In vivo measurement of 5-aminolaevulinic acid-induced protoporphyrin IX photobleaching: A comparison of red and blue light of various intensities

Photodermatology Photoimmunology and Photomedicine

Volumn 20, Issue 4, 2004, Pages 170-174

  Nadeau, Valerie ^a   O'Dwyer, Martin ^a   Hamdan, Khaled ^b   Tait, Iain ^b   Padgett, Miles ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Aminolaevulinic acid; Cancer detection; Fluorescence spectroscopy; Optical biopsy; Photobleaching

Indexed keywords

AMINOLEVULINIC ACID; PROTOPORPHYRIN;

ARTICLE; BLEACHING; BLUE LIGHT; CONTROLLED STUDY; CORRELATION ANALYSIS; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; LIGHT INTENSITY; NORMAL HUMAN; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; RADIATION DOSE; RED LIGHT; SKIN CANCER; SPECTROFLUOROMETRY;

AMINOLEVULINIC ACID; HUMANS; LIGHT; PHOTOCHEMOTHERAPY; PROTOPORPHYRINS; SKIN; SPECTROMETRY, FLUORESCENCE;

EID: 4043147193     PISSN: 09054383     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0781.2004.00100.x     Document Type: Article

References (23)

1. Peng Q, Warloe T, Berg K, et al. 5-aminolevulinic acid-based photodynamic therapy: clinical research and future challenges. Cancer 1997; 79: 2282-2308.
2. Wagnieres GA, Star WM, Wilson BC. In vivo fluorescence spectroscopy and imaging for oncological applications. Photochem Photobiol 1998; 68: 603-632.
3. Kennedy JC, Pottier RH, Pross DC. Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience. J Photochem Photobiol B. 1990; 6: 143-148.
4. Fritsch C, Stege H, Saalmann G, Goerz G, Ruzicka T, Krutmann J. Green light is effective and less painful than red light in photodynamic therapy of facial solar keratoses. Photodermatol Photoimmunol Photomed 1997; 13: 181-185.
5. Ackroyd R, Brown NJ, Davis MF, Stephenson TJ, Stoddard CJ, Reed MWR. Aminolaevulinic acid-induced photodynamic therapy in the treatment of dysplastic Barrett's oesophagus and adenocarcinoma. Lasers Med Sci 1999; 14: 278-285.
6. Morton CA, Whitehurst C, Moore JV, MacKie RM. Comparison of red and green light in the treatment of Bowen's disease by photodynamic therapy. Br J Dermatol 2000; 143: 767-772.
7. Ormrod D, Jarvis B. Topical aminolevulinic acid HCl photodynamic therapy. Am J Clin Dermatol 2000; 1: 133-139.
8. Stringer MR, Robinson DJ, Hudson EJ, Smith MA. In vivo monitoring of photosensitiser fluorescence during photodynamic therapy. Proc SPIE 1995; 2371: 104-108.
9. Orenstein A, Kostenich G, Malik Z. The kinetics of protoporphyrin fluorescence during ALA-PDT in human malignant skin tumours. Cancer Lett 1997; 120: 229-234.
10. af Klinteberg C, Enejder AMK, Wang I, Andersson-Engels S, Svanberg S, Svanberg K. Kinetic fluorescence studies of 5-aminolaevulinic acid-induced protoporphyrin IX accumulation in basal cell carcinomas. J Photochem Photobiol B 1999; 49: 120-128.
11. Jongen AJL, Sterenborg HJCM. Mathematical description of photobleaching in vivo describing the influence of tissue optics on measured fluorescence signals. Phys Med Biol. 1997; 42: 1701-1716.
12. Hewett J, Nadeau V, Ferguson J, et al. The application of a compact multispectral imaging system with integrated excitation source to in vivo monitoring of fluorescence during topical photodynamic therapy of superficial skin cancers. Photochem Photobiol 2001; 73: 278-282.
13. Jacques SL, Joseph R, Gofstein G. How photobleaching affects dosimetry and fluorescence monitoring of PDT in turbid media. Proc SPIE 1993; 1881: 168-179.
14. Robinson DJ, de Bruijn HS, van der Veen N, Stringer MR, Brown SB, Star WM. Fluorescence photobleaching of ALA-induced protoporphyrin IX during photodynamic therapy of normal hairless mouse skin: the effect of light dose and irradiance and the resulting biological effect. Photochem Photobiol 1998; 67: 140-149.
15. Sorensen R, Iani V, Moan J. Kinetics of photobleaching of protoporphyrin IX in the skin of nude mice exposed to different fluence rates of red light. Photochem Photobiol 1998; 68: 835-840.
16. Robinson DJ, de Bruijn HS, van der Veen N, Stringer MR, Brown SB, Star WM. Protoporphyrin IX fluorescence photobleaching during ALA-mediated photodynamic therapy of UVB-induced tumours in hairless mouse skin. Photochem Photobiol 1999; 69: 61-70.
17. Robinson DJ, de Bruijn HS, de Wolf WJ, Sterenborg HJCM, Star WM. Topical 5-aminolevulinic acid-photodynamic therapy of hairless mouse skin using two-fold illumination schemes: PpIX fluorescence kinetics, photobleaching and biological effect. Photochem Photobiol 2000; 72: 794-802.
18. Finlay JC, Cordover DL, Hull EL, Foster TH. Porphyrin bleaching and PDT-induced spectral changes are irradiance dependent in ALA-sensitized normal rat skin in vivo. Photochem Photobiol 2001; 73: 54-63.
19. Iinuma S, Schomacker KT, Wagnieres G, Rajadhyaksha M, Bamberg M, Momma T, Hasan T. In vivo fluence rate and fractionation effects on tumour response and photobleaching: photodynamic therapy with two photosensitizers in an orthotopic rat tumor model. Cancer Res 1999; 59: 6164-6170.
20. Moan J, Streckyte G, Bagdonas S, Bech O, Berg K. Photobleaching of protoporphyrin IX in cells incubated with 5-aminolevulinic acid. Int J Cancer 1997; 70: 90-97.
21. Nadeau V, Hamdan K, Hewett J, et al. Endoscopic fluorescence imaging and point spectroscopy system for the detection of gastro-intestinal cancers. Journal of Modern Optics 2002; 49: 731-741.
22. Gustafsson U, Paalsson S, Svanberg S. Compact fiber-optic fluorosensor using a continuous-wave violet diode laser and an integrated spectrometer. Rev Sci Instrum 2000; 71: 3004-3006.
23. Langmack K, Metha R, Twyman P, Norris P. Topical photodynamic therapy at low fluence rates - theory and practice. J Photochem Photobiol B 2001; 60: 37-43.