Transcriptional control of RAD51 expression in the ciliate Tetrahymena thermophila

Nucleic Acids Research

Volumn 32, Issue 14, 2004, Pages 4313-4321

  Smith, Joshua J ^b,c   Cole, Eric S ^a   Romero, Daniel P ^b  

^a ST OLAF COLLEGE   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TUBULIN; BETA TUBULIN; GENOMIC DNA; GREEN FLUORESCENT PROTEIN; LUCIFERASE; RAD51 PROTEIN; DNA BINDING PROTEIN;

5' UNTRANSLATED REGION; ARTICLE; CELL LYSATE; CHROMOSOME INVERSION; CONTROLLED STUDY; DNA DAMAGE; DNA FLANKING REGION; ENZYME INDUCTION; GENE CONSTRUCT; GENE CONTROL; GENE DELETION; GENE EXPRESSION; GENE INSERTION; GENE LOCUS; GENE SEQUENCE; GENE TARGETING; GENETIC CODE; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; MACRONUCLEUS; MEIOSIS; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTOZOAL GENETICS; QUANTITATIVE ANALYSIS; REPORTER GENE; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; STRAIN IDENTIFICATION; TETRAHYMENA THERMOPHILA; TRANSCRIPTION REGULATION; ULTRAVIOLET RADIATION; ANIMAL; CYTOLOGY; DNA RESPONSIVE ELEMENT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; TRANSACTIVATION;

CILIOPHORA; TETRAHYMENA THERMOPHILA;

ANIMALS; DNA DAMAGE; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GENES, REPORTER; LUCIFERASES; MEIOSIS; PROMOTER REGIONS (GENETICS); RAD51 RECOMBINASE; RESPONSE ELEMENTS; TETRAHYMENA THERMOPHILA; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC;

EID: 4043181367     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkh771     Document Type: Article

References (40)

1. Gasior,S.L., Olivares,H., Ear,U., Hari,D.M., Weichselbaum,R. and Bishop,D.K. (2001) Assembly of RecA-like recombinases: distinct roles for mediator proteins in mitosis and meiosis. Proc. Natl Acad. Sci. USA, 98, 8411-8418.
2. West,S.C. (2003) Molecular views of recombination proteins and their control. Nature Rev. Mol. Cell Biol., 4, 435-445.
3. Sung,P., Krejci,L., Van Komen,S. and Sehorn,M.G. (2003) Rad51 recombinase and recombination mediators. J. Biol. Chem., 278, 42729-42732.
4. Campbell,C. and Romero,D.P. (1998) Identification and characterization of the RAD51 gene from the ciliate Tetrahymena thermophila. Nucleic Acids Res., 26, 3165-3172.
5. Marsh,T.C., Cole,E.S., Stuart,K.R., Campbell,C. and Romero,D.P. (2000) RAD51 is required for propagation of the germinal nucleus in Tetrahymena thermophila. Genetics, 154, 1587-1596.
6. Bishop,D.K., Park,D., Xu,L. and Kleckner,N. (1992) DMC1: a meiosis-specific yeast homolog of E.coli recA required for recombination, synaptonemal complex formation, and cell cycle progression. Cell, 69, 439-456.
7. Habu,T., Taki,T., West,A., Nishimune,Y. and Morita,T. (1996) The mouse and human homologs of DMC1, the yeast meiosis-specific homologous recombination gene, have a common unique form of exon-skipped transcript in meiosis. Nucleic Acids Res., 24, 470-477.
8. Flygare,J., Benson,F. and Hellgren,D. (1996) Expression of the human RAD51 gene during the cell cycle in primary human peripheral blood lymphocytes. Biochim. Biophys. Acta, 1312, 231-236.
9. Jang,Y.K., Jin,Y.H., Shim,Y.S., Kim,M.J., Yoo,E.J., Choi,I.S., Lee,J.S., Seong,R.H., Hong,S.H. and Park,S.D. (1996) Identification of the DNA damage-responsive elements of the rhp51+ gene, a recA and RAD51 homolog from the fission yeast Schizosaccharomyces pombe. Mol. Gen. Genet., 251, 167-175.
10. Jang,Y.K., Jin,Y.H., Myung,K., Seong,R.H., Hong,S.H. and Park,S.D. (1996) Differential expression of the rhp51+ gene, a recA and RAD51 homolog from the fission yeast Schizosaccharomyces pombe. Gene, 169, 125-130.
11. Yamamoto,A., Taki,T., Yagi,H., Habu,T., Yoshida,K., Yoshimura,Y., Yamamoto,K., Matsushiro,A., Nishimune,Y. and Morita,T. (1996) Cell cycle-dependent expression of the mouse Rad51 gene in proliferating cells. Mol. Gen. Genet., 251, 1-12.
12. Mercier,G., Denis,Y., Marcb,P., Picard,L. and Dutreix,M. (2001) Transcriptional induction of repair genes during slowing of replication in irradiated Saccharomyces cerevisiae. Mutat. Res., 487, 157-172.
13. Huang,Y., Nakada,S., Ishiko,T., Utsugisawa,T., Datta,R., Kharbanda,S., Yoshida,K., Talanian,R.V., Weichselbaum,R., Kufe,D. et al. (1999) Role for caspase-mediated cleavage of Rad51 in induction of apoptosis by DNA damage. Mol. Cell. Biol., 19, 2986-2997.
14. Yuan,Z.M., Huang,Y., Ishiko,T., Kharbanda,S., Weichselbaum,R. and Kufe,D. (1997) Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase. Proc. Natl Acad. Sci. USA, 94, 1437-1440.
15. Yuan,Z.M., Huang,Y., Ishiko,T., Nakada,S., Utsugisawa,T., Kharbanda,S., Wang,R., Sung,P., Shinohara,A., Weichselbaum,R. et al. (1998) Regulation of Rad51 function by c-Abl in response to DNA damage. J. Biol. Chem., 273, 3799-3802.
16. Stargell,L.A., Karrer,K.M. and Gorovsky,M.A. (1990) Transcriptional regulation of gene expression in Tetrahymena thermophila. Nucleic Acids Res., 18, 6637-6639.
17. Love,H.D., Allen-Nash,A., Zhao,Q.A. and Bannon,G.A. (1988) mRNA stability plays a major role in regulating the temperature-specific expression of a Tetrahymena thermophila surface protein. Mol. Cell. Biol., 8, 427-432.
18. Yu,G.L. and Blackburn,E.H. (1990) Amplification of tandemly repeated origin control sequences confers a replication advantage on rDNA replicons in Tetrahymena thermophila. Mol. Cell. Biol., 10, 2070-2080.
19. Sambrook,J., Fritsch,E.F. and Maniatis,T. (1989) Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
20. McCormick-Graham,M. and Romero,D.P. (1996) A single telomerase RNA is sufficient for the synthesis of variable telomeric DNA repeats in ciliates of the Genus Paramecium. Mol. Cell. Biol., 16, 1871-1879.
21. Gaertig,J., Gao,Y., Tishgarten,T., Clark,T.G. and Dickerson,H.W. (1999) Surface display of a parasite antigen in the ciliate Tetrahymena thermophila. Nat. Biotechnol., 17, 462-465.
22. Kunkel,T.A., Roberts,J.D. and Zakour,R.A. (1987) Rapid and efficient site-directed mutagenesis without phenotypic selection. Methods Enzymol., 155, 166-178.
23. Gaertig,J., Thatcher,T.H., Gu,L. and Gorovsky,M.A. (1994) Electroporation-mediated replacement of a positively and negatively selectable β-tubulin gene in Tetrahymena thermophila. Proc. Natl Acad. Sci. USA, 91, 4549-4553.
24. Doerder,F.P., Deak,J.C. and Lief,J.H. (1992) Rate of phenotypic assortment in Tetrahymena thermophila. Dev. Genet., 13, 126-132.
25. Merriam,E.V. and Bruns,P.J. (1988) Phenotypic assortment in Tetrahymena thermophila: assortment kinetics of antibiotic-resistance markers, tsA, death, and the highly amplified rDNA locus. Genetics, 120, 389-395.
26. Yu,G.L., Hasson,M. and Blackburn,E.H. (1988) Circular ribosomal DNA plasmids transform Tetrahymena thermophila by homologous recombination with endogenous macronuclear ribosomal DNA. Proc. Natl Acad. Sci. USA, 85, 5151-5155.
27. Reeder,R.H. (1999) Regulation of RNA polymerase I transcription in yeast and vertebrates. Prog. Nucleic Acid Res. Mol. Biol., 62, 293-327.
28. Chedin,S., Ferri,M.L., Peyroche,G., Andrau,J.C., Jourdain,S., Lefebvre,O., Werner,M., Carles,C. and Sentenac,A. (1998) The yeast RNA polymerase III transcription machinery: a paradigm for eukaryotic gene activation. Cold Spring Harb. Symp. Quant. Biol., 63, 381-389.
29. Kornberg,R.D. (1998) Mechanism and regulation of yeast RNA polymerase II transcription. Cold Spring Harb. Symp. Quant. Biol., 63, 229-232.
30. Struhl,K. (1993) Yeast transcription factors. Curr. Opin. Cell Biol., 5, 513-520.
31. Bannon,G.A., Bowen,J.K., Yao,M.C. and Gorovsky,M.A. (1984) Tetrahymena H4 genes: structure, evolution and organization in macro- and micronuclei. Nucleic Acids Res., 12, 1961-1975.
32. Larsen,L.K. and Kristiansen,K. (1995) Transcription in vitro of Tetrahymena class II and class III genes. J. Biol. Chem., 270, 7601-7608.
33. Brunk,C.F. and Sadler,L.A. (1990) Characterization of the promoter region of Tetrahymena genes. Nucleic Acids Res., 18, 323-329.
34. Xiuwen,L. and Gorovsky,M.A. (1993) Mapping the 5′ and 3′ ends of Tetrahymena thermophila mRNA using RNA ligase mediated amplification of cDNA ends (RLM-RACE). Nucleic Acids Res., 21, 4954-4960.
35. Yu,G.L., Bradley,J.D., Attardi,L.D. and Blackburn,E.H. (1990) In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs. Nature, 344, 126-132.
36. Hargrove,B.W., Bhattacharyya,A., Domitrovich,A.M., Kapler,G.M., Kirk,K., Shippen,D.E. and Kunkel,G.R. (1999) Identification of an essential proximal sequence element in the promoter of the telomerase RNA gene of Tetrahymena thermophila. Nucleic Acids Res., 27, 4269-4275.
37. Shang,Y., Song,X., Bowen,J., Corstanje,R., Gao,Y., Gaertig,J. and Gorovsky,M.A. (2002) A robust inducible-repressible promoter greatly facilitates gene knockouts, conditional expression, and overexpression of homologous and heterologous genes in Tetrahymena thermophila. Proc. Natl Acad. Sci. USA, 99, 3734-3739.
38. Haddad,A. and Turkewitz,A.P. (1997) Analysis of exocytosis mutants indicates close coupling between regulated secretion and transcription activation in Tetrahymena. Proc. Natl Acad. Sci. USA, 94, 10675-10680.
39. Yuan,R., Fan,S., Wang,J.A., Meng,Q., Ma,Y., Schreiber,D., Goldberg,I.D. and Rosen,E.M. (1999) Coordinate alterations in the expression of BRCA1, BRCA2, p300, and RAD51 in response to genotoxic and other stresses in human prostate cancer cells. Prostate, 40, 37-49.
40. Peng,L., Rice,M. and Kmiec,E. (1998) Analysis of the human RAD51L1 promoter region and its activation by UV light. Genomics, 54, 529-541.