IL-5 links adaptive and natural immunity in reducing atherosclerotic disease

Journal of Clinical Investigation

Volumn 114, Issue 3, 2004, Pages 317-319

  Daugherty, Alan ^a,b   Rateri, Debra L ^a   King, Victoria L ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; APOLIPOPROTEIN E; AUTOANTIBODY; CD28 ANTIGEN; CYTOKINE; IMMUNOGLOBULIN G1 ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 5; LIPID; LOW DENSITY LIPOPROTEIN RECEPTOR; MALONALDEHYDE; OXIDIZED LOW DENSITY LIPOPROTEIN; PHOSPHOLIPID; SCAVENGER RECEPTOR;

ANTIBODY PRODUCTION; ANTIBODY TITER; ATHEROSCLEROSIS; B LYMPHOCYTE; CELLULAR IMMUNITY; HUMAN; HUMORAL IMMUNITY; IMMUNE SYSTEM; IMMUNITY; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE;

ANIMALS; ANTIBODY FORMATION; APOLIPOPROTEINS E; ARTERIOSCLEROSIS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, NATURAL; INTERLEUKIN-5; LIPOPROTEINS, LDL; MALONDIALDEHYDE; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; RECEPTORS, LDL; TH2 CELLS;

EID: 4043102054     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200422561     Document Type: Review

References (18)

1. Hentiksen, T., Mahoney, E.M., and Steinberg, D. 1981. Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: Recognition by receptors for acetylated low density lipoproteins. Proc. Natl. Acad. Sci. U. S. A. 78:6499-6503.
2. Steinberg, D., Parthasarathy, S., Carew, T.E., Khoo, J.C., and Witztum, J.L. 1989. Beyond cholesterol. Modifications of low density lipoprotein that increase its atherogenicity. N. Engl. J. Med. 320:915-924.
3. Stemme, S., et al. 1995. T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein. Proc. Natl. Acad. Sci. U. S. A. 92:3893-3897.
4. Palinski, W., et al. 1989. Low density lipoprotein undergoes oxidative modification in vivo. Proc. Natl. Acad. Sci. U. S. A. 86:1372-1376.
5. Salonen, J.T., et al. 1992. Autoantibody against oxidised LDL and progression of carotid atherosclerosis. Lancet. 339:883-887.
6. Palinski, W., Miller, E., and Witztum, J.L. 1995. Immunization of low density lipoprotein (LDL) receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesis. Proc. Natl. Acad. Sci. U. S. A. 92:821-825.
7. Ameli, S., et al. 1996. Effect of immunization with homologous LDL and oxidized LDL on early atherosclerosis in hypercholesterolemic rabbits. Arterioscler. Thromb. Vasc. Biol. 16:1074-1079.
8. Freigang, S., Horkko, S., Miller, E., Witztum, J.L., and Palinski, W. 1998. Immunization of LDL receptor-deficient mice with homologous malondialdehyde-modified and native LDL reduces progression of atherosclerosis by mechanisms other than induction of high titers of antibodies to oxidative neoepitopes. Arterioscler. Thromb. Vasc. Biol. 18:1972-1982.
9. Palinski, W., et al. 1994. ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis - Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum. Arterioscler. Thromb. 14:605-616.
10. Palinski, W., et al. 1996. Cloning of monoclonal autoantibodies to epitopes of oxidized lipoproteins from apolipoprotein E-deficient mice - Demonstration of epitopes of oxidized low density lipoprotein in human plasma. J. Clin. Invest. 98:800-814.
11. Horkko, S., et al. 1999. Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins. J. Clin. Invest. 103:117-128.
12. Shaw, P.X., et al. 2000. Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity. J. Clin. Invest. 105:1731-1740.
13. Binder, C.J., et al. 2003. Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat. Med. 9:736-743.
14. Binder, C.J., et al. 2004. IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. J. Clin. Invest. 114:427-437. doi:10.1172/JCI200420479.
15. Zhou, X.H., Paulsson, G., Stemme, S., and Hansson, G.K. 1998. Hypercholesterolemia is associated with a T helper (Th) 1/TH2 switch of the autoimmune response in atherosclerotic apoE-knockout mice. J. Clin. Invest. 101:1717-1725.
16. Pinderski, L.J., et al. 2002. Overexpression of interleukin-10 by activated T lymphocytes inhibits atherosclerosis in LDL receptor-deficient mice by altering lymphocyte and macrophage phenotypes. Circ. Res. 90:1064-1071.
17. Pinderski-Oslund, L.J., et al. 1999. Interleukin-10 blocks atherosclerotic events in vitro and in vivo. Arterioscler. Thromb. Vasc. Biol. 19:2847-2853.
18. Mallat, Z., et al. 1999. Protective role of interleukin-10 in atherosclerosis. Circ. Res. 85:E17-E24.