Cross tolerance to salbutamol occurs independently of β2 adrenoceptor genotype-16 in asthmatic patients receiving regular formoterol or salmeterol

Thorax

Volumn 59, Issue 8, 2004, Pages 662-667

  Lee, D K C ^a   Jackson, C M ^b   Bates, C E ^a   Lipworth, B J ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BUDESONIDE; BUDESONIDE PLUS FORMOTEROL; CORTICOSTEROID; FLUTICASONE PROPIONATE; FLUTICASONE PROPIONATE PLUS SALMETEROL; FORMOTEROL; IPRATROPIUM BROMIDE; METHACHOLINE; MONTELUKAST; PLACEBO; SALBUTAMOL; SALMETEROL; THEOPHYLLINE;

ADULT; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG RESPONSE; DRUG TOLERANCE; FEMALE; GENOTYPE; HUMAN; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADRENERGIC BETA-AGONISTS; ADULT; AGED; ALBUTEROL; ASTHMA; BRONCHODILATOR AGENTS; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DRUG TOLERANCE; ETHANOLAMINES; FEMALE; FORCED EXPIRATORY VOLUME; GENOTYPE; HOMOZYGOTE; HUMANS; MALE; MIDDLE AGED; PEAK EXPIRATORY FLOW RATE; RECEPTORS, ADRENERGIC, BETA-2;

EID: 4043128076     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.2003.019059     Document Type: Article

References (27)

1. Green SA, Cole G, Jacinto M, et al. A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor. J Biol Chem 1993;268:23116-21.
2. Green SA, Turki J, Bejarano P, et al. Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells. Am J Respir Cell Mol Biol 1995;13:25-33.
3. Tan S, Hall IP, Dewar J, et al. Association between beta 2-adrenoceptor polymorphism and susceptibility to bronchodilator desensitisation in moderately severe stable asthmatics. Lancet 1997;350:995-9.
4. Martinez FD, Graves PE, Baldini M, et al. Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing. J Clin Invest 1997;100:3184-8.
5. Lima JJ, Thomason DB, Mohamed MH, et al. Impact of genetic polymorphisms of the beta2-adrenergic receptor on albuterol bronchodilator pharmacodynamics. Clin Pharmacol Ther 1999;65:519-25.
6. Israel E, Drazen JM, Liggett SB, et al. The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma. Am J Respir Crit Care Med 2000;162:75-80.
7. Taylor DR, Drazen JM, Herbison GP, et al. Asthma exacerbations during long term beta agonist use: influence of beta(2) adrenoceptor polymorphism. Thorax 2000;55:762-7.
8. National Asthma Education and Prevention Program. Expert Panel Report: Guidelines for the diagnosis and management or asthma update on selected topics-2002. J Allergy Clin Immunol 2002;110:S141-219.
9. British Thoracic Society/Scottish Intercollegiate Guidelines Network. British guideline on the management of asthma. Thorax 2003;58(Suppl 1):i1-94.
10. Lee DK, Jackson CM, Currie GP, et al. Comparison of combination inhalers versus inhaled corticosteroids alone in moderate persistent asthma. Br J Clin Pharmacol 2003;56:494-500.
11. 2 agonists. Thorax 2001;56:529-35.
12. American Thoracic Society. Standardization of spirometry: 1994 update. Am J Respir Crit Care Med 1995;152:1107-36.
13. Lipworth BJ, Aziz I. A high dose of albuterol does not overcome bronchoprotective subsensitivity in asthmatic subjects receiving regular salmeterol or formoterol. J Allergy Clin Immunol 1999;103:88-92.
14. Kalra S, Swystun VA, Bhagat R, et al. Inhaled corticosteroids do not prevent the development of tolerance to the bronchoprotective effect of salmeterol. Chest 1996;109:953-6.
15. Grove A, Lipworth BJ. Bronchodilator subsensitivity to salbutamol after twice daily salmeterol in asthmatic patients. Lancet 1995;346:201-6.
16. Newnham DM, McDevitt DG, Lipworth BJ. Bronchodilator subsensitivity after chronic dosing with eformoferol in patients with asthma. Am J Med 1994;97:29-37.
17. Newnham DM, Grove A, McDevitt DG, et al. Subsensitivity of bronchodilator and systemic beta 2 adrenoceptor responses after regular twice daily treatment with eformoterol dry powder in asthmatic patients. Thorax 1995;50:497-504.
18. Grove A, Lipworth BJ. Evaluation of the beta 2 adrenoceptor agonist/ antagonist activity of formoterol and salmeterol. Thorax 1996;51:54-8.
19. Aziz I, Lipworth BJ. In vivo effect of albuterol on methacholine- contracted bronchi in conjunction with salmeterol and formoterol. J Allergy Clin Immunol 1999;103:816-22.
20. Hanania NA, Sharafkhaneh A, Barber R, et al. Beta-agonist intrinsic efficacy: measurement and clinical significance. Am J Respir Crit Care Med 2002;165:1353-8.
21. Pauwels RA, Lofdahl CG, Postma DS, et al. Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group. N Engl J Med 1997;337:1405-11.
22. Drysdale CM, McGraw DW, Stack CB, et al. Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc Natl Acad Sci USA 2000;97:10483-8.
23. Dishy V, Sofowora GG, Xie HG, et al. The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitization. N Engl J Med 2001;345:1030-5.
24. Dewar JC, Wheatley AP, Venn A, et al. Beta2-adrenoceptor polymorphisms are in linkage disequilibrium but are not associated with asthma in an adult population. Clin Exp Allergy 1998;28:442-8.
25. Linden A, Bergendal A, Ullman A, et al. Salmeterol, formoterol, and salbutamol in the isolated guinea pig trachea: differences in maximum relaxant effect and potency but not in functional antagonism. Thorax 1993;48:547-53.
26. Lipworth BJ, Dempsey OJ, Aziz I. Functional antagonism with formoterol and salmeterol in asthmatic patients expressing the homozygous glycine-16 beta(2)-adrenoceptor polymorphism. Chest 2000;118:321-8.
27. 2-adrenoceptor: regulation and bronchodilatation. Eur J Clin Pharmacol 1999;55:431-6.