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Volumn 21, Issue 1, 2008, Pages 29-41

New approaches in acute myeloid leukemia

Author keywords

acute myeloid leukemia; core binding factor; epigenetics; G3139 (oblimersen sodium, Genasense); KIT mutation; RAS mutation; ribonucleotide reductase; targeted therapy

Indexed keywords

3 PHENYLSULFAMOYLCINNAMOHYDROXAMIC ACID; 4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; 4 [N (2 HYDROXYETHYL) N [2 (3 INDOLYL)ETHYL]AMINOMETHYL]CINNAMOHYDROXAMIC ACID; 4 N ACETYLDINALINE; 5 AZA 2' DEOXYCYTIDINE; ANTINEOPLASTIC AGENT; ARYLBUTYRIC ACID DERIVATIVE; AZACITIDINE; CD135 ANTIGEN; CLOFARABINE; CLORETAZINE; CYTARABINE; CYTOTOXIC AGENT; DAUNORUBICIN; GTI 2040; HISTONE DEACETYLASE INHIBITOR; MIDOSTAURIN; N (2 AMINOPHENYL) 4 (3 PYRIDINYLMETHOXYCARBONYLAMINOMETHYL)BENZAMIDE; NUCLEOPHOSMIN; OBLIMERSEN; PANOBINOSTAT; PLACEBO; PROTEIN TYROSINE KINASE INHIBITOR; RAS PROTEIN; ROMIDEPSIN; TIPIFARNIB; UNINDEXED DRUG; VALPROIC ACID; VALSPODAR; VORINOSTAT;

EID: 40749100947     PISSN: 15216926     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.beha.2007.11.009     Document Type: Review
Times cited : (14)

References (73)
  • 2
    • 33846230449 scopus 로고    scopus 로고
    • Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?
    • Mrozek K., Marcucci G., Paschka P., et al. Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?. Blood 109 (2007) 431-448
    • (2007) Blood , vol.109 , pp. 431-448
    • Mrozek, K.1    Marcucci, G.2    Paschka, P.3
  • 3
    • 16544369516 scopus 로고    scopus 로고
    • Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia
    • Bullinger L., Dohner K., Bair E., et al. Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia. The New England Journal of Medicine 350 (2004) 1605-1616
    • (2004) The New England Journal of Medicine , vol.350 , pp. 1605-1616
    • Bullinger, L.1    Dohner, K.2    Bair, E.3
  • 4
    • 11144358111 scopus 로고    scopus 로고
    • Prognostically useful gene-expression profiles in acute myeloid leukemia
    • Valk P.J., Verhaak R.G., Beijen M.A., et al. Prognostically useful gene-expression profiles in acute myeloid leukemia. The New England Journal of Medicine 350 (2004) 1617-1628
    • (2004) The New England Journal of Medicine , vol.350 , pp. 1617-1628
    • Valk, P.J.1    Verhaak, R.G.2    Beijen, M.A.3
  • 5
    • 33747420007 scopus 로고    scopus 로고
    • Independent confirmation of a prognostic gene-expression signature in adult acute myeloid leukemia with a normal karyotype: a Cancer and Leukemia Group B study
    • Radmacher M.D., Marcucci G., Ruppert A.S., et al. Independent confirmation of a prognostic gene-expression signature in adult acute myeloid leukemia with a normal karyotype: a Cancer and Leukemia Group B study. Blood 108 (2006) 1677-1683
    • (2006) Blood , vol.108 , pp. 1677-1683
    • Radmacher, M.D.1    Marcucci, G.2    Ruppert, A.S.3
  • 6
    • 0037114753 scopus 로고    scopus 로고
    • Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461)
    • Byrd J.C., Mrozek K., Dodge R.K., et al. Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from Cancer and Leukemia Group B (CALGB 8461). Blood 100 (2002) 4325-4336
    • (2002) Blood , vol.100 , pp. 4325-4336
    • Byrd, J.C.1    Mrozek, K.2    Dodge, R.K.3
  • 7
    • 0032188805 scopus 로고    scopus 로고
    • The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties
    • Grimwade D., Walker H., Oliver F., et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood 92 (1998) 2322-2333
    • (1998) Blood , vol.92 , pp. 2322-2333
    • Grimwade, D.1    Walker, H.2    Oliver, F.3
  • 8
    • 0034672269 scopus 로고    scopus 로고
    • Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group Study
    • Slovak M.L., Kopecky K.J., Cassileth P.A., et al. Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group Study. Blood 96 (2000) 4075-4083
    • (2000) Blood , vol.96 , pp. 4075-4083
    • Slovak, M.L.1    Kopecky, K.J.2    Cassileth, P.A.3
  • 9
    • 0028108111 scopus 로고
    • Long-term results following treatment of newly-diagnosed acute myelogenous leukemia with continuous-infusion high-dose cytosine arabinoside
    • Ghaddar H.M., Plunkett W., Kantarjian H.M., et al. Long-term results following treatment of newly-diagnosed acute myelogenous leukemia with continuous-infusion high-dose cytosine arabinoside. Leukemia 8 (1994) 1269-1274
    • (1994) Leukemia , vol.8 , pp. 1269-1274
    • Ghaddar, H.M.1    Plunkett, W.2    Kantarjian, H.M.3
  • 10
    • 17544388046 scopus 로고    scopus 로고
    • Frequency of prolonged remission duration after high-dose cytarabine intensification in acute myeloid leukemia varies by cytogenetic subtype
    • Bloomfield C.D., Lawrence D., Byrd J.C., et al. Frequency of prolonged remission duration after high-dose cytarabine intensification in acute myeloid leukemia varies by cytogenetic subtype. Cancer Research 58 (1998) 4173-4179
    • (1998) Cancer Research , vol.58 , pp. 4173-4179
    • Bloomfield, C.D.1    Lawrence, D.2    Byrd, J.C.3
  • 11
    • 10544253077 scopus 로고    scopus 로고
    • Enhanced sensitivity to 1-beta-D-arabinofuranosylcytosine and topoisomerase II inhibitors in tumor cell lines harboring activated ras oncogenes
    • Koo H.M., Monks A., Mikheev A., et al. Enhanced sensitivity to 1-beta-D-arabinofuranosylcytosine and topoisomerase II inhibitors in tumor cell lines harboring activated ras oncogenes. Cancer Research 56 (1996) 5211-5216
    • (1996) Cancer Research , vol.56 , pp. 5211-5216
    • Koo, H.M.1    Monks, A.2    Mikheev, A.3
  • 12
    • 0033572310 scopus 로고    scopus 로고
    • Ras oncogene-induced sensitization to 1-beta-D-arabinofuranosylcytosine
    • Koo H.M., McWilliams M.J., Alvord W.G., et al. Ras oncogene-induced sensitization to 1-beta-D-arabinofuranosylcytosine. Cancer Research 59 (1999) 6057-6062
    • (1999) Cancer Research , vol.59 , pp. 6057-6062
    • Koo, H.M.1    McWilliams, M.J.2    Alvord, W.G.3
  • 13
    • 32144434156 scopus 로고    scopus 로고
    • Patients (pts) with acute myeloid leukemia (AML) and mutant RAS benefit from high-dose cytarabine (HDAC) intensification: a Cancer and Leukemia Group B (CALGB) study
    • [abstract 6514] Ref Type: Electronic Citation
    • Neubauer A., Maharry K., Marcucci G., et al. Patients (pts) with acute myeloid leukemia (AML) and mutant RAS benefit from high-dose cytarabine (HDAC) intensification: a Cancer and Leukemia Group B (CALGB) study. Journal of Clinical Oncology 23 (2005) 563s [abstract 6514] Ref Type: Electronic Citation
    • (2005) Journal of Clinical Oncology , vol.23
    • Neubauer, A.1    Maharry, K.2    Marcucci, G.3
  • 14
    • 40749083296 scopus 로고    scopus 로고
    • Risk-adapted therapy in younger adults with acute myeloid leukemia: Results of the AMLHD98a trial of the AMLSG
    • [abstract 14]
    • Schlenk R.F., Dohner K., Pralle H., et al. Risk-adapted therapy in younger adults with acute myeloid leukemia: Results of the AMLHD98a trial of the AMLSG. Blood 108 (2006) 8a [abstract 14]
    • (2006) Blood , vol.108
    • Schlenk, R.F.1    Dohner, K.2    Pralle, H.3
  • 15
    • 27744451026 scopus 로고    scopus 로고
    • No evidence that FLT3 status should be considered as an indicator for transplantation in acute myeloid leukemia (AML): an analysis of 1135 patients, excluding acute promyelocytic leukemia, from the UK MRC AML10 and 12 trials
    • Gale R.E., Hills R., Kottaridis P.D., et al. No evidence that FLT3 status should be considered as an indicator for transplantation in acute myeloid leukemia (AML): an analysis of 1135 patients, excluding acute promyelocytic leukemia, from the UK MRC AML10 and 12 trials. Blood 106 (2005) 3658-3665
    • (2005) Blood , vol.106 , pp. 3658-3665
    • Gale, R.E.1    Hills, R.2    Kottaridis, P.D.3
  • 16
    • 0036720398 scopus 로고    scopus 로고
    • The roles of FLT3 in hematopoiesis and leukemia
    • Gilliland D.G., and Griffin J.D. The roles of FLT3 in hematopoiesis and leukemia. Blood 100 (2002) 1532-1542
    • (2002) Blood , vol.100 , pp. 1532-1542
    • Gilliland, D.G.1    Griffin, J.D.2
  • 17
    • 0035885955 scopus 로고    scopus 로고
    • The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
    • Kottaridis P.D., Gale R.E., Frew M.E., et al. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood 98 (2001) 1752-1759
    • (2001) Blood , vol.98 , pp. 1752-1759
    • Kottaridis, P.D.1    Gale, R.E.2    Frew, M.E.3
  • 18
    • 0037114829 scopus 로고    scopus 로고
    • Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm
    • Frohling S., Schlenk R.F., Breitruck J., et al. Prognostic significance of activating FLT3 mutations in younger adults (16 to 60 years) with acute myeloid leukemia and normal cytogenetics: a study of the AML Study Group Ulm. Blood 100 (2002) 4372-4380
    • (2002) Blood , vol.100 , pp. 4372-4380
    • Frohling, S.1    Schlenk, R.F.2    Breitruck, J.3
  • 19
    • 0037097716 scopus 로고    scopus 로고
    • Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis
    • Thiede C., Steudel C., Mohr B., et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood 99 (2002) 4326-4335
    • (2002) Blood , vol.99 , pp. 4326-4335
    • Thiede, C.1    Steudel, C.2    Mohr, B.3
  • 20
    • 34249829699 scopus 로고    scopus 로고
    • Phase IB study of PKC412, an oral FLT3 kinase inhibitor, in sequential and simultaneous combinations with daunorubicin and cytarabine (DA) induction and high-dose cytarabine consolidation in newly diagnosed adult patients (pts) with acute myeloid leukemia (AML) under age 61
    • [abstract 157]
    • Stone R.M., Fischer T., Paquette R., et al. Phase IB study of PKC412, an oral FLT3 kinase inhibitor, in sequential and simultaneous combinations with daunorubicin and cytarabine (DA) induction and high-dose cytarabine consolidation in newly diagnosed adult patients (pts) with acute myeloid leukemia (AML) under age 61. Blood 108 (2006) 50a [abstract 157]
    • (2006) Blood , vol.108
    • Stone, R.M.1    Fischer, T.2    Paquette, R.3
  • 21
    • 38849174002 scopus 로고    scopus 로고
    • Phase 1/2 study of tandutinib (MLN518) plus standard induction chemotherapy in newly diagnosed acute myelogenous leukemia (AML)
    • [abstract 158]
    • DeAngelo D.J., Amrein P.C., Kovacsocics T.J., et al. Phase 1/2 study of tandutinib (MLN518) plus standard induction chemotherapy in newly diagnosed acute myelogenous leukemia (AML). Blood 108 (2006) 51a [abstract 158]
    • (2006) Blood , vol.108
    • DeAngelo, D.J.1    Amrein, P.C.2    Kovacsocics, T.J.3
  • 22
    • 33845240584 scopus 로고    scopus 로고
    • Phase 1 clinical results with tandutinib (MLN518), a novel FLT3 antagonist, in patients with acute myelogenous leukemia or high-risk myelodysplastic syndrome: safety, pharmacokinetics, and pharmacodynamics
    • DeAngelo D.J., Stone R.M., Heaney M.L., et al. Phase 1 clinical results with tandutinib (MLN518), a novel FLT3 antagonist, in patients with acute myelogenous leukemia or high-risk myelodysplastic syndrome: safety, pharmacokinetics, and pharmacodynamics. Blood 108 (2006) 3674-3681
    • (2006) Blood , vol.108 , pp. 3674-3681
    • DeAngelo, D.J.1    Stone, R.M.2    Heaney, M.L.3
  • 23
    • 0032793987 scopus 로고    scopus 로고
    • Patients with t(8;21)(q22;q22) and acute myeloid leukemia have superior failure-free and overall survival when repetitive cycles of high-dose cytarabine are administered
    • Byrd J.C., Dodge R.K., Carroll A., et al. Patients with t(8;21)(q22;q22) and acute myeloid leukemia have superior failure-free and overall survival when repetitive cycles of high-dose cytarabine are administered. Journal of Clinical Oncology 17 (1999) 3767-3775
    • (1999) Journal of Clinical Oncology , vol.17 , pp. 3767-3775
    • Byrd, J.C.1    Dodge, R.K.2    Carroll, A.3
  • 24
    • 24944464648 scopus 로고    scopus 로고
    • Prognostic factors and outcome of core binding factor acute myeloid leukemia patients with t(8;21) differ from those of patients with inv(16): a Cancer and Leukemia Group B study
    • Marcucci G., Mrozek K., Ruppert A.S., et al. Prognostic factors and outcome of core binding factor acute myeloid leukemia patients with t(8;21) differ from those of patients with inv(16): a Cancer and Leukemia Group B study. Journal of Clinical Oncology 23 (2005) 5705-5717
    • (2005) Journal of Clinical Oncology , vol.23 , pp. 5705-5717
    • Marcucci, G.1    Mrozek, K.2    Ruppert, A.S.3
  • 25
    • 33748467435 scopus 로고    scopus 로고
    • Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B Study
    • Paschka P., Marcucci G., Ruppert A.S., et al. Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B Study. Journal of Clinical Oncology 24 (2006) 3904-3911
    • (2006) Journal of Clinical Oncology , vol.24 , pp. 3904-3911
    • Paschka, P.1    Marcucci, G.2    Ruppert, A.S.3
  • 26
    • 27144506215 scopus 로고    scopus 로고
    • Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation
    • Gotlib J., Berube C., Growney J.D., et al. Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation. Blood 106 (2005) 2865-2870
    • (2005) Blood , vol.106 , pp. 2865-2870
    • Gotlib, J.1    Berube, C.2    Growney, J.D.3
  • 27
    • 30444446680 scopus 로고    scopus 로고
    • PKC412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mutated variant of KIT: comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects
    • Gleixner K.V., Mayerhofer M., Aichberger K.J., et al. PKC412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mutated variant of KIT: comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects. Blood 107 (2006) 752-759
    • (2006) Blood , vol.107 , pp. 752-759
    • Gleixner, K.V.1    Mayerhofer, M.2    Aichberger, K.J.3
  • 28
    • 21244467166 scopus 로고    scopus 로고
    • Epigenetic and chromatin modifiers as targeted therapy of hematologic malignancies
    • Bhalla K.N. Epigenetic and chromatin modifiers as targeted therapy of hematologic malignancies. Journal of Clinical Oncology 23 (2005) 3971-3993
    • (2005) Journal of Clinical Oncology , vol.23 , pp. 3971-3993
    • Bhalla, K.N.1
  • 29
    • 33745714230 scopus 로고    scopus 로고
    • Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms
    • Gore S.D., Baylin S., Sugar E., et al. Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms. Cancer Research 66 (2006) 6361-6369
    • (2006) Cancer Research , vol.66 , pp. 6361-6369
    • Gore, S.D.1    Baylin, S.2    Sugar, E.3
  • 30
    • 33750530675 scopus 로고    scopus 로고
    • Phase 1/2 study of the combination of 5-aza-2'-deoxycytidine with valproic acid in patients with leukemia
    • Garcia-Manero G., Kantarjian H.M., Sanchez-Gonzalez B., et al. Phase 1/2 study of the combination of 5-aza-2'-deoxycytidine with valproic acid in patients with leukemia. Blood 108 (2006) 3271-3279
    • (2006) Blood , vol.108 , pp. 3271-3279
    • Garcia-Manero, G.1    Kantarjian, H.M.2    Sanchez-Gonzalez, B.3
  • 31
    • 40749095735 scopus 로고    scopus 로고
    • Clinical, pharmacokinetic, and pharmacodynamic results of a phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia
    • Blum W., Klisovic R.B., Hackanson B., et al. Clinical, pharmacokinetic, and pharmacodynamic results of a phase I study of decitabine alone or in combination with valproic acid in acute myeloid leukemia. Journal of Clinical Oncology (2007)
    • (2007) Journal of Clinical Oncology
    • Blum, W.1    Klisovic, R.B.2    Hackanson, B.3
  • 32
    • 35948934399 scopus 로고    scopus 로고
    • Phase II study of low-dose decitabine for the front-line treatment of older patients with acute myeloid leukemia (AML)
    • [abstract 1984]
    • Cashen A., Schiller G.J., Larsen J.S., et al. Phase II study of low-dose decitabine for the front-line treatment of older patients with acute myeloid leukemia (AML). Blood 108 (2006) 561a [abstract 1984]
    • (2006) Blood , vol.108
    • Cashen, A.1    Schiller, G.J.2    Larsen, J.S.3
  • 33
    • 0035132538 scopus 로고    scopus 로고
    • Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro
    • End D.W., Smets G., Todd A.V., et al. Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro. Cancer Research 61 (2001) 131-137
    • (2001) Cancer Research , vol.61 , pp. 131-137
    • End, D.W.1    Smets, G.2    Todd, A.V.3
  • 34
    • 33847001315 scopus 로고    scopus 로고
    • A phase 2 study of the farnesyltransferase inhibitor tipifarnib in poor-risk and elderly patients with previously untreated acute myelogenous leukemia
    • Lancet J.E., Gojo I., Gotlib J., et al. A phase 2 study of the farnesyltransferase inhibitor tipifarnib in poor-risk and elderly patients with previously untreated acute myelogenous leukemia. Blood 109 (2007) 1387-1394
    • (2007) Blood , vol.109 , pp. 1387-1394
    • Lancet, J.E.1    Gojo, I.2    Gotlib, J.3
  • 35
    • 34250006852 scopus 로고    scopus 로고
    • A phase 2 study of the oral farnesyltransferase inhibitor tipifarnib in patients with refractory or relapsed acute myeloid leukemia
    • Harousseau J.L., Lancet J.E., Reiffers J., et al. A phase 2 study of the oral farnesyltransferase inhibitor tipifarnib in patients with refractory or relapsed acute myeloid leukemia. Blood 109 (2007) 5151-5156
    • (2007) Blood , vol.109 , pp. 5151-5156
    • Harousseau, J.L.1    Lancet, J.E.2    Reiffers, J.3
  • 36
    • 33646576509 scopus 로고    scopus 로고
    • Mode of action of the chloroethylating and carbamoylating moieties of the prodrug cloretazine
    • Ishiguro K., Seow H.A., Penketh P.G., et al. Mode of action of the chloroethylating and carbamoylating moieties of the prodrug cloretazine. Molecular Cancer Therapeutics 5 (2006) 969-976
    • (2006) Molecular Cancer Therapeutics , vol.5 , pp. 969-976
    • Ishiguro, K.1    Seow, H.A.2    Penketh, P.G.3
  • 37
    • 30444446785 scopus 로고    scopus 로고
    • The antineoplastic efficacy of the prodrug Cloretazine is produced by the synergistic interaction of carbamoylating and alkylating products of its activation
    • Baumann R.P., Seow H.A., Shyam K., et al. The antineoplastic efficacy of the prodrug Cloretazine is produced by the synergistic interaction of carbamoylating and alkylating products of its activation. Oncology Research 15 (2005) 313-325
    • (2005) Oncology Research , vol.15 , pp. 313-325
    • Baumann, R.P.1    Seow, H.A.2    Shyam, K.3
  • 38
    • 33750022018 scopus 로고    scopus 로고
    • A phase II study of cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, in patients with very high risk relapsed acute myeloid leukemia
    • Giles F., Verstovsek S., Faderl S., et al. A phase II study of cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, in patients with very high risk relapsed acute myeloid leukemia. Leukemia Research 30 (2006) 1591-1595
    • (2006) Leukemia Research , vol.30 , pp. 1591-1595
    • Giles, F.1    Verstovsek, S.2    Faderl, S.3
  • 39
    • 33846413076 scopus 로고    scopus 로고
    • Cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, in patients age 60 years or older with previously untreated acute myeloid leukemia
    • Giles F., Rizzieri D., Karp J., et al. Cloretazine (VNP40101M), a novel sulfonylhydrazine alkylating agent, in patients age 60 years or older with previously untreated acute myeloid leukemia. Journal of Clinical Oncology 25 (2007) 25-31
    • (2007) Journal of Clinical Oncology , vol.25 , pp. 25-31
    • Giles, F.1    Rizzieri, D.2    Karp, J.3
  • 40
    • 33846077453 scopus 로고    scopus 로고
    • Metabolism of GTI-2040, a phosphorothioate oligonucleotide antisense, using ion-pair reversed phase high performance liquid chromatography (HPLC) coupled with electrospray ion-trap mass spectrometry
    • Wei X., Dai G., Liu Z., et al. Metabolism of GTI-2040, a phosphorothioate oligonucleotide antisense, using ion-pair reversed phase high performance liquid chromatography (HPLC) coupled with electrospray ion-trap mass spectrometry. The AAPS Journal 8 (2006) E743-E755
    • (2006) The AAPS Journal , vol.8
    • Wei, X.1    Dai, G.2    Liu, Z.3
  • 41
    • 33745329502 scopus 로고    scopus 로고
    • A specific picomolar hybridization-based ELISA assay for the determination of phosphorothioate oligonucleotides in plasma and cellular matrices
    • Wei X., Dai G., Marcucci G., et al. A specific picomolar hybridization-based ELISA assay for the determination of phosphorothioate oligonucleotides in plasma and cellular matrices. Pharmaceutical Research 23 (2006) 1251-1264
    • (2006) Pharmaceutical Research , vol.23 , pp. 1251-1264
    • Wei, X.1    Dai, G.2    Marcucci, G.3
  • 42
    • 40749127734 scopus 로고    scopus 로고
    • A phase I study of GTI-2040, an antisense to ribonucleotide reductase (RNR) in combination with high-dose cytarabine (HiDAC) in relapsed or refractory acute myeloid leukemia (AML): pharmacokinetics (PK), pharmacodynamic (PD) and clinical results
    • [abstract 2790]
    • Klisovic R.B., Blum W., Wei X., et al. A phase I study of GTI-2040, an antisense to ribonucleotide reductase (RNR) in combination with high-dose cytarabine (HiDAC) in relapsed or refractory acute myeloid leukemia (AML): pharmacokinetics (PK), pharmacodynamic (PD) and clinical results. Blood 106 (2005) 782a [abstract 2790]
    • (2005) Blood , vol.106
    • Klisovic, R.B.1    Blum, W.2    Wei, X.3
  • 43
    • 33746057854 scopus 로고    scopus 로고
    • Clinical and pharmacokinetic study of clofarabine in chronic lymphocytic leukemia: strategy for treatment
    • Gandhi V., Plunkett W., Bonate P.L., et al. Clinical and pharmacokinetic study of clofarabine in chronic lymphocytic leukemia: strategy for treatment. Clinical Cancer Research 12 (2006) 4011-4017
    • (2006) Clinical Cancer Research , vol.12 , pp. 4011-4017
    • Gandhi, V.1    Plunkett, W.2    Bonate, P.L.3
  • 44
    • 34249821127 scopus 로고    scopus 로고
    • A phase II study (Biov-121) of clofarabine monotherapy first line in patients aged 65 years or older with acute myeloid leukemia for whom standard intensive chemotherapy is not considered suitable
    • [abstract 425]
    • Burnett A.K., Baccarani M., Johnson P., et al. A phase II study (Biov-121) of clofarabine monotherapy first line in patients aged 65 years or older with acute myeloid leukemia for whom standard intensive chemotherapy is not considered suitable. Blood 108 (2006) 130a [abstract 425]
    • (2006) Blood , vol.108
    • Burnett, A.K.1    Baccarani, M.2    Johnson, P.3
  • 45
    • 19944433802 scopus 로고    scopus 로고
    • Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias
    • Faderl S., Gandhi V., O'Brien S., et al. Results of a phase 1-2 study of clofarabine in combination with cytarabine (ara-C) in relapsed and refractory acute leukemias. Blood 105 (2005) 940-947
    • (2005) Blood , vol.105 , pp. 940-947
    • Faderl, S.1    Gandhi, V.2    O'Brien, S.3
  • 46
    • 0019964180 scopus 로고
    • DNA-mediated transfer of multiple drug resistance and plasma membrane glycoprotein expression
    • Debenham P.G., Kartner N., Siminovitch L., et al. DNA-mediated transfer of multiple drug resistance and plasma membrane glycoprotein expression. Molecular and Cellular Biology 2 (1982) 881-889
    • (1982) Molecular and Cellular Biology , vol.2 , pp. 881-889
    • Debenham, P.G.1    Kartner, N.2    Siminovitch, L.3
  • 47
    • 9444223257 scopus 로고    scopus 로고
    • P-glycoprotein expression in patients with acute leukemia-clinical relevance
    • Nussler V., Pelka-Fleischer R., Zwierzina H., et al. P-glycoprotein expression in patients with acute leukemia-clinical relevance. Leukemia 10 Suppl 3 (1996) S23-S31
    • (1996) Leukemia , vol.10 , Issue.SUPPL. 3
    • Nussler, V.1    Pelka-Fleischer, R.2    Zwierzina, H.3
  • 48
    • 0027274736 scopus 로고
    • Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia
    • List A.F., Spier C., Greer J., et al. Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia. Journal of Clinical Oncology 11 (1993) 1652-1660
    • (1993) Journal of Clinical Oncology , vol.11 , pp. 1652-1660
    • List, A.F.1    Spier, C.2    Greer, J.3
  • 49
    • 0037103189 scopus 로고    scopus 로고
    • Phase 3 study of the multidrug resistance modulator PSC-833 in previously untreated patients 60 years of age and older with acute myeloid leukemia: Cancer and Leukemia Group B Study 9720
    • Baer M.R., George S.L., Dodge R.K., et al. Phase 3 study of the multidrug resistance modulator PSC-833 in previously untreated patients 60 years of age and older with acute myeloid leukemia: Cancer and Leukemia Group B Study 9720. Blood 100 (2002) 1224-1232
    • (2002) Blood , vol.100 , pp. 1224-1232
    • Baer, M.R.1    George, S.L.2    Dodge, R.K.3
  • 50
    • 32544437036 scopus 로고    scopus 로고
    • Phase III study of PSC-833 (valspodar) in combination with vincristine, doxorubicin, and dexamethasone (valspodar/VAD) versus VAD alone in patients with recurring or refractory multiple myeloma (E1A95): a trial of the Eastern Cooperative Oncology Group
    • Friedenberg W.R., Rue M., Blood E.A., et al. Phase III study of PSC-833 (valspodar) in combination with vincristine, doxorubicin, and dexamethasone (valspodar/VAD) versus VAD alone in patients with recurring or refractory multiple myeloma (E1A95): a trial of the Eastern Cooperative Oncology Group. Cancer 106 (2006) 830-838
    • (2006) Cancer , vol.106 , pp. 830-838
    • Friedenberg, W.R.1    Rue, M.2    Blood, E.A.3
  • 51
    • 0029984098 scopus 로고    scopus 로고
    • Bcl-2 expression prevents activation of the ICE protease cascade
    • Shimizu S., Eguchi Y., Kamiike W., et al. Bcl-2 expression prevents activation of the ICE protease cascade. Oncogene 12 (1996) 2251-2257
    • (1996) Oncogene , vol.12 , pp. 2251-2257
    • Shimizu, S.1    Eguchi, Y.2    Kamiike, W.3
  • 52
    • 8944219768 scopus 로고    scopus 로고
    • A bcl-2/IgH antisense transcript deregulates bcl-2 gene expression in human follicular lymphoma t(14;18) cell lines
    • Capaccioli S., Quattrone A., Schiavone N., et al. A bcl-2/IgH antisense transcript deregulates bcl-2 gene expression in human follicular lymphoma t(14;18) cell lines. Oncogene 13 (1996) 105-115
    • (1996) Oncogene , vol.13 , pp. 105-115
    • Capaccioli, S.1    Quattrone, A.2    Schiavone, N.3
  • 53
    • 34250013672 scopus 로고    scopus 로고
    • Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice
    • Raveche E.S., Salerno E., Scaglione B.J., et al. Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice. Blood 109 (2007) 5079-5086
    • (2007) Blood , vol.109 , pp. 5079-5086
    • Raveche, E.S.1    Salerno, E.2    Scaglione, B.J.3
  • 55
    • 27244434788 scopus 로고    scopus 로고
    • A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia
    • Calin G.A., Ferracin M., Cimmino A., et al. A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. The New England Journal of Medicine 353 (2005) 1793-1801
    • (2005) The New England Journal of Medicine , vol.353 , pp. 1793-1801
    • Calin, G.A.1    Ferracin, M.2    Cimmino, A.3
  • 56
    • 0031889769 scopus 로고    scopus 로고
    • High expression of bcl-2 mRNA as a determinant of poor prognosis in acute myeloid leukemia
    • Karakas T., Maurer U., Weidmann E., et al. High expression of bcl-2 mRNA as a determinant of poor prognosis in acute myeloid leukemia. Annals of Oncology 9 (1998) 159-165
    • (1998) Annals of Oncology , vol.9 , pp. 159-165
    • Karakas, T.1    Maurer, U.2    Weidmann, E.3
  • 57
    • 0037438586 scopus 로고    scopus 로고
    • Phase 1 and pharmacodynamic studies of G3139, a Bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia
    • Marcucci G., Byrd J.C., Dai G., et al. Phase 1 and pharmacodynamic studies of G3139, a Bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia. Blood 101 (2003) 425-432
    • (2003) Blood , vol.101 , pp. 425-432
    • Marcucci, G.1    Byrd, J.C.2    Dai, G.3
  • 58
    • 20644469046 scopus 로고    scopus 로고
    • Phase I study of oblimersen sodium, an antisense to Bcl-2, in untreated older patients with acute myeloid leukemia: pharmacokinetics, pharmacodynamics, and clinical activity
    • Marcucci G., Stock W., Dai G., et al. Phase I study of oblimersen sodium, an antisense to Bcl-2, in untreated older patients with acute myeloid leukemia: pharmacokinetics, pharmacodynamics, and clinical activity. Journal of Clinical Oncology 23 (2005) 3404-3411
    • (2005) Journal of Clinical Oncology , vol.23 , pp. 3404-3411
    • Marcucci, G.1    Stock, W.2    Dai, G.3
  • 59
    • 40749088625 scopus 로고    scopus 로고
    • A phase III randomized trial of intensive induction and consolidation chemotherapy ± oblimersen, a pro-apoptotic Bcl-2 antisense oligonucleotide in untreated acute myeloid leukemia patients >60 years old
    • [abstract 7012]
    • Marcucci G., Moser B., Blum W., et al. A phase III randomized trial of intensive induction and consolidation chemotherapy ± oblimersen, a pro-apoptotic Bcl-2 antisense oligonucleotide in untreated acute myeloid leukemia patients >60 years old. Journal of Clinical Oncology 25 (2007) 360s [abstract 7012]
    • (2007) Journal of Clinical Oncology , vol.25
    • Marcucci, G.1    Moser, B.2    Blum, W.3
  • 60
    • 0032874876 scopus 로고    scopus 로고
    • The BH3 domain of Bcl-x(S) is required for inhibition of the antiapoptotic function of Bcl-x(L)
    • Chang B.S., Kelekar A., Harris M.H., et al. The BH3 domain of Bcl-x(S) is required for inhibition of the antiapoptotic function of Bcl-x(L). Molecular and Cellular Biology 19 (1999) 6673-6681
    • (1999) Molecular and Cellular Biology , vol.19 , pp. 6673-6681
    • Chang, B.S.1    Kelekar, A.2    Harris, M.H.3
  • 61
    • 34147142477 scopus 로고    scopus 로고
    • A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma
    • Chauhan D., Velankar M., Brahmandam M., et al. A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma. Oncogene 26 (2007) 2374-2380
    • (2007) Oncogene , vol.26 , pp. 2374-2380
    • Chauhan, D.1    Velankar, M.2    Brahmandam, M.3
  • 62
    • 34248362003 scopus 로고    scopus 로고
    • The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak
    • Perez-Galan P., Roue G., Villamor N., et al. The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak. Blood 109 (2007) 4441-4449
    • (2007) Blood , vol.109 , pp. 4441-4449
    • Perez-Galan, P.1    Roue, G.2    Villamor, N.3
  • 63
    • 33846219417 scopus 로고    scopus 로고
    • Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia
    • Byrd J.C., Lin T.S., Dalton J.T., et al. Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia. Blood 109 (2007) 399-404
    • (2007) Blood , vol.109 , pp. 399-404
    • Byrd, J.C.1    Lin, T.S.2    Dalton, J.T.3
  • 64
    • 28544443503 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of flavopiridol followed by 1-beta-D-arabinofuranosylcytosine and mitoxantrone in relapsed and refractory adult acute leukemias
    • Karp J.E., Passaniti A., Gojo I., et al. Phase I and pharmacokinetic study of flavopiridol followed by 1-beta-D-arabinofuranosylcytosine and mitoxantrone in relapsed and refractory adult acute leukemias. Clinical Cancer Research 11 (2005) 8403-8412
    • (2005) Clinical Cancer Research , vol.11 , pp. 8403-8412
    • Karp, J.E.1    Passaniti, A.2    Gojo, I.3
  • 65
    • 34547650860 scopus 로고    scopus 로고
    • Sequential flavopiridol, cytosine arabinoside, and mitoxantrone: a phase II trial in adults with poor-risk acute myelogenous leukemia
    • Karp J.E., Smith B.D., Levis M.J., et al. Sequential flavopiridol, cytosine arabinoside, and mitoxantrone: a phase II trial in adults with poor-risk acute myelogenous leukemia. Clinical Cancer Research 13 (2007) 4467-4473
    • (2007) Clinical Cancer Research , vol.13 , pp. 4467-4473
    • Karp, J.E.1    Smith, B.D.2    Levis, M.J.3
  • 66
    • 33745585409 scopus 로고    scopus 로고
    • Addition of bortezomib (velcade) to AML induction chemotherapy is well tolerated and results in a high complete remission rate
    • [abstract 2782]
    • Attar E.C., De Angelo D.J., Sirulnik A., et al. Addition of bortezomib (velcade) to AML induction chemotherapy is well tolerated and results in a high complete remission rate. Blood 106 (2005) 780a [abstract 2782]
    • (2005) Blood , vol.106
    • Attar, E.C.1    De Angelo, D.J.2    Sirulnik, A.3
  • 67
    • 10744230708 scopus 로고    scopus 로고
    • A feasibility study of simultaneous administration of gemtuzumab ozogamicin with intensive chemotherapy in induction and consolidation in younger patients with acute myeloid leukemia
    • Kell W.J., Burnett A.K., Chopra R., et al. A feasibility study of simultaneous administration of gemtuzumab ozogamicin with intensive chemotherapy in induction and consolidation in younger patients with acute myeloid leukemia. Blood 102 (2003) 4277-4283
    • (2003) Blood , vol.102 , pp. 4277-4283
    • Kell, W.J.1    Burnett, A.K.2    Chopra, R.3
  • 68
    • 34249775270 scopus 로고    scopus 로고
    • The addition of gemtuzumab ozogamicin to induction chemotherapy for AML improves disease free survival without extra toxicity: preliminary analysis of 1115 patients in the MRC AML15 trial
    • [abstract 13]
    • Burnett A.K., Kell W.J., Goldstone A.H., et al. The addition of gemtuzumab ozogamicin to induction chemotherapy for AML improves disease free survival without extra toxicity: preliminary analysis of 1115 patients in the MRC AML15 trial. Blood 108 (2006) 8a [abstract 13]
    • (2006) Blood , vol.108
    • Burnett, A.K.1    Kell, W.J.2    Goldstone, A.H.3
  • 69
    • 0033485961 scopus 로고    scopus 로고
    • Cellular vascular endothelial growth factor is a predictor of outcome in patients with acute myeloid leukemia
    • Aguayo A., Estey E., Kantarjian H., et al. Cellular vascular endothelial growth factor is a predictor of outcome in patients with acute myeloid leukemia. Blood 94 (1999) 3717-3721
    • (1999) Blood , vol.94 , pp. 3717-3721
    • Aguayo, A.1    Estey, E.2    Kantarjian, H.3
  • 70
    • 19944431093 scopus 로고    scopus 로고
    • A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease
    • Fiedler W., Serve H., Dohner H., et al. A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML) or not amenable to conventional therapy for the disease. Blood 105 (2005) 986-993
    • (2005) Blood , vol.105 , pp. 986-993
    • Fiedler, W.1    Serve, H.2    Dohner, H.3
  • 71
    • 33744482540 scopus 로고    scopus 로고
    • Phase 1 study of PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor, for the treatment of acute myeloid leukemia and myelodysplastic syndrome
    • Roboz G.J., Giles F.J., List A.F., et al. Phase 1 study of PTK787/ZK 222584, a small molecule tyrosine kinase receptor inhibitor, for the treatment of acute myeloid leukemia and myelodysplastic syndrome. Leukemia 20 (2006) 952-957
    • (2006) Leukemia , vol.20 , pp. 952-957
    • Roboz, G.J.1    Giles, F.J.2    List, A.F.3
  • 72
    • 2542547507 scopus 로고    scopus 로고
    • Targeting vascular endothelial growth factor for relapsed and refractory adult acute myelogenous leukemias: therapy with sequential 1-beta-d-arabinofuranosylcytosine, mitoxantrone, and bevacizumab
    • Karp J.E., Gojo I., Pili R., et al. Targeting vascular endothelial growth factor for relapsed and refractory adult acute myelogenous leukemias: therapy with sequential 1-beta-d-arabinofuranosylcytosine, mitoxantrone, and bevacizumab. Clinical Cancer Research 10 (2004) 3577-3585
    • (2004) Clinical Cancer Research , vol.10 , pp. 3577-3585
    • Karp, J.E.1    Gojo, I.2    Pili, R.3
  • 73
    • 33846426411 scopus 로고    scopus 로고
    • Practical considerations in the use of lenalidomide therapy for myelodysplastic syndromes
    • Kurtin S., and Sokol L. Practical considerations in the use of lenalidomide therapy for myelodysplastic syndromes. Cancer Control 13 Suppl (2006) 26-31
    • (2006) Cancer Control , vol.13 , Issue.SUPPL , pp. 26-31
    • Kurtin, S.1    Sokol, L.2


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