Excess FGF-7 in corneal epithelium causes corneal intraepithelial neoplasia in young mice and epithelium hyperplasia in adult mice

American Journal of Pathology

Volumn 172, Issue 3, 2008, Pages 638-649

  Chikama, Taiichiro ^a,b   Liu, Chia Yang ^a   Meij, Johanna T A ^a   Hayashi, Yasuhito ^a,c   Wang, I Jong ^d   Yang, Liu ^b   Nishida, Teruo ^b   Kao, Winston W Y ^a  

^a UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

^b YAMAGUCHI UNIVERSITY   (Japan)

^c EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; BROXURIDINE; CYTOKERATIN 14; DOXYCYCLINE; KERATINOCYTE GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; CORNEA; CORNEA DISEASE; CORNEA EPITHELIUM; CORNEA LIMBUS; DOWN REGULATION; EPITHELIUM HYPERPLASIA; FEMALE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; OCULAR SURFACE SQUAMOUS NEOPLASIA; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL; TRANSGENIC MOUSE; UPREGULATION; WESTERN BLOTTING;

EID: 40449090317     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2008.070897     Document Type: Article

References (39)

1. HE Grossniklaus WR Green M Lukenback CC Chan Conjunctival lesions in adults: a clinical and histopathologic review Cornea 6 1987 78 116
2. GA Lee LW Hirst Ocular surface squamous neoplasia Surv Ophthalmol 39 1995 429 450
3. SCG Tseng Concept and application of limbal stem cells Eye 3 1989 141 157
4. PW Finch JS Rubin T Miki D Ron SA Aaronson Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth Science 245 1989 752 755
5. JS Rubin H Osada PW Finch WG Taylor S Rudikoff SA Aaronson Purification and characterization of a newly identified growth factor specific for epithelial cells Proc Nat Acad Sci USA 86 1989 802 806
6. JS Rubin DP Bottaro M Chedid T Miki D Ron G Cheon WG Taylor E Fortney H Sakata PW Finch WJ LaRochelle Keratinocyte growth factor Cell Biol Intern 19 1995 399 412
7. M Igarashi PW Finch SA Aaronson Characterization of recombinant human fibroblast growth factor (FGF)-10 reveals functional similarities with keratinocyte growth factor (FGF-7) J Biol Chem 273 1998 13230 13235
8. DQ Li SC Tseng Differential regulation of cytokine and receptor transcript expression in human corneal and limbal fibroblasts by epidermal growth factor, transforming growth factor-alpha, platelet-derived growth factor B, and interleukin-1 beta Invest Ophthalmol Vis Sci 37 1996 2068 2080
9. DQ Li SC Tseng Differential regulation of keratinocyte growth factor and hepatocyte growth factor/scatter factor by different cytokines in human corneal and limbal fibroblasts J Cell Physiol 172 1997 361 372
10. HP Makarenkova M Ito V Govindarajan SC Faber L Sun G McMahon PA Overbeek RA Lang FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development Development 127 2000 2563 2572
11. V Govindarajan M Ito HP Makarenkova RA Lang PA Overbeek Endogenous and ectopic gland induction by FGF-10 Dev Biol 225 2000 188 200
12. FJ Lovicu WW Kao PA Overbeek Ectopic gland induction by lens-specific expression of keratinocyte growth factor (FGF-7) in transgenic mice Mech Dev 88 1999 43 53
13. T Chikama Y Hayashi CY Liu N Terai K Terai CW Kao L Wang M Hayashi T Nishida P Sanford T Doestchman WW Kao Characterization of tetracycline-inducible double transgenic Krt12rtTA/+/tet-O-LacZ mice Invest Ophthalmol Vis Sci 46 2005 1966 1972
14. JW Tichelaar W Lu JA Whitsett Conditional expression of fibroblast growth factor-7 in the developing and mature lung J Biol Chem 275 2000 11858 11864
15. AR Utomo AY Nikitin WH Lee Temporal, spatial, and cell type-specific control of Cre-mediated DNA recombination in transgenic mice Nat Biotechnol 17 1999 1091 1096
16. CY Liu G Zhu R Converse CW Kao H Nakamura SC Tseng MM Mui J Seyer MJ Justice ME Stech GM Hansen WW Kao Characterization and chromosomal localization of the cornea-specific murine keratin gene Krt1.12 J Biol Chem 269 1994 24627 24636
17. CY Liu DE Birk JR Hassell B Kane WW Kao Keratocan-deficient mice display alterations in corneal structure J Biol Chem 278 2003 21672 21677
18. CY Liu G Zhu A Westerhausen-Larson RL Converse CW Kao TT Sun WW Kao Cornea-specific expression of K12 keratin during mouse development Curr Eye Res 12 1993 963 974
19. N Tanifuji-Terai K Terai Y Hayashi T Chikama WW Kao Expression of keratin 12 and maturation of corneal epithelium during development and postnatal growth Invest Ophthalmol Vis Sci 47 2006 545 551
20. M Hayashi Y Hayashi CY Liu JW Tichelaar WW Kao Over expression of FGF7 enhances cell proliferation but fails to cause pathology in corneal epithelium of Kerapr-rtTA/FGF7 bitransgenic mice Mol Vis 11 2005 201 207
21. PA Coulombe R Kopan E Fuchs Expression of keratin K14 in the epidermis and hair follicle: insights into complex programs of differentiation J Cell Biol 109 1989 2295 2312
22. SE Wilson YG He J Weng JD Zieske JV Jester GS Schultz Effect of epidermal growth factor, hepatocyte growth factor, keratinocyte growth factor on the motility, differentiation of human corneal epithelial cells Exp Eye Res 59 1994 665 678
23. A Rosner K Miyoshi E Landesman-Bollag X Xu DC Seldin AR Moser CL MacLeod G Shyamala AE Gillgrass RD Cardiff Pathway pathology: histological differences between ErbB/Ras and Wnt pathway transgenic mammary tumors Am J Pathol 161 2002 1087 1097
24. W Holnthoner M Pillinger M Groger K Wolff AW Ashton C Albanese P Neumeister RG Pestell P Petzelbauer Fibroblast growth factor-2 induces Lef/Tcf-dependent transcription in human endothelial cells J Biol Chem 277 2002 45847 45853
25. CL Shields JA Shields Tumors of the conjunctiva and cornea Surv Ophthalmol 49 2004 3 24
26. K Cho T Ishiwata E Uchida N Nakazawa M Korc Z Naito T Tajiri Enhanced expression of keratinocyte growth factor and its receptor correlates with venous invasion in pancreatic cancer Am J Pathol 170 2007 1964 1974
27. M Manavi G Hudelist A Fink-Retter D Gschwandtler-Kaulich K Pischinger K Czerwenka Gene profiling in Pap-cell smears of high-risk human papillomavirus-positive squamous cervical carcinoma Gynecol Oncol 105 2007 418 426
28. Y Hishikawa N Tamaru K Ejima T Hayashi T Koji Expression of keratinocyte growth factor and its receptor in human breast cancer: its inhibitory role in the induction of apoptosis possibly through the over-expression of Bcl-2 Arch Histol Cytol 67 2004 455 464
29. PB Mehta CN Robson DE Neal HY Leung Serum keratinocyte growth factor measurement in patients with prostate cancer J Urol 164 2000 2151 2155
30. D Kovacs C Cota G Cardinali N Aspite G Bolasco A Amantea MR Torrisi M Picardo Expression of keratinocyte growth factor and its receptor in clear cell acanthoma Exp Dermatol 15 2006 762 768
31. J Niu Z Chang B Peng Q Xia W Lu P Huang MS Tsao PJ Chiao Keratinocyte growth factor/fibroblast growth factor-7-regulated cell migration and invasion through activation of NF-kappaB transcription factors J Biol Chem 282 2007 6001 6011
32. JM Arbeit DC Olson D Hanahan Upregulation of fibroblast growth factors and their receptors during multi-stage epidermal carcinogenesis in K14-HPV16 transgenic mice Oncogene 13 1996 1847 1857
33. C Napora EJ Cohen GI Genvert AC Presson JJ Arentsen RC Eagle PR Laibson Factors associated with conjunctival intraepithelial neoplasia: a case control study Ophthalmic Surg 21 1990 27 30
34. IU Scott CL Karp GJ Nuovo Human papillomavirus 16 and 18 expression in conjunctival intraepithelial neoplasia Ophthalmology 109 2002 542 547
35. CL Karp IU Scott TS Chang SC Pflugfelder Conjunctival intraepithelial neoplasia: a possible marker for human immunodeficiency virus infection? Arch Ophthalmol 114 1996 257 261
36. CA Kiire B Dhillon The aetiology and associations of conjunctival intraepithelial neoplasia Br J Ophthalmol 90 2006 109 113
37. A Schermer S Galvin TT Sun Differentiation-related expression of a major 64K corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cells J Cell Biol 103 1986 49 62
38. SZ Cotsarelis G Cheng G Dong TT Sun RM Lavker Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells Cell 57 1989 201 209
39. J Alvarado C Murphy R Juster Age-related changes in the basement membrane of the human corneal epithelium Invest Ophthalmol Vis Sci 24 1983 1015 1028