메뉴 건너뛰기




Volumn 93, Issue 2, 2008, Pages 248-256

Human cytomegalovirus-specific CD4+ and CD8+ T-cell reconstitution in adult allogeneic hematopoietic stem cell transplant recipients and immune control of viral infection

Author keywords

Human cytomegalovirus; Specific T cells; Stem cell transplantation

Indexed keywords

CORTICOSTEROID; GAMMA INTERFERON; INTERLEUKIN 2;

EID: 40849098721     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: 10.3324/haematol.11912     Document Type: Article
Times cited : (90)

References (45)
  • 1
    • 0002881578 scopus 로고    scopus 로고
    • Cytomegalovirus infection after bone marrow transplantation
    • Paya C, ed, Philadelphia, PA: Lippincott-Raven;
    • Boeckh M, Ljungman P. Cytomegalovirus infection after bone marrow transplantation. In: Paya C, ed. Transplant Infections. Philadelphia, PA: Lippincott-Raven; 1998. p. 215-27.
    • (1998) Transplant Infections , pp. 215-227
    • Boeckh, M.1    Ljungman, P.2
  • 2
    • 0027455417 scopus 로고
    • Ganciclovir prophylaxis to prevent cytomegalovirus disease after allogeneic marrow transplant
    • Goodrich JM, Bowden RA, Fisher L, Keller C, Schoch G, Meyers JD. Ganciclovir prophylaxis to prevent cytomegalovirus disease after allogeneic marrow transplant. Ann Itern Med 1993;118:173-8.
    • (1993) Ann Itern Med , vol.118 , pp. 173-178
    • Goodrich, J.M.1    Bowden, R.A.2    Fisher, L.3    Keller, C.4    Schoch, G.5    Meyers, J.D.6
  • 3
    • 0028016207 scopus 로고
    • Human cytomegalovirus (HCMV) infection in paediatric patients given allogeneic bone marrow transplantation: Role of early antiviral treatment for HCMV antigenaemia on patients' outcome
    • Locatelli F, Percivalle E, Comoli P, Maccario R, Zecca M, Giorgiani G, et al. Human cytomegalovirus (HCMV) infection in paediatric patients given allogeneic bone marrow transplantation: role of early antiviral treatment for HCMV antigenaemia on patients' outcome. Br J Haematol 1994;88:64-71.
    • (1994) Br J Haematol , vol.88 , pp. 64-71
    • Locatelli, F.1    Percivalle, E.2    Comoli, P.3    Maccario, R.4    Zecca, M.5    Giorgiani, G.6
  • 4
    • 0029800728 scopus 로고    scopus 로고
    • Cytomegalovirus pp65 antigenemia-guided early treatment with ganciclovir versus ganciclovir at engraftment after allogeneic marrow transplantation: A randomized double-blind study
    • Boeckh M, Gooley TA, Myerson D, Cunningham T, Schoch G, Bowden RA. Cytomegalovirus pp65 antigenemia-guided early treatment with ganciclovir versus ganciclovir at engraftment after allogeneic marrow transplantation: a randomized double-blind study. Blood 1996;88:4063-71.
    • (1996) Blood , vol.88 , pp. 4063-4071
    • Boeckh, M.1    Gooley, T.A.2    Myerson, D.3    Cunningham, T.4    Schoch, G.5    Bowden, R.A.6
  • 5
    • 0019989495 scopus 로고
    • Cytotoxic T cells in cytomegalovirus infection: HLA-restricted T-lymphocyte and non-T-lymphocyte cytotoxic responses correlate with recovery from cytomegalovirus infection in bone-marrow-transplant recipients
    • Quinnan GV Jr, Kirmani N, Rook AH, Manischewitz J, Jackson L, Santos GW, et al. Cytotoxic T cells in cytomegalovirus infection: HLA-restricted T-lymphocyte and non-T-lymphocyte cytotoxic responses correlate with recovery from cytomegalovirus infection in bone-marrow-transplant recipients. N Engl J Med 1982;307:7-13.
    • (1982) N Engl J Med , vol.307 , pp. 7-13
    • Quinnan Jr, G.V.1    Kirmani, N.2    Rook, A.H.3    Manischewitz, J.4    Jackson, L.5    Santos, G.W.6
  • 6
    • 0025995695 scopus 로고
    • Cytotoxic T-lymphocyte response to cytomegalovirus after human allogeneic bone marrow transplantation: Pattern of recovery and correlation with cytomegalovirus infection and disease
    • Reusser P, Riddell SR, Meyers JD, Greenberg PD. Cytotoxic T-lymphocyte response to cytomegalovirus after human allogeneic bone marrow transplantation: pattern of recovery and correlation with cytomegalovirus infection and disease. Blood 1991; 78:1373-80.
    • (1991) Blood , vol.78 , pp. 1373-1380
    • Reusser, P.1    Riddell, S.R.2    Meyers, J.D.3    Greenberg, P.D.4
  • 7
    • 0028353829 scopus 로고
    • Recovery of HLA-restricted cytomegalovirus (CMV)-specific T-cell responses after allogeneic bone marrow transplant: Correlation with CMV disease and effect of ganciclovir prophylaxis
    • Li CR, Greenberg PD, Gilbert MJ, Goodrich JM, Riddell SR. Recovery of HLA-restricted cytomegalovirus (CMV)-specific T-cell responses after allogeneic bone marrow transplant: Correlation with CMV disease and effect of ganciclovir prophylaxis. Blood 1994;83:1971-9.
    • (1994) Blood , vol.83 , pp. 1971-1979
    • Li, C.R.1    Greenberg, P.D.2    Gilbert, M.J.3    Goodrich, J.M.4    Riddell, S.R.5
  • 8
    • 0035282725 scopus 로고    scopus 로고
    • Direct visualization of cytomegalovirus-specific T-cell reconstitution after allogeneic stem cell transplantation
    • Cwynarski K, Ainsworth J, Cobbold M, Wagner S, Mahendra P, Apperley J, et al. Direct visualization of cytomegalovirus-specific T-cell reconstitution after allogeneic stem cell transplantation. Blood 2001;97:1232-40.
    • (2001) Blood , vol.97 , pp. 1232-1240
    • Cwynarski, K.1    Ainsworth, J.2    Cobbold, M.3    Wagner, S.4    Mahendra, P.5    Apperley, J.6
  • 9
    • 0035469815 scopus 로고    scopus 로고
    • + T lymphocytes in T-cell-depleted stem cell grafts and after transplantation may identify patients at risk for progressive CMV infection
    • + T lymphocytes in T-cell-depleted stem cell grafts and after transplantation may identify patients at risk for progressive CMV infection. Blood 2001;98:1358-64.
    • (2001) Blood , vol.98 , pp. 1358-1364
    • Gratama, J.W.1    van Esser, J.W.2    Lamers, C.H.3    Tournay, C.4    Lowenberg, B.5
  • 10
    • 0030993182 scopus 로고    scopus 로고
    • Screening for CMV-specific T cell proliferation to identify patients at risk of developing late onset CMV disease
    • Krause H, Hebart H, Jahn G, Muller CA, Einsele H. Screening for CMV-specific T cell proliferation to identify patients at risk of developing late onset CMV disease. Bone Marrow Transplant 1997;19:111-6.
    • (1997) Bone Marrow Transplant , vol.19 , pp. 111-116
    • Krause, H.1    Hebart, H.2    Jahn, G.3    Muller, C.A.4    Einsele, H.5
  • 11
    • 0037093102 scopus 로고    scopus 로고
    • Sensitive detection of human cytomegalovirus peptide-specific cytotoxic T-lymphocyte responses by interferon-γ-enzyme-linked immunospot assay and flow cytometry in healthy individuals and in patients after allogeneic stem cell transplantation
    • Hebart H, Daginik S, Stevanovic S, Grigoleit U, Dobler A, Baur M, et al. Sensitive detection of human cytomegalovirus peptide-specific cytotoxic T-lymphocyte responses by interferon-γ-enzyme-linked immunospot assay and flow cytometry in healthy individuals and in patients after allogeneic stem cell transplantation. Blood 2002;99:3830-7.
    • (2002) Blood , vol.99 , pp. 3830-3837
    • Hebart, H.1    Daginik, S.2    Stevanovic, S.3    Grigoleit, U.4    Dobler, A.5    Baur, M.6
  • 12
    • 0023230293 scopus 로고
    • Immunoaffinity purification of a 72K early antigen of human cytomegalovirus: Analysis of humoral and cell-mediated immunity to the purified polypeptide
    • Rodgers B, Borysiewicz L, Mundin J, Graham S, Sissons P. Immunoaffinity purification of a 72K early antigen of human cytomegalovirus: analysis of humoral and cell-mediated immunity to the purified polypeptide. J Gen Virol 1987;68:2371-8.
    • (1987) J Gen Virol , vol.68 , pp. 2371-2378
    • Rodgers, B.1    Borysiewicz, L.2    Mundin, J.3    Graham, S.4    Sissons, P.5
  • 13
    • 0029847916 scopus 로고    scopus 로고
    • The human cytotoxic T-lympho-cyte (CTL) response to human cytomegalovirus is dominated by structural protein pp65: Frequency, specificity, and T-cell receptor usage of pp65-specific CTL
    • Wills MR, Carmichael AJ, Mynard K, Jin X, Weeks MP, Plachter B, et al. The human cytotoxic T-lympho-cyte (CTL) response to human cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL. J Virol 1996;70:7659-79.
    • (1996) J Virol , vol.70 , pp. 7659-7679
    • Wills, M.R.1    Carmichael, A.J.2    Mynard, K.3    Jin, X.4    Weeks, M.P.5    Plachter, B.6
  • 14
    • 0345373932 scopus 로고    scopus 로고
    • +-T-cell responses to human cytomegalovirus reveals broad and multispecific reactivities in healthy virus carriers
    • +-T-cell responses to human cytomegalovirus reveals broad and multispecific reactivities in healthy virus carriers. J Virol 2003;77:7401-10.
    • (2003) J Virol , vol.77 , pp. 7401-7410
    • Elkington, R.1    Walker, S.2    Crough, T.3    Menzies, M.4    Tellam, J.5    Bharadwaj, M.6
  • 16
    • 34447134842 scopus 로고    scopus 로고
    • Inconsistent responses of cytomegalovirus-specific T cells to pp65 and IE-1 vs infected dendritic cells in organ transplant recipients
    • Lilleri D, Zelini P, Fornara C, Comolli G, Gerna G. Inconsistent responses of cytomegalovirus-specific T cells to pp65 and IE-1 vs infected dendritic cells in organ transplant recipients. Am J Transplant 2007;7:1-9.
    • (2007) Am J Transplant , vol.7 , pp. 1-9
    • Lilleri, D.1    Zelini, P.2    Fornara, C.3    Comolli, G.4    Gerna, G.5
  • 19
    • 0037090071 scopus 로고    scopus 로고
    • Definition of HCMV infection and disease in transplant recipients
    • Ljungman P, Griffiths P, Paya C. Definition of HCMV infection and disease in transplant recipients. Clin Infect Dis 2002;34:1094-7.
    • (2002) Clin Infect Dis , vol.34 , pp. 1094-1097
    • Ljungman, P.1    Griffiths, P.2    Paya, C.3
  • 20
    • 0026593734 scopus 로고
    • Comparison of different immunostaining techniques and monoclonal antibodies to the lower matrix phosphoprotein (pp65) for optimal quantitation of human cytomegalovirus antigenemia
    • Gerna G, Revello MG, Percivalle E, Morini F. Comparison of different immunostaining techniques and monoclonal antibodies to the lower matrix phosphoprotein (pp65) for optimal quantitation of human cytomegalovirus antigenemia. J Clin Microbiol 1992; 30:1232-7.
    • (1992) J Clin Microbiol , vol.30 , pp. 1232-1237
    • Gerna, G.1    Revello, M.G.2    Percivalle, E.3    Morini, F.4
  • 21
    • 33644662479 scopus 로고    scopus 로고
    • Impact of human metapneumovirus and human cytomegalovirus versus other respiratory viruses on lower respiratory tract infections of lung transplant recipients
    • Gerna G, Vitulo P, Rovida F, Lilleri D, Pellegrini C, Oggionni T, et al. Impact of human metapneumovirus and human cytomegalovirus versus other respiratory viruses on lower respiratory tract infections of lung transplant recipients. J Med Virol 2006;78: 408-16.
    • (2006) J Med Virol , vol.78 , pp. 408-416
    • Gerna, G.1    Vitulo, P.2    Rovida, F.3    Lilleri, D.4    Pellegrini, C.5    Oggionni, T.6
  • 22
    • 10744222486 scopus 로고    scopus 로고
    • Human cytomegalovirus immediate-early mRNAemia versus pp65 antigenemia for guiding pre-emptive therapy in children and young adults undergoing hematopoietic stem cell transplantation: A prospective randomized open-label trial
    • Gerna G, Lilleri D, Baldanti F, Torsellini M, Giorgiani G, Zecca M, et al. Human cytomegalovirus immediate-early mRNAemia versus pp65 antigenemia for guiding pre-emptive therapy in children and young adults undergoing hematopoietic stem cell transplantation: a prospective randomized open-label trial. Blood 2003;101:5053-60.
    • (2003) Blood , vol.101 , pp. 5053-5060
    • Gerna, G.1    Lilleri, D.2    Baldanti, F.3    Torsellini, M.4    Giorgiani, G.5    Zecca, M.6
  • 23
    • 0025221730 scopus 로고
    • Quantification of human cytomegalovirus viremia by using monoclonal antibodies to different viral proteins
    • Gerna G, Revello MG, Percivalle E, Zavattoni M, Parea M, Battaglia M. Quantification of human cytomegalovirus viremia by using monoclonal antibodies to different viral proteins. J Clin Microbiol 1990; 28:2681-8.
    • (1990) J Clin Microbiol , vol.28 , pp. 2681-2688
    • Gerna, G.1    Revello, M.G.2    Percivalle, E.3    Zavattoni, M.4    Parea, M.5    Battaglia, M.6
  • 24
    • 0025153184 scopus 로고
    • A 6-h microneutralization assay for human cytomegalovirus antibody by using monoclonal antibodies
    • Gerna G, Revello MG, Percivalle E, Torsellini M. A 6-h microneutralization assay for human cytomegalovirus antibody by using monoclonal antibodies. Serodiagn Immunother Infect Dis 1990; 4:243-7.
    • (1990) Serodiagn Immunother Infect Dis , vol.4 , pp. 243-247
    • Gerna, G.1    Revello, M.G.2    Percivalle, E.3    Torsellini, M.4
  • 25
    • 0028289244 scopus 로고
    • Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
    • Sallusto F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 1994;179:1109-18.
    • (1994) J Exp Med , vol.179 , pp. 1109-1118
    • Sallusto, F.1    Lanzavecchia, A.2
  • 27
    • 0033616908 scopus 로고    scopus 로고
    • Estimation of failure probabilities in the presence of competing risks: New representations of old estimators
    • Gooley TA, Leisenring W, Crowley J, Storer BE. Estimation of failure probabilities in the presence of competing risks: new representations of old estimators. Statist Med 1999;18:695-706.
    • (1999) Statist Med , vol.18 , pp. 695-706
    • Gooley, T.A.1    Leisenring, W.2    Crowley, J.3    Storer, B.E.4
  • 28
    • 0035203456 scopus 로고    scopus 로고
    • Statistical methods for analysis and presentation of the results of bone marrow transplants, part I: Unadjusted analysis
    • Klein JP, Rizzo JD, Zhang M-J, Keiding N. Statistical methods for analysis and presentation of the results of bone marrow transplants, part I: unadjusted analysis. Bone Marrow Transplant 2001;28:909-15.
    • (2001) Bone Marrow Transplant , vol.28 , pp. 909-915
    • Klein, J.P.1    Rizzo, J.D.2    Zhang, M.-J.3    Keiding, N.4
  • 30
    • 0642308424 scopus 로고    scopus 로고
    • Reconstitution of T-cell repertoire after autologous stem cell transplantation: Influence of CD34 selection and cytomegalovirus infection
    • Peggs KS, Verfuerth S, Pizzey A, Khan N, Moss P, Goldstone AH, et al. Reconstitution of T-cell repertoire after autologous stem cell transplantation: influence of CD34 selection and cytomegalovirus infection. Biol Blood Marrow Transplant 2003;9: 198-205.
    • (2003) Biol Blood Marrow Transplant , vol.9 , pp. 198-205
    • Peggs, K.S.1    Verfuerth, S.2    Pizzey, A.3    Khan, N.4    Moss, P.5    Goldstone, A.H.6
  • 31
    • 0027935476 scopus 로고
    • Antigen-independent activation of naive and memory resting T cells by a cytokine combination
    • Unutmaz D, Pileri P, Abrignani S. Antigen-independent activation of naive and memory resting T cells by a cytokine combination. J Exp Med 1994; 180:1159-64.
    • (1994) J Exp Med , vol.180 , pp. 1159-1164
    • Unutmaz, D.1    Pileri, P.2    Abrignani, S.3
  • 32
    • 0035905477 scopus 로고    scopus 로고
    • Cytokine-driven proliferation and differentiation of human naive, central memory and effector memory CD4 T cells
    • Geginat J, Sallusto F, Lanzavecchia A. Cytokine-driven proliferation and differentiation of human naive, central memory and effector memory CD4 T cells. J Exp Med 2001;194:1711-9.
    • (2001) J Exp Med , vol.194 , pp. 1711-1719
    • Geginat, J.1    Sallusto, F.2    Lanzavecchia, A.3
  • 33
    • 0038375013 scopus 로고    scopus 로고
    • + memory T-cell subsets in response to antigen or homeostatic cytokines
    • + memory T-cell subsets in response to antigen or homeostatic cytokines. Blood 2003; 101:4260-6.
    • (2003) Blood , vol.101 , pp. 4260-4266
    • Geginat, J.1    Lanzavecchia, A.2    Sallusto, F.3
  • 34
    • 0036467791 scopus 로고    scopus 로고
    • High risk of death due to bacterial and fungal infection among cytomegalovirus (CMV)-seronegative recipients of stem cell transplants from seropositive donors: Evidence for indirect effects of primary CMV infection
    • Nichols WG, Corey L, Gooley T, Davis C, Boeckh M. High risk of death due to bacterial and fungal infection among cytomegalovirus (CMV)-seronegative recipients of stem cell transplants from seropositive donors: evidence for indirect effects of primary CMV infection. J Infect Dis 2002;185:273-82.
    • (2002) J Infect Dis , vol.185 , pp. 273-282
    • Nichols, W.G.1    Corey, L.2    Gooley, T.3    Davis, C.4    Boeckh, M.5
  • 35
    • 0344305505 scopus 로고    scopus 로고
    • Donor CMV serologic status and outcome of CMV-seropositive recipients after unrelated donor stem cell transplantation: An EBMT megafile analysis
    • Ljungman P, Brand R, Einsele H, Frassoni F, Niederwieser D, Cordonnier C. Donor CMV serologic status and outcome of CMV-seropositive recipients after unrelated donor stem cell transplantation: an EBMT megafile analysis. Blood 2003;102:4255-60.
    • (2003) Blood , vol.102 , pp. 4255-4260
    • Ljungman, P.1    Brand, R.2    Einsele, H.3    Frassoni, F.4    Niederwieser, D.5    Cordonnier, C.6
  • 37
    • 0029163414 scopus 로고
    • T cell reconstitution after bone marrow transplantation into adult patients does not resemble T cell development in early life
    • Storek J, Whitherspoon RP, Storb R. T cell reconstitution after bone marrow transplantation into adult patients does not resemble T cell development in early life. Bone Marrow Transplant 1995; 16:413-25.
    • (1995) Bone Marrow Transplant , vol.16 , pp. 413-425
    • Storek, J.1    Whitherspoon, R.P.2    Storb, R.3
  • 38
    • 0035383814 scopus 로고    scopus 로고
    • Immune reconstitution after allogeneic marrow transplantation compared with blood stem cell transplantation
    • Storek J, Dawson MA, Storer B, Stevens-Ayers T, Maloney DG, Marr KA, et al. Immune reconstitution after allogeneic marrow transplantation compared with blood stem cell transplantation. Blood 2001;97:3380-9.
    • (2001) Blood , vol.97 , pp. 3380-3389
    • Storek, J.1    Dawson, M.A.2    Storer, B.3    Stevens-Ayers, T.4    Maloney, D.G.5    Marr, K.A.6
  • 41
    • 0141889231 scopus 로고    scopus 로고
    • Immune reconstitution to cytomegalovirus after allogeneic hematopoietic stem cell transplantation: Impact of host factors, drug therapy, and subclinical reactivation
    • Hakki M, Riddell SR, Storek J, Carter RA, Stevens-Ayers T, Sudour P, et al. Immune reconstitution to cytomegalovirus after allogeneic hematopoietic stem cell transplantation: impact of host factors, drug therapy, and subclinical reactivation. Blood 2003; 102:3060-7.
    • (2003) Blood , vol.102 , pp. 3060-3067
    • Hakki, M.1    Riddell, S.R.2    Storek, J.3    Carter, R.A.4    Stevens-Ayers, T.5    Sudour, P.6
  • 43
    • 2442684151 scopus 로고    scopus 로고
    • Memory CD8 T-cell differentiation during viral infection
    • Wherry EJ, Ahmed R. Memory CD8 T-cell differentiation during viral infection. J Virol 2004;78:5535-45.
    • (2004) J Virol , vol.78 , pp. 5535-5545
    • Wherry, E.J.1    Ahmed, R.2
  • 44
    • 33646380363 scopus 로고    scopus 로고
    • Functional signatures in antiviral T-cell immunity for monitoring virus-associated diseases
    • Pantaleo G, Harari A. Functional signatures in antiviral T-cell immunity for monitoring virus-associated diseases. Nat Rev Immunol 2006;6:417-22.
    • (2006) Nat Rev Immunol , vol.6 , pp. 417-422
    • Pantaleo, G.1    Harari, A.2
  • 45
    • 1642500367 scopus 로고    scopus 로고
    • Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1-infected subjects with progressive disease: Changes after antiretroviral therapy
    • Harari A, Petitpierre S, Vallelian F, Pantaleo G. Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1-infected subjects with progressive disease: changes after antiretroviral therapy. Blood 2004;103:966-72.
    • (2004) Blood , vol.103 , pp. 966-972
    • Harari, A.1    Petitpierre, S.2    Vallelian, F.3    Pantaleo, G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.