The effect of dietary l-carnitine supplementation on pulmonary hypertension syndrome mortality in broilers exposed to low temperatures

Journal of Animal Physiology and Animal Nutrition

Volumn 92, Issue 2, 2008, Pages 203-210

  Tan, X ^a,b   Hu, S H ^a   Wang, X L ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b NANJING AGRICULTURAL UNIVERSITY   (China)

Author keywords

Broiler; Heart; L carnitine; Lipid peroxidation; Pulmonary hypertension; Pulmonary vascular remodelling

Indexed keywords

CARNITINE; MALONALDEHYDE; SUPEROXIDE DISMUTASE;

ANIMAL; ANIMAL DISEASE; ARTICLE; BIRD DISEASE; BLOOD; BODY WEIGHT; CHICKEN; COLD; DIET SUPPLEMENTATION; DRUG EFFECT; FEMALE; LUNG; MALE; MORTALITY; OXIDATIVE STRESS; PULMONARY HYPERTENSION; RANDOMIZATION; VASCULARIZATION; WEIGHT GAIN;

ANIMALS; BODY WEIGHT; CARNITINE; CHICKENS; COLD; DIETARY SUPPLEMENTS; FEMALE; HYPERTENSION, PULMONARY; LUNG; MALE; MALONDIALDEHYDE; OXIDATIVE STRESS; POULTRY DISEASES; RANDOM ALLOCATION; SUPEROXIDE DISMUTASE; WEIGHT GAIN;

AVES;

EID: 40649083121     PISSN: 09312439     EISSN: 14390396     Source Type: Journal    
DOI: 10.1111/j.1439-0396.2007.00727.x     Document Type: Article

References (50)

1. Barth, P. J. Kimpel, C. Roy, S. Wagner, U., 1993 : An improved mathematical approach for the assessment of the medial thickness of pulmonary arteries. Pathology, Research and Practice 189, 567 576.
2. Baumgartner, M. Blum, R., 1997 : Typical L-carnitine contents in feedstuffs. In : M. Baumgartner (ed. L-Carnitine in Animal Nutrition, pp. 2. Lonza, Basle
3. Bertelli, A. Conte, A. Ronca, G., 1994 : L-propionyl carnitine protects erythrocytes and low density lipoproteins against peroxidation. Drugs under Experimental and Clinical Research 20, 191 197.
4. Bottje, W. G. Enkvetchakul, B. Moore, R. McNew, R., 1995 : Effect of α-tocopherol on antioxidants, lipid peroxidation, and the incidence of pulmonary hypertension syndrome (ascites) in broilers. Poultry Science 74, 1356 1369.
5. Bremer, J., 1983 : Carnitine-metabolism and functions. Physiological Reviews 63, 1420 1480.
6. Buyse, J. Janssens, G. P. J. Decuypere, E., 2001 : The effects of dietary L-carnitine supplementation on the performance, organ weights and circulating hormone and metabolite concentrations of broiler chickens reared under a normal or low temperature schedule. British Poultry Science 42, 230 240.
7. Calo, L. A. Pagnin, E. Davis, P. A. Semplicini, A. Nicolai, R. Calvani, M. Pessina, A. C., 2006 : Antioxidant effect of L-carnitine and its short chain esters: relevance for the protection from oxidative stress related cardiovascular damage. International Journal of Cardiology 107, 54 60.
8. Chandel, N. S. Maltepe, E. Goldwasser, E. Mathieu, C. E. Simon, M. C. Schumacker, P. T., 1998 : Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proceedings of the National Academy of Sciences of the United States of America 95, 11715 11720.
9. Cueva, S. Sillau, H. Valenzuela, A. Ploog, H., 1974 : High altitude induced pulmonary hypertension and right ventricle failure in broiler chickens. Research in Veterinary Science 16, 370 374.
10. Da Silva, J. M. L. Dale, N. Batista-Luchesi, J., 1988 : Effect of pelleted feed on the incidence of ascites in broilers reared at low altitudes. Avian Diseases 32, 376 378.
11. Deng, K. Wong, C. W. Nolan, J. V., 2006 : Long-term effects of early-life dietary L-carnitine on lymphoid organs and immune responses in Leghorn-type chickens. Journal of Animal Physiology and Animal Nutrition 90, 81 86.
12. Diaz-Cruz, A. Nava, C. Villanueva, R. Serret, M. Guinzberg, R. Pina, E., 1996 : Hepatic and cardiac oxidative stress and other metabolic changes in broilers with the ascites syndrome. Poultry Science 75, 900 903.
13. Enkvetchakul, B. Bottje, W. Anthony, N. Moore, R. Huff, W., 1993 : Compromised antioxidant status associated with ascites in broilers. Poultry Science 72, 2272 2280.
14. Enkvetchakul, B. Beasley, J. Bottje, W., 1995 : Pulmonary arteriole hypertrophy in broilers with pulmonary hypertension syndrome (ascites). Poultry Science 74, 1676 1682.
15. Ferrari, R. Merli, E. Cicchitelli, G. Mele, D. Fucili, A. Ceconi, C., 2004 : Therapeutic effects of L-carnitine and propionyl-L-carnitine on cardiovascular diseases: a review. Annals of the New York Academy of Sciences 1033, 79 91.
16. Geng, A. Guo, Y. Yuan, J., 2004 : Effects of dietary L-carnitine and coenzyme Q10 supplementation on performance and ascites mortality of broilers. Achieves of Animal Nutrition 58, 473 482.
17. Gorur, S. Bagdatoglu, O. T. Polat, G., 2005 : Protective effect of L-carnitine on renal ischaemia-reperfusion injury in the rat. Cell Biochemistry and Function 23, 151 155.
18. Gulcin, I., 2006 : Antioxidant and antiradical activities of L-carnitine. Life Science 78, 803 811.
19. 2: role in cell survival following oxidant injury. The Journal of Biological Chemistry 271, 4138 4142.
20. Hartung, H. P. Parnham, M. J. Winkelmann, J. Englberger, W. Hadding, U., 1983 : Platelet activating factor (PAF) induces the oxidative burst in macrophages. International Journal of Immunopharmacology 5, 115 121.
21. Iqbal, M. Cawthon, D. Wideman, R. F. Bottje, W. G., 2001a : Lung mitochondrial dysfunction in pulmonary hypertension syndrome. I. Site-specific defects in electron transport chain. Poultry Science 80, 485 495.
22. Iqbal, M. Cawthon, D. Wideman, R. F., Jr. Bottje, W. G., 2001b : Lung mitochondrial dysfunction in pulmonary hypertension syndrome. ii. oxidative stress and inability to improve function with repeated additions of adenosine diphosphate. Poultry Science 80, 656 665.
23. Julian, R. J., 2000 : Physiological, management and environmental triggers of the ascites syndrome: a review. Avian Pathology 29, 519 527.
24. Julian, R. J. McMillan, I. Quinton, M., 1989 : The effect of cold and dietary energy on right ventricle hypertrophy, right ventricle failure and ascites in meat-type chickens. Avian Pathology 18, 675 684.
25. Kalaiselvi, T. Panneerselvam, C., 1998 : Effect of L-carnitine on the status of lipid peroxidation and antioxidants in aging rats. The Journal of Nutritional Biochemistry 9, 575 581.
26. Lewus, M. S. Whatley, R. E. Cain, P. McIntyre, T. M. Prescott, S. M. Zimmerman, G. A., 1988 : Hydrogen peroxide stimulates the synthesis of platelet-activating factor by endothelium and induces endothelial cell-dependent neutrophil adhesion. The Journal of Clinical Investigation 82, 2045 2055.
27. Lien, T. F. Horng, Y. M., 2001 : The effect of supplementary dietary L-carnitine on the growth performance, serum components, carcase traits and enzyme activities in relation to fatty acid beta-oxidation of broiler chickens. British Poultry Science 42, 92 95.
28. Longoni, B. Giovannini, L. Migliori, M. Bertelli, A. A. Bertelli, A., 1999 : Cyclosporine-induced lipid peroxidation and propionyl carnitine protective effect. International Journal of Tissue Reactions 21, 7 11.
29. Mast, J. Buyse, J. Goddeeris, B. M., 2000 : Dietary L-carnitine supplementation increases antigen-specific immunoglobulin G production in broiler chickens. British Journal of Nutrition 83, 161 166.
30. Matsui, H. Shimosawa, T. Itakura, K. Guanqun, X. Ando, K. Fujita, T., 2004 : Adrenomedullin can protect against pulmonary vascular remodelling induced by hypoxia. Circulation 109, 2246 2251.
31. Media Cybernetics, 1998 : Image-Pro® Plus User's Guide. Media Cybernetics, Silver Spring, MD.
32. Nakagawa, T. Sunamori, M. Suzuki, A. A., 1994 : The myocardial distribution and plasma concentration of carnitine in patients with mitral valve disease. Surgery Today 24, 313 317.
33. National Research Council, 1994 : Nutrient Requirements of Poultry, 9th rev. National Academy Press, Washington, DC.
34. Numan, S. L. Lin, T. L. Hester, P. Y., 2002 : The effect of dietary carnitine on semen traits of white Leghorn roosters. Poultry Science 81, 495 503.
35. Olander, H. J. Burton, R. R. Adler, H. E., 1967 : The pathophysiology of chronic hypoxia in chickens. Avian Diseases 11, 609 620.
36. Ono, S. Westcott, J. Y. Voelkel, N. F., 1992 : PAF antagonists inhibit pulmonary vascular remodeling induced hypobaric hypoxia in rats. Journal of Applied Physiology 73, 1084 1092.
37. Pan, J.-Q. Tan, X. Li, J.-C. Sun, W.-D. Wang, X.-L., 2005 : Effects of early feed restriction on lipid peroxidation, pulmonary vascular remodelling and ascites morbidity in broilers. British Poultry Science 46, 374 381.
38. Rabie, M. H. Szilagyi, M., 1998 : Effects of L-carnitine supplementation of diets differing in energy levels on performance, abdominal fat content, and yield and composition of edible meat of broilers. British Journal of Nutrition 80, 391 400.
39. Rebouche, C. J. Seim, H., 1998 : Carnitine metabolism and its regulation in microorganisms and mammals. Annual Review of Nutrition 18, 39 61.
40. SAS Institute, 1994 : SAS® User's Guide: Statistics. SAS Institute, Cary, NC.
41. Springer, J. Fischer, A., 2003 : Substance P-induced pulmonary vascular remodelling in precision cut lung slices. The European Respiratory Journal 22, 596 601.
42. Springer, J. Juricko, J. Braun-Dullaeus, R. C. Fischer, A. Kummer, W., 2000 : Hypoxia induces proliferation in the pulmonary vascular bed in vitro. American Journal of Respiratory and Critical Care Medicine 161, A422.
43. Tan, X. Liu, Y. J. Li, J. C. Pan, J. Q. Sun, W. D. Wang, X. L., 2005. Activation of PKCα and pulmonary vascular remodelling in broilers. Research in Veterinary Science 79, 131 137.
44. Vanella, A. Russo, A. Acquaviva, R. Campisi, A. Di Giacomo, C. Sorrenti, V. Barcellona, M. L., 2000 : L-propionyl-carnitine as superoxide scavenger, antioxidant, and DNA cleavage protector. Cell Biology and Toxicology 16, 99 104.
45. Waypa, G. B. Chandel, N. S. Schumacker, P. T., 2001 : Model of hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing. Circulation Research 88, 1259 1266.
46. Waypa, G. B. Marks, J. D. Mack, M. M. Boriboun, C. Mungai, P. T. Schumacker, P. T., 2002 : Mitochondrial reactive oxygen species trigger calcium increases during hypoxia in pulmonary arterial myocytes. Circulation Research 91, 719 726.
47. Wedgwood, S. Black, S. M., 2003 : Role of reactive oxygen species in vascular remodeling associated with pulmonary hypertension. Antioxidants & Redox Signaling 5, 759 769.
48. Wedgwood, S. Dettman, R. W. Black, S. M., 2001 : ET-1 stimulates pulmonary arterial smooth muscle cell proliferation via induction of reactive oxygen species. The American Journal of Physiology 281, L1058 L1067.
49. Wideman, R. F. Kirby, Y. K. Tackett, C. D. Marson, N. E. Tressler, C. J. McNew, R. W., 1996 : Independent and simultaneous unilateral occlusion of the pulmonary artery and extra-pulmonary primary bronchus in broilers. Poultry Science 75, 1417 1427.
50. Xiang, R. P. Sun, W. D. Wang, J. Y. Wang, X. L., 2002 : Effect of vitamin C on pulmonary hypertension and muscularisation of pulmonary arterioles in broilers. British Poultry Science 43, 705 712.