Distinct functional effects of human 5-HT4 receptor isoforms on β-amyloid secretion

Neurodegenerative Diseases

Volumn 5, Issue 3-4, 2008, Pages 163-165

  Robert, Sylvain J ^a   Lezoualc'h, Frank ^a  

^a INSERM   (France)

Author keywords

Amyloid secretion; Alzheimer's disease; G protein coupled receptors; Serotonin 5 HT4 receptor

Indexed keywords

AMYLOID BETA PROTEIN; BETA SECRETASE; GAMMA SECRETASE; RECEPTOR SUBTYPE; SEROTONIN 4 RECEPTOR;

ANIMAL CELL; CARBOXY TERMINAL SEQUENCE; CHO CELL; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOBLOTTING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN SECRETION;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; HUMANS; NEURAL PATHWAYS; PROTEIN ISOFORMS; RECEPTORS, SEROTONIN, 5-HT4;

EID: 40449125903     PISSN: 16602854     EISSN: 16602862     Source Type: Journal    
DOI: 10.1159/000113691     Document Type: Conference Paper

References (10)

1. Dumuis A, Bouhelal R, Sebben M, Cory R, Bockaert J: A nonclassical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system. Mol Pharmacol 1988;34:880-887.
2. 4 receptors: a novel therapeutic target for Alzheimer's disease? Curr Alzheimer Res 2004;1:79-86.
3. 4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival. Exp Neurol 2007;203:274-278.
4. 4 receptor and Alzheimer's disease: the amyloid connection. Exp Neurol 2007;205:325-329.
5. 4 receptors. Curr Drug Targets CNS Neurol Disord 2004;3:39-51.
6. Blondel O, Gastineau M, Dahmoune Y, Langlois M, Fischmeister R: Cloning, expression, and pharmacology of four human 5-hydroxytryptamine 4 receptor isoforms produced by alternative splicing in the carboxyl terminus. J Neurochem 1998;70:2252-2261.
7. 4(e) receptor from human heart and comparative analysis of its pharmacological profile in C6-glial and CHO cell lines. Br J Pharmacol 2000;129:771-781.
8. 4(d) receptor splice variant stably expressed in Chinese hamster ovary cells. Br J Pharmacol 2000;131:827-835.
9. 4 receptor and Epac. FEBS Lett 2005;579:1136-1142.
10. Cachard-Chastel M, Lezoualc'h F, Dewachter I, Delomenie C, Croes S, Devijver H, Langlois M, Van Leuven F, Sicsic S, Gardier AM: 5-HT4 receptor agonists increase sAPPalpha levels in the cortex and hippocampus of male C57BL/6j mice. Br J Pharmacol 2007;150:883-892.