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Volumn 22, Issue 3, 2008, Pages 318-322

Effect of sugar cane policosanol on lipid profile in primary hypercholesterolemia

Author keywords

Clinical trial; Hypercholesterolemia; Sugar cane policosanol

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; POLICOSANOL; TRIACYLGLYCEROL;

EID: 40849094376     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2315     Document Type: Article
Times cited : (34)

References (37)
  • 1
    • 0027957267 scopus 로고
    • A 12-month study of policosanol oral toxicity in Sprague Dawley rats
    • Aleman CL, Mas R, Hernandez et al. 1994. A 12-month study of policosanol oral toxicity in Sprague Dawley rats. Toxicol Lett 70: 77-87.
    • (1994) Toxicol Lett , vol.70 , pp. 77-87
    • Aleman, C.L.1    Mas, R.2    Hernandez3
  • 2
    • 0029164702 scopus 로고
    • Carcinogenicity of policosanol in mice: An 18-month study
    • Aleman CL, Puig MN, Elias EC et al. 1995. Carcinogenicity of policosanol in mice: an 18-month study. Food Chem Toxicol 33: 573-578.
    • (1995) Food Chem Toxicol , vol.33 , pp. 573-578
    • Aleman, C.L.1    Puig, M.N.2    Elias, E.C.3
  • 3
    • 0034955357 scopus 로고    scopus 로고
    • One-year dog toxicity study of D-002, a mixture of aliphatic alcohols
    • Aleman C, Rodeiro I, Noa M et al. 2001. One-year dog toxicity study of D-002, a mixture of aliphatic alcohols. J Appl Toxicol 21: 179-184.
    • (2001) J Appl Toxicol , vol.21 , pp. 179-184
    • Aleman, C.1    Rodeiro, I.2    Noa, M.3
  • 4
    • 0033866211 scopus 로고    scopus 로고
    • Protective effect of policosanol on atherosclerotic lesions in rabbits with exogenous hypercholesterolemia
    • Arruzazabala ML, Noa M, Menendez R et al. 2000. Protective effect of policosanol on atherosclerotic lesions in rabbits with exogenous hypercholesterolemia. Braz J Med Biol Res 33: 835-840.
    • (2000) Braz J Med Biol Res , vol.33 , pp. 835-840
    • Arruzazabala, M.L.1    Noa, M.2    Menendez, R.3
  • 5
    • 33646675819 scopus 로고    scopus 로고
    • Effect of policosanol on lipid levels among patients with hypercholesterolemia or combined hyperlipidemia
    • Berthold HK, Unverdorben S, Degenhardt R, Bulitta M, Gouni-Berthold I. 2006. Effect of policosanol on lipid levels among patients with hypercholesterolemia or combined hyperlipidemia. JAMA 295: 2262-2269.
    • (2006) JAMA , vol.295 , pp. 2262-2269
    • Berthold, H.K.1    Unverdorben, S.2    Degenhardt, R.3    Bulitta, M.4    Gouni-Berthold, I.5
  • 6
    • 0029589212 scopus 로고
    • A two-year study on the efficacy and tolerability of policosanol in patients with type II hyperlipoproteinaemia
    • Canetti M, Moreira M, Mas R et al. 1995. A two-year study on the efficacy and tolerability of policosanol in patients with type II hyperlipoproteinaemia. Int J Clin Pharmacol Res 15: 159-165.
    • (1995) Int J Clin Pharmacol Res , vol.15 , pp. 159-165
    • Canetti, M.1    Moreira, M.2    Mas, R.3
  • 7
    • 0036457642 scopus 로고    scopus 로고
    • Comparison of the efficacy, safety and tolerability of original policosanol versus other mixtures of higher aliphatic primary alcohols in patients with type II hypercholesterolemia
    • Castano G, Fernandez L, Mas R et al. 2002. Comparison of the efficacy, safety and tolerability of original policosanol versus other mixtures of higher aliphatic primary alcohols in patients with type II hypercholesterolemia. Int J Clin Pharmacol Res 22: 55-66.
    • (2002) Int J Clin Pharmacol Res , vol.22 , pp. 55-66
    • Castano, G.1    Fernandez, L.2    Mas, R.3
  • 8
    • 0343526455 scopus 로고    scopus 로고
    • Effects of policosanol and pravastatin on lipid profile, platelet aggregation and endothelemia in older hypercholesterolemic patients
    • Castano G, Mas R, Arruzazabala ML et al. 1999. Effects of policosanol and pravastatin on lipid profile, platelet aggregation and endothelemia in older hypercholesterolemic patients. Int J Clin Pharmacol Res 19: 105-116.
    • (1999) Int J Clin Pharmacol Res , vol.19 , pp. 105-116
    • Castano, G.1    Mas, R.2    Arruzazabala, M.L.3
  • 9
    • 0345505338 scopus 로고    scopus 로고
    • Comparison of the efficacy and tolerability of policosanol with atorvastatin in elderly patients with type II hypercholesterolemia
    • Castano G, Mas R, Fernandez L et al. 2003. Comparison of the efficacy and tolerability of policosanol with atorvastatin in elderly patients with type II hypercholesterolemia. Drugs Aging 20: 153-163.
    • (2003) Drugs Aging , vol.20 , pp. 153-163
    • Castano, G.1    Mas, R.2    Fernandez, L.3
  • 10
    • 0033358535 scopus 로고    scopus 로고
    • Comparative study of the efficacy and tolerability of policosanol and lovastatin in patients with hypercholesterolemia and noninsulin dependent diabetes mellitus
    • Crespo N, Illnait J, Mas R, Fernandez L, Fernandez J, Castano G. 1999. Comparative study of the efficacy and tolerability of policosanol and lovastatin in patients with hypercholesterolemia and noninsulin dependent diabetes mellitus. Int J Clin Pharmacol Res 19: 117-127.
    • (1999) Int J Clin Pharmacol Res , vol.19 , pp. 117-127
    • Crespo, N.1    Illnait, J.2    Mas, R.3    Fernandez, L.4    Fernandez, J.5    Castano, G.6
  • 11
    • 33845496494 scopus 로고    scopus 로고
    • Policosanol is ineffective in the treatment of hypercholesterolemia: A randomized controlled trial
    • Dulin MF, Hatcher LF, Sasser HC, Barringer TA. 2006. Policosanol is ineffective in the treatment of hypercholesterolemia: a randomized controlled trial. Am J Clin Nutr 84: 1543-1548.
    • (2006) Am J Clin Nutr , vol.84 , pp. 1543-1548
    • Dulin, M.F.1    Hatcher, L.F.2    Sasser, H.C.3    Barringer, T.A.4
  • 12
    • 0035897696 scopus 로고    scopus 로고
    • Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults. Executive summary of the third report of the national cholesterol education program (NCEP) (Adult Treatment Panel III). 2001. JAMA 285: 2486-2497.
    • Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults. Executive summary of the third report of the national cholesterol education program (NCEP) (Adult Treatment Panel III). 2001. JAMA 285: 2486-2497.
  • 13
    • 0035092189 scopus 로고    scopus 로고
    • Comparison of the efficacy, safety and tolerability of policosanol versus fluvastatin in elderly hypercholesterolaemic women
    • Fernandez JC, Mas R, Castano G et al. 2001. Comparison of the efficacy, safety and tolerability of policosanol versus fluvastatin in elderly hypercholesterolaemic women. Clin Drug Investig 21: 103-113.
    • (2001) Clin Drug Investig , vol.21 , pp. 103-113
    • Fernandez, J.C.1    Mas, R.2    Castano, G.3
  • 14
    • 0015348189 scopus 로고
    • Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
    • Friedewald WT, Levy RI, Fredrickson DS. 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18: 499-502.
    • (1972) Clin Chem , vol.18 , pp. 499-502
    • Friedewald, W.T.1    Levy, R.I.2    Fredrickson, D.S.3
  • 15
    • 0034906478 scopus 로고    scopus 로고
    • A 6-month study on the toxicity of high doses of policosanol orally administered to Sprague-Dawley rats
    • Gamez R, Aleman CL, Mas R et al. 2001. A 6-month study on the toxicity of high doses of policosanol orally administered to Sprague-Dawley rats. J Med Food 4: 57-65.
    • (2001) J Med Food , vol.4 , pp. 57-65
    • Gamez, R.1    Aleman, C.L.2    Mas, R.3
  • 16
    • 0033163436 scopus 로고    scopus 로고
    • Validation of a gas chromatographic method for determining fatty alcohol that compose policosanol in five-milligram film-coated tablets
    • Gonzalez VL, Hernandez J. 1999. Validation of a gas chromatographic method for determining fatty alcohol that compose policosanol in five-milligram film-coated tablets. AOAC Int 82: 834-839.
    • (1999) AOAC Int , vol.82 , pp. 834-839
    • Gonzalez, V.L.1    Hernandez, J.2
  • 17
    • 0036481621 scopus 로고    scopus 로고
    • Policosanol: Clinical pharmacology and therapeutic significance of a new lipid-lowering agent
    • Gouni-Berthold I, Berthold HK. 2002. Policosanol: clinical pharmacology and therapeutic significance of a new lipid-lowering agent. Am Heart J 143: 356-365.
    • (2002) Am Heart J , vol.143 , pp. 356-365
    • Gouni-Berthold, I.1    Berthold, H.K.2
  • 18
    • 33744458949 scopus 로고    scopus 로고
    • Effects of a policosanol supplement on serum lipid concentrations in hypercholesterolaemic and heterozygous familial hypercholesterolaemic subjects
    • Greyling A, De Witt C, Oosthuizen W, Jerling JC. 2006. Effects of a policosanol supplement on serum lipid concentrations in hypercholesterolaemic and heterozygous familial hypercholesterolaemic subjects. Br J Nutr 95: 968-975.
    • (2006) Br J Nutr , vol.95 , pp. 968-975
    • Greyling, A.1    De Witt, C.2    Oosthuizen, W.3    Jerling, J.C.4
  • 19
    • 1442350714 scopus 로고    scopus 로고
    • Nutritional significance and metabolism of very long chain fatty alcohols and acids from dietary waxes
    • Hargrove JL, Greenspan P, Hartle DK. 2004. Nutritional significance and metabolism of very long chain fatty alcohols and acids from dietary waxes. Exp Biol Med 229: 215-226.
    • (2004) Exp Biol Med , vol.229 , pp. 215-226
    • Hargrove, J.L.1    Greenspan, P.2    Hartle, D.K.3
  • 20
    • 0029132124 scopus 로고
    • Effects of sex and ethnicity on responses to a low-fat diet: A study of African Americans and whites
    • Howard BV, Hannah JS, Heiser CC, Jablonski KA. 1995. Effects of sex and ethnicity on responses to a low-fat diet: a study of African Americans and whites. Am J Clin Nutr 62: 488S-492S.
    • (1995) Am J Clin Nutr , vol.62
    • Howard, B.V.1    Hannah, J.S.2    Heiser, C.C.3    Jablonski, K.A.4
  • 21
    • 0036304788 scopus 로고    scopus 로고
    • Policosanol: A new treatment for cardiovascular disease?
    • Janikula M. 2002. Policosanol: a new treatment for cardiovascular disease? Altern Med Rev 7: 203-217.
    • (2002) Altern Med Rev , vol.7 , pp. 203-217
    • Janikula, M.1
  • 22
    • 33750908247 scopus 로고    scopus 로고
    • Lack of cholesterol-lowering efficacy of Cuban sugar cane policosanols in hypercholesterolemic persons
    • Kassis AN, Jones PJ. 2006. Lack of cholesterol-lowering efficacy of Cuban sugar cane policosanols in hypercholesterolemic persons. Am J Clin Nutr 84: 1003-1008.
    • (2006) Am J Clin Nutr , vol.84 , pp. 1003-1008
    • Kassis, A.N.1    Jones, P.J.2
  • 23
    • 4544224336 scopus 로고    scopus 로고
    • Wheat germ policosanol failed to lower plasma cholesterol in subjects with normal to mildly elevated cholesterol concentrations
    • Lin Y, Rudrum M, van der Wielen RP et al. 2004. Wheat germ policosanol failed to lower plasma cholesterol in subjects with normal to mildly elevated cholesterol concentrations. Metabolism 53: 1309-1314.
    • (2004) Metabolism , vol.53 , pp. 1309-1314
    • Lin, Y.1    Rudrum, M.2    van der Wielen, R.P.3
  • 25
    • 0035098624 scopus 로고    scopus 로고
    • Policosanol modulates HMG-CoA reductase activity in cultured fibroblasts
    • Menendez R, Amor AM, Rodeiro I et al. 2001. Policosanol modulates HMG-CoA reductase activity in cultured fibroblasts. Arch Med Res 32: 8-12.
    • (2001) Arch Med Res , vol.32 , pp. 8-12
    • Menendez, R.1    Amor, A.M.2    Rodeiro, I.3
  • 26
    • 0343052967 scopus 로고    scopus 로고
    • Cholesterol-lowering effect of policosanol on rabbits with hypercholesterolaemia induced by a wheat starch-casein diet
    • Menendez R, Arruzazabala L, Mas R. 1997. Cholesterol-lowering effect of policosanol on rabbits with hypercholesterolaemia induced by a wheat starch-casein diet. Br J Nutr 77: 923-932.
    • (1997) Br J Nutr , vol.77 , pp. 923-932
    • Menendez, R.1    Arruzazabala, L.2    Mas, R.3
  • 27
    • 0028568193 scopus 로고
    • Policosanol inhibits cholesterol biosynthesis and enhances low density lipoprotein processing in cultured human fibroblasts
    • Menendez R, Fernandez SI, Del Rio A et al. 1994. Policosanol inhibits cholesterol biosynthesis and enhances low density lipoprotein processing in cultured human fibroblasts. Biol Res 27: 199-203.
    • (1994) Biol Res , vol.27 , pp. 199-203
    • Menendez, R.1    Fernandez, S.I.2    Del Rio, A.3
  • 28
    • 33744481822 scopus 로고    scopus 로고
    • Lack of effect of sugar cane and sunflower seed policosanols on plasma cholesterol in rabbits
    • Murphy KJ, Saint DA, Howe PR. 2004. Lack of effect of sugar cane and sunflower seed policosanols on plasma cholesterol in rabbits. Asia Pac J Clin Nutr 13: S69.
    • (2004) Asia Pac J Clin Nutr , vol.13
    • Murphy, K.J.1    Saint, D.A.2    Howe, P.R.3
  • 29
    • 18244390229 scopus 로고    scopus 로고
    • A community-based, randomized trial of ezetimibe added to statin therapy to attain NCEP ATP III goals for LDL cholesterol in hypercholesterolemic patients: The Ezetimibe Add-on to Statin for Effectiveness (EASE) trial
    • Pearson TA, Denke MA, McBride PE, Battisti WP, Brady WE, Palmisano J. 2005. A community-based, randomized trial of ezetimibe added to statin therapy to attain NCEP ATP III goals for LDL cholesterol in hypercholesterolemic patients: the Ezetimibe Add-on to Statin for Effectiveness (EASE) trial. Mayo Clin Proc 80: 587-595.
    • (2005) Mayo Clin Proc , vol.80 , pp. 587-595
    • Pearson, T.A.1    Denke, M.A.2    McBride, P.E.3    Battisti, W.P.4    Brady, W.E.5    Palmisano, J.6
  • 30
    • 0028227198 scopus 로고
    • Effects of successive dose increases of policosanol on the lipid profile of patients with type II hypercholesterolaemia and tolerability to treatment
    • Pons P, Rodriguez M, Robaina C et al. 1994. Effects of successive dose increases of policosanol on the lipid profile of patients with type II hypercholesterolaemia and tolerability to treatment. Int J Clin Pharmacol Res 14: 27-33.
    • (1994) Int J Clin Pharmacol Res , vol.14 , pp. 27-33
    • Pons, P.1    Rodriguez, M.2    Robaina, C.3
  • 31
    • 0028174497 scopus 로고
    • Teratogenic and reproductive studies of policosanol in the rat and rabbit
    • Rodriguez MD, Garcia H. 1994. Teratogenic and reproductive studies of policosanol in the rat and rabbit. Teratog Carcinog Mutagen 14: 107-113.
    • (1994) Teratog Carcinog Mutagen , vol.14 , pp. 107-113
    • Rodriguez, M.D.1    Garcia, H.2
  • 32
    • 0031864685 scopus 로고    scopus 로고
    • Evaluation of peri- and post-natal toxicity of policosanol in rats
    • Rodriguez MD, Garcia H. 1998. Evaluation of peri- and post-natal toxicity of policosanol in rats. Teratog Carcinog Mutagen 18: 1-7.
    • (1998) Teratog Carcinog Mutagen , vol.18 , pp. 1-7
    • Rodriguez, M.D.1    Garcia, H.2
  • 33
    • 0028122593 scopus 로고
    • Effects of policosanol chronically administered in male monkeys (Macaca arctoides)
    • Rodriguez-Echenique C, Mesa R, Mas R et al. 1994. Effects of policosanol chronically administered in male monkeys (Macaca arctoides). Food Chem Toxicol 32: 565-575.
    • (1994) Food Chem Toxicol , vol.32 , pp. 565-575
    • Rodriguez-Echenique, C.1    Mesa, R.2    Mas, R.3
  • 34
    • 33747597580 scopus 로고    scopus 로고
    • Policosanol inhibits cholesterol synthesis in hepatoma cells by activation of AMP-kinase
    • Singh DK, Li L, Porter TD. 2006. Policosanol inhibits cholesterol synthesis in hepatoma cells by activation of AMP-kinase. J Pharmacol Exp Ther 318: 1020-1026.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 1020-1026
    • Singh, D.K.1    Li, L.2    Porter, T.D.3
  • 35
    • 1642340397 scopus 로고    scopus 로고
    • Do Singapore patients require lower doses of statins? the SGH Lipid Clinic experience
    • Tan CE, Loh LM, Tai ES. 2003. Do Singapore patients require lower doses of statins? the SGH Lipid Clinic experience. Singapore Med J 44: 635-638.
    • (2003) Singapore Med J , vol.44 , pp. 635-638
    • Tan, C.E.1    Loh, L.M.2    Tai, E.S.3
  • 37
    • 0037316361 scopus 로고    scopus 로고
    • Effects of policosanols and phytosterols on lipid levels and cholesterol biosynthesis in hamsters
    • Wang YW, Jones PJ, Pischel I, Fairow C. 2003. Effects of policosanols and phytosterols on lipid levels and cholesterol biosynthesis in hamsters. Lipids 38: 165-170.
    • (2003) Lipids , vol.38 , pp. 165-170
    • Wang, Y.W.1    Jones, P.J.2    Pischel, I.3    Fairow, C.4


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