Effects of intercept pathogen inactivation on platelet function as analysed by free oscillation rheometry

Transfusion and Apheresis Science

Volumn 38, Issue 1, 2008, Pages 85-88

  Tynngård, Nahreen ^a   Johansson, Britt Marie ^b   Lindahl, Tomas L ^a   Berlin, Gösta ^a   Hansson, Mona ^b  

^a LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Apheresis; Pathogen inactivation; Platelet concentrates; Platelet function

Indexed keywords

AMOTOSALEN; PADGEM PROTEIN;

APHERESIS; ARTICLE; BLOOD CLOTTING; BLOOD CLOTTING TIME; BLOOD LEVEL; BLOOD STORAGE; DILUTION; FLOW MEASUREMENT; FREE OSCILLATION RHEOMETRY; PATHOGENESIS; THROMBOCYTE ACTIVATION; THROMBOCYTE FUNCTION; ULTRAVIOLET A RADIATION; VIRUS INACTIVATION;

BLOOD COAGULATION; BLOOD PRESERVATION; BLOOD-BORNE PATHOGENS; HEMORHEOLOGY; HUMANS; OSCILLOMETRY; P-SELECTIN; PILOT PROJECTS; PLATELET ACTIVATION; REFERENCE VALUES; RHEOLOGY; SOLUBILITY; WHOLE BLOOD COAGULATION TIME;

EID: 40849097318     PISSN: 14730502     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transci.2007.12.012     Document Type: Article

References (14)

1. Lin L., Cook D.N., Wiesehahn G.P., Alfonso R., Behrman B., Cimino G.D., et al. Photochemical inactivation of viruses and bacteria in platelet concentrates by use of a novel psoralen and long-wavelength ultraviolet light. Transfusion 37 (1997) 423-435
2. Ciaravino V., McCullough T., and Dayan A. Pharmacokinetic and toxicology assessment of INTERCEPT (S-59 and UVA treated) platelets. Hum Exp Toxicol 20 (2001) 533-550
3. Knutson F., Alfonso R., Dupuis K., Mayaudon V., Lin L., Corash L., et al. Photochemical inactivation of bacteria and HIV in buffy-coat-derived platelet concentrates under conditions that preserve in vitro platelet function. Vox Sang 78 (2000) 209-216
4. Lin L., Dikeman R., Molini B., Lukehart S.A., Lane R., Dupuis K., et al. Photochemical treatment of platelet concentrates with amotosalen and long-wavelength ultraviolet light inactivates a broad spectrum of pathogenic bacteria. Transfusion 44 (2004) 1496-1504
5. Simonsen A.C., Johansson P.I., Conlan M.G., Jacquet M., Lin J.S., Junge K., et al. Transfusion of 7-day-old amotosalen photochemically treated buffy-coat platelets to patients with thrombocytopenia: a pilot study. Transfusion 46 (2006) 424-433
6. Gulliksson H., Eriksson L., Högman C.F., and Payrat J.M. Buffy-coat-derived platelet concentrates prepared from half-strength citrate CPD and CPD whole-blood units. Comparison between three additive solutions: in vitro studies. Vox Sang 68 (1995) 152-159
7. Ramström S., Rånby M., and Lindahl T.L. Platelet phosphatidylserine exposure and procoagulant activity in clotting whole blood - different effects of collagen, TRAP and calcium ionophore A23187. Thromb Haemost 89 (2003) 132-141
8. Tynngård N., Lindahl T., Ramstrom S., and Berlin G. Effects of different blood components on clot retraction analysed by measuring elasticity with a free oscillating rheometer. Platelets 17 (2006) 545-554
9. Rånby M., Ramström S., Svensson P.O., and Lindahl T.L. Clotting time by free oscillation rheometry and visual inspection and a viscoelastic description of the clotting phenomenon. Scand J Clin Lab Invest 63 (2003) 397-406
10. Apelseth T.O., Bruserud O., Wentzel-Larsen T., Bakken A.M., Bjorsvik S., and Hervig T. In vitro evaluation of metabolic changes and residual platelet responsiveness in photochemical treated and gamma-irradiated single-donor platelet concentrates during long-term storage. Transfusion 47 (2007) 653-665
11. Snyder E., Raife T., Lin L., Cimino G., Metzel P., Rheinschmidt M., et al. Recovery and life span of 111indium-radiolabeled platelets treated with pathogen inactivation with amotosalen HCl (S-59) and ultraviolet A light. Transfusion 44 (2004) 1732-1740
12. McCullough J., Vesole D.H., Benjamin R.J., Slichter S.J., Pineda A., Snyder E., et al. Therapeutic efficacy and safety of platelets treated with a photochemical process for pathogen inactivation: the SPRINT Trial. Blood 104 (2004) 1534-1541
13. Slichter S.J., Raife T.J., Davis K., Rheinschmidt M., Buchholz D.H., Corash L., et al. Platelets photochemically treated with amotosalen HCl and ultraviolet A light correct prolonged bleeding times in patients with thrombocytopenia. Transfusion 46 (2006) 731-740
14. Murphy S., Snyder E., Cable R., Slichter S.J., Strauss R.G., McCullough J., et al. Platelet dose consistency and its effect on the number of platelet transfusions for support of thrombocytopenia: an analysis of the SPRINT trial of platelets photochemically treated with amotosalen HCl and ultraviolet A light. Transfusion 46 (2006) 24-33