Extract of Ginkgo biloba induces glutamate cysteine ligase catalytic subunit (GCLC)

Phytotherapy Research

Volumn 22, Issue 3, 2008, Pages 367-371

  Liu, Xiao Ping ^a,b   Goldring, Christopher E P ^c   Wang, Hai Yi ^c   Copple, Ian M ^c   Kitteringham, Neil R ^d   Park, B Kevin ^c   Wei, Wei ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b WANNAN MEDICAL COLLEGE   (China)

^c UNIVERSITY OF LIVERPOOL   (United Kingdom)

^d NONE

Author keywords

Extract of Ginkgo biloba; GCLC; Herb

Indexed keywords

GINKGO BILOBA EXTRACT; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INDUCTION; GINKGO BILOBA; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; STATISTICAL ANALYSIS; WESTERN BLOTTING;

ACTINS; ANALYSIS OF VARIANCE; ANIMALS; ANTIBODIES; BLOTTING, WESTERN; CATALYTIC DOMAIN; CELL LINE; GENE EXPRESSION REGULATION, PLANT; GINKGO BILOBA; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HUMANS; MICE; PLANT EXTRACTS;

ANIMALIA; GINKGO BILOBA;

EID: 40849118207     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2328     Document Type: Article

References (23)

1. Ahmad M, Saleem S, Ahmad AS et al. 2005. Ginkgo biloba affords dose-dependent protection against 6-hydroxydopamine-induced Parkinsonism in rats: neurobehavioural, neurochemical and immunohistochemical evidences. J Neurochem 93: 94-104.
2. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
3. Bridi R, Crossetti FP, Steffen VM, Henriques AT. 2001. The antioxidant activity of standardized extract of Ginkgo biloba (EGb 761) in rats. Phytother Res 15: 449-451.
4. Chen JX, Zeng H, Chen X, Su CY, Lai CC. 2001. Induction of heme oxygenase-1 by Ginkgo biloba extract but not its terpenoids partially mediated its protective effect against lysophosphatidylcholine-induced damage. Pharmacol Res 43: 63-69.
5. DeFeudis FV, Papadopoulos V, Drieu K. 2003. Ginkgo biloba extracts and cancer: a research area in its infancy. Fundam Clin Pharmacol 17: 405-417.
6. Dickinson DA, Iles KE, Watanabe N et al. 2002. 4-Hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cells. Free Radic Biol Med 33: 974-987.
7. Droy-Lefaix MT, Cluzel J, Menerath JM, Bonhomme B, Doly M. 1995. Antioxidant effect of a Ginkgo biloba extract (EGb 761) on the retina. Int J Tissue React 17: 93-100.
8. Gohil K, Moy RK, Farzin S, Maguire JJ, Packer L. 2000. mRNA expression profile of a human cancer cell line in response to Ginkgo biloba extract: induction of antioxidant response and the Golgi system. Free Radic Res 33: 831-849.
9. Huang C, Anderson ME, Meister A. 1993a. Amino acid sequence and function of the light subunit of rat kidney γ-glutamylcysteine synthetase. J Biol Chem 268: 20578-20583.
10. Huang C, Chang L, Anderson ME, Meister A. 1993b. Catalytic and regulatory properties of the heavy subunit of rat kidney γ-glutamylcysteine synthetase. J Biol Chem 268: 19675-19680.
11. Iwanaga M, Mori K, Iida T et al. 1998. Nuclear factor kappa B dependent induction of gamma glutamylcysteine synthetase by ionizing radiation in T98G human glioblastoma cells. Free Radic Biol Med 24: 1256-1268.
12. Kleijnen J, Knipschild P. 1992. Ginkgo biloba. Lancet 340: 1136-1139.
13. Lu SC. 1999. Regulation of hepatic glutathione synthesis: current concept and controversies. FASEB J 13: 1169-1183.
14. Mulcahy RT, Gipp JJ. 1995. Identification of a putative antioxidant response element in the 5V-flanking region of the human g-glutamylcysteine synthetase heavy subunit gene. Biochem Biophys Res Commun 209: 227-233.
15. Mulcahy RT, Wartman MA, Bailey HH, Gipp JJ. 1997. Constitutive and h-naphthoflavone-induced expression of the human gamma-glutamylcysteine synthetase heavy subunit gene is regulated by a distal antioxidant response element/TRE sequence. J Biol Chem 272: 7445-7454.
16. Rahman I, Antonicelli F, MacNee W. 1999. Molecular mechanism of the regulation of glutathione synthesis by tumor necrosis factor alpha and dexamethasone in human alveolar epithelial cells. J Biol Chem 274: 5088-5096.
17. Rahman I, Bel A, Mulier B et al. 1996a. Transcriptional regulation of γ-glutamylcysteine synthetase-heavy subunit by oxidants in human alveolar epithelial cells. Biochem Biophys Res Commun 229: 832-837.
18. Rahman I, Smith CAD, Lawson MF, Harrison DJ, MacNee W. 1996b. Induction of γ-glutamylcysteine synthetase by cigarette smoke is associated with AP-1 in human alveolar epithelial cells. FEBS Lett 396: 21-25.
19. Rong Y, Geng Z, Lau BH. 1996. Ginkgo biloba attenuates oxidative stress in macrophages and endothelial cells. Free Radic Biol Med 20: 121-127.
20. Sierra-Rivera ESM, Dasouki M, Krishnamani MR, Phillips JA, Freeman ML. 1995. Assignment of the gene (GCLC) that encodes the heavy subunit of γ-glutamylcysteine synthetase to human chromosome 6. Cytogenet Cell Genet 70: 278-279.
21. Sierra-Rivera ESM, Dasouki M, Summar ML et al. 1996. Assignment of the human gene (GLCLR) that encodes the regulatory subunit of γ-glutamylcysteine synthetase to chromosome 1p21. Cytogenet Cell Genet 72: 252-254.
22. Vandeputte C, Guizon I, Genestie-Denis I, Vannier B, Lorenzon G. 1994. A microtiter plate assay for total glutathione and glutathione disulfide contents in cultured/isolated cells: performance study of a new miniaturized protocol. Cell Biol Toxicol 10: 415-421.
23. Zhou Z, Zheng S. 2003. The missing link in Ginkgo evolution. Nature 423: 821-822.