Structure-activity relationships for the impact of selected isothiazol-3-one biocides on glutathione metabolism and glutathione reductase of the human liver cell line Hep G2

Toxicology

Volumn 246, Issue 2-3, 2008, Pages 203-212

  Arning, Jürgen ^a   Dringen, Ralf ^a   Schmidt, Maike ^a   Thiessen, Anette ^a   Stolte, Stefan ^a   Matzke, Marianne ^a   Bottin Weber, Ulrike ^a   Caesar Geertz, Birgit ^a   Jastorff, Bernd ^a   Ranke, Johannes ^a  

^a UNIVERSITY OF BREMEN   (Germany)

Author keywords

Cellular reduction potential; Electrophilic toxicants; Glutathione depletion; Glutathione reductase activity; Isothiazol 3 one biocides; Thinking in terms of structure activity relationships (T SAR)

Indexed keywords

2 METHYL 4 ISOTHIAZOLIN 3 ONE; 4,5 DICHLORO N OCTYLISOTHIAZOL 3 ONE; 5 CHLORO N METHYLISOTHIAZOL 3 ONE; BIOCIDE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE REDUCTASE; ISOTHIAZOLE DERIVATIVE; N OCTYLISOTHIAZOL 3 ONE; UNCLASSIFIED DRUG;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INHIBITION; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; LIVER CELL; PRIORITY JOURNAL; PROTEIN CONTENT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUBSTITUTION REACTION;

EID: 40649098175     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2008.01.011     Document Type: Article

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