Platelet CD61 expression in vascular calcineurin inhibitor toxicity of renal allografts

Human Pathology

Volumn 39, Issue 4, 2008, Pages 550-556

  Meehan, Shane M ^a   Baliga, Rajendra ^a   Poduval, Rajiv ^a   Chang, Anthony ^a   Kadambi, Pradeep V ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Allograft; Arteriolopathy; Calcineurin inhibitor toxicity; CD61; Kidney; Platelet; Thrombotic microangiopathy

Indexed keywords

CALCINEURIN INHIBITOR; CD61 ANTIGEN;

ANTIGEN EXPRESSION; ANTIGEN RECOGNITION; ARTICLE; BLOOD VESSEL INJURY; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY ALLOGRAFT; KIDNEY BIOPSY; MAJOR CLINICAL STUDY; THROMBOCYTE ACTIVATION; THROMBOTIC THROMBOCYTOPENIC PURPURA;

ARTERIOLES; BLOOD PLATELETS; CALCINEURIN; ENZYME INHIBITORS; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTEGRIN BETA3; KIDNEY DISEASES; KIDNEY GLOMERULUS; KIDNEY TRANSPLANTATION; MALE; PLATELET ACTIVATION; PLATELET AGGREGATION;

EID: 40649100500     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2007.08.012     Document Type: Article

References (37)

1. Mihatsch M.J., Thiel G., and Ryffel B. Histopathology of cyclosporine nephrotoxicity. Transplant Proc 20 3 (Suppl 3) (1988) 759-771
2. Mihatsch M.J., Ryffel B., Gudat F., and Thiel G. Cyclosporine nephropathy. In: Tisher C.C., and Brenner B.M. (Eds). Renal pathology with clinical and functional correlations (1994), Lippincott, Philadelphia (PA) 1641-1681
3. Rossmann P., Jirka J., Chadimova M., Reneltova I., and Saudek F. Arteriolosclerosis of the human renal allograft: morphology, origin, life history and relationship to cyclosporine therapy. Virchows Archiv A Pathol Anat 418 (1991) 129-141
4. Strom E.H., Thiel G., and Mihatsch M.J. Prevalence of cyclosporine associated arteriolopathy in renal transplant biopsies from 1981 to 1992. Transplant Proc 26 (1994) 2585-2587
5. Nankivell B.J., Borrows R.J., Fung C.L.-S., O'Connell P.J., Chapman J.R., and Allen R.D.M. Calcineurin inhibitor nephrotoxicity: longitudinal assessment by protocol histology. Transplantation 78 (2004) 557-565
6. Falkenhain M.E., Cosio F.G., and Sedmak D.D. Progressive histologic injury in kidneys from heart and liver transplant recipients receiving cyclosporine. Transplantation 62 (1996) 364-370
7. Neild G.H., Reuben R., Hartley R.B., and Cameron J.S. Glomerular thrombi in renal allografts associated with cyclosporin treatment. J Clin Pathol 38 (1985) 253-258
8. Shulman H., Striker G., Deeg H.J., Kennedy M., Storb R., and Thomas E.D. Nephrotoxicity of cyclosporin A after allogeneic marrow transplantation. Lancet 305 (1981) 1392-1395
9. Colvin R.B. Renal transplant pathology. In: Jennette J.C., Olson J.L., Schwartz M.M., and Silva F.G. (Eds). Heptinstall's pathology of the kidney. 5th ed (1998), Lippincott-Raven, Philadelphia (PA) 1471-1489
10. Larsen S., Brun C., Duun S., Lokkegaard H., and Thomsen H.S. Early arteriolpathy following "high dose" cyclosporine in kidney transplantation. APMIS S4 (1988) 66-73
11. Sommer B.G., Innes J.T., Whitehurst R.M., Sharma H.M., and Ferguson R.M. Cyclosporine associated renal arteriolopathy resulting in loss of allograft function. Am J Surgery 149 (1985) 756-764
12. Farnsworth A., Hall B.M., Ng A.B.P., et al. Renal biopsy morphology in renal transplantation. Am J Surg Pathol 8 (1984) 243-252
13. Yamaguchi Y., Teraoka S., Yagisawa T., Takahashi K., Toma H., and Ota K. Ultrastructural study of cyclosporine-associated arteriolopathy in renal allografts. Transplant Proc 21 (1989) 1517-1522
14. Randhawa P.S., Shapiro R., Jordan M.L., Starzl T.E., and Demetris A.J. The histopathological changes associated with allograft rejection and drug toxicity in renal transplant recipients maintained on FK506: clinical significance and comparison with cyclosporine. Am J Surg Pathol 17 (1993) 60-68
15. Mihatsch M.J., Kyo M., Morozumi K., Yamaguchi Y., Nickeleit V., and Ryffel B. The side effects of cyclosporine-A and tacrolimus. Clin Nephrol 49 (1998) 356-363
16. Nizze H., Mihatsch M.J., Zollinger H.U., et al. Cyclosporine-associated nephropathy in patients with heart and bone marrow transplants. Clin Nephrol 30 (1988) 248-260
17. Morozumi K., Thiel G., Albert F.W., Banfi G., Gudat F., and Mihatsch M.J. Studies on the morphological outcome of cyclosporine associated arteriolopathy after discontinuation of cyclosporine in renal allografts. Clin Nephrol 38 (1992) 1-8
18. Collins B.S., Davis C.L., Marsh C.L., McVicar J.P., Perkins J.D., and Alpers C.E. Reversible cyclosporine arteriolopathy. Transplantation 54 (1992) 732-765
19. Wolfe J.A., McCann R.L., and Sanfilippo F. Cyclosporine associated microangiopathy in renal transplantation: a severe but potentially reversible form of early graft injury. Transplantation 41 (1986) 541-544
20. Randhawa P.S., Tsamandas A.C., Magnone M., et al. Microvascular changes in renal allografts associated with FK506 (tacrolimus) therapy. Am J Surg Pathol 20 (1996) 306-312
21. Young B.A., Marsh C.L., Alpers C.E., and Davia C.L. Cyclosporine associated thrombotic microangiopathy/hemolytic uremic syndrome following kidney and kidney-pancreas transplantation. Am J Kidney Dis 28 (1996) 561-571
22. Zarifian A., Meleg-Smith S., O'Donovan R., Tesi R.J., and Batuman V. Cyclosporine-associated thrombotic microangiopathy in renal allografts. Kidney Int 55 (1999) 2457-2466
23. Trimarchi H.M., Truong L.D., Brennan S., Gonzalez J.M., and Suki W.N. FK506-associated thrombotic microangiopathy: a report of 2 cases and review of the literature. Transplantation 67 (1999) 539-544
24. Pham P.T.T., Peng A., Wilkinson A.H., et al. Cyclosporine and tacrolimus-associated thrombotic microangiopathy. Am J Kidney Dis 36 (2000) 844-850
25. Schwimmer J., Nadasdy T.A., Spitalnik P.F., Kaplan K.L., and Zand M.S. De novo thrombotic microangiopathy in renal transplant recipients: a comparison of hemolytic uremic syndrome with localized renal thrombotic microangiopathy. Am J Kidney Dis 41 (2003) 471-479
26. Fernandes J.B., Naik U.P., Markell M.S., and Kornecki E. Comparative investigation of the effects of the immunosuppressant cyclosporine A, cyclosporine G and FK506 on platelet activation. Cell Mol Biol Res 39 (1993) 265-274
27. Fox S.C., Judge H.M., Allen B.R., and Heptinstall S. Platelet aggregation and intracellular calcium mobilization responses are enhanced by cyclosporine A but not by pimecrolimus (SDZ ASM 981). Platelets 13 (2002) 213-218
28. Neild G.H., Rocchi G., Imberti L., et al. Effects of cyclosporine on prostacyclin synthesis by vascular tissue in rabbits. Transplant Proc 15 (1983) 2398-2400
29. Zoja C., Furci L., Ghilardi F., Zilio P., Benigni A., and Remuzzi G. Cyclosporine induced endothelial injury. Lab Invest 55 (1986) 455-462
30. Barry O., and Fitzgerald G.A. Mechanisms of cellular activation by platelet microparticles. Thromb Haemost 82 (1999) 794-800
31. Merten M., Pakala R., Thiagarajan P., and Benedict C. Platelet microparticles promote platelet interaction with subendothelial matrix in a glycoprotein IIb/IIIa-dependent mechanism. Circulation 99 (1999) 2577-2582
32. Gatter K.C., Crodell J.C., Thurley H., et al. The immunohistological detection of platelets, megakaryocytes and thrombi in routinely processed specimens. Histopathology 13 (1988) 257-267
33. Dunnill M.S., Gatter K.C., Mason D.Y., and Morris P.J. Immunosuppression and thrombosis in renal transplantation: an immunohistological study. Histopathology 16 (1990) 79-82
34. Meehan S.M., Limsrichamrern S., Manaligod J.R., et al. Platelets and capillary injury in acute humoral rejection of renal allografts. HUM PATHOL 34 (2003) 533-540
35. Poduval R.D., Kadambi P.V., Josephson M.A., et al. Implications of immunohistochemical detection of C4d along peritubular capillaries in late acute renal allograft rejection. Transplantation 79 (2005) 228-235
36. Ducloux D., Rebibou J.M., Semhoun-Ducloux S., et al. Recurrence of hemolytic uremic syndrome in renal transplant recipients. A meta-analysis. Transplantation 65 (1998) 1405-1407
37. Gore I. Disseminated arteriolar and capillary platelet thrombosis: a morphologic study of its histogenesis. Am J Pathol 26 (1950) 155-175