Tumorigenicity and genotoxicity of an environmental pollutant 2,7-dinitrofluorene after systemic administration at a low dose level to female rats

International Journal of Cancer

Volumn 122, Issue 9, 2008, Pages 1958-1965

  Malejka Giganti, Danuta ^a,b,e   Parkin, Daniel R ^a   Decker, Richard W ^b   Niehans, Gloria A ^a,b   Bliss, Robin L ^c   Churchwell, Mona I ^d   Beland, Frederick A ^d  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^e VA MEDICAL CENTER   (United States)

Author keywords

Environmental nitroaromatic; Genotoxicity; Mammary cancer; Rat

Indexed keywords

2 NITROSO 7 NITROFLUORENE; 9 OXO 2 NITROSO 7 NITROFLUORENE; AROMATIC NITRO COMPOUND; DEOXYADENOSINE; DEOXYGUANOSINE; NUCLEOTIDE; UNCLASSIFIED DRUG; 2 NITROSO 7 NITRO 9 OXOFLUORENE; 2,7 DINITROFLUORENE; 2,7-DINITROFLUORENE; 2-NITROSO-7-NITRO-9-OXOFLUORENE; 2-NITROSO-7-NITROFLUORENE; ASCORBIC ACID; CARCINOGEN; FLUORENE DERIVATIVE; MUTAGENIC AGENT; NITROSO DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; BREAST TUMOR; CANCER INCIDENCE; CARCINOGENICITY; CHEMICAL ANALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA ADDUCT; DNA DETERMINATION; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; GENOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LATENT PERIOD; LIVER; MAMMARY GLAND; NONHUMAN; POLLUTANT; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT; STATISTICAL SIGNIFICANCE; TANDEM MASS SPECTROMETRY; TISSUE LEVEL; ANIMAL; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DRUG EFFECT; EXPERIMENTAL NEOPLASM; INCIDENCE; INTRAPERITONEAL DRUG ADMINISTRATION; KAPLAN MEIER METHOD; LIVER TUMOR; METABOLISM; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ANIMALS; ASCORBIC ACID; CARCINOGENS, ENVIRONMENTAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEOXYGUANOSINE; DNA ADDUCTS; ENVIRONMENTAL POLLUTANTS; FEMALE; FLUORENES; INCIDENCE; INJECTIONS, INTRAPERITONEAL; KAPLAN-MEIERS ESTIMATE; LIVER NEOPLASMS, EXPERIMENTAL; MAMMARY NEOPLASMS, EXPERIMENTAL; MUTAGENS; NITROSO COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; TANDEM MASS SPECTROMETRY;

EID: 40749147289     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.23352     Document Type: Article

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