Impact of inappropriate antibiotic therapy on mortality in patients with ventilator-associated pneumonia and blood stream infection: A meta-analysis

Journal of Critical Care

Volumn 23, Issue 1, 2008, Pages 91-100

  Kuti, Effie L ^a,b   Patel, Aarti A ^a,b   Coleman, Craig I ^a,b  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b HARTFORD HOSPITAL   (United States)

Author keywords

Antibiotic; Bacteremia; Meta analysis; Mortality; Pneumonia; Ventilators

Indexed keywords

ANTIINFECTIVE AGENT; CEPHALOSPORIN; CORTICOSTEROID;

ANTIBIOTIC THERAPY; ANTIMICROBIAL THERAPY; ARTICLE; CLINICAL TRIAL; CONFIDENCE INTERVAL; DATA BASE; HUMAN; INFECTION; MEDICAL ERROR; META ANALYSIS; MORTALITY; RISK ASSESSMENT; SYSTEMATIC REVIEW; VENTILATOR ASSOCIATED PNEUMONIA;

ANTI-BACTERIAL AGENTS; BACTEREMIA; DATA INTERPRETATION, STATISTICAL; HUMANS; PNEUMONIA, VENTILATOR-ASSOCIATED;

EID: 40849114633     PISSN: 08839441     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcrc.2007.08.007     Document Type: Article

References (43)

1. Richards M.J., Edwards J.R., Culver D.H., and Gaynes R.P. Nosocomial infections in medical intensive care units in the United States. Crit Care Med 27 5 (1999) 887-892
2. American Thoracic Society. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 171 (2005) 388-416
3. Garrouste-Orgeas M., Timsit J.F., Tafflet M., et al. Excess risk of death from intensive care unit-acquired nosocomial bloodstream infections: a reappraisal. Clin Infect Dis 42 (2006) 1118-1126
4. Kollef M.H. Optimizing antibiotic therapy in the intensive care unit setting. Crit Care 5 (2001) 189-195
5. Anderson D.J., Engemann J.J., Harrell L.J., Carmeli Y., Reller L.B., and Kaye K.S. Predictors of mortality in patients with bloodstream infection due to ceftazidime-resistant Klebsiella pneumoniae. Antimicrob Agents Chemother 50 (2006) 1715-1720
6. Kang C.I., Kim S.H., Park W.B., et al. Bloodstream infections due to extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae: risk factors for mortality and treatment outcome, with special emphasis on antimicrobial therapy. Antimicrob Agents Chemother 48 12 (2004) 4574-4581
7. Kang C.I., Kim S.H., Park W.B., et al. Bloodstream infections caused by antibiotic-resistant Gram-negative bacilli: factors for mortality and impact of inappropriate initial antimicrobial therapy on outcome. Antimicrob Agents Chemother 49 2 (2005) 760-766
8. Kim S.H., Park W.B., Lee K.D., et al. Outcome of inappropriate initial antimicrobial treatment in patients with methicillin-resistant Staphylococcus aureus bacteraemia. J Antimicrob Chemother 54 (2004) 489-497
9. Lodise T.P., McKinnon P.S., Swiderski L., and Rybak M.J. Outcomes analysis of delayed antibiotic treatment for hospital-acquired Staphylococcus aureus bacteremia. Clin Infect Dis 36 (2003) 1418-1423
10. MacArthur R.D., Miller M., Albertson T., Panacek E., Johnson D., and Barchuk W. Adequacy of early empiric antibiotic treatment and survival in severe sepsis: experience from the MONARCS trial. Clin Infect Dis 38 (2004) 284-288
11. Zaragoza R., Artero A., Camarena J.J., Sancho S., Gonzalez R., and Nogueira J.M. The influence of inadequate empirical antimicrobial treatment on patients with bloodstream infections in an intensive care unit. Clin Microbiol Infect 9 (2003) 412-418
12. Kim S.H., Park W.B., Lee C.S., et al. Outcome of inappropriate empirical antibiotic therapy in patients with Staphylococcus aureus bacteraemia: analytical strategy using propensity scores. Clin Microbiol Infect 12 (2006) 13-21
13. Poh C.H., Oh H.M.L., and Tan A.L. Epidemiology and clinical outcome of enterococcal bacteremia in an acute care hospital. J Infect 52 (2006) 383-386
14. Falagas M.E., Kasiakou S.K., Rafaildis P.I., Zouglakis G., and Morfou P. Comparison of mortality of patients with Acinetobacter baumannii bacteremia receiving appropriate and inappropriate empirical therapy. J Antimicrob Chemother 57 6 (2006) 1251-1254
15. Clec'h C., Timsit J.F., De Lassence A., et al. Efficacy of adequate early antibiotic therapy in ventilator-associated pneumonia: influence of disease severity. Intensive Care Med 30 (2004) 1327-1333
16. Dupont H., Mentec H., Sollet J.P., and Bleichner G. Impact of appropriateness of initial antibiotic therapy on the outcome of ventilator-associated pneumonia. Intensive Care Med 27 (2001) 355-362
17. Kollef M.H., and Ward S. The influence of Mini-BAL cultures on patient outcomes: implication for the antibiotic management of ventilator-associated pneumonia. Chest 113 (1998) 412-420
18. Leroy O., Meybeck A., d'Escrivan T., Devos P., Kipnis E., and Georges H. Impact of adequacy of initial antimicrobial therapy on the prognosis of patients with ventilator-associated pneumonia. Intensive Care Med 29 (2003) 2170-2173
19. Rello J., Gallego M., Mariscal D., Sonora R., and Valles J. The value of routine microbial investigation in ventilator-associated pneumonia. Am J Respir Crit Care Med 156 (1997) 196-200
20. Sanchez-Nieto J.M., Torres A., Garcia-Cordoba F., et al. Impact of invasive and noninvasive quantitative culture sampling on outcome of ventilator-associated pneumonia. Am J Respir Crit Care Med 157 (1998) 371-376
21. Timsit J.F., Cheval C., Gachot B., Bruneel F., Wolff M., Carlet J., et al. Usefulness of a strategy on bronchoscopy with direct examination of bronchoalveolar lavage fluid in the initial antibiotic therapy of suspected ventilator-associated pneumonia. Intensive Care Med 27 (2001) 640-647
22. Fowler R.A., Flavin K.E., Barr J., Weinacker A.N., Parsonnet J., and Gould M. Variability in antibiotic prescribing patterns and outcomes in patients with clinically suspected ventilator-associated pneumonia. Chest 123 (2003) 835-844
23. Siegman-Igra Y., Ravona R., Primerman H., and Giladi M. Pseudomonas aeruginosa bacteremia: an analysis of 123 episodes, with particular emphasis on the effect of antibiotic therapy. Int J Infect Dis 2 (1998) 211-215
24. Stroup D.F., Berlin J.A., Morton S.C., et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting Meta-analysis of Observational Studies in Epidemiology (MOOSE) group. JAMA 283 (2000) 2008-2012
25. Micek S.T., Llyod A.E., Ritchie D.J., Reichley R.M., Fraser V.J., and Kollef M.H. Pseudomonas aeruginosa infection: importance of appropriate initial antimicrobial treatment. Antimicrob Agents Chemother 49 4 (2005) 1306-1311
26. Ibrahim E.H., Sherman G., Ward S., Fraser V.J., and Kollef M.H. The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest 118 (2000) 146-155
27. Vergis E.N., Hayden M.K., Chow J.W., et al. Determinants of vancomycin resistance and mortality rate in enterococcal bacteremia. Ann Intern Med 135 (2001) 484-492
28. Anderson D.J., Engemann J.J., Harrell L.J., Carmeli Y., Reller L.B., and Kaye K.S. Predictors of mortality in patients with bloodstream infection due to ceftazidime-resistant Klebsiella pneumoniae. Antimicrob Agents Chemother 50 5 (2006) 1715-1720
29. Valles J., Rello J., Ochagavia A., Garnacho J., and Alcala M.A. Community-acquired bloodstream infection in critically ill patients: impact of shock and inappropriate antibiotic therapy on survival. Chest 123 (2003) 1615-1624
30. Leibovici L., Paul M., Poznanski O., et al. Monotherapy versus β-lactam aminoglycoside combination treatment for Gram-negative bacteremia: a prospective, observational study. Antimicrob Agents Chemother 41 5 (1997) 1127-1133
31. Leibovici L., Shraga I., Drucker M., Konigsberger H., Samra Z., and Pitlik S.D. The benefit of appropriate empirical antibiotic treatment in patients with bloodstream infection. J Intern Med 244 (1998) 379-386
32. Hanon F.X., Monnet D.L., Sorensen T.L., Molbak K., Pedersen G., and Schonheyder H. Survival of patients with bacteremia in relation to initial empirical antimicrobial treatment. Scand J Infect Dis 34 (2002) 520-528
33. Paterson D.L., Ko W.C., Von Gottber A., et al. Antibiotic therapy for Klebsiella pneumonia bacteremia: implications of production of extended-spectrum β-lactamases. Clin Infect Dis 39 (2004) 31-37
34. Spanik S., West D., Pichna P., et al. Inappropriate antibiotic therapy in febrile cancer patients with bacteremia. Clin Perform Qual Health Care 6 (1998) 109-113
35. Kang C.I., Kim S.H., Kim H.B., et al. Pseudomonas aeruginosa bacteremia: risk factors for mortality and influence of delayed receipt of effective antimicrobial therapy on clinical outcome. Clin Infect Dis 37 (2003) 745-751
36. Iregui M., Ward S., Sherman G., Fraser V.J., and Kollef M.H. Clinical importance of delays in the initiation of appropriate antibiotic treatment of ventilator-associated pneumonia. Chest 122 (2002) 262-268
37. Luna C.M., Vujacich P., Niederman M.S., et al. Impact of BAL data on the therapy and outcome of ventilator-associated pneumonia. Chest 111 (1997) 676-685
38. Khatib R., Saeed S., Sharma M., Riederer K., Fakih M.G., and Johnson L.B. Impact of initial antibiotic choice and delayed appropriate treatment on the outcome of Staphylococcus aureus bacteremia. Eur J Clin Microbiol Infect Dis 25 (2006) 181-185
39. Higgins J.P.T., Thompson S.G., Deeks J.J., and Altman D.G. Measuring inconsistency in meta-analyses. BMJ 327 (2003) 557-560
40. Ramphal R. Importance of adequate initial antimicrobial therapy. Chemother 51 (2005) 171-176
41. Meehan T.P., Fine M.J., Krumholz H.M., et al. Quality of care, process, and outcomes in elderly patients with pneumonia. JAMA 278 (1997) 2080-2084
42. Houck P.M., Bratzler D.W., Nsa W., Ma A., and Bartlett J.G. Timing of antibiotic administration and outcomes for Medicare patients hospitalized with community-acquired pneumonia. Arch Intern Med 164 (2004) 637-644
43. Kumar A., Roberts D., Wook K.E., et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 34 (2006) 1589-1596