Vitamin C supply to bronchial epithelial cells linked to glutathione availability in elf - A role for secreted γ-glutamyltransferase?

Journal of Cystic Fibrosis

Volumn 7, Issue 2, 2008, Pages 174-178

  Corti, Alessandro ^a   Franzini, Maria ^a   Casini, Alessandro F ^a   Paolicchi, Aldo ^a   Pompella, Alfonso ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

Airway inflamation; Epithetial lining fluid; Gamma glutamyltransferase; Glutathione; Oxidative stress; Vitamin C supply

Indexed keywords

ASCORBIC ACID; COMPLEMENTARY DNA; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE;

ANTIOXIDANT ACTIVITY; ARTICLE; BRONCHUS MUCOSA; CONTROLLED STUDY; CYSTIC FIBROSIS; ENZYME ACTIVITY; ENZYME RELEASE; EPITHELIUM CELL; GENETIC TRANSFECTION; GLUTATHIONE METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; LUNG FLUID; OXIDATIVE STRESS; PROTEIN EXPRESSION; SPECTROPHOTOMETRY;

ANTIOXIDANTS; ASCORBIC ACID; BRONCHI; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYSTIC FIBROSIS; EPHRINS; EPITHELIAL CELLS; GAMMA-GLUTAMYLTRANSFERASE; GLUTATHIONE; HUMANS; RESPIRATORY MUCOSA; SIGNAL TRANSDUCTION; SPECTROPHOTOMETRY;

EID: 40649099802     PISSN: 15691993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcf.2007.07.003     Document Type: Article

References (24)

1. McGrath L.T., Mallon P., Dowey L., et al. Oxidative stress during acute respiratory exacerbations in cystic fibrosis. Thorax 54 (1999) 518-523
2. Wood L.G., Fitzgerald D.A., Lee A.K., et al. Improved antioxidant and fatty acid status of patients with cystic fibrosis after antioxidant supplementation is linked to improved lung function. Am J Clin Nutr 77 (2003) 150-159
3. Cross C.E., van der Vliet A., O'Neill C.A., et al. Oxidants, antioxidants, and respiratory tract lining fluids. Environ Health Perspect 102 (1994) 185-191
4. Brown L.A., Harris F.L., and Jones D.P. Ascorbate deficiency and oxidative stress in the alveolar type II cell. Am J Physiol 273 (1997) L782-L788
5. Dominici S., Valentini M., Maellaro E., et al. Redox modulation of cell surface protein thiols in U937 lymphoma cells: the role of gamma-glutamyl transpeptidase-dependent H202 production and S-thiolation. Free Radic Biol Med 27 (1999) 623-635
6. Corti A., Raggi C., Franzini M., et al. Plasma membrane gamma-glutamyltransferase activity facilitates the uptake of vitamin C in melanoma cells. Free Radic Biol Med 37 (2004) 1906-1915
7. Corti A., Paolicchi A., Franzini M., et al. The S-thiolating activity of membrane γ-glutamyltransferase: formation of cysteinyl-glycine mixed disulfides with cellular proteins and in the cell microenvironment. Antioxid Redox Signal 7 (2005) 911-918
8. Van Klaveren R.J., Hoet P.H., Pype J.L., et al. Increase in gamma-glutamyltransferase by glutathione depletion in rat type II pneumocytes. Free Radic Biol Med 22 (1997) 525-534
9. Gao L., Kim K.J., Yankaskas J.R., et al. Abnormal glutathione transport in cystic fibrosis airway epithelia. Am J Physiol 277 (1999) L113-L118
10. Stites S.W., Plautz M.W., Bailey K., et al. Increased concentrations of iron and isoferritins in the lower respiratory tract of patients with stable cystic fibrosis. Am J Respir Crit Care Med 160 (1999) 796-801
11. Choi J., Liu R.M., and Forman H.J. Adaptation to oxidative stress: quinone-mediated protection of signaling in rat lung epithelial L2 cells. Biochem Pharmacol 53 (1997) 987-993
12. Dominici S., Paolicchi A., Corti A., et al. Prooxidant reactions promoted by soluble and cell-bound gamma-glutamyltransferase activity. Methods Enzymol 401 (2005) 483-500
13. Del Bello B., Paolicchi A., Comporti M., et al. Hydrogen peroxide produced during γ-glutamyl transpeptidase activity is involved in prevention of apoptosis and maintainance of proliferation in U937 cells. FASEB J 13 (1999) 69-79
14. Paolicchi A., Dominici S., Pieri L., et al. Glutathione catabolism as a signalling mechanism. Biochem Pharmacol 64 (2002) 1029-1037
15. Hanigan M.H., Gallagher B.C., Townsend D.M., et al. Gamma-glutamyl transpeptidase accelerates tumor growth and increases the resistance of tumors to cisplatin in vivo. Carcinogenesis 20 (1999) 553-559
16. Karp D.R., Shimooku K., and Lipsky P.E. Expression of gamma-glutamyl transpeptidase protects ramos B cells from oxidation-induced cell death. J Biol Chem 276 (2001) 3798-3804
17. Franzini M., Corti A., Lorenzini E., et al. Modulation of cell growth and cisplatin sensitivity by membrane γ-glutamyltransferase in melanoma cells. Eur J Cancer 42 (2006) 2623-2630
18. Pompella A., De Tata V., Paolicchi A., et al. Expression of gamma-glutamyltransferase in cancer cells and its significance in drug resistance. Biochem Pharmacol 71 (2006) 231-238
19. Knickelbein R.G., Seres T., Lam G., et al. Characterization of multiple cysteine and cystine transporters in rat alveolar type II cells. Am J Physiol 273 (1997) L1147-L1155
20. Joyce-Brady M., Takahashi Y., Oakes S.M., et al. Synthesis and release of amphipathic glutamyl transferase from the pulmonary alveolar type 2 cell. J Biol Chem 269 (1994) 14219-14226
21. Hull J., Vervaart P., Grimwood K., et al. Pulmonary oxidative stress response in young children with cystic fibrosis. Thorax 52 (1997) 557-560
22. Roum J.H., Buhl R., McElvaney N., et al. Systemic deficiency of glutathione in cystic fibrosis. J Appl Physiol 75 (1993) 2419-2424
23. Hudson V.M. New insights into the pathogenesis of cystic fibrosis: pivotal role of glutathione system dysfunction and implications for therapy. Treat Respir Med 3 (2004) 353-363
24. Back E.I., Frindt C., Nohr D., et al. Antioxidant deficiency in cystic fibrosis: when is the right time to take action. Am J Clin Nutr 80 (2004) 374-384