Involvement of P2Y1 and P2Y11 purinoceptors in parasympathetic inhibition of colonic smooth muscle

Journal of Pharmacology and Experimental Therapeutics

Volumn 324, Issue 3, 2008, Pages 1055-1063

  King, Brian F ^a   Townsend Nicholson, Andrea ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2' DEOXY 6 N METHYLADENOSINE 3',5' BISPHOSPHATE; 5 [[(3 PHENOXYBENZYL)(1,2,3,4 TETRAHYDRO 1 NAPHTHYL)AMINO]CARBONYL]TRIMELLITIC ACID; ADENOSINE DEAMINASE; ADENOSINE TRIPHOSPHATE; ALPHABETA METHYLENE ADENOSINE TRIPHOSPHATE; CALCIUM ACTIVATED POTASSIUM CHANNEL; CYCLIC AMP; DEQUALINIUM; DIBENZOYL ADENOSINE TRIPHOSPHATE; DYE; IBERIOTOXIN; ISOPRENALINE; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; PHENOLSULFONPHTHALEIN; PROTEIN SUBUNIT; PURINERGIC P2X2 RECEPTOR; PURINERGIC P2X3 RECEPTOR; PURINERGIC P2Y1 RECEPTOR; PURINERGIC P2Y11 RECEPTOR; PURINERGIC RECEPTOR STIMULATING AGENT; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; REACTIVE RED; SURAMIN; UNCLASSIFIED DRUG; CHOLINERGIC RECEPTOR BLOCKING AGENT; PURINERGIC P2 RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; CELLULAR DISTRIBUTION; CHOLINERGIC TRANSMISSION; COLON; COLON TENIA; CONTROLLED STUDY; DRUG MECHANISM; GUINEA PIG; IMMUNOHISTOCHEMISTRY; MOTONEURON; MYENTERIC PLEXUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; SMOOTH MUSCLE; SMOOTH MUSCLE RELAXATION; ANIMAL; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; IN VITRO STUDY; MOLECULAR GENETICS; MUSCLE RELAXATION; NERVE CELL INHIBITION; PARASYMPATHETIC NERVE; PHYSIOLOGY; TUMOR CELL LINE;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE, TUMOR; COLON; GUINEA PIGS; HUMANS; MOLECULAR SEQUENCE DATA; MUSCLE RELAXATION; MUSCLE, SMOOTH; NEURAL INHIBITION; PARASYMPATHETIC FIBERS, POSTGANGLIONIC; PARASYMPATHOLYTICS; RECEPTORS, PURINERGIC P2;

EID: 40849113305     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.131169     Document Type: Article

References (32)

1. Abbracchio MP, Burnstock G, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Knight GE, Fumagalli M, Gachet C, Jacobson KA, et al. (2006) International Union of Pharmacology LVIII. Update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev 58:281-341.
2. Albert AP and Large WA (2001) Comparison of spontaneous and noradrenaline-evoked non-selective cation channels in rabbit portal vein myocytes. J Physiol 530:457-468.
3. 2-purinoceptors in guinea-pig taenia coli. Naunyn Schmiedebergs Arch Pharmacol 353:445-451.
4. Burnstock G, Campbell G, and Rand MJ (1966) The inhibitory innervation of the taenia of the guinea-pig caecum. J Physiol 182:504-526.
5. Burnstock G, Campbell G, Satchell D, and Smythe A (1970) Evidence that adenosine triphosphate or a related nucleotide is the transmitter substance released by non-adrenergic inhibitory nerves in the gut. Br J Pharmacol 40:668-688.
6. + channels in electrical activity of longitudinal and circular muscle layers of canine colon. Am J Physiol Cell Physiol 268:C619-C627.
7. 2 receptors in the guinea-pig enteric nervous system. Histochem Cell Biol 117:415-422.
8. 2 receptor on undifferentiated HL-60 leukemia cells. Br J Pharmacol 124:1580-1585.
9. 2-purinoceptors in guinea-pig taenia coli and urinary bladder. Br J Pharmacol 90:791-795.
10. Den Hertog A, Pielkenrood J, and Van den Akker J (1985) Effector mechanisms for α,β-methylene ATP and ATP derivatives in guinea-pig taenia caeci. Eur J Pharmacol 110:95-101.
11. 2-purinoceptors in guinea-pig taenia caeci. Naunyn Schmiedebergs Arch Pharmacol 351:107-110.
12. 1 receptors mediate inhibitory purinergic neuromuscular transmission in the human colon. Am J Physiol Gastrointest Liver Physiol 291:G584-G594.
13. Hata F, Takeuchi T, Nishio H, and Fujita A (2000) Mediators and intracellular mechanisms of NANC relaxation of smooth muscle in the gastrointestinal tract. J Smooth Muscle Res 36:181-204.
14. 3 allosteric modulator, cibacron blue. Br J Pharmacol 132:259-269.
15. 1-purinoceptor activation. J Auton Nerv Syst 48:55-63.
16. King BF and Townsend-Nicholson A (2003) Nucleotide and nucleoside receptors. Tocris Rev 23:1-12.
17. King BF, Townsend-Nicholson A, and Burnstock G (1998) Metabotropic receptors for ATP and UTP: correspondence between native and recombinant nucleotide receptors. Trends Pharmacol Sci 19:506-514.
18. Koh SD, Monaghan K, Sergeant GP, Ro S, Walker RL, Sanders KM, and Horowitz B (2001) TREK-1 regulation by nitric oxide and cGMP-dependent protein kinase. J Biol Chem 276:44338-44346.
19. Kong ID, Koh SD, and Sanders KM (2000) Purinergic activation of spontaneous transient outward currents in guinea pig taenia colonic myocytes. Am J Physiol Cell Physiol 278:C352-C362.
20. Langley JN (1898) On inhibitory fibres in the vagus for the end of the oeophagus and the stomach. J Physiol 23:407-414.
21. Lecci A, Santicioli P, and Maggi CA (2002) Pharmacology of transmission to gastrointestinal muscle. Curr Opin Pharmacol 2:630-641.
22. Liu YC, Patel HJ, Khawaja AM, Belvisi MG, and Rogers DF (1999) Neuroregulation by vasoactive intestinal peptide (VIP) of mucus secretion in ferret trachea: activation of BK(Ca) channels and inhibition of neurotransmitter release. Br J Pharmacol 126:147-158.
23. 3 purine receptor subunits in the guinea pig enteric nervous system. Auton Neurosci 101:39-47.
24. Ralevic V and Burnstock G (1998) Receptors for purines and pyrimidines. Pharmacol Rev 50:413-492.
25. 2/3 heteromeric receptors. Br J Pharmacol 135:1524-1530.
26. 11 receptor in stably transfected haematological cell lines. Mol Cell Biochem 213:75-81.
27. van der Weyden L, Rakyan V, Luttrell BM, Morris MB, and Conigrave AD (2000b) Extracellular ATP couples to cAMP generation and granulocytic differentiation in human NB4 promyelocytic leukaemia cells. Immunol Cell Biol 78:467-473.
28. 1 receptors and of platelet aggregation. Biochem Biophys Res Commun 256:94-97.
29. + channels by purinergic agonists in smooth muscle cells of the mouse ileum. J Physiol 502:497-508.
30. + channel from colonic smooth muscle. Am J Physiol Gastrointest Liver Physiol 271:G629-G639.
31. 1 purinergic receptor in guinea pig small intestine. Am J Physiol Gastrointest Liver Physiol 292:G1483-G1489.
32. Ca channel by cGMP and cAMP kinase. J Biol Chem 276:43239-43245.