Mutation analysis of AML1 gene in pediatric primary myelodysplastic syndrome and juvenile myelomonocytic leukemia

Leukemia Research

Volumn 32, Issue 6, 2008, Pages 995-997

  Masunaga, Atsuko ^a   Mitsuya, Toshiyuki ^a   Kadofuku, Tsuyoki ^b   Iwamoto, Sanju ^b   Miyazaki, Akira ^b   Manabe, Atsushi ^c   Zaike, Yuji ^d   Tsuchida, Masahiro ^e   Nakahata, Tatsutoshi ^f  

^a SHOWA UNIVERSITY FUJIGAOKA HOSPITAL   (Japan)

^b SHOWA UNIVERSITY   (Japan)

^c ST LUKE'S INTERNATIONAL HOSPITAL   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e Ibaraki Children's Hospital   (Japan)

^f KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; TRANSCRIPTION FACTOR POLYOMAVIRUS ENHANCER BINDING PROTEIN 2; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG;

CANCER PATIENT; CARBOXY TERMINAL SEQUENCE; CHILD CARE; CHROMOSOME TRANSLOCATION; DNA BINDING; EXON; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; LETTER; MYELODYSPLASTIC SYNDROME; MYELOMONOCYTIC LEUKEMIA; PRIORITY JOURNAL;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; CORE BINDING FACTOR ALPHA 2 SUBUNIT; DNA MUTATIONAL ANALYSIS; FEMALE; HUMANS; INFANT; LEUKEMIA, MYELOMONOCYTIC, JUVENILE; MALE; MUTATION; MYELODYSPLASTIC SYNDROMES;

EID: 40849086140     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2007.09.004     Document Type: Letter

References (6)

1. Miyoshi Y., Shimizu K., Kozu T., Maseki N., Kaneko Y., and Ohki M. t(8;21) breakpoints in chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene AML1. Proc Natl Acad Sci USA 88 (1991) 10431-10434
2. Miyoshi H., Ohira M., Shimizu K., Mitani K., Hirai H., Imai T., et al. Alternative splicing and genomic structure of the AML1 gene involved in acute myeloid leukemia. Nucl Acids Res 23 (1995) 2762-2769
3. Osato M. Point mutations in the RUNX1/AML1 gene: another actor in RUNX leukemia. Oncogene 23 (2004) 4284-4296
4. Harada H., Harada Y., Tanaka H., Kimura A., and Inaba T. Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related myelodysplastic syndrome/acute myeloid leukemia. Blood 101 (2003) 673-680
5. Harada H., Harada Y., Niimi H., Kyo T., Kimura A., and Inaba T. High incidence of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome and low blast percentage myeloid leukemia with myelodysplasia. Blood 103 (2004) 2316-2324
6. Christiansen D.H., Anderson M.K., and Pedersen-Bjergaard J. Mutations of AML1 are common in therapy-related myelodysplasia following therapy with alkylating agents and are significantly associated with deletion or loss of chromosome arm 7q and with subsequent leukemic transformation. Blood 104 (2004) 1474-1481