Apical and basolateral 4F2hc and the amino acid exchange of L-DOPA in renal LLC-PK1 cells

Amino Acids

Volumn 29, Issue 3, 2005, Pages 213-219

  Soares Da Silva, P ^a   Serrao M P ^a  

^a Institute of Pharmacology and Therapeutics   (Portugal)

Author keywords

4F2hc; Amino acid exchanger; L DOPA; LAT2; LLC PK1 cells

Indexed keywords

AMINO ACID; AMINO ACID TRANSPORTER; ANTISENSE OLIGODEOXYNUCLEOTIDE; CARBON 14; GLYCOPROTEIN; ISOPROTEIN; LAT2 PROTEIN; LEUCINE; LEVODOPA; MESSENGER RNA; PROTEIN 4F2HC; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; ANIMAL CELL; APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; BIOLOGICAL ACTIVITY; CELL LEVEL; CELLULAR DISTRIBUTION; CHEMICAL LABELING; CONTROLLED STUDY; INCUBATION TIME; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

AMINO ACID TRANSPORT SYSTEMS; AMINO ACIDS; ANIMALS; ANTIGENS, CD98 HEAVY CHAIN; BIOLOGICAL TRANSPORT; CARBON RADIOISOTOPES; CELL POLARITY; CELLS, CULTURED; GENE EXPRESSION REGULATION; KIDNEY; LEVODOPA; LLC-PK1 CELLS; OLIGONUCLEOTIDES, ANTISENSE; RNA, MESSENGER; SWINE;

ANIMALIA;

EID: 28644433970     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-005-0242-5     Document Type: Article

References (29)

1. S Bröer A Bröer B Hamprecht 1997 Expression of the surface antigen 4F2hc affects system-L-like neutral-amino-acid-transport activity in mammalian cells. Biochem J 324 535 541
2. 0,+, exchange L-DOPA with neutral and basic amino acids in two clonal renal cell lines. J Membr Biol 186 63 80
3. T Hussain MF Lokhandwala 1998 Renal dopamine receptor function in hypertension. Hypertens 32 187 197
4. PA Jose GM Eisner RA Felder 2002a Dopamine receptor-coupling defect in hypertension. Curr Hypertens Rep 4 237 244
5. PA Jose GM Eisner RA Felder 2002b Role of dopamine receptors in the kidney in the regulation of blood pressure. Curr Opinion Nephrol Hypertens 11 87 92
6. Y Kanai H Endou 2001 Heterodimeric amino acid transporters: molecular biology and pathological and pharmacological relevance. Curr Drug Metabol 2 339 354
7. Y Kanai H Segawa K Miyamoto H Uchino E Takeda H Endou 1998 Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98). J Biol Chem 273 23629 23632
8. + atpase to inhibition by dopamine in spontaneous hypertensive and Wistar-Kyoto rats. Clin Exp Hypertens 22 455 469
9. L Mastroberardino B Spindler R Pfeiffer PJ Skelly J Loffing CB Shoemaker F Verrey 1998 Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family. Nature 395 288 291
10. M Palacin Y Kanai 2004 The ancillary proteins of HATs: SLC3 family of amino acid transporters. Pflugers Arch 447 490 494
11. M Pineda E Fernandez D Torrents R Estevez C Lopez M Camps J Lloberas A Zorzano M Palacin 1999 Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids. J Biol Chem 274 19738 19744
12. MJ Pinho P Gomes MP Serrao MJ Bonifacio P Soares-da-Silva 2003 Organ-specific overexpression of renal LAT2 and enhanced tubular L-DOPA uptake precede the onset of hypertension. Hypertension 42 613 618
13. MJ Pinho MP Serrão P Gomes U Hopfer PA Jose P Soares-da-Silva 2004 Over-expression of renal LAT1 and LAT2 and enhanced L-DOPA uptake in SHR immortalized renal proximal tubular cells. Kidney Int 66 216 226
14. PD Prasad H Wang W Huang R Kekuda DP Rajan FH Leibach V Ganapathy 1999 Human LAT1, a subunit of system L amino acid transporter: molecular cloning and transport function. Biochem Biophys Res Commun 255 283 288
15. EJ Quackenbush A Gougos R Baumal M Letarte 1986 Differential localization within human kidney of five membrane proteins expressed on acute lymphoblastic leukemia cells. J Immunol 136 118 124
16. K Racz O Kuchel NT Buu S Tenneson 1985 Peripheral dopamine synthesis and metabolism in spontaneously hypertensive rats. Circ Res 57 889 897
17. G Rossier C Meier C Bauch V Summa B Sordat F Verrey LC Kuhn 1999 LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine. J Biol Chem 274 34948 34954
18. H Sanada H Watanabe S Shigetomi S Fukuchi 1995 Gene expression of aromatic L-amino acid decarboxylase mRNA in the kidney of normotensive and hypertensive rats. Hypertens Res 18 [Suppl 1] S179 S181
19. +-independent neutral amino acid transporter with broad substrate selectivity. J Biol Chem 274 19745 51971
20. P Soares-da-Silva MH Fernandes 1992 Sodium-dependence and ouabain-sensitivity of the synthesis of dopamine in renal tissues of the rat. Br J Pharmacol 105 811 816
21. 1 renal cells. Am J Physiol Renal Physiol 287 F252 F261
22. P Soares-da-Silva MH Fernandes M Pestana 1993a Studies on the role of sodium on the synthesis of dopamine in the rat kidney. J Pharmacol Exp Ther 264 406 414
23. P Soares-da-Silva M Pestana MH Fernandes 1993b Involvement of tubular sodium in the formation of dopamine in the human renal cortex. J Am Soc Nephrol 3 1591 1599
24. P Soares-da-Silva MP Serrao MJ Pinho MJ Bonifacio 2004 Cloning and gene silencing of LAT2, the L-3,4-dihydroxyphenylalanine (L-DOPA) transporter, in pig renal LLC-PK1 epithelial cells. FASEB J 18 1489 1498
25. F Verrey 2003 System L: heteromeric exchangers of large, neutral amino acids involved in directional transport. Pflugers Arch 445 529 533
26. F Verrey C Meier G Rossier LC Kuhn 2000 Glycoprotein-associated amino acid exchangers: broadening the range of transport specificity. Pflugers Arch 440 503 512
27. MA Vieira-Coelho T Hussain V Kansra MP Serrao JT Guimaraes M Pestana P Soares-Da-Silva MF Lokhandwala 1999 Aging, high salt intake, and renal dopaminergic activity in Fischer 344 rats. Hypertens 34 666 672
28. CA Wagner F Lang S Broer 2001 Function and structure of heterodimeric amino acid transporters. Am J Physiol Cell Physiol 281 C1077 C1093
29. M Yoshimura I Ikegaki M Nishimura H Takahashi 1990 Role of dopaminergic mechanisms in the kidney for the pathogenesis of hypertension. J Auton Pharmacol 10 S67 S72