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Volumn 22, Issue 3, 2008, Pages 671-681

Unliganded estrogen receptor α inhibits breast cancer cell growth through interaction with a cyclin-dependent kinase inhibitor (p21 WAF1)

Author keywords

Cell cycle; Proliferation; Steroid

Indexed keywords

AMINO ACID; ANTIESTROGEN; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN E; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; FULVESTRANT; MUTANT PROTEIN;

EID: 40449117681     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.07-9322com     Document Type: Article
Times cited : (20)

References (48)
  • 1
    • 0033386954 scopus 로고    scopus 로고
    • Estrogen receptor β - a new dimension in estrogen mechanism of action
    • Gustafsson, J. A. (1999) Estrogen receptor β - a new dimension in estrogen mechanism of action. J. Endocrinol. 163, 379-383
    • (1999) J. Endocrinol , vol.163 , pp. 379-383
    • Gustafsson, J.A.1
  • 2
    • 0028625491 scopus 로고
    • Insights from the study of animals lacking functional estrogen receptor
    • Korach, K. S. (1994) Insights from the study of animals lacking functional estrogen receptor. Science 266, 1524-1527
    • (1994) Science , vol.266 , pp. 1524-1527
    • Korach, K.S.1
  • 4
    • 0025695290 scopus 로고
    • Activation of the ovalbumin gene by the estrogen receptor involves the Fos-Jun complex
    • Gaub, M. P., Bellard, M., Scheuer, I., Chambon, P., and Sassone-Corsi, P. (1990) Activation of the ovalbumin gene by the estrogen receptor involves the Fos-Jun complex. Cell 63, 1267-1276
    • (1990) Cell , vol.63 , pp. 1267-1276
    • Gaub, M.P.1    Bellard, M.2    Scheuer, I.3    Chambon, P.4    Sassone-Corsi, P.5
  • 6
    • 0035965362 scopus 로고    scopus 로고
    • Characterization of the physical interaction between estrogen receptor α and JUN proteins
    • Teyssier, C., Belguise, K., Galtier, F., and Chalbos, D. (2001) Characterization of the physical interaction between estrogen receptor α and JUN proteins. J. Biol. Chem. 276, 36361-36369
    • (2001) J. Biol. Chem , vol.276 , pp. 36361-36369
    • Teyssier, C.1    Belguise, K.2    Galtier, F.3    Chalbos, D.4
  • 7
    • 0029147741 scopus 로고
    • Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-κB and C/EBPβ
    • Stein, B., and Yang, M. X. (1995) Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-κB and C/EBPβ. Mol. Cell. Biol. 15, 4971-4979
    • (1995) Mol. Cell. Biol , vol.15 , pp. 4971-4979
    • Stein, B.1    Yang, M.X.2
  • 8
    • 0000545998 scopus 로고    scopus 로고
    • Functional interactions between the estrogen receptor and the transcription activator Sp1 regulate the estrogen-dependent transcriptional activity of the vitellogenin A1 io promoter
    • Batistuzzo de Medeiros, S. R., Krey, G., Hihi, A. K., and Wahli, W. (1997) Functional interactions between the estrogen receptor and the transcription activator Sp1 regulate the estrogen-dependent transcriptional activity of the vitellogenin A1 io promoter. J. Biol. Chem. 272, 18250-18260
    • (1997) J. Biol. Chem , vol.272 , pp. 18250-18260
    • Batistuzzo de Medeiros, S.R.1    Krey, G.2    Hihi, A.K.3    Wahli, W.4
  • 9
    • 0031840580 scopus 로고    scopus 로고
    • Ligand-independent activation of steroid hormone receptors
    • Weigel, N. L., and Zhang, Y. (1998) Ligand-independent activation of steroid hormone receptors. J. Mol. Med. 76, 469-479
    • (1998) J. Mol. Med , vol.76 , pp. 469-479
    • Weigel, N.L.1    Zhang, Y.2
  • 10
    • 0017102124 scopus 로고
    • The effects of estrogens and antiestrogens on hormone-responsive human breast cancer in long-term tissue culture
    • Lippman, M., Bolan, G., and Huff, K. (1976) The effects of estrogens and antiestrogens on hormone-responsive human breast cancer in long-term tissue culture. Cancer Res. 36, 4595-4601
    • (1976) Cancer Res , vol.36 , pp. 4595-4601
    • Lippman, M.1    Bolan, G.2    Huff, K.3
  • 11
    • 0018219234 scopus 로고
    • Hormone receptors: Their role in predicting prognosis and response to endocrine therapy
    • McGuire, W. L. (1978) Hormone receptors: their role in predicting prognosis and response to endocrine therapy. Semin. Oncol. 5, 428-433
    • (1978) Semin. Oncol , vol.5 , pp. 428-433
    • McGuire, W.L.1
  • 12
    • 0024044464 scopus 로고
    • Relative worth of estrogen or progesterone receptor and pathologic characteristics of differentiation as indicators of prognosis in node negative breast cancer patients: Findings from National Surgical Adjuvant Breast and Bowel Project Protocol B-06
    • Fisher, B., Redmond, C., Fisher, E. R., and Caplan, R. (1988) Relative worth of estrogen or progesterone receptor and pathologic characteristics of differentiation as indicators of prognosis in node negative breast cancer patients: findings from National Surgical Adjuvant Breast and Bowel Project Protocol B-06. J. Clin. Oncol. 6, 1076-1087
    • (1988) J. Clin. Oncol , vol.6 , pp. 1076-1087
    • Fisher, B.1    Redmond, C.2    Fisher, E.R.3    Caplan, R.4
  • 14
    • 0031915998 scopus 로고    scopus 로고
    • Prognostic and predictive factors in breast cancer by immunohistochemical analysis
    • Allred, D. C., Harvey, J. M., Berardo, M., and Clark, G. M. (1998) Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod. Pathol. 11, 155-168
    • (1998) Mod. Pathol , vol.11 , pp. 155-168
    • Allred, D.C.1    Harvey, J.M.2    Berardo, M.3    Clark, G.M.4
  • 15
    • 33646439130 scopus 로고    scopus 로고
    • Prognosis and management of patients with node-negative invasive breast carcinoma that is 1 cm or smaller in size (stage 1; T1a,bN0M0): A review of the literature
    • Hanrahan, E. O., Valero, V., Gonzalez-Angulo, A. M., and Hortobagyi, G. N. (2006) Prognosis and management of patients with node-negative invasive breast carcinoma that is 1 cm or smaller in size (stage 1; T1a,bN0M0): a review of the literature. J. Clin. Oncol. 24, 2113-2122
    • (2006) J. Clin. Oncol , vol.24 , pp. 2113-2122
    • Hanrahan, E.O.1    Valero, V.2    Gonzalez-Angulo, A.M.3    Hortobagyi, G.N.4
  • 17
    • 0034464660 scopus 로고    scopus 로고
    • Unliganded and liganded estrogen receptors protect against cancer invasion via different mechanisms
    • Platet, N., Cunat, S., Chalbos, D., Rochefort, H., and Garcia, M. (2000) Unliganded and liganded estrogen receptors protect against cancer invasion via different mechanisms. Mol. Endocrinol. 14, 999-1009
    • (2000) Mol. Endocrinol , vol.14 , pp. 999-1009
    • Platet, N.1    Cunat, S.2    Chalbos, D.3    Rochefort, H.4    Garcia, M.5
  • 18
    • 10644220369 scopus 로고    scopus 로고
    • Fibronectin and type IV collagen activate ERα AF-1 by c-Src pathway: Effect on breast cancer cell motility
    • Sisci, D., Aquila, S., Middea, E., Gentile, M., Maggiolini, M., Mastroianni, F., Montanaro, D., and Ando, S. (2004) Fibronectin and type IV collagen activate ERα AF-1 by c-Src pathway: effect on breast cancer cell motility. Oncogene 23, 8920-8930
    • (2004) Oncogene , vol.23 , pp. 8920-8930
    • Sisci, D.1    Aquila, S.2    Middea, E.3    Gentile, M.4    Maggiolini, M.5    Mastroianni, F.6    Montanaro, D.7    Ando, S.8
  • 19
    • 0024440781 scopus 로고
    • The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties
    • Tora, L., Mullick, A., Metzger, D., Ponglikitmongkol, M., Park, I., and Chambon, P. (1989) The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties. EMBO J. 8, 1981-1986
    • (1989) EMBO J , vol.8 , pp. 1981-1986
    • Tora, L.1    Mullick, A.2    Metzger, D.3    Ponglikitmongkol, M.4    Park, I.5    Chambon, P.6
  • 20
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • Gossen, M., and Bujard, H. (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. U. S. A. 89, 5547-5551
    • (1992) Proc. Natl. Acad. Sci. U. S. A , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 21
    • 0032511893 scopus 로고    scopus 로고
    • Interaction with cyclin-dependent kinases and PCNA modulates proteasome-dependent degradation of p21
    • Cayrol, C., and Ducommun, B. (1998) Interaction with cyclin-dependent kinases and PCNA modulates proteasome-dependent degradation of p21. Oncogene 17, 2437-2444
    • (1998) Oncogene , vol.17 , pp. 2437-2444
    • Cayrol, C.1    Ducommun, B.2
  • 23
    • 0028973212 scopus 로고
    • Overexpression of p21WAF1/CIP1 induces growth arrest, giant cell formation and apoptosis in human breast carcinoma cell lines
    • Sheikh, M. S., Rochefort, H., and Garcia, M. (1995) Overexpression of p21WAF1/CIP1 induces growth arrest, giant cell formation and apoptosis in human breast carcinoma cell lines. Oncogene 11, 1899-1905
    • (1995) Oncogene , vol.11 , pp. 1899-1905
    • Sheikh, M.S.1    Rochefort, H.2    Garcia, M.3
  • 24
    • 0036676298 scopus 로고    scopus 로고
    • Down-regulation of cathepsin-D expression by antisense gene transfer inhibits tumor growth and experimental lung metastasis of human breast cancer cells
    • Glondu, M., Liaudet-Coopman, E., Derocq, D., Platet, N., Rochefort, H., and Garcia, M. (2002) Down-regulation of cathepsin-D expression by antisense gene transfer inhibits tumor growth and experimental lung metastasis of human breast cancer cells. Oncogene 21, 5127-5134
    • (2002) Oncogene , vol.21 , pp. 5127-5134
    • Glondu, M.1    Liaudet-Coopman, E.2    Derocq, D.3    Platet, N.4    Rochefort, H.5    Garcia, M.6
  • 25
    • 0035976926 scopus 로고    scopus 로고
    • A low abundance pool of nascent p21WAF1/Cip1 is targeted by estrogen to activate cyclin E*Cdk2
    • Prall, O. W., Carroll, J. S., and Sutherland, R. L. (2001) A low abundance pool of nascent p21WAF1/Cip1 is targeted by estrogen to activate cyclin E*Cdk2. J. Biol. Chem. 276, 45433-45442
    • (2001) J. Biol. Chem , vol.276 , pp. 45433-45442
    • Prall, O.W.1    Carroll, J.S.2    Sutherland, R.L.3
  • 26
    • 0025251798 scopus 로고
    • Several regions of human estrogen receptor are involved in the formation of receptor-heat shock protein 90 complexes
    • Chambraud, B., Berry, M., Redeuilh, G., Chambon, P., and Baulieu, E. E. (1990) Several regions of human estrogen receptor are involved in the formation of receptor-heat shock protein 90 complexes. J. Biol. Chem. 265, 20686-20691
    • (1990) J. Biol. Chem , vol.265 , pp. 20686-20691
    • Chambraud, B.1    Berry, M.2    Redeuilh, G.3    Chambon, P.4    Baulieu, E.E.5
  • 27
    • 0027322411 scopus 로고
    • Defining a minimal estrogen receptor DNA binding domain
    • Mader, S., Chambon, P., and White, J. H. (1993) Defining a minimal estrogen receptor DNA binding domain. Nucleic Acids Res. 21, 1125-1132
    • (1993) Nucleic Acids Res , vol.21 , pp. 1125-1132
    • Mader, S.1    Chambon, P.2    White, J.H.3
  • 28
    • 0026450958 scopus 로고
    • Activation of estrogen receptor transfected into a receptor-negative breast cancer cell line decreases the metastatic and invasive potential of the cells
    • Garcia, M., Derocq, D., Freiss, G., and Rochefort, H. (1992) Activation of estrogen receptor transfected into a receptor-negative breast cancer cell line decreases the metastatic and invasive potential of the cells. Proc. Natl. Acad. Sci. U. S. A. 89, 11538-11542
    • (1992) Proc. Natl. Acad. Sci. U. S. A , vol.89 , pp. 11538-11542
    • Garcia, M.1    Derocq, D.2    Freiss, G.3    Rochefort, H.4
  • 29
    • 0027496935 scopus 로고
    • The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
    • Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K., and Elledge, S. J. (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75, 805-816
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 31
    • 0030888284 scopus 로고    scopus 로고
    • 1-S phase progression is accompanied by increased cyclin D1 expression and decreased cyclin-dependent kinase inhibitor association with cyclin E-Cdk2
    • 1-S phase progression is accompanied by increased cyclin D1 expression and decreased cyclin-dependent kinase inhibitor association with cyclin E-Cdk2. J. Biol. Chem. 272, 10882-10894
    • (1997) J. Biol. Chem , vol.272 , pp. 10882-10894
    • Prall, O.W.1    Sarcevic, B.2    Musgrove, E.A.3    Watts, C.K.4    Sutherland, R.L.5
  • 32
    • 0021958425 scopus 로고
    • Effect of estrogens and antiestrogens on growth of human breast cancer cells in athymic nude mice
    • Osborne, C. K., Hobbs, K., and Clark, G. M. (1985) Effect of estrogens and antiestrogens on growth of human breast cancer cells in athymic nude mice. Cancer Res. 45, 584-590
    • (1985) Cancer Res , vol.45 , pp. 584-590
    • Osborne, C.K.1    Hobbs, K.2    Clark, G.M.3
  • 33
    • 0022358182 scopus 로고    scopus 로고
    • McCarty, K. S., Jr., Miller, L. S., Cox, E. B., Konrath, J., and McCarty, K. S., Sr. (1985) Estrogen receptor analyses: correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies. Arch. Pathol. Lab. Med. 109, 716-721
    • McCarty, K. S., Jr., Miller, L. S., Cox, E. B., Konrath, J., and McCarty, K. S., Sr. (1985) Estrogen receptor analyses: correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies. Arch. Pathol. Lab. Med. 109, 716-721
  • 34
    • 0028884216 scopus 로고
    • Growth factors in breast cancer
    • Dickson, R. B., and Lippman, M. E. (1995) Growth factors in breast cancer. Endocr. Rev. 16, 559-589
    • (1995) Endocr. Rev , vol.16 , pp. 559-589
    • Dickson, R.B.1    Lippman, M.E.2
  • 35
    • 0019881506 scopus 로고
    • Breast cancer and the oestrogen window hypothesis
    • Henderson, B. E., Pike, M. C., and Casagrande, J. T. (1981) Breast cancer and the oestrogen window hypothesis. Lancet 2, 363-364
    • (1981) Lancet , vol.2 , pp. 363-364
    • Henderson, B.E.1    Pike, M.C.2    Casagrande, J.T.3
  • 36
    • 0023766378 scopus 로고
    • Breast cancer epidemiology
    • Kelsey, J. L., and Berkowitz, G. S. (1988) Breast cancer epidemiology. Cancer Res. 48, 5615-5623
    • (1988) Cancer Res , vol.48 , pp. 5615-5623
    • Kelsey, J.L.1    Berkowitz, G.S.2
  • 38
    • 10644274482 scopus 로고    scopus 로고
    • Estrogen receptor mutations in human disease
    • Herynk, M. H., and Fuqua, S. A. (2004) Estrogen receptor mutations in human disease. Endocr. Rev. 25, 869-898
    • (2004) Endocr. Rev , vol.25 , pp. 869-898
    • Herynk, M.H.1    Fuqua, S.A.2
  • 39
    • 0030778152 scopus 로고    scopus 로고
    • αΔ3) in breast cancer and the consequences of its reexpression: interference with estrogen-stimulated properties of malignant transformation. Mol. Endocrinol. 11, 2004-2015
    • αΔ3) in breast cancer and the consequences of its reexpression: interference with estrogen-stimulated properties of malignant transformation. Mol. Endocrinol. 11, 2004-2015
  • 40
    • 0027731971 scopus 로고
    • Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit
    • Gu, Y., Turck, C. W., and Morgan, D. O. (1993) Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit. Nature 366, 707-710
    • (1993) Nature , vol.366 , pp. 707-710
    • Gu, Y.1    Turck, C.W.2    Morgan, D.O.3
  • 41
    • 0028169236 scopus 로고
    • p21-containing cyclin kinases exist in both active and inactive states
    • Zhang, H., Hannon, G. J., and Beach, D. (1994) p21-containing cyclin kinases exist in both active and inactive states. Genes Dev. 8, 1750-1758
    • (1994) Genes Dev , vol.8 , pp. 1750-1758
    • Zhang, H.1    Hannon, G.J.2    Beach, D.3
  • 42
    • 0030927929 scopus 로고    scopus 로고
    • Estrogen-dependent cyclin E-cdk2 activation through p21 redistribution
    • Planas-Silva, M. D., and Weinberg, R. A. (1997) Estrogen-dependent cyclin E-cdk2 activation through p21 redistribution. Mol. Cell. Biol. 17, 4059-4069
    • (1997) Mol. Cell. Biol , vol.17 , pp. 4059-4069
    • Planas-Silva, M.D.1    Weinberg, R.A.2
  • 44
    • 0037085290 scopus 로고    scopus 로고
    • WAF1/Cip1 is an antiestrogen-regulated inhibitor of Cdk4 in human breast cancer cells
    • WAF1/Cip1 is an antiestrogen-regulated inhibitor of Cdk4 in human breast cancer cells. J. Biol. Chem. 277, 5145-5152
    • (2002) J. Biol. Chem , vol.277 , pp. 5145-5152
    • Skildum, A.J.1    Mukherjee, S.2    Conrad, S.E.3
  • 46
    • 0035110997 scopus 로고    scopus 로고
    • Kip1 and cyclin D1 proteins in breast ductal carcinoma in situ: Relation with clinicopathologic characteristics and with p53 expression and estrogen receptor status
    • Kip1 and cyclin D1 proteins in breast ductal carcinoma in situ: relation with clinicopathologic characteristics and with p53 expression and estrogen receptor status. Pathol. Int. 51, 94-99
    • (2001) Pathol. Int , vol.51 , pp. 94-99
    • Oh, Y.L.1    Choi, J.S.2    Song, S.Y.3    Ko, Y.H.4    Han, B.K.5    Nam, S.J.6    Yang, J.H.7


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