Endothelial cells do not express GSTA1: Potential relevance to busulfan-mediated endothelial damage during haematopoietic stem cell transplantation

European Journal of Haematology

Volumn 80, Issue 4, 2008, Pages 299-302

  Vassord, Camille ^a   Lapouméroulie, Claudine ^a   Koumaravelou, Kailasam ^a   Srivastava, Alok ^b   Krishnamoorthy, Rajagopal ^a  

^a HÔPITAL ROBERT DEBRÉ   (France)

^b CHRISTIAN MEDICAL COLLEGE   (India)

Author keywords

Busulfan; Endothelial cell; Endothelial damage; Glutathione S transferase alpha; Haematopoietic stem cell transplantation; Human umbilical vein

Indexed keywords

BUSULFAN; GLUTATHIONE TRANSFERASE A1; MESSENGER RNA;

ARTICLE; BONE MARROW CELL; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENDOTHELIUM CELL; ENDOTHELIUM LESION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; HUMAN CELL; LIVER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; UMBILICAL CORD;

BUSULFAN; CELLS, CULTURED; ENDOTHELIAL CELLS; GENOTYPE; GLUTATHIONE TRANSFERASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; PROMOTER REGIONS (GENETICS);

EID: 40449085705     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/j.1600-0609.2008.01031.x     Document Type: Article

References (23)

1. Meresse V, Hartmann O, Vassal G, Benhamou E, Valteau-Couanet D, Brugieres L, Lemerle J. Risk factors for hepatic veno-occlusive disease after high-dose busulfan-containing regimens followed by autologous bone marrow transplantation: a study in 136 children. Bone Marrow Transplant 1992 10 : 135 41.
2. Cesaro S, Pillon M, Talenti E, et al. A prospective survey on incidence, risk factors and therapy of hepatic veno-occlusive disease in children after hematopoietic stem cell transplantation. Haematologica 2005 90 : 1396 404.
3. Woywodt A, Scheer J, Hambach L, Buchholz S, Ganser A, Haller H, Hertenstein B, Haubitz M. Circulating endothelial cells as a marker of endothelial damage in allogeneic hematopoietic stem cell transplantation. Blood 2004 103 : 3603 5.
4. Czerwinski M, Gibbs JP, Slattery JT. Busulfan conjugation by glutathione S-transferases alpha, mu, and pi. Drug Metab Dispos 1996 24 : 1015 9.
5. + cells do not express glutathione S-transferases alpha. Gene Ther 1997 4 : 268 70.
6. Beckett GJ, Hayes JD. Glutathione S-transferases: biomedical applications. Adv Clin Chem 1993 30 : 281 380.
7. Beckett GJ, Dyson EH, Chapman BJ, Templeton AJ, Hayes JD. Plasma glutathione S-transferase measurements by radioimmunoassay: a sensitive index of hepatocellular damage in man. Clin Chim Acta 1985 146 : 11 9.
8. Bredschneider M, Klein K, Murdter TE, Marx C, Eichelbaum M, Nussler AK, Neuhaus P, Zanger UM, Schwab M. Genetic polymorphisms of glutathione S-transferase A1, the major glutathione S-transferase in human liver: consequences for enzyme expression and busulfan conjugation. Clin Pharmacol Ther 2002 71 : 479 87.
9. Coles BF, Morel F, Rauch C, Huber WW, Yang M, Teitel CH, Green B, Lang NP, Kadlubar FF. Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression. Pharmacogenetics 2001 11 : 663 9.
10. Kusama M, Kubota T, Matsukura Y, Matsuno K, Ogawa S, Kanda Y, Iga T. Influence of glutathione S-transferase A1 polymorphism on the pharmacokinetics of busulfan. Clin Chim Acta 2006 368 : 93 8.
11. Schweitzer KM, Vicart P, Delouis C, Paulin D, Drager AM, Langenhuijsen MM, Weksler BB. Characterization of a newly established human bone marrow endothelial cell line: distinct adhesive properties for hematopoietic progenitors compared with human umbilical vein endothelial cells. Lab Invest 1997 76 : 25 36.
12. Jaffe EA, Nachman RL, Becker CG, Minick CR. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 1973 52 : 2745 56.
13. Knowles BB, Howe CC, Aden DP. Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. Science 1980 209 : 497 9.
14. Ping J, Wang H, Huang M, Liu ZS. Genetic analysis of glutathione S-transferase A1 polymorphism in the Chinese population and the influence of genotype on enzymatic properties. Toxicol Sci 2006 89 : 438 43.
15. Ritter CA, Sperker B, Grube M, Dressel D, Kunert-Keil C, Kroemer HK. Overexpression of glutathione S-transferase A1-1 in ECV 304 cells protects against busulfan mediated G2-arrest and induces tissue factor expression. Br J Pharmacol 2002 137 : 1100 6.
16. Brown J, Reading SJ, Jones S, Fitchett CJ, Howl J, Martin A, Longland CL, Michelangeli F, Dubrova YE, Brown CA. Critical evaluation of ECV304 as a human endothelial cell model defined by genetic analysis and functional responses: a comparison with the human bladder cancer derived epithelial cell line T24/83. Lab Invest 2000 80 : 37 45.
17. Drexler HG, Quentmeier H, Dirks WG, MacLeod RA. Bladder carcinoma cell line ECV304 is not a model system for endothelial cells. In Vitro Cell Dev Biol Anim 2002 38 : 185 6 author reply 187.
18. DeLeve LD, Wang X, Kuhlenkamp JF, Kaplowitz N. Toxicity of azathioprine and monocrotaline in murine sinusoidal endothelial cells and hepatocytes: the role of glutathione and relevance to hepatic venoocclusive disease. Hepatology 1996 23 : 589 99.
19. Hassan M, Ehrsson H, Ljungman P. Aspects concerning busulfan pharmacokinetics and bioavailability. Leuk Lymphoma 1996 22 : 395 407.
20. He NG, Singhal SS, Chaubey M, Awasthi S, Zimniak P, Partridge CA, Awasthi YC. Purification and characterization of a 4-hydroxynonenal metabolizing glutathione S-transferase isozyme from bovine pulmonary microvessel endothelial cells. Biochim Biophys Acta 1996 1291 : 182 8.
21. Steinberg P, Schramm H, Schladt L, Robertson LW, Thomas H, Oesch F. The distribution, induction and isoenzyme profile of glutathione S-transferase and glutathione peroxidase in isolated rat liver parenchymal, Kupffer and endothelial cells. Biochem J 1989 264 : 737 44.
22. Black SM, Wolf CR. The role of glutathione-dependent enzymes in drug resistance. Pharmacol Ther 1991 51 : 139 54.
23. Srivastava A, Poonkuzhali B, Shaji RV, George B, Mathews V, Chandy M, Krishnamoorthy R. Glutathione S-transferase M1 polymorphism: a risk factor for hepatic venoocclusive disease in bone marrow transplantation. Blood 2004 104 : 1574 7.