Safety of assisted reproduction, assessed by risk of abnormalities in children born after use of in vitro fertilization techniques

Nature Clinical Practice Urology

Volumn 5, Issue 3, 2008, Pages 140-150

  Alukal, Joseph P ^a   Lipshultz, Larry I ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIRTH DEFECT; CONGENITAL DISORDER; DEVELOPMENTAL DISORDER; EMBRYO TRANSFER; ENDOCRINE DISEASE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; FOLLOW UP; GENETIC DISORDER; HUMAN; INFERTILITY THERAPY; INTRACYTOPLASMIC SPERM INJECTION; MALE INFERTILITY; MULTIPLE PREGNANCY; NEUROLOGIC DISEASE; PATIENT SAFETY; PERINATAL MORTALITY; PREGNANCY OUTCOME; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT;

CHILD; CONGENITAL ABNORMALITIES; DEVELOPMENTAL DISABILITIES; FEMALE; FERTILIZATION IN VITRO; HUMANS; MALE; PREGNANCY; REPRODUCTIVE TECHNIQUES, ASSISTED; RISK FACTORS;

EID: 40749114730     PISSN: 17434270     EISSN: 17434289     Source Type: Journal    
DOI: 10.1038/ncpuro1045     Document Type: Review

References (73)

1. Steptoe PC and Edwards RG (1978) Birth after the reimplantation of a human embryo. Lancet 2: 366
2. Andersen AN et al. (2007) Assisted reproductive technology in Europe, 2003. Results generated from European registers by ESHRE. Hum Reprod 22: 1513-1525
3. Wright VC et al. (2006) Assisted reproductive technology surveillance - United States, 2003. MMWR Surveill Summ 55: 1-22
4. Wright VC et al. (2005) Assisted reproductive technology surveillance - United States, 2002. MMWR Surveill Summ 54: 1-24
5. Pinborg A (2005) IVF/ICSI twin pregnancies: Risks and prevention. Hum Reprod Update 11: 575-593
6. Kaufman GE et al. (1998) Neonatal morbidity and mortality associated with triplet pregnancy. Obstet Gynecol 91: 342-348
7. Klemetti R et al. (2005) Children born after assisted fertilization have an increased rate of major congenital anomalies. Fertil Steril 84: 1300-1307
8. Reddy UM et al. (2007) Infertility, assisted reproductive technology, and adverse pregnancy outcomes: Executive summary of a National Institute of Child Health and Human Development workshop. Obstet Gynecol 109: 967-977
9. Schieve LA et al. (2005) Risk of birth defects among children conceived with assisted reproductive technology: Providing an epidemiologic context to the data. Fertil Steril 84: 1320-1324
10. Zegers-Hochschild F et al. (2006) The ICMART glossary on ART terminology. Hum Reprod 21: 1968-1970
11. Helmerhorst FM et al. (2004) Perinatal outcome of singletons and twins after assisted conception: A systematic review of controlled studies. BMJ 328: 261
12. Jackson RA et al. Perinatal outcomes in singletons following in vitro fertilization: A meta-analysis. Obstet Gynecol 103: 551-563
13. Rimm AA et al. (2004) A meta-analysis of controlled studies comparing major malformation rates in IVF and ICSI infants with naturally conceived children. J Assist Reprod Genet 21: 437-443
14. McGovern PG et al. Increased risk of preterm birth in singleton pregnancies resulting from in vitro fertilization-embryo transfer or gamete intrafallopian transfer: A meta-analysis. Fertit Steril 82: 1514-1520
15. Dhont M et al. (1997) Perinatal outcome of pregnancies after assisted reproduction: A case-control study. J Assist Reprod Genet 14: 575-580
16. Gerris J et al. (2004) A real-life prospective health economic study of elective single embryo transfer versus two-embryo transfer in first IVF/ICSI cycles. Hum Reprod 19: 917-923
17. Pinborg A et al. (2003) Morbidity in a Danish national cohort of 472 IVF/ICSI twins, 1132 non-IVF/ICSI twins and 634 IVF/ICSI singletons: health-related and social implications for the children and their families. Hum Reprod 18: 1234-1243
18. Pinborg A et al. (2004) Neonatal outcome in a Danish national cohort of 8602 children born after in vitro fertilization or intracytoplasmic sperm injection: The role of twin pregnancy. Acta Obstet Gynecol Scand 83: 1071-1078
19. Pinborg A et al. (2004) Hospital care utilization of IVF/ICSI twins followed until 2-7 years of age: A controlled Danish national cohort study. Hum Reprod 19: 2529-2536
20. Pinborg A et al. (2007) Vanishing twins: A predictor of small-for-gestational age in IVF singletons. Hum Reprod 22: 2707-2714
21. Tiitinen A et al. (2003) Impact of elective single embryo transfer on the twin pregnancy rate. Hum Reprod 18: 1449-1453
22. Klemetti R et al. (2006) Health of children born as a result of in vitro fertilization. Pediatrics 118: 1819-1827
23. Poikkeus P et al. (2007) Obstetric and neonatal outcome after single embryo transfer. Hum. Reprod 22: 1073-1079
24. Thurin A et al. (2004) Elective single-embryo transfer versus double-embryo transfer in in vitro fertilization. N Engl J Med 351: 2392-2402
25. Bergh T et al. (1999) Deliveries and children born after in-vitro fertilisation in Sweden 1982-95: A retrospective cohort study. Lancet 354: 1579-1585
26. Kallen B et al. (2005) Temporal trends in multiple births after in vitro fertilisation in Sweden, 1982-2001: A register study. BMJ 331: 382-383
27. Schieve LA et al. Low and very low birth weight in infants conceived with use of assisted reproductive technology. N Engl J Med 346: 731-737
28. Gerris JM (2005) Single embryo transfer and IVF/ICSI outcome: A balanced appraisal. Hum Reprod Update 11: 105-121
29. Bowen JR et al. (1998) Medical and developmental outcome at 1 year for children conceived by intracytoplasmic sperm injection. Lancet 351: 1529-1534
30. Leslie GI et al. (2003) Children conceived using ICSI do not have an increased risk of delayed mental development at 5 years of age. Hum Reprod 18: 2067-2072
31. Bonduelle M et al. (1998) Mental development of 201 ICSI children at 2 years of age. Lancet 351: 1553
32. Bonduelle M et al. (2003) Developmental outcome at 2 years of age for children born after ICSI compared with children born after IVF. Hum Reprod 18: 342-350
33. Place I and Englert Y (2003) A prospective longitudinal study of the physical, psychomotor, and intellectual development of singleton children up to 5 years who were conceived by intracytoplasmic sperm injection compared with children conceived spontaneously and by in vitro fertilization. Fertil Steril 80: 1388-1397
34. Leunens L et al. (2006) Cognitive and motor development of 8-year-old children born after ICSI compared to spontaneously conceived children. Hum Reprod 21: 2922-2929
35. Ponjaert-Kristoffersen I et al. (2005) International collaborative study of intracytoplasmic sperm injection-conceived, in vitro fertilization-conceived, and naturally conceived 5-year-old child outcomes: Cognitive and motor assessments. Pediatrics 115: e283-e289
36. Koivurova S et al. (2003) Growth, psychomotor development and morbidity up to 3 years of age in children born after IVF. Hum Reprod 18: 2328-2336
37. Stromberg B et al. (2002) Neurological sequelae in children born after in-vitro fertilisation: A population-based study. Lancet 359: 461-465
38. Sutcliffe AG et al. (2001) Outcome in the second year of life after in-vitro fertilisation by intracytoplasmic sperm injection: a UK case-control study. Lancet 357: 2080-2084
39. Neri QV et al. (2002) Screening for cognitive and motor development of 3-year-old ICSI and IVF children. Fertil Steril 78: S250-s251
40. Neri QV et al. (2001) Genetic assessment and development of children that result from assisted reproductive technology. Clin Obstet Gynecol 49: 134-137
41. Belva F et al. (2007) Medical outcome of 8-year-old singleton ICSI children (born > or=32 weeks' gestation) and a spontaneously conceived comparison group. Hum Reprod 22: 506-515
42. Hvidtjorn D et al. (2006) Cerebral palsy among children born after in vitro fertilization: The role of preterm delivery-a population-based, cohort study. Pediatrics 118: 475-482
43. Anthony S et al. (2002) Congenital malformations in 4224 children conceived after IVF. Hum Reprod 17: 2089-2095
44. Hansen M et al. (2002) The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. N Engl J Med 346: 725-730
45. Westergaard HB et al. (1999) Danish National In-Vitro Fertilization Registry 1994 and 1995: A controlled study of births, malformations and cytogenetic findings. Hum Reprod 14: 1896-1902
46. Loft A et al. (1999) A Danish national cohort of 730 infants born after intracytoplasmic sperm injection (ICSI) 1994-1997. Hum Reprod 14: 2143-2148
47. Zhu JL et al. (2006) Infertility, infertility treatment, and congenital malformations: Danish national birth cohort. BMJ 333 679
48. Koivurova S et al. (2002) Neonatal outcome and congenital malformations in children born after in-vitro fertilization. Hum Reprod 17: 1391-1398
49. Ludwig M and Katalinic A (2002) Malformation rate in fetuses and children conceived after ICSI: Results of a prospective cohort study. Reprod Biomed Online 5: 171-178
50. Katalinic A et al. (2004) Pregnancy course and outcome after intracytoplasmic sperm injection: A controlled, prospective cohort study. Fertit Steril 81: 1604-1616
51. Zadori J et al. (2003) Dilemma of increased obstetric risk in pregnancies following IVF-ET. J Assist Reprod Genet 20: 216-221
52. Wennerholm UB et al. (2000) Incidence of congenital malformations in children born after ICSI. Hum Reprod 15: 944-948
53. Ericson A and Kallen B (2001) Congenital malformations in infants born after IVF: A population-based study. Hum Reprod 16:504-509
54. Sutcliffe AG et al. (1995) Minor congenital anomalies, major congenital malformations and development in children conceived from cryopreserved embryos. Hum Reprod 10: 3332-3337
55. Olson CK et al. In vitro fertilization is associated with an increase in major birth defects. Fertil Steril 84: 1308-1315
56. Lie RT et al. Birth defects in children conceived by ICSI compared with children conceived by other IVF-methods; a meta-analysis. Int J Epidemiol 34: 696-701
57. Hansen M et al. Assisted reproductive technologies and the risk of birth defects-a systematic review. Hum Reprod 20:328-338
58. Kurinczuk JJ and Bower C (1997) Birth defects in infants conceived by intracytoplasmic sperm injection: An alternative interpretation. BMJ 315: 1260-1265
59. Bonduelle M et al. (1996) Prospective follow-up study of 423 children born after intracytoplasmic sperm injection. Hum Reprod 11: 1558-1564
60. Mau Kai C et al. (2007) Reduced serum testosterone levels in infant boys conceived by intracytoplasmic sperm injection. J Clin Endocrinol Metab 92: 2598-2603
61. Soderstrom-Anttila V et al. (2006) Obstetric and perinatal outcome and preliminary results of development of children born after in vitro maturation of oocytes. Hum Reprod 21: 1508-1513
62. Cox GF et al. (2002) Intracytoplasmic sperm injection may increase the risk of imprinting defects. Am J Hum Genet 71: 162-164
63. Maher ER et al. (2003) Beckwith-Wiedemann syndrome and assisted reproduction technology (ART). J Med Genet 40:62-64
64. Maher ER (2005) Imprinting and assisted reproductive technology. Hum Mol Genet 14: R133-R138
65. Ludwig M et al. (2005) Increased prevalence of imprinting defects in patients with Angelman syndrome born to subfertile couples. J Med Genet 42: 289-291
66. Klip H et al. (2001) Risk of cancer in the offspring of women who underwent ovarian stimulation for IVF. Hum Reprod 16: 2451-2458
67. Bruinsma F et al. (2000) Incidence of cancer in children born after in-vitro fertilization. Hum Reprod 15: 604-607
68. Moll AC et al. (2003) Incidence of retinoblastoma in children born after in-vitro fertilisation. Lancet 361: 309-310
69. Bonduelle M et al. (2002) Prenatal testing in ICSI pregnancies: incidence of chromosomal anomalies in 1586 karyotypes and relation to sperm parameters. Hum Reprod 17: 2600-2614
70. Foresta C et al. (2005) Genetic abnormalities among severely oligospermic men who are candidates for intracytoplasmic sperm injection. J Clin Endocrinol Metab 90: 152-156
71. Simpson JL and Lamb DJ (2001) Genetic effects of intracytoplasmic sperm injection. Semin Reprod Med 19: 239-249
72. Hansen M et al. (2007) Practitioner reporting of birth defects in children born following assisted reproductive technology: Does it still have a role in surveillance of birth defects? Hum Reprod 22: 516-520
73. Buck Louis GM et al. (2005) Research hurdles complicating the analysis of infertility treatment and child health. Hum Reprod 20: 12-18