ZAP-70 is highly expressed in most cases of childhood pre-B cell acute lymphoblastic leukemia

International Journal of Laboratory Hematology

Volumn 30, Issue 2, 2008, Pages 149-157

  Wandroo, F ^a,b   Bell, A ^a   Darbyshire, P ^c   Pratt, G ^a,d   Stankovic, T ^a   Gordon, J ^e   Lawson, S ^c   Moss, P ^a,b  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b QUEEN ELIZABETH HOSPITAL   (United Kingdom)

^c BIRMINGHAM CHILDREN S HOSPITAL   (United Kingdom)

^d BIRMINGHAM HEARTLANDS HOSPITAL   (United Kingdom)

^e MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

Acute lymphoblastic leukemia; ZAP 70

Indexed keywords

MESSENGER RNA; PROTEIN KINASE ZAP 70;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ARTICLE; BONE MARROW CELL; CHILD; CLINICAL ARTICLE; FEMALE; HUMAN; LYMPHOBLAST; MALE; NATURAL KILLER CELL; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION;

ADOLESCENT; B-LYMPHOCYTES; BLOTTING, WESTERN; BONE MARROW CELLS; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CHILD; CHILD, PRESCHOOL; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMANS; JURKAT CELLS; MALE; POLYMERASE CHAIN REACTION; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PRECURSOR CELLS, B-LYMPHOID; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 40549099407     PISSN: 17515521     EISSN: 1751553X     Source Type: Journal    
DOI: 10.1111/j.1751-553X.2007.00915.x     Document Type: Article

References (22)

1. Admirand J.H., Rassidakis G.Z., Abruzzo L.V., Valbuena J.R., Jones D. Medeiros L.J. (2004) Immunohistochemical detection of ZAP-70 in 341 cases of non-Hodgkin and Hodgkin lymphoma. Modern Pathology 17, 954 961.
2. Ashe J.M., Wiest D.L., Abe R. Singer A. (1999) ZAP-70 protein promotes tyrosine phosphorylation of T cell receptor signaling motifs (ITAMs) in immature CD4(+)8(+) thymocytes with limiting p56(lck). Journal of Experimental Medicine 189, 1163 1168.
3. Chan A.C., van Oers N.S., Tran A., Turka L., Law C.L., Ryan J.C., Clark E.A. Weiss A. (1994) Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. Journal of Immunology 152, 4758 4766.
4. Chen L., Widhopf G., Huynh L., Rassenti L., Rai K.R., Weiss A. Kipps T.J. (2002) Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia. Blood 100, 4609 4614.
5. Chiaretti S., Guarini A., De Propris M.S., Tarolaro S., Intoppa S., Vitale A., Iacobelli S., Elia L., Ariola C., Ritz J. Foa R. (2006) ZAP-70 expression in acute lymphoblastic leukemia: association with the E2A/PBX1 rearrangement and the pre-B stage of differentiation and prognostic implications. Blood 107, 197 204.
6. Crespo M., Bosch F., Villamor N., Bellossillo B., Colomer D., Rozman M., Marce S., Lopez-Guillermo A., Campo E. Montserrat E. (2003) ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia. New England Journal of Medicine 348, 1764 1775.
7. Crespo M., Villamor N., Gine E., Muntanola A., Colomer D., Marafioti T., Jones M., Camos M., Campo E., Montserrat E. Bosch F. (2006) ZAP-70 expression in normal pro/pre-B cells, mature B cells and in acute lymphoblastic leukaemia. Clinical Cancer Research 12, 726 734.
8. Elder M.E. (1998) ZAP-70 and defects of T-cell receptor signaling. Seminars in Hematology 35, 310 320.
9. Goodman P.A., Wood C.M., Vassilev A., Mao C. Uckun F.M. (2001) Spleen tyrosine kinase (Syk) deficiency in childhood pro-B cell acute lymphoblastic leukemia. Oncogene 20, 3969 3978.
10. Guillaume N., Alleaume C., Munfus D, Capiod J.C., Touati G., Pautard B., Desablens B., Lefrere J.J., Gouilleux F., Lassoued K. Gouilleux-Gruart V. (2005) ZAP-70 tyrosine kinase is constitutively expressed and phosphorylated in B-lineage acute lymphoblastic leukemia cells. Haematologica 90, 899 905.
11. Kadlecek T.A., van Oers N.S., Lefrancois L Olson S., Finlay D., Chu D.H., Connolly K., Killeen N. Weiss A. (1998) Differential requirements for ZAP-70 in TCR signaling and T cell development. Journal of Immunology 161, 4688 4694.
12. Kong G., Dalton M., Wardenburg J.B, Strauss D., Kurosaki T. Chan A.C. (1996) Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function. Molecular and Cellular Biology 16, 5026 5035.
13. Law C.L., Sidorenko S.P., Chandran K.A., Drares K.E., Chan A.C., Weiss A., Edelhoff S., Disteche C.M. Clark E.A. (1994) Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex. Journal of Biological Chemistry 269, 12310 12319.
14. Nagai M., Fujita M., Ohmori M, Matsubara S., Taniwaki M., Horiike S., Tasaka T., Koeffler H.P. Takahara J. (1997) Establishment of a novel human B-cell line (OZ) with t(14;18)(q32;q21) and aberrant p53 expression was associated with the homozygous deletions of p15INK4B and p16INK4A genes. Hematological Oncology 15, 109 119.
15. Nolz J.C., Tschumper R.C., Pittner B.T., Darce J.R., Kay N.E. Jelinek D.F. (2005) ZAP-70 is expressed by a subset of normal human B-lymphocytes displaying an activated phenotype. Leukemia 19, 1018 1024
16. van Oers N.S., von Boehmer H. Weiss A. (1995) The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunit. Journal of Experimental Medicine 182, 1585 1590.
17. Orchard J.A., Ibbotson R.E., Davis Z, Wiestner A., Rosenwald A., Thomas P.W., Hamblin T.J., Staudt L.M. Oscier D.G. (2004) ZAP-70 expression and prognosis in chronic lymphocytic leukemia. Lancet 363, 105 111.
18. Rassenti L.Z., Huynh L., Toy T.L, Chen L., Keating M.J., Gribben J.G., Neuberg D.S., Flinn I.W., Rai K.P., Byrd J.C., Kay N.E., Greaves A., Weiss A. Kipps T.J. (2004) ZAP-70 compared with immunoglobulin heavy-chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia. New England Journal of Medicine 351, 893 901.
19. Rosenwald A., Alizadeh A.A., Widhopf G, Simon R., Davis R.E., Yu X., Yang L., Pickeral O.K., Rassenti C.Z., Powell J., Bolstein D., Byrd J.C., Grever M.R., Cheson B.D., Chiorazzi N., Wilson W.H., Kipps T.J., Brown P.O. Staudt L.M. (2001) Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. Journal of Experimental Medicine 194, 1639 1647.
20. Schweighoffer E., Vanes L., Mathiot A., Nakamura T. Tybulewicz V.L. (2003) Unexpected requirement for ZAP-70 in pre-B cell development and allelic exclusion. Immunity 18, 523 533.
21. Sup S.J., Domiati-Saad R., Kelley T.W., Steinle R., Zhao X. His E.D. (2004) ZAP-70 expression in B-cell hematologic malignancy is not limited to CLL/SLL. American Journal of Clinical Pathology 122, 582 587.
22. Wiestner A., Rosenwald A., Barry T.S, Wright G., Davis R.E., Henrickson S.E., Zhao H., Ibbotson R.E., Orchard J.A., Davis Z., Stetler-Stevenson M., Raffield M., Arthur D.C., Marti G.E., Wilson W.H., Hamblin T.J., Oscier D.G. Staudt L.M. (2003) ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated genes, inferior clinical outcome, and distinct gene expression profile. Blood 101, 4944 4951.