Functional antagonism with formoterol and salmeterol in asthmatic patients expressing the homozygous glycine-16 β2-adrenoceptor polymorphism

Chest

Volumn 118, Issue 2, 2000, Pages 321-328

  Lipworth, Brian J ^a   Dempsey, Owen J ^a   Aziz, Imran ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Asthma; Formoterol; Methacholine; Polymorphism; Sal meterol; 2 adrenoceptor

Indexed keywords

BECLOMETASONE DIPROPIONATE; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; CORTICOSTEROID; FLUTICASONE; FORMOTEROL; FORMOTEROL FUMARATE; GLYCINE; IPRATROPIUM BROMIDE; METHACHOLINE; PLACEBO; SALBUTAMOL; SALMETEROL XINAFOATE; TERBUTALINE;

ADULT; ARTICLE; ASTHMA; BRONCHOSPASM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; FEMALE; FORCED EXPIRATORY FLOW; FORCED EXPIRATORY VOLUME; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; INHALATION TEST; INTRINSIC SYMPATHOMIMETIC ACTIVITY; MALE; PEAK EXPIRATORY FLOW; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECEPTOR DOWN REGULATION; VITAL CAPACITY;

EID: 0033883483     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.118.2.321     Document Type: Article

References (32)

1. 1 National Asthma Education and Prevention Program. Expert panel report 2: guidelines for the diagnosis and management of asthma. Bethesda, MD: National Institutes of Health, April 1997; Publication No. 97-4051
2. 2 Greening AP, Ind PW, Northfield M, et al. Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid. Lancet 1994; 344:219-224
3. 3 Woolcock A, Lundback B, Ringdal N, et al. Comparison of addition of salmeterol to inhaled steroids with doubling of the dose of inhaled steroids. Am J Respir Crit Care Med 1996; 153:1481-1488
4. 4 Pauwels R, Lofdahl CG, Postma D, et al. Effect of inhaled formoterol and budesonide on exacerbations of asthma. N Engl J Med 1997; 337:1405-1411
5. 5 Van Noord JA, Schrereus AJM, Mol SJM, et al. Addition of salmeterol versus doubling the dose of fluticasone propionate in patients with mild to moderate asthma. Thorax 1999; 54:207-209
6. 2-adrenoceptor agonist: interactions in human-contracted bronchi. Eur Respir J 1998; 11:583-588
7. 2-agonists: is there cause for concern? Drug Safety 1997; 16:295-308
8. 2-adrenergic receptor genotypes on signal transduction in human airways smooth muscle cells. Am J Respir Cell Mol Biol 1995; 13:25-33
9. 2-adrenoceptor polymorphism is associated with elevated IgE levels in asthmatic families. J Allergy Clin Immunol 1997; 100:261-265
10. 2-adrenoceptor polymorphism and susceptibility to bronchodilator desensitization in moderately severe stable asthmatics. Lancet 1997; 350:995-999
11. 2-agonist therapy. Clin Sci 1999; 96:253-259
12. 12 American Thoracic Society. Standards for diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am Rev Respir Dis 1997; 136:225-244
13. 13 American Thoracic Society. Standardization of spirometry: update. Am Rev Respir Dis 1987; 136:1285-1298
14. 14 Beach JR, Jung CL, Avery HA, et al. Measurement of airway responsiveness to methacholine: relative importance of the precision of drug delivery and the method of assessing response. Thorax 1993; 418:239-243
15. 2-adenoceptor polymorphisms are in linkage disequilibrium but are not associated with asthma in an adult population. Clin Exp Allergy 1998; 28:442-448
16. 2-adrenoceptor regulation and bronchodilation. Eur J Clin Pharmacol 1999; 55:431-436
17. 17 Rabe KF, Jorres R, Nowak D, et al. Comparison of the effects of salmeterol and formoterol on airway tone and responsiveness over 24 hours in bronchial asthma. Am Rev Respir Dis 1993; 147:1436-1441
18. 18 Lipworth BJ, Aziz I. A high dose of albuterol does not overcome bronchoprotective subsensitivity in asthmatic patients receiving regular salmeterol or formoterol. J Allergy Clin Immunol 1999; 103:88-92
19. 19 Lipworth B, Tan S, Devlin M, et al. Effects of treatment with formoterol on bronchoprotection against methacholine. Am J Med 1998; 104:431-438
20. 2-adrenoceptor agonist, salmeterol on airway hyperresponsiveness in patients with mild asthma. N Engl J Med 1992; 327:1198-1203
21. 21 Kalra S, Swyston VA, Bhagat R, et al. Inhaled steroids do not prevent the development of tolerance to the bronchoprotective effect of salmeterol. Chest 1996; 109:953-956
22. 22 Drotar DE, David EE, Cockcroft DW. Tolerance to the bronchoprotective effect of salmeterol 12 hours after starting twice daily treatment. Ann Allergy Asthma Immunol 1998; 80:31-34
23. 2-adrenoceptors in asthmatic patients. Chest 1999; 115:324-328
24. 2-adrenoceptor and response to albuterol in children with and without a history of wheezing. J Clin Invest 1997; 100:3184-3188
25. 2-adrenoceptor responses after regular twice daily treatment with eformoterol dry powder in asthmatic patients. Thorax 1995; 50:497-504
26. 26 Newnham DM, McDevitt DG, Lipworth BJ. Bronchodilator subsensitivity after chronic dosing with eformoterol in patients with asthma. Am J Med 1994; 97:29-37
27. 27 Tan KS, Grove A, McLean A, et al. Systemic corticosteroid rapidly reverses bronchodilator subsensitivity induced by formoterol in asthmatic patients. Am J Respir Crit Care Med 1997; 156:28-35
28. 28 Grove A, Lipworth BJ. Bronchodilator subsensitivity to inhaled salbutamol after twice daily salmeterol in asthmatic patients. Lancet 1995; 346:201-216
29. 29 Langley SJ, Masterson CM, Batty EP, et al. Bronchodilator response to salbutamol after chronic dosing with salmeterol or placebo. Eur Respir J 1998; 11:1081-1085
30. 30 Wilding P, Clark M, Coon J, et al. Effects of long term treatments with salmeterol and asthma control: a double blind randomised crossover study. BMJ 1997; 314:1441-1446
31. 31 Fuglsang G, Vikre-Jorgensen J, Pedersen S. Effect of salmeterol treatment on nitric oxide level in exhaled air and dose-response to terbutaline in children with mild asthma. Pediatr Pulmonol 1998; 25:314-321
32. 32 Nelson HS, Berkowitz RB, Tinkleman DA, et al. Lack of subsensitivity to albuterol after treatment with salmeterol in patients with asthma. Am J Respir Crit Care Med 1999; 159:1556-1561