Genotype prevalence, viral load and outcome of hepatitis B virus precore mutant infection in stable patients and in patients after liver transplantation

Clinical Transplantation

Volumn 18, Issue 4, 2004, Pages 415-422

  Ben Ari, Ziv ^a,c   Ashur, Yaffa ^b   Daudi, Nili ^b   Shmilovitz Wiess, Hemda ^a   Brown, Marius ^a   Sulkes, Jacqueline ^a   Klein, Athalia ^b   Mor, Eytan ^a   Tur Kaspa, Ran ^a   Shouval, Daniel ^b  

^a TEL AVIV UNIVERSITY   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c RABIN MEDICAL CENTER   (Israel)

Author keywords

Genotype; Hepatitis B; Liver transplantation; Precore mutant; Viral load

Indexed keywords

FAMCICLOVIR; HEPATITIS B ANTIBODY; INTERFERON; LAMIVUDINE; VIRUS DNA;

ADULT; AMPLICON; ANTIBODY BLOOD LEVEL; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; DISEASE ACTIVITY; DNA HYBRIDIZATION; FEMALE; FOLLOW UP; GENOTYPE; GRAFT INFECTION; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN TISSUE; IMMUNOPROPHYLAXIS; IMMUNOSUPPRESSIVE TREATMENT; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MIDDLE EAST; PREVALENCE; PRIORITY JOURNAL; PROGNOSIS; RECURRENT INFECTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; VIRUS LOAD; VIRUS MUTANT; VIRUS RESISTANCE;

ADULT; CODON, TERMINATOR; DNA, VIRAL; FEMALE; GENOTYPE; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LAMIVUDINE; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; MUTATION; POSTOPERATIVE PERIOD; RECURRENCE; REVERSE TRANSCRIPTASE INHIBITORS; SEROEPIDEMIOLOGIC STUDIES; VIRAL LOAD; VIRUS REPLICATION;

EID: 4043184076     PISSN: 09020063     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-0012.2004.00182.x     Document Type: Article

References (32)

1. Carman W, Jacyma MR, Hadziyannis S et al. Mutation preventing formation of hepatitis Be antigen in patients with chronic hepatitis B infection. Lancet 1989: 2: 588.
2. Brown J, Carman W, Thomas H. The clinical significance of molecular variation within the hepatitis B virus genome. Hepatology 1992: 15: 144.
3. Brunetto M, Giarin M, Oliveri F et al. Wild-type and e antigen-minus hepatitis B viruses and course of chronic hepatitis. Proc Natl Acad Sci USA 1991: 88: 4186.
4. Gunther S, Meisel H, Reip A, Miska S, Kruger DH, Will H. Frequent and rapid emergence of mutated pre-c sequences in HBV from c-antigen positive carriers who seroconvert to anti-HBe during interferon treatment. Virology 1992: 187: 271.
5. Hamasaki K, Nakata K, Nagayama Y et al. Changes in the prevalence of HBeAg-negative mutant hepatitis B virus during the course of chronic hepatitis B. Hepatology 1994: 20: 8.
6. Lok A, Akarca U, Greene S. Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pregenome encapsidation signal. Proc Natl Acad Sci USA 1994: 91: 4077.
7. Okamoto H, Tsuda F, Akahane Y et al. Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen. J Virol 1994: 68: 8102.
8. Fattovich G, Brollo L, Alberti A, Pontisso P, Giustina G, Realdi G. Long-term follow-up of anti-HBe-positive chronic active hepatitis B. Hepatology 1988: 8: 1651.
9. Grandjacques C, Pradat P, Stuyver L et al. Rapid detection of genotypes and mutations in the pre-core promoter and the pre-core region of hepatitis B virus genome: correlation with viral persistence and disease severity. J Hepatol 2000: 33: 430.
10. Karino Y. Toyota J, Sato T et al, Early mutation of precore (A1896) region prior to core promoter region mutation leads to decrease of HBV replication and remission of hepatic inflammation. Dig Dis Sci 2000: 45: 2207.
11. Tong SP, Li JS, Vitvitski L, Trepo C. Replication capacities of natural and artificial precore stop codon mutants of hepatitis B virus: relevance of pregenome encapsidation signal. Virology 1992: 191: 237.
12. Buckwold Ve, Xu Z, Chen M, Ten TS, Ou JH. Effects of a naturally occurring mutation in the hepatitis B virus based core promoter on precore gene expression and viral replication. J Virol 1996: 70: 5845.
13. Hasegawa K, Huang J, Rogers S, Blum HE, Liang TJ. Enhanced replication of a hepatitis B virus mutant associated with an epidemic of fulminant hepatitis. J Virol 1994: 68: 1651.
14. Bozdayi AM, Bozkaya H, Turkyilmaz AR et al. Nucleotide divergence in the core promoter and precore region of genotype D hepatitis B virus in patients with persistently elevated or normal ALT levels. J Clin Virol 2001: 21: 91.
15. Tur-Kaspa R, Keshet E, Eliakim M, Shouval D. Detection and characterization of hepatitis B virus DNA in serum of HBe antigen negative HBsAg carriers. J Med Virol 1984: 14: 17.
16. Tur-Kapsa R, Klein A, Aharonson S. Hepatitis B virus precore mutants are identical in carriers from various ethnic origins and are associated with a range of liver disease severity. Hepatology 1992: 16: 1338.
17. Norder H, Hammas B, Löfdahl S, Courouce AM, Magnius LO. Comparison of the amino acid sequences of nine different serotypes of hepatitis B surface antigen and genomic classification of the corresponding hepatitis B virus strains. J Gen Virol 1992: 73: 1201.
18. Stuyver L, De Gendt S, Van Geyt C et al. A new genotype of hepatitis B virus: complete genome and phylogenetic relatedness. J Gen Virol 2000: 81: 67.
19. Li J-S, Tong S-P, Wen Y-M, Vitvitski L, Zhang O, Trepo C. Hepatitis B virus genotype A circulates as an HBe-minus mutant: possible contribution of a single nucleotide in the precore region. J Virol 1993: 67: 5402.
20. Rogriguez-Frias F, Buti M, Jardi R et al. Hepatitis B virus infection: precore mutants and its relation to viral genotypes and core mutations. Hepatology 1995: 22: 1641.
21. Lindh M, Andersson AS, Gusdal A. Genotypes, nt 1858 variants, and geographic origin of hepatitis B virus - large-scale analysis using a new genotyping method. J Infect Dis 1997: 175: 1285.
22. Adler R, Safadi R, Caraco Y et al. Comparison of immune reactivity and pharmacokinetics of two hepatitis B immune globulins in patients after liver transplantation. Hepatology 1999: 29: 1299.
23. Allen MI, Gauthier J, Deslauriers M et al. Two sensitive PCR-based methods for detection of hepatitis B virus variants associated with reduced susceptibility to lamivudine. J Clin Microbiol 1999: 37: 3338.
24. Knodell RG, Ishak KG. Black WC et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981: 1: 431.
25. Loriot M. Marcellin P. Talbodec N et al. Low frequency of precore hepatitis B virus mutants in anti-hepatitis Be-positive reactivation after loss of hepatitis Be antigen in patients with chronic hepatitis B. Hepatology 1995: 21: 627.
26. Shouval D, Samuel D. Hepatitis B immune globulin to prevent hepatitis B virus graft reinfection following liver transplantation: a concise review. Hepatology 2000: 32: 1189.
27. McMillan JS, Bowden DS, Angus PW, Mccaughan G, Locarnini S. Mutations in the hepatitis B virus precore/core gene and core promoter in patients with severe recurrent disease following liver transplantation. Hepatology 1996: 24: 1371.
28. Gunther S, Piwon N, Iwanska A, Schilling R, Meisel H, Will H. Type, prevalence, and significance of core promoter/enhancer II mutations in hepatitis B viruses from immunosuppressed patients with severe liver disease. J Virol 1996: 70: 8318.
29. Steinberg JL, Yeo W, Zhong S et al. Hepatitis B virus reactivation in patients undergoing cytotoxic chemotherapy for solid tumors: precore-/core mutations may play an important role. J Med Virol 2000: 60: 249.
30. Tur-Kaspa R, Shaul Y, Moore DD et al. The glucocorticoid receptor recognizes a specific nucleotide sequence in hepatitis B virus DNA causing increased activity of the HBV enhancer. Virology 1988: 167: 630.
31. Angus PW, Locarnini SA, McCaughan GW, Jones RM, McMillan J, Bowden D. Hepatitis B virus precore mutant infection is associated with severe recurrent disease after liver transplantation. Hepatology 1995: 21: 14.
32. Zollner B, Petersen J, Schroter M, Laufs R, Schoder V, Feucht H.H. 20-fold increase in risk of lamivudine resistance in hepatitis B versus subtype adw. Lancet 2001: 357: 934.