Anti-Ca2+ channel antibody attenuates Ca2+ currents and mimics cerebellar ataxia in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 7, 2008, Pages 2705-2710

  Liao, Yaping Joyce ^a   Safa, Parsa ^a   Chen, Yi Ren ^a   Sobel, Raymond A ^a   Boyden, Edward S ^a   Tsien, Richard W ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Lambert Eaton myasthenic syndrome; N type; Neurotransmission; P Q type; Paraneoplastic

Indexed keywords

CALCIUM CHANNEL P TYPE; CALCIUM CHANNEL Q TYPE; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL ANTIBODY; ANTIBODY; CALCIUM; CALCIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CEREBELLAR ATAXIA; CEREBELLUM DISEASE; CONTROLLED STUDY; EATON LAMBERT SYNDROME; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; IN VIVO STUDY; MEMBRANE CHANNEL; MOUSE; NEUROPATHOLOGY; NEUROTRANSMISSION; NONHUMAN; PARANEOPLASTIC NEUROPATHY; PRIORITY JOURNAL; PROTEIN DOMAIN; SYNAPTIC TRANSMISSION; AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; CELL CULTURE; CHEMISTRY; ELECTROPHYSIOLOGY; GENETICS; IMMUNOLOGY; METABOLISM; MOLECULAR MIMICRY; PATCH CLAMP; PATHOLOGY; SCANNING ELECTRON MICROSCOPY;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; CALCIUM; CALCIUM CHANNELS; CELLS, CULTURED; CEREBELLAR ATAXIA; ELECTROPHYSIOLOGY; MICE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON, SCANNING; MOLECULAR MIMICRY; PATCH-CLAMP TECHNIQUES;

EID: 40649106247     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0710771105     Document Type: Article

References (41)

1. Eaton LM, Lambert EH (1957) Electromyography and electric stimulation of nerves in diseases of motor unit: Observations on myasthenic syndrome associated with malignant tumors. J Am Med Assoc 163:1117-1124.
2. Satoyoshi E, Kowa H, Fukunaga N (1973) Subacute cerebellar degeneration and Eaton-Lambert syndrome with bronchogenic carcinoma: A case report. Neurology 23:764-768.
3. Pelucchi A, et al. (1993) Calcium channel autoantibodies in myasthenic syndrome and small-cell lung cancer. Am Rev Respir Dis 147:1229-1232.
4. Lennon VA, et al. (1995) Calcium channel antibodies in the Lambert-Eaton syndrome and other paraneoplastic syndromes. N Engl J Med 332:1467-1474.
5. Lang B, Newsom-Davis J (1995) Immunopathology of the Lambert-Eaton myasthenic syndrome. Springer Semin Immunopathol 17:3-15.
6. Darnell RB, Posner JB (2003) Paraneoplastic syndromes involving the nervous system. N Engl J Med 349:1543-1554.
7. Whitney KD, McNamara JO (1999) Autoimmunity and neurological disease: Antibody modulation of synaptic transmission. Annu Rev Neurosci 22:175-195.
8. Meriney SD, Hulsizer SC, Lennon VA, Grinnell AD (1996) Lambert-Eaton myasthenic syndrome immunoglobulins react with multiple types of calcium channels in small-cell lung carcinoma. Ann Neurol 40:739-749.
9. Vincent A, Lang B, Newsom-Davis J (1989) Autoimmunity to the voltage-gated calcium channel underlies the Lambert-Eaton myasthenic syndrome, a paraneoplastic disorder. Trends Neurosci 12:496-502.
10. Dalmau J, Gultekin HS, Posner JB (1999) Paraneoplastic neurologic syndromes: Pathogenesis and physiopathology. Brain Pathol 9:275-284.
11. Hillman D, et al. (1991) Localization of P-type calcium channels in the central nervous system. Proc Natl Acad Sci USA 88:7076-7080.
12. Mintz IM, Sabatini BL, Regehr WG (1995) Calcium control of transmitter release at a cerebellar synapse. Neuron 15:675-688.
13. Fletcher CF, Lennon VA (2003) Do calcium channel autoantibodies cause cerebellar ataxia with Lambert-Eaton syndrome? Ann Neurol 53:5-7.
14. Mason WP, et al. (1997) Small-cell lung cancer, paraneoplastic cerebellar degeneration, and the Lambert-Eaton myasthenic syndrome. Brain 120:1279-1300.
15. Wirtz PW, et al. (2005) P/Q-type calcium channel antibodies, Lambert-Eaton myasthenic syndrome, and survival in small-cell lung cancer. J Neuroimmunol 164:161-165.
16. Graus F, et al. (2002) P/Q type calcium channel antibodies in paraneoplastic cerebellar degeneration with lung cancer. Neurology 59:764-766.
17. Clouston PD, et al. (1992) Paraneoplastic cerebellar degeneration. III. Cerebellar degeneration, cancer, and the Lambert-Eaton myasthenic syndrome. Neurology 42:1944-1950.
18. Fukuda T, et al. (2003) Reduction of P/Q-type calcium channels in the postmortem cerebellum of paraneoplastic cerebellar degeneration with Lambert-Eaton myasthenic syndrome. Ann Neurol 53:21-28.
19. -1A calcium channel subunit reduce both P-type and Q-type calcium currents in cerebellar neurons. Proc Natl Acad Sci USA 95:8328-8333.
20. 2+ channel currents in rat cerebellar granule neurons. J Neurosci 15:2995-3012.
21. McDonough SI, Boland LM, Mintz IM, Bean BP (2002) Interactions among toxins that inhibit N-type and P-type calcium channels. J Gen Physiol 119:313-328.
22. Barry EL, Viglione MP, Kim YI, Froehner SC (1995) Expression and antibody inhibition of P-type calcium channels in human small-cell lung carcinoma cells. J Neurosci 15:274-283.
23. Black JL, et al. (1998) Lambert-Eaton myasthenic syndrome: Antigenicity of recombinant human P/Q-type calcium channel -1 subunit putative ion pore region (domain IV, S5-S6). Ann NY Acad Sci 841:691-695.
24. Newsom-Davis J, et al. (1982) Lambert-Eaton myasthenic syndrome: Electrophysiological evidence for a humoral factor. Muscle Nerve 5:S17-S20.
25. Fukunaga H, Engel AG, Lang B, Newsom-Davis J, Vincent A (1983) Passive transfer of Lambert-Eaton myasthenic syndrome with IgG from man to mouse depletes the presynaptic membrane active zones. Proc Natl Acad Sci USA 80:7636-7640.
26. Sillevis Smitt P, et al. (2000) Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor. N Engl J Med 342:21-27.
27. 2+ currents in murine dorsal root ganglion neurons. Proc Natl Acad Sci USA 93:9264-9269.
28. Parsons KT, Kwok WW (2002) Linear B-cell epitopes in Lambert-Eaton myasthenic syndrome defined by cell-free synthetic peptide binding. J Neuroimmunol 126:190-195.
29. Komai K, Iwasa K, Takamori M (1999) Calcium channel peptide can cause an autoimmune-mediated model of Lambert-Eaton myasthenic syndrome in rats. J Neurol Sci 166:126-130.
30. Lennon VA, Lambert EH (1989) Autoantibodies bind solubilized calcium channel-ω-conotoxin complexes from small-cell lung carcinoma: A diagnostic aid for Lambert-Eaton myasthenic syndrome. Mayo Clin Proc 64:1498-1504.
31. Sher E, et al. (1989) Specificity of calcium channel autoantibodies in Lambert-Eaton myasthenic syndrome. Lancet 2:640-643.
32. Protti DA, Reisin R, Mackinley TA, Uchitel OD (1996) Calcium channel blockers and transmitter release at the normal human neuromuscular junction. Neurology 46:1391-1396.
33. 2+ channels in mammalian central neurons. Trends Neurosci 18:89-98.
34. Wheeler DB, Sather WA, Randall A, Tsien RW (1994) Distinctive properties of a neuronal calcium channel and its contribution to excitatory synaptic transmission in the central nervous system. Adv Second Messenger Phosphoprotein Res 29:155-171.
35. Mintz IM (1994) Block of calcium channels in rat central neurons by the spider toxin ω-Aga-IIIA. J Neurosci 14:2844-2853.
36. 2+ channels by the spider venom toxin ω-Aga-IIIA. Proc Natl Acad Sci USA 88:6628-6631.
37. Ellinor PT, Zhang JF, Horne WA, Tsien RW (1994) Structural determinants of the blockade of N-type calcium channels by a peptide neurotoxin. Nature 372:272-275.
38. Feng ZP, et al. (2001) Residue Gly-1326 of the N-type calcium channel -1B subunit controls reversibility of ω-conotoxin GVIA and MVIIA block. J Biol Chem 276:15728-15735.
39. Iwasa K, Takamori M, Komai K, Mori Y (2000) Recombinant calcium channel is recognized by Lambert-Eaton myasthenic syndrome antibodies. Neurology 54:757-759.
40. Feng ZP, et al. (2001) Amino acid residues outside of the pore region contribute to N-type calcium channel permeation. J Biol Chem 276:5726-5730.
41. 2+ channels and their role in neurotransmitter release. Cell Calcium 24:307-323.