The effects of pentoxifylline into the kidneys of rats in a model of unilateral hindlimb ischemia/reperfusion injury

Acta Cirurgica Brasileira

Volumn 23, Issue 1, 2008, Pages 29-35

  Teruya, Roberto ^a,c   Fagundes, Djalma José ^b   Oshima, Celina Tizuko Fujiyama ^b   Brasileiro, José Lacerda ^a   Marks, Guido ^a   Ynouye, Celso Massachi ^a   Simões, Manuel Jesus ^b  

^a FEDERAL UNIVERSITY OF MATO GROSSO DO SUL   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c NONE   (Brazil)

Author keywords

Caspase 3; Ischemia; Kidney; Muscle, skeletal; Pentoxifylline; Rats

Indexed keywords

CASPASE 3; CREATINE KINASE; CREATININE; KETAMINE; PENTOXIFYLLINE; POTASSIUM; SODIUM; SODIUM CHLORIDE; UREA; XYLAZINE;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; GLOMERULUS; HINDLIMB ISCHEMIA; HISTOLOGY; ILIAC ARTERY; IMMUNOHISTOCHEMISTRY; ISCHEMIA; KIDNEY; KIDNEY INJURY; KIDNEY TUBULE; KRUSKAL WALLIS TEST; MESANGIUM; NONHUMAN; PROTEIN EXPRESSION; RANK SUM TEST; RAT; REPERFUSION INJURY; STAINING;

ANIMALS; APOPTOSIS; CASPASE 3; DISEASE MODELS, ANIMAL; HINDLIMB; KIDNEY; KIDNEY DISEASES; MALE; MUSCLE, SKELETAL; PENTOXIFYLLINE; RATS; RATS, WISTAR; REPERFUSION INJURY; STATISTICS, NONPARAMETRIC; VASODILATOR AGENTS;

EID: 40749096456     PISSN: 01028650     EISSN: 16782674     Source Type: Journal    
DOI: 10.1590/S0102-86502008000100006     Document Type: Article

References (16)

1. Coe DA, Freischlag JA, Johnson D, Mudaliar JH, Kosciesza SA, Traul DK, Chiang PC, Cambria RA, Seabrook GR, Towne JB. Pentoxifylline prevents endothelial damage due to ischemia and reperfusion injury. J Surg Res. 1997;67(1):21-5.
2. Yassin MM, Harkin DW, Barros D'Sa AA, Halliday MI, Rowlands BJ. Lower limb ischemia-reperfusion injury triggers a systemic inflammatory. World J Surg. 2002;26(1):115-21.
3. Emrecan B, Tulukoglu E, Bozok S, Kestelli M, Onem G, Küpelioglu A, Yagdi S, Gürbüz. A Effects of lloprost and pentoxifylline on renal ischemia-reperfusion in rabbit model. Eur J Med Res. 2006;11(7):295-9.
4. Gradl G, Gaida S, Finke B, Lindenblatt N, Gierer P, Menger MD, Mittlmeier T, Vollmar B. Supernatant of traumatized muscle induces inflammation and pain, but not microcirculatory perfusion failure and apoptotic cell death. Shock. 2005;24(3):219-25.
5. Wang WZ, Stepheson LL, Fang XH, Khiabani KT, Zamboni WA. Ischemic preconditioning-induced microvascular protection at a distance. J Reconstr Microsurg. 2004;20(2):175-81.
6. Olguner C, Koca U, Kar A, Karci A, Islekel H, Canyilmaz M, Mavioglu O, Kizildag S, Unlü G, Elar Z. Ischemic preconditioning attenuates the lipid peroxidation and remote lung injury in the rat model of unilateral lower limb ischemia reperfusion. Acta Anaesthesiol Scand. 2006;50(2):150-5.
7. Stafford-Smith M. Evidence-based renal protection in cardiac surgery. Semin Cardiothorac Vasc Anesth. 2005;9(1):65-76.
8. Vadiel K, Brunner LJ, Luke DR. Effects of pentoxyfilline in experimental acute renal failure. Kidney Int. 1989;36(3):466-70.
9. Emrecan B, Tulukoglu E, Bozok S, Kestelli M, Onem G, Kupelioglu A, Yagdi S, Gurbuz A. Effects of lloprost and pentoxyfilline on renal ischemia-reperfusion in rabbit model. Eur J Med Res. 2006;11(7):295-9.
10. Dávila-Esqueda ME, Martinez-Morales F. Pentoxifylline diminishes the oxydative damage renal tissue induced by streptozotocin in the rat. Exp Diabesity Res. 2004;5(4):245-51.
11. Gunduz Z, Canoz O, Per H, Dusunsel R, Poyrazoglu MH, Tez C, Saraymen R The effects of pentoxifylline on diabetic renal changes in streptozotocin- induced diabetes mellitus. Ren Fail. 2004;26(6):597-605.
12. Lin SL, Chen YM, Chiang WC, Tsai TJ, Chen WY Pentoxifylline: a potential therapy for chronic kidney disease. Nephrology. 2004;9(4):198-204.
13. DiPetrillo K, Gesek FA. Pentoxifylline ameliorates renal tumor necrosis factor expression, sodium retention, and renal hypertrophy in diabetic rats. Am J Nephrol. 2004;24(3):352-9.
14. Aslan A, Karagüzel G, Güngör F, Izgüt-Uysal N, Aydin F, Melikoglu M. The effects of pentoxifylline on renal function and free radical production in unilateral ureteral obstruction. Urol Res. 2003;31(5):317-22.
15. Yagmurlu A, Boleken ME, Ertoy D, Ozsan M, Gokcora IH, Dindar H. Preventive effect of pentoxifylline on renal scarring in rat model of pyelonephritis. Urology. 2003;61(5):1037-41.
16. Savic V, Vlahovic P, Djordjevic V, Mitic-Zlatkovic M, Avramovic V, Stefanovic V. Nephroprotective effects of pentoxifylline in experimental myoglobinuric acute renal failure. Pathol Biol. (Paris) 2002;50(10):599-607.