM; NEUROLOGY;

ENZYMES;

ASPARTOACYLASE; CARBOXYPEPTIDASE; N ACETYLASPARTIC ACID; N PHOSPHONOMETHYL ASPARTATE; UNCLASSIFIED DRUG;

ARTICLE; ATOM; BRAIN; CATALYSIS; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME MECHANISM; HUMAN; HYDROLYSIS; MOLECULAR INTERACTION; MOLECULAR STABILITY; PRIORITY JOURNAL;

AMIDOHYDROLASES; APOENZYMES; ASPARTIC ACID; BINDING SITES; BRAIN; CARBOXYPEPTIDASES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; GLYCOSYLATION; HUMANS; MUTAGENESIS, SITE-DIRECTED; ORGANOPHOSPHORUS COMPOUNDS; PROTEIN BINDING;

EID: 40849124078     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi702400x     Document Type: Article

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