Efficacy of pradofloxacin in cats with feline upper respiratory tract disease due to Chlamydophila felis or Mycoplasma infections

Journal of Veterinary Internal Medicine

Volumn 22, Issue 1, 2008, Pages 44-52

  Hartmann, A D ^a   Helps, C R ^b   Lappin, M R ^c   Werckenthin, C ^a   Hartmann, K ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c Veterinary Dentistry and Oral Surgery   (United States)

Author keywords

Conjunctivitis; Doxycycline; Feline upper respiratory tract disease; Fluoroquinolone; Polymerase chain reaction; Treatment.

Indexed keywords

ANIMALIA; BACTERIA (MICROORGANISMS); CHLAMYDOPHILA; CHLAMYDOPHILA FELIS; FELIDAE; MYCOPLASMA;

EID: 40549123024     PISSN: 08916640     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1939-1676.2007.0012.x     Document Type: Article

References (42)

1. 1 Binns S, Dawson S. Feline infectious upper respiratory disease. In Pract 1995 ; 17: 458–461.
2. 2 Bannasch MJ, Foley JE. Epidemiologic evaluation of multiple respiratory pathogens in cats in animal shelters. J Feline Med Surg 2005 ; 7: 109–119.
3. 3 Helps CR, Lait P, Damhuis A, et al. Factors associated with upper respiratory tract disease caused by feline herpesvirus, feline calicivirus, Chlamydophila felis and Bordetella bronchiseptica in cats: Experience from 218 European catteries. Vet Rec 2005 ; 156: 669–673.
4. 4 Zapirain Gastón J, Stengel C, Harbour D, et al. Prevalence of feline herpesvirus‐1, feline calicivirus and Chlamydophila felis in multi‐cat households. Kleintierpraxis 2005 ; 49: 689–698.
5. 5 Leirisalo‐Repo M. Are antibiotics of any use in reactive arthritis? APMIS 1993 ; 101: 575–581.
6. 6 Tan RJS, Miles JAR. Incidence and significance of mycoplasmas in sick cats. Res Vet Sci 1974 ; 16: 27–34.
7. 7 Haesebrouck F, Devriese LA, Van Rijssen B, et al. Incidence and significance of isolation of Mycoplasma felis from conjunctival swabs of cats. Vet Microbiol 1991 ; 26: 95–101.
8. 8 Low HC, Powell CC, Veir JK, et al. Prevalence of feline herpesvirus 1, Chlamydophila felis, and Mycoplasma spp. DNA in conjunctival cells collected from cats with and without conjunctivitis. Am J Vet Res 2007 ; 68: 643–648.
9. 9 Gerhardt N, Schulz BS, Werckenthin C, et al. Pharmacokinetics of enrofloxacin and its efficacy in comparison with doxycycline in the treatment of Chlamydophila felis infection in cats with conjunctivitis. Vet Rec 2006 ; 159: 591–594.
10. 10 Greene CE. Chlamydial infections. In: Greene CE, ed. Infectious Diseases of the Dog and Cat, 3rd ed. St Louis: Saunders Elsevier Inc ; 2006: 245–252.
11. 11 Dean R, Harley R, Helps C, et al. Use of quantitative real‐time PCR to monitor the response of Chlamydophila felis infection to doxycycline treatment. J Clin Microbiol 2005 ; 43: 1858–1864.
12. 12 Sykes JE, Studdert VP, Browning GF. Comparison of the polymerase chain reaction and culture for the detection of feline Chlamydia psittaci in untreated and doxycycline‐treated experimentally infected cats. J Vet Intern Med 1999 ; 13: 146–152.
13. 13 Sparkes AH, Caney SM, Sturgess CP, et al. The clinical efficacy of topical and systemic therapy for the treatment of feline ocular chlamydiosis. J Feline Med Surg 1999 ; 1: 31–35.
14. 14 Majcherczyk J, Szymanska‐Jachimczak EI. Discoloration of the teeth and bones in young animals caused by tetracycline. Zahnarztl Prax 1965 ; 16: 61–63.
15. 15 German AJ, Cannon MJ, Dye C, et al. Oesophageal strictures in cats associated with doxycycline therapy. J Feline Med Surg 2005 ; 7: 33–41.
16. 16 Greene CE, Watson ADJ. Antibacterial chemotherapy. In: Greene CE, ed. Infectious Diseases of the Dog and Cat, 3rd ed. St Louis: Saunders Elsevier Inc ; 2006: 274–301.
17. 17 Gelatt KN, Van Der Woerdt A, Ketring KL, et al. Enrofloxacin‐associated retinal degeneration in cats. Vet Ophthalmol 2001 ; 4: 99–106.
18. 18 Loria GR, Sammartino C, Nicholas RA, et al. In vitro susceptibilities of field isolates of Mycoplasma agalactiae to oxytetracycline, tylosin, enrofloxacin, spiramycin and lincomycin‐spectinomycin. Res Vet Sci 2003 ; 75: 3–7.
19. 19 Francoz D, Fortin M, Fecteau G, et al. Determination of Mycoplasma bovis susceptibilities against six antimicrobial agents using the E test method. Vet Microbiol 2005 ; 105: 57–64.
20. 20 Hartmann K, Kuffer M. Karnofsky's score modified for cats. Eur J Med Res 1998 ; 3: 95–98.
21. 21 Helps C, Reeves N, Egan K, et al. Detection of Chlamydophila felis and feline herpesvirus by multiplex real‐time PCR analysis. J Clin Microbiol 2003 ; 41: 2734–2736.
22. 22 Takashi U, Kiyozo A, Ikunoshin D, et al. Amplification of the 16S‐23S spacer region in rRNA operons of mycoplasmas by the polymerase chain reaction. Syst Appl Microbiol 1992 ; 15: 181–186.
23. 23 Baird SC, Carman J, Dinsmore RP, et al. Detection and identification of Mycoplasma from bovine mastitis infections using a nested polymerase chain reaction. J Vet Diagn Invest 1999 ; 11: 432–435.
24. 24 Nasisse MP, Guy JS, Stevens JB, et al. Clinical and laboratory findings in chronic conjunctivitis in cats: 91 cases (1983–1991). J Am Vet Med Assoc 1993 ; 203: 834–837.
25. 25 Sykes JE, Anderson GA, Studdert VP, et al. Prevalence of feline Chlamydia psittaci and feline herpesvirus‐1 in cats with upper respiratory tract disease. J Vet Intern Med 1999 ; 13: 153–162.
26. 26 Harbour DA, Howard PE, Gaskell RM. Isolation of feline calicivirus and feline herpesvirus from domestic cats (1980–1989). Vet Rec 1991 ; 128: 77–80.
27. 27 Hargis AM, Prieur DJ, Gaillard ET. Chlamydial infection of the gastric mucosa in twelve cats. Vet Pathol 1983 ; 20: 170–178.
28. 28 Dossin O, Gruet P, Thomas E. Comparative field evaluation of marbofloxacin tablets in the treatment of feline upper respiratory infections. J Small Anim Pract 1998 ; 39: 286–289.
29. 29 Andrew SE. Ocular manifestations of feline herpesvirus. J Feline Med Surg 2001 ; 3: 9–16.
30. 30 Daube G, Krebber R, Greife HA. Pharmacokinetic properties of pradofloxacin administered as an oral suspension to cats. J Vet Pharm Ther 2006 ; 29 (Suppl 1): 266–267.
31. 31 Fraatz K. Serum pharmacokinetics of pradofloxacin after oral administration to cats. J Vet Pharm Ther 2006 ; 29 (Suppl 1): 266.
32. 32 Owen WM, Sturgess CP, Harbour DA, et al. Efficacy of azithromycin for the treatment of feline chlamydophilosis. J Feline Med Surg 2003 ; 5: 305–311.
33. 33 Suchland RJ, Geisler WM, Stamm WE. Methodologies and cell lines used for antimicrobial susceptibility testing of Chlamydia spp. Antimicrob Agents Chemother 2003 ; 47: 636–642.
34. 34 Jones RB, Van der Pol B, Martin DH, et al. Partial characterization of Chlamydia trachomatis isolates resistant to multiple antibiotics. J Infect Dis 1990 ; 162: 1309–1315.
35. 35 Lefevre JC, Lepargneur JP, Guion D, et al. Tetracycline‐resistant Chlamydia trachomatis in Toulouse, France. Pathol Biol (Paris) 1997 ; 45: 376–378.
36. 36 Somani J, Bhullar VB, Workowski KA, et al. Multiple drug‐resistant Chlamydia trachomatis associated with clinical treatment failure. J Infect Dis 2000 ; 181: 1421–1427.
37. 37 Dessus‐Babus S, Bebear CM, Charron A, et al. Sequencing of gyrase and topoisomerase IV quinolone‐resistance‐determining regions of Chlamydia trachomatis and characterization of quinolone‐resistant mutants obtained in vitro. Antimicrob Agents Chemother 1998 ; 42: 2474–2481.
38. 38 Morrissey I, Salman H, Bakker S, et al. Serial passage of Chlamydia spp. in sub‐inhibitory fluoroquinolone concentrations. J Antimicrob Chemother 2002 ; 49: 757–761.
39. 39 Kenny GE, Cartwright FD. Susceptibility of Mycoplasma pneumoniae to several new quinolones, tetracycline, and erythromycin. Antimicrob Agents Chemother 1991 ; 35: 587–589.
40. 40 Cooper AC, Fuller JR, Fuller MK, et al. In vitro activity of danofloxacin, tylosin and oxytetracycline against mycoplasmas of veterinary importance. Res Vet Sci 1993 ; 54: 329–334.
41. 41 Kaufman AC, Greene CE. Increased alanine transaminase activity associated with tetracycline administration in a cat. J Am Vet Med Assoc 1993 ; 202: 628–630.
42. 42 Bjellerup M, Ljunggren B. Double blind cross‐over studies on phototoxicity to three tetracycline derivatives in human volunteers. Photodermatology 1987 ; 4: 281–287.